S100A6 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description S100 calcium binding protein A6|The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6277)
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Genes

343 genes differentially expressed following the S100A6 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
BLNK B-cell linker 2.77469
NPFFR1 neuropeptide FF receptor 1 2.77469
MMP12 matrix metallopeptidase 12 2.77469
KLF5 Kruppel-like factor 5 (intestinal) 2.77469
C11ORF87 chromosome 11 open reading frame 87 2.77469
GDPD4 glycerophosphodiester phosphodiesterase domain containing 4 2.77469
RASSF10 Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 2.77469
DNAI2 dynein, axonemal, intermediate chain 2 2.77469
ANKRD55 ankyrin repeat domain 55 2.77469
ZNF311 zinc finger protein 311 2.77469
POTEJ POTE ankyrin domain family, member J 2.77469
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G 2.77469
RGS22 regulator of G-protein signaling 22 2.77469
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 2.77469
LIPH lipase, member H 2.77469
DRC1 dynein regulatory complex subunit 1 2.77469
DIO1 deiodinase, iodothyronine, type I 2.77469
HIC1 hypermethylated in cancer 1 2.77469
ARR3 arrestin 3, retinal (X-arrestin) 2.77469
ACVRL1 activin A receptor type II-like 1 2.77469
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 2.77469
IRF2-DT IRF2 divergent transcript 2.77469
FSCN3 fascin actin-bundling protein 3, testicular 2.77469
TSNAXIP1 translin-associated factor X interacting protein 1 2.77469
RASL10A RAS-like, family 10, member A 2.77469
GSTM5 glutathione S-transferase mu 5 2.74397
AFM afamin 2.74397
SELPLG selectin P ligand 2.74397
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 2.74397
OR52H1 olfactory receptor, family 52, subfamily H, member 1 2.74397
SCG2 secretogranin II 2.74397
UNC13C unc-13 homolog C (C. elegans) 2.74397
TM4SF1 transmembrane 4 L six family member 1 2.74397
PCDHB7 protocadherin beta 7 2.74397
HCRTR1 hypocretin (orexin) receptor 1 2.74397
PLIN1 perilipin 1 2.74397
HES3 hes family bHLH transcription factor 3 2.74397
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 2.74397
CCL1 chemokine (C-C motif) ligand 1 2.74397
FFAR4 free fatty acid receptor 4 2.74397
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.74397
PTGER3 prostaglandin E receptor 3 (subtype EP3) 2.74397
PCDH8 protocadherin 8 2.74397
CRX cone-rod homeobox 2.74397
OCSTAMP osteoclast stimulatory transmembrane protein 2.74397
DPPA3 developmental pluripotency associated 3 2.74397
DLL4 delta-like 4 (Drosophila) 2.74397
S100A7 S100 calcium binding protein A7 2.74397
LRRC61 leucine rich repeat containing 61 2.74397
BHMT2 betaine--homocysteine S-methyltransferase 2 2.74397
C3ORF22 chromosome 3 open reading frame 22 2.74397
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 2.74397
SFTPB surfactant protein B 2.74397
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 2.74397
SIGLEC7 sialic acid binding Ig-like lectin 7 2.74397
F2 coagulation factor II (thrombin) 2.74397
ASB14 ankyrin repeat and SOCS box containing 14 2.74397
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 2.74397
TNIP3 TNFAIP3 interacting protein 3 2.74397
RFPL3 ret finger protein-like 3 2.74397
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 2.74397
POSTN periostin, osteoblast specific factor 2.74397
RAPSN receptor-associated protein of the synapse 2.74397
MSC musculin 2.74397
