SARS2 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description seryl-tRNA synthetase 2, mitochondrial|This gene encodes the mitochondrial seryl-tRNA synthethase precursor, a member of the class II tRNA synthetase family. The mature enzyme catalyzes the ligation of Serine to tRNA(Ser) and participates in the biosynthesis of selenocysteinyl-tRNA(sec) in mitochondria. The enzyme contains an N-terminal tRNA binding domain and a core catalytic domain. It functions in a homodimeric form, which is stabilized by tRNA binding. This gene is regulated by a bidirectional promoter that also controls the expression of mitochondrial ribosomal protein S12. Both genes are within the critical interval for the autosomal dominant deafness locus DFNA4 and might be linked to this disease. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009] (NCBI Entrez Gene Database, 54938)
External Link http://www.ncbi.nlm.nih.gov/gene/54938
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358 interacting proteins for SARS2 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AARS2 alanyl-tRNA synthetase 2, mitochondrial
AASS aminoadipate-semialdehyde synthase
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7
ABHD10 abhydrolase domain containing 10
ACAD9 acyl-CoA dehydrogenase family, member 9
ACADVL acyl-CoA dehydrogenase, very long chain
ACOT9 acyl-CoA thioesterase 9
ADCK3 aarF domain containing kinase 3
AFG3L2 AFG3-like AAA ATPase 2
AGK acylglycerol kinase
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
ALB albumin
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
ALDH1B1 aldehyde dehydrogenase 1 family, member B1
ALDH1L2 aldehyde dehydrogenase 1 family, member L2
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ANXA1 annexin A1
AP2M1 adaptor-related protein complex 2, mu 1 subunit
ASPH aspartate beta-hydroxylase
ATAD3A ATPase family, AAA domain containing 3A
ATAD3B ATPase family, AAA domain containing 3B
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
ATP5F1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1
ATP5H ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d
ATP5L ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G
BLM Bloom syndrome, RecQ helicase-like
BLOC1S5 biogenesis of lysosomal organelles complex-1, subunit 5, muted
C10ORF2 chromosome 10 open reading frame 2
C1QBP complement component 1, q subcomponent binding protein
C6ORF203 chromosome 6 open reading frame 203
CALU calumenin
CAPZB capping protein (actin filament) muscle Z-line, beta
CARS2 cysteinyl-tRNA synthetase 2, mitochondrial (putative)
CASP3 caspase 3, apoptosis-related cysteine peptidase
CDC37 cell division cycle 37
CDC45 cell division cycle 45
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CECR5 cat eye syndrome chromosome region, candidate 5
CEP78 centrosomal protein 78kDa
CETN2 centrin, EF-hand protein, 2
CHCHD1 coiled-coil-helix-coiled-coil-helix domain containing 1
CHEK1 checkpoint kinase 1
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
COX11 COX11 cytochrome c oxidase copper chaperone
COX4I1 cytochrome c oxidase subunit IV isoform 1
CPT2 carnitine palmitoyltransferase 2
CRNN cornulin
CSNK2A2 casein kinase 2, alpha prime polypeptide
CTNND1 catenin (cadherin-associated protein), delta 1
CTSB cathepsin B
CUL3 cullin 3
DAP3 death associated protein 3
DBT dihydrolipoamide branched chain transacylase E2
DCXR dicarbonyl/L-xylulose reductase
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DHX30 DEAH (Asp-Glu-Ala-His) box helicase 30
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila)
DLD dihydrolipoamide dehydrogenase
DMWD dystrophia myotonica, WD repeat containing
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
