SACS Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description sacsin molecular chaperone|This gene encodes the sacsin protein, which includes a UbL domain at the N-terminus, a DnaJ domain, and a HEPN domain at the C-terminus. The gene is highly expressed in the central nervous system, also found in skin, skeletal muscles and at low levels in the pancreas. This gene includes a very large exon spanning more than 12.8 kb. Mutations in this gene result in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), a neurodegenerative disorder characterized by early-onset cerebellar ataxia with spasticity and peripheral neuropathy. The authors of a publication on the effects of siRNA-mediated sacsin knockdown concluded that sacsin protects against mutant ataxin-1 and suggest that "the large multi-domain sacsin protein is able to recruit Hsp70 chaperone action and has the potential to regulate the effects of other ataxia proteins" (Parfitt et al., PubMed: 19208651). A pseudogene associated with this gene is located on chromosome 11. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013] (NCBI Entrez Gene Database, 26278)
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Genes

338 genes differentially expressed following the SACS gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
OR5P3 olfactory receptor, family 5, subfamily P, member 3 2.94904
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 2.94904
PEAR1 platelet endothelial aggregation receptor 1 2.94904
SH2D7 SH2 domain containing 7 2.94904
AADACL3 arylacetamide deacetylase-like 3 2.94904
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5 2.94904
PAX2 paired box 2 2.94904
PAX7 paired box 7 2.94904
FOLR2 folate receptor 2 (fetal) 2.94904
ASB14 ankyrin repeat and SOCS box containing 14 2.94904
SLC30A4 solute carrier family 30 (zinc transporter), member 4 2.94904
DDO D-aspartate oxidase 2.94904
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 2.94904
NECAB1 N-terminal EF-hand calcium binding protein 1 2.94904
FGF20 fibroblast growth factor 20 2.94904
UCN urocortin 2.94904
CHRNG cholinergic receptor, nicotinic, gamma (muscle) 2.94904
ZSCAN5B zinc finger and SCAN domain containing 5B 2.94904
IGFL3 IGF-like family member 3 2.94904
CD19 CD19 molecule 2.94904
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 2.94904
IL22RA1 interleukin 22 receptor, alpha 1 2.94904
PLIN1 perilipin 1 2.94904
GRIA2 glutamate receptor, ionotropic, AMPA 2 2.94904
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 2.94904
SFXN3 sideroflexin 3 2.94904
C1GALT1C1L C1GALT1-specific chaperone 1 like 2.94904
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 2.94904
LBX2 ladybird homeobox 2 2.94904
PRAMEF2 PRAME family member 2 2.94904
ASGR2 asialoglycoprotein receptor 2 2.94904
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 2.94904
PRR22 proline rich 22 2.94904
IL18R1 interleukin 18 receptor 1 2.94904
CLCF1 cardiotrophin-like cytokine factor 1 2.94904
TECTB tectorin beta 2.94904
LGR6 leucine-rich repeat containing G protein-coupled receptor 6 2.94904
GNG13 guanine nucleotide binding protein (G protein), gamma 13 2.94904
TAL2 T-cell acute lymphocytic leukemia 2 2.94904
C11ORF86 chromosome 11 open reading frame 86 2.94904
ASMT acetylserotonin O-methyltransferase 2.94904
C3ORF22 chromosome 3 open reading frame 22 2.94904
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 2.94904
RGPD3 RANBP2-like and GRIP domain containing 3 2.94904
ZNF324B zinc finger protein 324B 2.94904
TTPA tocopherol (alpha) transfer protein 2.94904
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 2.94904