SPATA31G1 SPATA31 subfamily G member 1 2.74397
GGTA1 glycoprotein alpha-galactosyltransferase 1 (inactive) 2.74397
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 2.74397
SPATS1 spermatogenesis associated, serine-rich 1 2.74397
HTATSF1 HIV-1 Tat specific factor 1 2.74397
GPR35 G protein-coupled receptor 35 2.74397
PNLIPRP1 pancreatic lipase-related protein 1 2.74397
C20ORF202 chromosome 20 open reading frame 202 2.74397
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) 2.74397
TMPRSS3 transmembrane protease, serine 3 2.74397
MYEOV myeloma overexpressed 2.74397
DOK3 docking protein 3 2.74397
MATCAP2 microtubule associated tyrosine carboxypeptidase 2 2.74397
RTL9 retrotransposon Gag like 9 2.74397
SPMAP2L sperm microtubule associated protein 2 like 2.74397
OR56B2 olfactory receptor family 56 subfamily B member 2 2.74397
SPEGNB SPEG neighbor 2.74397
MAP3K4-AS1 MAP3K4 antisense RNA 1 2.74397
C1ORF232 chromosome 1 open reading frame 230 2.74397
C17ORF113 chromosome 17 open reading frame 113 2.74397
MDFIC2 MyoD family inhibitor domain containing 2 2.74397
MUCL3 mucin like 3 2.74397
CFAP299 cilia and flagella associated protein 299 2.74397
GARIN6 golgi associated RAB2 interactor family member 6 2.74397
DUSP29 dual specificity phosphatase 29 2.74397
GPR37L1 G protein-coupled receptor 37 like 1 2.74397
ZNF705D zinc finger protein 705D 2.74397
MEOX1 mesenchyme homeobox 1 2.74397
LIX1 Lix1 homolog (chicken) 2.74397
CCDC17 coiled-coil domain containing 17 2.74397
ARL5C ADP-ribosylation factor-like 5C 2.74397
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 2.74397
MTNR1B melatonin receptor 1B 2.74397
CXCL16 chemokine (C-X-C motif) ligand 16 2.74397
ELAVL4 ELAV like neuron-specific RNA binding protein 4 2.74397
HHEX hematopoietically expressed homeobox 2.74397
OR2A25 olfactory receptor, family 2, subfamily A, member 25 2.74397
FPR2 formyl peptide receptor 2 2.74397
CD79A CD79a molecule, immunoglobulin-associated alpha 2.74397
CATSPER3 cation channel, sperm associated 3 2.74397
KL klotho 2.74397
CSAG3 CSAG family, member 3 2.74397
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 2.74397
UGT2A1 UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus 2.74397
HNF1B HNF1 homeobox B 2.74397
PABPC1L2A poly(A) binding protein, cytoplasmic 1-like 2A 2.74397
ALG10B ALG10B, alpha-1,2-glucosyltransferase 2.74397
GZMM granzyme M (lymphocyte met-ase 1) 2.74397
AWAT1 acyl-CoA wax alcohol acyltransferase 1 2.74397
TLR7 toll-like receptor 7 2.74397
POLR2D polymerase (RNA) II (DNA directed) polypeptide D 2.74397
KLHL35 kelch-like family member 35 2.74397
ZMYND15 zinc finger, MYND-type containing 15 2.74397
TDRD10 tudor domain containing 10 2.74397
CYS1 cystin 1 2.74397
FAM209B family with sequence similarity 209, member B 2.74397
DRD2 dopamine receptor D2 2.74397
CRHR1 corticotropin releasing hormone receptor 1 2.74397
LMOD3 leiomodin 3 (fetal) 2.74397
VWA3A von Willebrand factor A domain containing 3A 2.74397
BCO1 beta-carotene oxygenase 1 2.74397
MS4A7 membrane-spanning 4-domains, subfamily A, member 7 2.74397
ISL2 ISL LIM homeobox 2 2.74397
BPIFB4 BPI fold containing family B, member 4 2.74397
THTPA thiamine triphosphatase 2.74397
PLEKHS1 pleckstrin homology domain containing, family S member 1 2.74397
MPZL1 myelin protein zero-like 1 2.74397
PCDHGB2 protocadherin gamma subfamily B, 2 2.74397
GAL3ST2 galactose-3-O-sulfotransferase 2 2.74397
CTF1 cardiotrophin 1 2.74397