ECH1 enoyl CoA hydratase 1, peroxisomal
ECI1 enoyl-CoA delta isomerase 1
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EMILIN3 elastin microfibril interfacer 3
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPDR1 ependymin related 1
EPPK1 epiplakin 1
ERAL1 Era-like 12S mitochondrial rRNA chaperone 1
ERLIN2 ER lipid raft associated 2
ETF1 eukaryotic translation termination factor 1
ETFA electron-transfer-flavoprotein, alpha polypeptide
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial
FASTKD1 FAST kinase domains 1
FASTKD2 FAST kinase domains 2
FLAD1 flavin adenine dinucleotide synthetase 1
FLNA filamin A, alpha
FTSJ1 FtsJ RNA methyltransferase homolog 1 (E. coli)
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1
GALK1 galactokinase 1
GBAS glioblastoma amplified sequence
GLDC glycine dehydrogenase (decarboxylating)
GLG1 golgi glycoprotein 1
GLUD1 glutamate dehydrogenase 1
GLUD2 glutamate dehydrogenase 2
GPC4 glypican 4
GRPEL1 GrpE-like 1, mitochondrial (E. coli)
GRSF1 G-rich RNA sequence binding factor 1
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa
GTPBP10 GTP-binding protein 10 (putative)
HACD3 3-hydroxyacyl-CoA dehydratase 3
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
HARS2 histidyl-tRNA synthetase 2, mitochondrial
HBB hemoglobin, beta
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HK1 hexokinase 1
HLA-H major histocompatibility complex, class I, H (pseudogene)
HNF4A hepatocyte nuclear factor 4, alpha
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1B heat shock 70kDa protein 1B
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPB1 heat shock 27kDa protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ICT1 immature colon carcinoma transcript 1
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
ILF2 interleukin enhancer binding factor 2
ILF3 interleukin enhancer binding factor 3, 90kDa
IMMT inner membrane protein, mitochondrial
INA internexin neuronal intermediate filament protein, alpha
ISCA1 iron-sulfur cluster assembly 1
KARS lysyl-tRNA synthetase
KDM1A lysine (K)-specific demethylase 1A
KEAP1 kelch-like ECH-associated protein 1
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIAA0391 KIAA0391
KIFC1 kinesin family member C1
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast)
KRT4 keratin 4, type II
KRT73 keratin 73, type II
LAGE3 L antigen family, member 3
LETM1 leucine zipper-EF-hand containing transmembrane protein 1
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LONP1 lon peptidase 1, mitochondrial
LRPPRC leucine-rich pentatricopeptide repeat containing
MALSU1 mitochondrial assembly of ribosomal large subunit 1
MARK2 MAP/microtubule affinity-regulating kinase 2
MATR3 matrin 3
MCAT malonyl CoA:ACP acyltransferase (mitochondrial)
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta)
MCU mitochondrial calcium uniporter
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
METTL17 methyltransferase like 17
MICU1 mitochondrial calcium uptake 1
MICU2 mitochondrial calcium uptake 2
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type
MOV10 Mov10 RISC complex RNA helicase
MPDZ multiple PDZ domain protein
MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MRPL1 mitochondrial ribosomal protein L1
MRPL10 mitochondrial ribosomal protein L10
MRPL11 mitochondrial ribosomal protein L11
MRPL12 mitochondrial ribosomal protein L12
MRPL13 mitochondrial ribosomal protein L13
MRPL14 mitochondrial ribosomal protein L14
MRPL15 mitochondrial ribosomal protein L15
MRPL16 mitochondrial ribosomal protein L16
MRPL17 mitochondrial ribosomal protein L17
MRPL18 mitochondrial ribosomal protein L18
MRPL19 mitochondrial ribosomal protein L19
MRPL2 mitochondrial ribosomal protein L2