DLL4 delta-like 4 (Drosophila) 2.94904
RNASE9 ribonuclease, RNase A family, 9 (non-active) 2.94904
SIX3 SIX homeobox 3 2.94904
SPMAP2L sperm microtubule associated protein 2 like 2.94904
SMIM41 small integral membrane protein 41 2.94904
CCN3 cellular communication network factor 3 2.94904
ZG16 zymogen granule protein 16 2.94904
BNC1 basonuclin 1 2.94904
FMO1 flavin containing monooxygenase 1 2.94904
PIRT phosphoinositide-interacting regulator of transient receptor potential channels 2.94904
PCP4L1 Purkinje cell protein 4 like 1 2.94904
TBX10 T-box 10 2.94904
GATA3 GATA binding protein 3 2.94904
MROH5 maestro heat-like repeat family member 5 2.94904
LOC112694756 uncharaterized LOC112694756 2.94904
DEPP1 DEPP autophagy regulator 1 2.94904
PNMA6F PNMA family member 6F 2.94904
SMIM32 small integral membrane protein 32 2.94904
NPIPA6 nuclear pore complex interacting protein family, member A6 2.94904
H3C13 H3 clustered histone 13 2.94904
TMEM225B transmembrane protein 225B 2.94904
GARIN1A golgi associated RAB2 interactor 1A 2.94904
H2AP H2A.P histone 2.94904
RTL5 retrotransposon Gag like 5 2.94904
DNAAF8 dynein axonemal assembly factor 8 2.94904
CCN5 cellular communication network factor 5 2.94904
HNF1A HNF1 homeobox A 2.94904
DLK2 delta-like 2 homolog (Drosophila) 2.94904
ASIC3 acid sensing (proton gated) ion channel 3 2.94904
FAM178B family with sequence similarity 178, member B 2.94904
C3ORF80 chromosome 3 open reading frame 80 2.94904
BIK BCL2-interacting killer (apoptosis-inducing) 2.94904
IRF5 interferon regulatory factor 5 2.94904
PCDHB13 protocadherin beta 13 2.94904
PRB3 proline-rich protein BstNI subfamily 3 2.94904
OASL 2'-5'-oligoadenylate synthetase-like 2.94904
ACTL8 actin-like 8 2.94904
TMEM229A transmembrane protein 229A 2.94904
EFHB EF-hand domain family, member B 2.94904
SCRT2 scratch family zinc finger 2 2.94904
TLR2 toll-like receptor 2 2.94904
ZAR1L zygote arrest 1-like 2.94904
OOSP1 oocyte secreted protein 1, pseudogene 2.94904
IL1R1 interleukin 1 receptor, type I 2.94904
CCR8 chemokine (C-C motif) receptor 8 2.94904
NPFF neuropeptide FF-amide peptide precursor 2.94904
RASAL3 RAS protein activator like 3 2.94904
C1QTNF1 C1q and tumor necrosis factor related protein 1 2.94904
GLP2R glucagon-like peptide 2 receptor 2.94904
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 2.94904
AWAT1 acyl-CoA wax alcohol acyltransferase 1 2.94904
GPR6 G protein-coupled receptor 6 2.94904
ACSM5 acyl-CoA synthetase medium-chain family member 5 2.94904
KLHL1 kelch-like family member 1 2.94904
PIH1D2 PIH1 domain containing 2 2.94904
ETNPPL ethanolamine-phosphate phospho-lyase 2.94904
RETNLB resistin like beta 2.94904
DPRX divergent-paired related homeobox 2.94904
CLRN2 clarin 2 2.94904
ANKRD63 ankyrin repeat domain 63 2.94904
KLF9 Kruppel-like factor 9 2.94904
ZSCAN12 zinc finger and SCAN domain containing 12 2.94904
RNASE10 ribonuclease, RNase A family, 10 (non-active) 2.94904
CT55 cancer/testis antigen 55 2.94904
CLIC6 chloride intracellular channel 6 2.94904
TOPAZ1 testis and ovary specific PAZ domain containing 1 2.94904
PLA2G4E phospholipase A2, group IVE 2.94904
GABRD gamma-aminobutyric acid (GABA) A receptor, delta 2.94904
EPYC epiphycan 2.94904
APOF apolipoprotein F 2.94904
LRRC46 leucine rich repeat containing 46 2.94904
CCL25 chemokine (C-C motif) ligand 25 2.94904
CCL20 chemokine (C-C motif) ligand 20 2.94904
ZNF132 zinc finger protein 132 2.94904
BRDT bromodomain, testis-specific 2.94904
C11ORF16 chromosome 11 open reading frame 16 2.94904
GABRR3 gamma-aminobutyric acid (GABA) A receptor, rho 3 (gene/pseudogene) 2.94904