ZNF132 zinc finger protein 132 2.74397
CDR2L cerebellar degeneration-related protein 2-like 2.74397
BTN2A1 butyrophilin, subfamily 2, member A1 2.74397
MYADML2 myeloid-associated differentiation marker-like 2 2.74397
SV2C synaptic vesicle glycoprotein 2C 2.74397
TEKT2 tektin 2 (testicular) 2.74397
CHI3L2 chitinase 3-like 2 2.74397
TRIM7 tripartite motif containing 7 2.74397
TYR tyrosinase 2.74397
TSPAN16 tetraspanin 16 2.74397
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 2.74397
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 2.74397
IL26 interleukin 26 2.74397
DRC7 dynein regulatory complex subunit 7 2.74397
TEX29 testis expressed 29 2.74397
ZNF835 zinc finger protein 835 2.74397
EIF4E1B eukaryotic translation initiation factor 4E family member 1B 2.74397
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 2.74397
NOBOX NOBOX oogenesis homeobox 2.74397
COL17A1 collagen, type XVII, alpha 1 2.74397
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C 2.74397
CFAP47 cilia and flagella associated protein 47 2.74397
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 2.74397
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 2.74397
GLRB glycine receptor, beta 2.74397
SMIM17 small integral membrane protein 17 2.74397
LRRC3 leucine rich repeat containing 3 2.74397
CTSW cathepsin W 2.74397
CTSS cathepsin S 2.74397
SLC13A4 solute carrier family 13 (sodium/sulfate symporter), member 4 2.74397
LHB luteinizing hormone beta polypeptide 2.74397
LOXL4 lysyl oxidase-like 4 2.74397
DEFB134 defensin, beta 134 2.74397
C5ORF46 chromosome 5 open reading frame 46 2.74397
VAC14 Vac14 homolog (S. cerevisiae) 2.74397
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6 2.74397
RAB7B RAB7B, member RAS oncogene family 2.74397
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase) 2.74397
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 2.74397
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 2.74397
AGBL4 ATP/GTP binding protein-like 4 2.74397
XCR1 chemokine (C motif) receptor 1 2.74397
SDSL serine dehydratase-like 2.74397
HRG histidine-rich glycoprotein 2.74397
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 2.74397
THSD1 thrombospondin, type I, domain containing 1 2.74397
RPEL1 ribulose-5-phosphate-3-epimerase-like 1 2.74397
SPHK1 sphingosine kinase 1 2.74397
STEAP4 STEAP family member 4 2.74397
SPAG8 sperm associated antigen 8 2.74397
ZNF319 zinc finger protein 319 2.74397
POU3F3 POU class 3 homeobox 3 2.74397
LST1 leukocyte specific transcript 1 2.74397
CLEC2A C-type lectin domain family 2, member A 2.74397
RNASE6 ribonuclease, RNase A family, k6 2.74397
RNASE7 ribonuclease, RNase A family, 7 2.74397
KLLN killin, p53-regulated DNA replication inhibitor 2.74397
PBK PDZ binding kinase 2.68569
GID4 GID complex subunit 4 2.64092
ESR2 estrogen receptor 2 (ER beta) 2.63219
CLCC1 chloride channel CLIC-like 1 2.62837
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4) 2.61312
PLIN4 perilipin 4 2.57944
ZBTB42 zinc finger and BTB domain containing 42 2.57944
HAPLN1 hyaluronan and proteoglycan link protein 1 2.57944
DYDC1 DPY30 domain containing 1 2.57944
FHOD1 formin homology 2 domain containing 1 2.5331
RPTOR regulatory associated protein of MTOR, complex 1 2.52931
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 2.51546
TBC1D30 TBC1 domain family, member 30 2.48629
ZNF71 zinc finger protein 71 2.44063
TALDO1 transaldolase 1 2.44063
MDFI MyoD family inhibitor 2.43789