MRPL20 mitochondrial ribosomal protein L20
MRPL21 mitochondrial ribosomal protein L21
MRPL22 mitochondrial ribosomal protein L22
MRPL23 mitochondrial ribosomal protein L23
MRPL24 mitochondrial ribosomal protein L24
MRPL27 mitochondrial ribosomal protein L27
MRPL28 mitochondrial ribosomal protein L28
MRPL3 mitochondrial ribosomal protein L3
MRPL32 mitochondrial ribosomal protein L32
MRPL37 mitochondrial ribosomal protein L37
MRPL38 mitochondrial ribosomal protein L38
MRPL39 mitochondrial ribosomal protein L39
MRPL4 mitochondrial ribosomal protein L4
MRPL40 mitochondrial ribosomal protein L40
MRPL41 mitochondrial ribosomal protein L41
MRPL43 mitochondrial ribosomal protein L43
MRPL44 mitochondrial ribosomal protein L44
MRPL46 mitochondrial ribosomal protein L46
MRPL47 mitochondrial ribosomal protein L47
MRPL48 mitochondrial ribosomal protein L48
MRPL49 mitochondrial ribosomal protein L49
MRPL50 mitochondrial ribosomal protein L50
MRPL51 mitochondrial ribosomal protein L51
MRPL53 mitochondrial ribosomal protein L53
MRPL54 mitochondrial ribosomal protein L54
MRPL55 mitochondrial ribosomal protein L55
MRPL9 mitochondrial ribosomal protein L9
MRPS10 mitochondrial ribosomal protein S10
MRPS11 mitochondrial ribosomal protein S11
MRPS14 mitochondrial ribosomal protein S14
MRPS15 mitochondrial ribosomal protein S15
MRPS16 mitochondrial ribosomal protein S16
MRPS17 mitochondrial ribosomal protein S17
MRPS18A mitochondrial ribosomal protein S18A
MRPS18B mitochondrial ribosomal protein S18B
MRPS2 mitochondrial ribosomal protein S2
MRPS21 mitochondrial ribosomal protein S21
MRPS22 mitochondrial ribosomal protein S22
MRPS23 mitochondrial ribosomal protein S23
MRPS24 mitochondrial ribosomal protein S24
MRPS25 mitochondrial ribosomal protein S25
MRPS26 mitochondrial ribosomal protein S26
MRPS27 mitochondrial ribosomal protein S27
MRPS28 mitochondrial ribosomal protein S28
MRPS30 mitochondrial ribosomal protein S30
MRPS31 mitochondrial ribosomal protein S31
MRPS34 mitochondrial ribosomal protein S34
MRPS35 mitochondrial ribosomal protein S35
MRPS5 mitochondrial ribosomal protein S5
MRPS6 mitochondrial ribosomal protein S6
MRPS7 mitochondrial ribosomal protein S7
MRPS9 mitochondrial ribosomal protein S9
MRRF mitochondrial ribosome recycling factor
MTG1 mitochondrial ribosome-associated GTPase 1
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MTIF2 mitochondrial translational initiation factor 2
MTPAP mitochondrial poly(A) polymerase
MUT methylmalonyl CoA mutase
NBR1 neighbor of BRCA1 gene 1
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)
NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa
NEFM neurofilament, medium polypeptide
NENF neudesin neurotrophic factor
NEURL4 neuralized E3 ubiquitin protein ligase 4
NGRN neugrin, neurite outgrowth associated
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOA1 nitric oxide associated 1
NPEPPS aminopeptidase puromycin sensitive
NRD1 nardilysin (N-arginine dibasic convertase)
NRF1 nuclear respiratory factor 1
NSUN4 NOP2/Sun domain family, member 4
NT5C2 5'-nucleotidase, cytosolic II
NT5DC2 5'-nucleotidase domain containing 2
NUP155 nucleoporin 155kDa
OAT ornithine aminotransferase
OBSL1 obscurin-like 1
OSBPL8 oxysterol binding protein-like 8
OXA1L oxidase (cytochrome c) assembly 1-like
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PARD3 par-3 family cell polarity regulator
PARS2 prolyl-tRNA synthetase 2, mitochondrial (putative)
PCCB propionyl CoA carboxylase, beta polypeptide
PDIA5 protein disulfide isomerase family A, member 5
PDK3 pyruvate dehydrogenase kinase, isozyme 3
PFKP phosphofructokinase, platelet
PGAM5 phosphoglycerate mutase family member 5
PHB prohibitin
PHB2 prohibitin 2