FIBIN fin bud initiation factor homolog (zebrafish) 2.94904
INCA1 inhibitor of CDK, cyclin A1 interacting protein 1 2.94904
CTSS cathepsin S 2.94904
DAW1 dynein assembly factor with WDR repeat domains 1 2.94904
SOSTDC1 sclerostin domain containing 1 2.94904
FAIM2 Fas apoptotic inhibitory molecule 2 2.94904
GPR142 G protein-coupled receptor 142 2.94904
OPTC opticin 2.94904
GBX2 gastrulation brain homeobox 2 2.94904
LMX1B LIM homeobox transcription factor 1, beta 2.94904
WNT4 wingless-type MMTV integration site family, member 4 2.94904
TMEM31 transmembrane protein 31 2.94904
NT5C1B 5'-nucleotidase, cytosolic IB 2.94904
CAGE1 cancer antigen 1 2.94904
RAD9B RAD9 homolog B (S. pombe) 2.94904
DRD2 dopamine receptor D2 2.94904
BCO1 beta-carotene oxygenase 1 2.94904
FBXO47 F-box protein 47 2.94904
SLCO2B1 solute carrier organic anion transporter family, member 2B1 2.94904
ARHGEF37 Rho guanine nucleotide exchange factor (GEF) 37 2.94904
OCM oncomodulin 2.94904
RIPPLY2 ripply transcriptional repressor 2 2.94904
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2.94904
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 2.94904
CLCNKA chloride channel, voltage-sensitive Ka 2.94904
CLEC2A C-type lectin domain family 2, member A 2.94904
LCP1 lymphocyte cytosolic protein 1 (L-plastin) 2.94904
GCM2 glial cells missing homolog 2 (Drosophila) 2.94904
SPINT4 serine peptidase inhibitor, Kunitz type 4 2.94904
GPRC5D G protein-coupled receptor, class C, group 5, member D 2.94904
NLRP8 NLR family, pyrin domain containing 8 2.94904
NLRP6 NLR family, pyrin domain containing 6 2.94904
CD8B CD8b molecule 2.94904
RP1 retinitis pigmentosa 1 (autosomal dominant) 2.94904
BIN2 bridging integrator 2 2.94904
CHRDL2 chordin-like 2 2.94904
KRTAP9-9 keratin associated protein 9-9 2.94904
IL17B interleukin 17B 2.94904
ITPKA inositol-trisphosphate 3-kinase A 2.94904
APOL6 apolipoprotein L, 6 2.94904
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 2.94904
GPR78 G protein-coupled receptor 78 2.94904
TGM5 transglutaminase 5 2.94904
SPDEF SAM pointed domain containing ETS transcription factor 2.94904
GPRC5B G protein-coupled receptor, class C, group 5, member B 2.94904
THEM5 thioesterase superfamily member 5 2.94904
CD3E CD3e molecule, epsilon (CD3-TCR complex) 2.94904
SDSL serine dehydratase-like 2.94904
ACKR3 atypical chemokine receptor 3 2.94904
CD36 CD36 molecule (thrombospondin receptor) 2.94904
ROM1 retinal outer segment membrane protein 1 2.94904
CD34 CD34 molecule 2.94904
HDHD2 haloacid dehalogenase-like hydrolase domain containing 2 2.92273
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 2.88047
PAN3 PAN3 poly(A) specific ribonuclease subunit 2.87721
ETFBKMT electron transfer flavoprotein subunit beta lysine methyltransferase 2.87721
FAT2 FAT atypical cadherin 2 2.87721
PGAM1 phosphoglycerate mutase 1 (brain) 2.70519
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 2.70116
APLN apelin 2.70116
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.66989
CTHRC1 collagen triple helix repeat containing 1 2.6661
USP20 ubiquitin specific peptidase 20 2.65332
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 2.61607
DHX33 DEAH (Asp-Glu-Ala-His) box polypeptide 33 2.58532
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7 2.58383
FDX1 ferredoxin 1 2.5667
MTRF1L mitochondrial translational release factor 1-like 2.51906
RAI1 retinoic acid induced 1 2.51751
STAC2 SH3 and cysteine rich domain 2 2.50393
FNBP1L formin binding protein 1-like 2.49123
DEXI Dexi homolog (mouse) 2.48964
PCDHB9 protocadherin beta 9 2.485
MFF mitochondrial fission factor 2.40136