MEIOSIN meiosis initiator 2.43716
ZMPSTE24 zinc metallopeptidase STE24 2.42431
MYO16 myosin XVI 2.4205
CHD5 chromodomain helicase DNA binding protein 5 2.4205
AFF2 AF4/FMR2 family, member 2 2.40276
TBCA tubulin folding cofactor A 2.38775
C9ORF72 chromosome 9 open reading frame 72 2.37516
ZSCAN9 zinc finger and SCAN domain containing 9 2.372
SHISA9 shisa family member 9 2.36199
PHETA1 PH domain containing endocytic trafficking adaptor 1 2.35115
ANKRD33 ankyrin repeat domain 33 2.35114
BTNL8 butyrophilin-like 8 2.33889
TMEM102 transmembrane protein 102 2.32261
OPRL1 opiate receptor-like 1 2.32261
PAM peptidylglycine alpha-amidating monooxygenase 2.32138
TMUB1 transmembrane and ubiquitin-like domain containing 1 2.30977
ZDHHC11 zinc finger, DHHC-type containing 11 2.30977
PHYKPL 5-phosphohydroxy-L-lysine phospho-lyase 2.29508
EHD2 EH-domain containing 2 2.27314
DISP1 dispatched homolog 1 (Drosophila) 2.24065
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 2.18219
PRKCB protein kinase C, beta 2.16941
RPL23A ribosomal protein L23a 2.14803
CHMP1B charged multivesicular body protein 1B 2.1276
DNAAF9 dynein axonemal assembly factor 9 2.11855
ZNF189 zinc finger protein 189 2.10143
DCXR dicarbonyl/L-xylulose reductase 2.08587
GLIS3 GLIS family zinc finger 3 2.08014
SLX4IP SLX4 interacting protein 2.06677
PHLDA1 pleckstrin homology-like domain, family A, member 1 2.06481
CDRT4 CMT1A duplicated region transcript 4 2.06034
DACH2 dachshund family transcription factor 2 2.05938
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 2.05443
CD24 CD24 molecule 2.05245
MAP1S microtubule-associated protein 1S 2.04963
PKD1L2 polycystic kidney disease 1-like 2 (gene/pseudogene) 2.03514
FBP1 fructose-1,6-bisphosphatase 1 2.03514
TACC3 transforming, acidic coiled-coil containing protein 3 2.02636
GRN granulin 2.00924
RGL1 ral guanine nucleotide dissociation stimulator-like 1 2.00566
DUSP18 dual specificity phosphatase 18 2.00566
UQCC2 ubiquinol-cytochrome c reductase complex assembly factor 2 2.00498

decreased expression

Symbol Name Standardized Value
CPM carboxypeptidase M -2.77469
GPR183 G protein-coupled receptor 183 -2.77469
ZFP28 ZFP28 zinc finger protein -2.77469
CABIN1 calcineurin binding protein 1 -2.74879
NPIPA7 nuclear pore complex interacting protein family, member A7 -2.74397
GOLGA6L7 golgin A6 family like 7 -2.74397
S100A6 S100 calcium binding protein A6 -2.74397
DCP1A decapping mRNA 1A -2.74397
TDRD6 tudor domain containing 6 -2.74397
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 -2.74397
PGBD4 piggyBac transposable element derived 4 -2.74397
FAM110D family with sequence similarity 110, member D -2.74397
MYL5 myosin, light chain 5, regulatory -2.74397
FLOT1 flotillin 1 -2.74397
LEP leptin -2.74397
ACRBP acrosin binding protein -2.74397
MAFA v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A -2.74397
WDR59 WD repeat domain 59 -2.74397
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) -2.74397
SERF1B small EDRK-rich factor 1B (centromeric) -2.74397
RHCG Rh family, C glycoprotein -2.74397
C9ORF43 chromosome 9 open reading frame 43 -2.74397
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 -2.74397
C17ORF114 chromosome 17 open reading frame 114 -2.74397
GDF9 growth differentiation factor 9 -2.74397
BHLHA9 basic helix-loop-helix family, member a9 -2.74397
TAS2R5 taste receptor, type 2, member 5 -2.74397
NVL nuclear VCP-like -2.74397