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PKP2 plakophilin 2
PLEC plectin
PLK1 polo-like kinase 1
PMPCA peptidase (mitochondrial processing) alpha
PMPCB peptidase (mitochondrial processing) beta
PNPT1 polyribonucleotide nucleotidyltransferase 1
POLDIP2 polymerase (DNA-directed), delta interacting protein 2
POLR2G polymerase (RNA) II (DNA directed) polypeptide G
POLRMT polymerase (RNA) mitochondrial (DNA directed)
PPT2 palmitoyl-protein thioesterase 2
PRDX4 peroxiredoxin 4
PRDX5 peroxiredoxin 5
PRKCDBP protein kinase C, delta binding protein
PRKCI protein kinase C, iota
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5
PTCD1 pentatricopeptide repeat domain 1
PTCD3 pentatricopeptide repeat domain 3
PUF60 poly-U binding splicing factor 60KDa
PUS1 pseudouridylate synthase 1
PUSL1 pseudouridylate synthase-like 1
PYCR2 pyrroline-5-carboxylate reductase family, member 2
RAD21 RAD21 homolog (S. pombe)
RAD54L2 RAD54-like 2 (S. cerevisiae)
RANBP9 RAN binding protein 9
RARS2 arginyl-tRNA synthetase 2, mitochondrial
RBFA ribosome binding factor A (putative)
RNMTL1 RNA methyltransferase like 1
RPUSD3 RNA pseudouridylate synthase domain containing 3
RPUSD4 RNA pseudouridylate synthase domain containing 4
RTCB RNA 2',3'-cyclic phosphate and 5'-OH ligase
S100A8 S100 calcium binding protein A8
SAV1 salvador family WW domain containing protein 1
SCRIB scribbled planar cell polarity protein
SDF2 stromal cell-derived factor 2
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
SFXN1 sideroflexin 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC25A18 solute carrier family 25 (glutamate carrier), member 18
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLIRP SRA stem-loop interacting RNA binding protein
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SPTAN1 spectrin, alpha, non-erythrocytic 1
SQSTM1 sequestosome 1
SRM spermidine synthase
SSBP1 single-stranded DNA binding protein 1, mitochondrial
STK3 serine/threonine kinase 3
STK4 serine/threonine kinase 4
STOML2 stomatin (EPB72)-like 2
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative)
TBL2 transducin (beta)-like 2
TCEAL2 transcription elongation factor A (SII)-like 2
TCOF1 Treacher Collins-Franceschetti syndrome 1
TEFM transcription elongation factor, mitochondrial
TFAM transcription factor A, mitochondrial
TFB1M transcription factor B1, mitochondrial
THNSL1 threonine synthase-like 1 (S. cerevisiae)
TIMM21 translocase of inner mitochondrial membrane 21 homolog (yeast)
TMEM160 transmembrane protein 160
TMLHE trimethyllysine hydroxylase, epsilon
TMX1 thioredoxin-related transmembrane protein 1
TOP1 topoisomerase (DNA) I
TOP3A topoisomerase (DNA) III alpha
TP53 tumor protein p53
TRMT10C tRNA methyltransferase 10 homolog C (S. cerevisiae)
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TRMT61B tRNA methyltransferase 61B
TRUB2 TruB pseudouridine (psi) synthase family member 2
TSNAX translin-associated factor X
TUFM Tu translation elongation factor, mitochondrial
UBC ubiquitin C
UQCRC1 ubiquinol-cytochrome c reductase core protein I
UQCRC2 ubiquinol-cytochrome c reductase core protein II
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
USP12 ubiquitin specific peptidase 12
USP44 ubiquitin specific peptidase 44
USP46 ubiquitin specific peptidase 46
VARS valyl-tRNA synthetase
VARS2 valyl-tRNA synthetase 2, mitochondrial
VDAC1 voltage-dependent anion channel 1
VDAC3 voltage-dependent anion channel 3
VIM vimentin
WBSCR16 Williams-Beuren syndrome chromosome region 16
WDR48 WD repeat domain 48
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial
YME1L1 YME1-like 1 ATPase
YTHDC2 YTH domain containing 2
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta