SAGA complex Gene Set

Dataset GO Cellular Component Annotations 2025
Category structural or functional annotations
Type cellular component
Description A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery. (Gene Ontology, GO_0000124)
External Link http://amigo.geneontology.org/amigo/term/GO:0000124
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Genes

26 proteins localized to the SAGA complex cellular component from the curated GO Cellular Component Annotations 2025 dataset.

Symbol Name
ATXN7 ataxin 7
ATXN7L3 ataxin 7-like 3
ENY2 enhancer of yellow 2 homolog (Drosophila)
KAT2A K(lysine) acetyltransferase 2A
KAT2B K(lysine) acetyltransferase 2B
PAAF1 proteasomal ATPase-associated factor 1
SF3B3 splicing factor 3b, subunit 3, 130kDa
SF3B5 splicing factor 3b, subunit 5, 10kDa
SGF29 SAGA complex associated factor 29
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae)
SUPT20HL1 suppressor of Ty 20 homolog (S. cerevisiae)-like 1
SUPT20HL2 suppressor of Ty 20 homolog (S. cerevisiae)-like 2
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)
SUPT7L suppressor of Ty 7 (S. cerevisiae)-like
TADA1 transcriptional adaptor 1
TADA2A transcriptional adaptor 2A
TADA2B transcriptional adaptor 2B
TADA3 transcriptional adaptor 3
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
TRRAP transformation/transcription domain-associated protein
USP22 ubiquitin specific peptidase 22