CD200 CD200 molecule -2.74397
TIAM2 T-cell lymphoma invasion and metastasis 2 -2.74397
AADACL3 arylacetamide deacetylase-like 3 -2.74397
HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2 -2.74397
TNC tenascin C -2.74397
ARHGAP11B Rho GTPase activating protein 11B -2.74397
C11ORF86 chromosome 11 open reading frame 86 -2.74397
TRIM73 tripartite motif containing 73 -2.74397
KCTD4 potassium channel tetramerization domain containing 4 -2.74397
ERICH6 glutamate-rich 6 -2.74397
GPR12 G protein-coupled receptor 12 -2.74397
ERVV-2 endogenous retrovirus group V, member 2 -2.74397
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1 -2.74397
CLEC4C C-type lectin domain family 4, member C -2.74397
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 -2.74397
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like -2.74397
INSL6 insulin-like 6 -2.74397
GFI1B growth factor independent 1B transcription repressor -2.74397
KLC3 kinesin light chain 3 -2.74397
GOLGA8H golgin A8 family, member H -2.74397
SUN3 Sad1 and UNC84 domain containing 3 -2.74397
C4ORF51 chromosome 4 open reading frame 51 -2.74397
PRKG2 protein kinase, cGMP-dependent, type II -2.74397
UBN2 ubinuclein 2 -2.73041
MUC19 mucin 19, oligomeric -2.66101
MROH8 maestro heat-like repeat family member 8 -2.66101
BIK BCL2-interacting killer (apoptosis-inducing) -2.58669
SUSD5 sushi domain containing 5 -2.58669
TCEANC transcription elongation factor A (SII) N-terminal and central domain containing -2.58669
AMBP alpha-1-microglobulin/bikunin precursor -2.58669
CNRIP1 cannabinoid receptor interacting protein 1 -2.58339
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) -2.56454
ACSS2 acyl-CoA synthetase short-chain family member 2 -2.47544
MBD5 methyl-CpG binding domain protein 5 -2.46413
SIGMAR1 sigma non-opioid intracellular receptor 1 -2.46413
CPNE2 copine II -2.45712
IRAK2 interleukin-1 receptor-associated kinase 2 -2.44532
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6 -2.44161
LIN7B lin-7 homolog B (C. elegans) -2.40725
SMIM29 small integral membrane protein 29 -2.39254
PRKD2 protein kinase D2 -2.38775
ALX3 ALX homeobox 3 -2.35834
CDK5RAP3 CDK5 regulatory subunit associated protein 3 -2.35115
DDRGK1 DDRGK domain containing 1 -2.33889
HSF2BP heat shock transcription factor 2 binding protein -2.311
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -2.27721
SLC41A1 solute carrier family 41 (magnesium transporter), member 1 -2.27489
LYSMD2 LysM, putative peptidoglycan-binding, domain containing 2 -2.24374
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive) -2.24374
C6ORF132 chromosome 6 open reading frame 132 -2.23439
TRIM5 tripartite motif containing 5 -2.21098
ADAP2 ArfGAP with dual PH domains 2 -2.19764
HLA-A major histocompatibility complex, class I, A -2.16142
JAM3 junctional adhesion molecule 3 -2.1562
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 -2.14803
MTMR9 myotubularin related protein 9 -2.11387
MRPL37 mitochondrial ribosomal protein L37 -2.10201
CKAP4 cytoskeleton-associated protein 4 -2.09891
ZNF763 zinc finger protein 763 -2.08005
DMXL2 Dmx-like 2 -2.07658
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae) -2.06478
ANK2 ankyrin 2, neuronal -2.05938
ALDH9A1 aldehyde dehydrogenase 9 family, member A1 -2.02636
ADGRL2 adhesion G protein-coupled receptor L2 -2.02636
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2 -2.01603
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -2.00924