ARAF A-Raf proto-oncogene, serine/threonine kinase 2.38982
SLC8A3 solute carrier family 8 (sodium/calcium exchanger), member 3 2.3863
HIPK4 homeodomain interacting protein kinase 4 2.3863
ABTB1 ankyrin repeat and BTB (POZ) domain containing 1 2.3863
FAM47E family with sequence similarity 47, member E 2.36731
SH2D4A SH2 domain containing 4A 2.36401
ZNF706 zinc finger protein 706 2.31279
ZNF48 zinc finger protein 48 2.30319
UBE2Z ubiquitin-conjugating enzyme E2Z 2.30319
TMEM132B transmembrane protein 132B 2.30317
C5ORF24 chromosome 5 open reading frame 24 2.29477
RLN2 relaxin 2 2.28907
AMPD2 adenosine monophosphate deaminase 2 2.26034
METTL6 methyltransferase like 6 2.22206
RPS18 ribosomal protein S18 2.2139
ZSWIM7 zinc finger, SWIM-type containing 7 2.2139
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) 2.18251
FBXO5 F-box protein 5 2.17673
PALLD palladin, cytoskeletal associated protein 2.17644
CNKSR3 CNKSR family member 3 2.16437
ALG3 ALG3, alpha-1,3- mannosyltransferase 2.16276
ZBTB41 zinc finger and BTB domain containing 41 2.14877
MSL2 male-specific lethal 2 homolog (Drosophila) 2.14622
NDC1 NDC1 transmembrane nucleoporin 2.143
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 2.12496
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1 2.11363
NDC80 NDC80 kinetochore complex component 2.11234
GAR1 GAR1 ribonucleoprotein 2.10322
EBNA1BP2 EBNA1 binding protein 2 2.08376
ZC3H13 zinc finger CCCH-type containing 13 2.078
DSCC1 DNA replication and sister chromatid cohesion 1 2.07245
BTBD1 BTB (POZ) domain containing 1 2.05457
PSME4 proteasome (prosome, macropain) activator subunit 4 2.04115
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae) 2.02691
COQ9 coenzyme Q9 2.00856
SENP7 SUMO1/sentrin specific peptidase 7 2.00804
TMEM26 transmembrane protein 26 2.00596

decreased expression

Symbol Name Standardized Value
EEF1AKMT4 EEF1A lysine methyltransferase 4 -2.94904
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 -2.94904
INPP5A inositol polyphosphate-5-phosphatase, 40kDa -2.94904
C20ORF203 chromosome 20 open reading frame 203 -2.94904
CHRM5 cholinergic receptor, muscarinic 5 -2.94904
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) -2.94904
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic -2.94904
WFDC1 WAP four-disulfide core domain 1 -2.94904
CLASP2 cytoplasmic linker associated protein 2 -2.90107
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 -2.87721
OR2A12 olfactory receptor, family 2, subfamily A, member 12 -2.87721
TACSTD2 tumor-associated calcium signal transducer 2 -2.87721
H2BC8 H2B clustered histone 8 -2.87721
ZFP36 ZFP36 ring finger protein -2.87721
GALNT9 polypeptide N-acetylgalactosaminyltransferase 9 -2.87721
SGPP2 sphingosine-1-phosphate phosphatase 2 -2.87721
PTGDS prostaglandin D2 synthase 21kDa (brain) -2.87721
ANXA1 annexin A1 -2.87721
CLCN1 chloride channel, voltage-sensitive 1 -2.87721
SHISA7 shisa family member 7 -2.87721
GREM2 gremlin 2, DAN family BMP antagonist -2.87721
BCAS1 breast carcinoma amplified sequence 1 -2.87721
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1 -2.87721
MYH15 myosin, heavy chain 15 -2.87721
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) -2.87721
COL17A1 collagen, type XVII, alpha 1 -2.87721
FAM107A family with sequence similarity 107, member A -2.87721
HCLS1 hematopoietic cell-specific Lyn substrate 1 -2.87721
THSD1 thrombospondin, type I, domain containing 1 -2.87721
SLC5A11 solute carrier family 5 (sodium/inositol cotransporter), member 11 -2.87721
ADGRD2 adhesion G protein-coupled receptor D2 -2.87721
LMO2 LIM domain only 2 (rhombotin-like 1) -2.87721
