S0-EE-YRH3_1uM Gene Set

Dataset NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category transcriptomics
Type drug perturbation
Description Dose=1uM, [3-[[4-(aminomethyl)-1-(5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carbonyl]amino]phenyl] N,N-dimethylcarbamate, LIMK2 gene inhibitor;LIMK1 gene inhibitor targeting LIMK1, LIMK2 (Novartis, 127047919)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/127047919
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Genes

119 genes differentially expressed following the S0-EE-YRH3_1uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol Name Standardized Value
TIMP1 TIMP metallopeptidase inhibitor 1 1.83866
NMUR2 neuromedin U receptor 2 1.38164
RPS14 ribosomal protein S14 1.27029
RPL18 ribosomal protein L18 1.16045
RPS18 ribosomal protein S18 1.08981
MT2A metallothionein 2A 1.0477
ATOX1 antioxidant 1 copper chaperone 0.866256
RPS5 ribosomal protein S5 0.676131
CCDC85B coiled-coil domain containing 85B 0.554515
LGALS1 lectin, galactoside-binding, soluble, 1 0.54997
RPL8 ribosomal protein L8 0.548088
RPLP2 ribosomal protein, large, P2 0.544607
FBXL15 F-box and leucine-rich repeat protein 15 0.540994
RABAC1 Rab acceptor 1 (prenylated) 0.540266
TSTD1 thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 0.520356
ZNHIT1 zinc finger, HIT-type containing 1 0.510774
RPL38 ribosomal protein L38 0.491579
A1BG alpha-1-B glycoprotein 0.466515
MRPL41 mitochondrial ribosomal protein L41 0.446681
ELOB elongin B 0.418278
OBSL1 obscurin-like 1 0.386293
TMEM205 transmembrane protein 205 0.382212
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa 0.382212
GSN gelsolin 0.356734
SYTL3 synaptotagmin-like 3 0.356734
OST4 oligosaccharyltransferase 4 homolog (S. cerevisiae) 0.35478
STMN4 stathmin-like 4 0.344492
METRN meteorin, glial cell differentiation regulator 0.344492
SF3B5 splicing factor 3b, subunit 5, 10kDa 0.324558
RPL28 ribosomal protein L28 0.324558
CKB creatine kinase, brain 0.323936
FOLR2 folate receptor 2 (fetal) 0.312375
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.312375
POLR2J polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa 0.305119
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 0.303667
RPS16 ribosomal protein S16 0.30241
BLVRB biliverdin reductase B 0.29682
MRPL52 mitochondrial ribosomal protein L52 0.287945
TMEM256 transmembrane protein 256 0.286085
RPL36 ribosomal protein L36 0.285293
RPS15 ribosomal protein S15 0.282058
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) 0.271029
FBXW5 F-box and WD repeat domain containing 5 0.266481
TRPV2 transient receptor potential cation channel, subfamily V, member 2 0.259679
COX5B cytochrome c oxidase subunit Vb 0.258718
LAMTOR4 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 0.258718
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI 0.256271
MYCT1 myc target 1 0.251189
TGFBI transforming growth factor, beta-induced, 68kDa 0.245375
ROMO1 reactive oxygen species modulator 1 0.236445
MRPS34 mitochondrial ribosomal protein S34 0.228136
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa 0.222473
PPM1J protein phosphatase, Mg2+/Mn2+ dependent, 1J 0.214995
CLU clusterin 0.212337
SPANXB1 SPANX family, member B1 0.203586

decreased expression

Symbol Name Standardized Value
GLS2 glutaminase 2 (liver, mitochondrial) -0.73884
TNNT2 troponin T type 2 (cardiac) -0.708682
ZNF410 zinc finger protein 410 -0.644277
SMIM29 small integral membrane protein 29 -0.587544
SMYD2 SET and MYND domain containing 2 -0.575848
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) -0.544879
NEK6 NIMA-related kinase 6 -0.50665
SKI SKI proto-oncogene -0.446681
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) -0.444461
SUMO2 small ubiquitin-like modifier 2 -0.421906
ORMDL1 ORMDL sphingolipid biosynthesis regulator 1 -0.418278
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) -0.406471
GPC1 glypican 1 -0.39389
WIZ widely interspaced zinc finger motifs -0.385717
CXXC5 CXXC finger protein 5 -0.385717
GNAS GNAS complex locus -0.384609
MYH9 myosin, heavy chain 9, non-muscle -0.38126
TMSB4X thymosin beta 4, X-linked -0.38043
ANXA8L1 annexin A8-like 1 -0.377034
AVEN apoptosis, caspase activation inhibitor -0.35478
FSTL1 follistatin-like 1 -0.344492
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 -0.333245
MARCKSL1 MARCKS-like 1 -0.327949
MMP23B matrix metallopeptidase 23B -0.315977
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.312375
BBC3 BCL2 binding component 3 -0.312375
SRSF2 serine/arginine-rich splicing factor 2 -0.306878
SPATS2L spermatogenesis associated, serine-rich 2-like -0.305119
MAB21L4 mab-21 like 4 -0.303189
MEPCE methylphosphate capping enzyme -0.30241
HEBP2 heme binding protein 2 -0.299207
UBE2H ubiquitin-conjugating enzyme E2H -0.295641
CEBPD CCAAT/enhancer binding protein (C/EBP), delta -0.292777
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) -0.281378
ELAVL1 ELAV like RNA binding protein 1 -0.277702
PMF1-BGLAP PMF1-BGLAP readthrough -0.271029
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.269395
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit -0.267743
FAAP24 FA core complex associated protein 24 -0.267239
SEPTIN7 septin 7 -0.266358
IFT20 intraflagellar transport 20 -0.259679
TBC1D14 TBC1 domain family, member 14 -0.259679
PEF1 penta-EF-hand domain containing 1 -0.251189
DNAL4 dynein, axonemal, light chain 4 -0.242551
RPL4 ribosomal protein L4 -0.236445
ANXA2 annexin A2 -0.235687
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.235687
ZNF740 zinc finger protein 740 -0.227445
KPNB1 karyopherin (importin) beta 1 -0.225801
AP1M2 adaptor-related protein complex 1, mu 2 subunit -0.222134
AOPEP aminopeptidase O (putative) -0.222126
ADI1 acireductone dioxygenase 1 -0.221003
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B -0.221003
SYNPO synaptopodin -0.218589
TWSG1 twisted gastrulation BMP signaling modulator 1 -0.216375
PGAM4 phosphoglycerate mutase family member 4 -0.214241
DDIT4 DNA-damage-inducible transcript 4 -0.213918
CDK4 cyclin-dependent kinase 4 -0.212337
CPA4 carboxypeptidase A4 -0.211065
FBXL12 F-box and leucine-rich repeat protein 12 -0.209697
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 -0.205421
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase -0.202496
TYMS thymidylate synthetase -0.202042
SEPTIN2 septin 2 -0.200805