LEKR1 leucine, glutamate and lysine rich 1 -2.87721
NIPSNAP3B nipsnap homolog 3B (C. elegans) -2.87721
ATG4A autophagy related 4A, cysteine peptidase -2.87721
AGO3 argonaute RISC catalytic component 3 -2.78206
IST1 increased sodium tolerance 1 homolog (yeast) -2.76407
HBP1 HMG-box transcription factor 1 -2.74741
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) -2.74741
CTCFL CCCTC-binding factor (zinc finger protein)-like -2.74419
DPF2 D4, zinc and double PHD fingers family 2 -2.73858
FCHSD1 FCH and double SH3 domains 1 -2.72731
HIPK2 homeodomain interacting protein kinase 2 -2.72731
ZSCAN31 zinc finger and SCAN domain containing 31 -2.7146
NDRG2 NDRG family member 2 -2.70969
ADPRHL1 ADP-ribosylhydrolase like 1 -2.66982
COMMD4 COMM domain containing 4 -2.65245
CYB5D1 cytochrome b5 domain containing 1 -2.59267
ADI1 acireductone dioxygenase 1 -2.5576
NAP1L4 nucleosome assembly protein 1-like 4 -2.55466
XPO1 exportin 1 -2.53437
C6ORF47 chromosome 6 open reading frame 47 -2.43658
CP ceruloplasmin (ferroxidase) -2.40136
TIGAR TP53 induced glycolysis regulatory phosphatase -2.39104
NPAS3 neuronal PAS domain protein 3 -2.3863
SMC1B structural maintenance of chromosomes 1B -2.36931
FBXO8 F-box protein 8 -2.36731
STBD1 starch binding domain 1 -2.36312
POLR1G RNA polymerase I subunit G -2.3448
C2CD3 C2 calcium-dependent domain containing 3 -2.30319
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1 -2.29477
GTPBP6 GTP binding protein 6 (putative) -2.27033
STRIP1 striatin interacting protein 1 -2.26898
MTAP methylthioadenosine phosphorylase -2.26284
UBE2H ubiquitin-conjugating enzyme E2H -2.24355
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.24355
TRAPPC11 trafficking protein particle complex 11 -2.24202
FNTA farnesyltransferase, CAAX box, alpha -2.23144
FAM156A family with sequence similarity 156, member A -2.22312
TMEM130 transmembrane protein 130 -2.22206
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 -2.22206
MAP1LC3B2 microtubule-associated protein 1 light chain 3 beta 2 -2.22206
TRIP10 thyroid hormone receptor interactor 10 -2.21629
CFD complement factor D (adipsin) -2.21486
YY1 YY1 transcription factor -2.2139
PITRM1 pitrilysin metallopeptidase 1 -2.21367
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae) -2.21206
ARL4D ADP-ribosylation factor-like 4D -2.20735
ZNF548 zinc finger protein 548 -2.20735
SAP130 Sin3A-associated protein, 130kDa -2.20463
DYSF dysferlin -2.20394
MIER1 mesoderm induction early response 1, transcriptional regulator -2.17673
RAB6A RAB6A, member RAS oncogene family -2.17673
RBM14 RNA binding motif protein 14 -2.14984
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 -2.14972
LETM2 leucine zipper-EF-hand containing transmembrane protein 2 -2.14423
CTU2 cytosolic thiouridylase subunit 2 homolog (S. pombe) -2.143
ONECUT1 one cut homeobox 1 -2.143
TFIP11 tuftelin interacting protein 11 -2.143
SARDH sarcosine dehydrogenase -2.143
CNOT4 CCR4-NOT transcription complex, subunit 4 -2.11899
ZNF628 zinc finger protein 628 -2.11363
CMTM6 CKLF-like MARVEL transmembrane domain containing 6 -2.06226
CDC25B cell division cycle 25B -2.05374
CTNS cystinosin, lysosomal cystine transporter -2.04115
DHRSX dehydrogenase/reductase (SDR family) X-linked -2.03571
FAM133B family with sequence similarity 133, member B -2.0328
TP53RK TP53 regulating kinase -2.02497
KRT10 keratin 10, type I -2.01596
MAP7D2 MAP7 domain containing 2 -2.01075
CGREF1 cell growth regulator with EF-hand domain 1 -2.01075
LYSMD2 LysM, putative peptidoglycan-binding, domain containing 2 -2.01075
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 -2.00999