SAS Gene Set

Dataset DepMap CRISPR Gene Dependency
Category disease or phenotype associations
Type cell line
External Link https://depmap.org/portal/cell_line/ACH-002029
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Genes

241 gene knockdowns changing fitness of SAS relative to other cell lines from the DepMap CRISPR Gene Dependency Dataset.

Symbol Name Standardized Value
VGLL3 vestigial-like family member 3 8.11165
MAML2 mastermind-like 2 (Drosophila) 8.10441
EGR1 early growth response 1 7.86377
TRMT10A tRNA methyltransferase 10 homolog A (S. cerevisiae) 7.04229
CASC1 cancer susceptibility candidate 1 6.25427
RAD23B RAD23 homolog B (S. cerevisiae) 5.89905
AXIN1 axin 1 5.7386
TMEM208 transmembrane protein 208 5.55147
NT5DC2 5'-nucleotidase domain containing 2 5.389
GRM2 glutamate receptor, metabotropic 2 5.22659
RBBP7 retinoblastoma binding protein 7 4.71223
KDM4E lysine (K)-specific demethylase 4E 4.67009
PPP5C protein phosphatase 5, catalytic subunit 4.49677
DQX1 DEAQ box RNA-dependent ATPase 1 4.48543
JAK1 Janus kinase 1 4.44372
ZNF180 zinc finger protein 180 4.38843
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 4.3791
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 4.34755
MTX2 metaxin 2 4.18984
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 4.17432
MRPL30 mitochondrial ribosomal protein L30 4.15174
STAB1 stabilin 1 4.11693
KDM4B lysine (K)-specific demethylase 4B 4.09502
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2 4.03776
TPH2 tryptophan hydroxylase 2 3.99915
AP3D1 adaptor-related protein complex 3, delta 1 subunit 3.93121
TDG thymine-DNA glycosylase 3.91767
GRIP1 glutamate receptor interacting protein 1 3.88448
MUSTN1 musculoskeletal, embryonic nuclear protein 1 3.80545
AP3B1 adaptor-related protein complex 3, beta 1 subunit 3.7448
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 3.70542
UFSP1 UFM1-specific peptidase 1 (non-functional) 3.69819
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 3.69401
ZNF229 zinc finger protein 229 3.69158
ENDOD1 endonuclease domain containing 1 3.65376
C3ORF18 chromosome 3 open reading frame 18 3.63824
MORC2 MORC family CW-type zinc finger 2 3.6286
ASF1A anti-silencing function 1A histone chaperone 3.62557
DALRD3 DALR anticodon binding domain containing 3 3.61108
TP63 tumor protein p63 3.57939
TBRG4 transforming growth factor beta regulator 4 3.52066
USP16 ubiquitin specific peptidase 16 3.47881
CHD1 chromodomain helicase DNA binding protein 1 3.47462
LRTM1 leucine-rich repeats and transmembrane domains 1 3.44674
GAB1 GRB2-associated binding protein 1 3.44206
SIN3B SIN3 transcription regulator family member B 3.43403
CENPQ centromere protein Q 3.3381
EDF1 endothelial differentiation-related factor 1 3.30682
FBXO42 F-box protein 42 3.29497
COQ9 coenzyme Q9 3.2855
NFX1 nuclear transcription factor, X-box binding 1 3.28392
USP19 ubiquitin specific peptidase 19 3.28207
THUMPD1 THUMP domain containing 1 3.26978
PLIN4 perilipin 4 3.26812
TBC1D17 TBC1 domain family, member 17 3.20672
CELF1 CUGBP, Elav-like family member 1 3.19924
ALMS1 Alstrom syndrome protein 1 3.19849
RIF1 replication timing regulatory factor 1 3.1666
REC8 REC8 meiotic recombination protein 3.13982
TMEM41A transmembrane protein 41A 3.13301
TMEM126A transmembrane protein 126A 3.12266
KCNK7 potassium channel, two pore domain subfamily K, member 7 3.08595
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 3.07314
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4 3.03991
ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif, 10 3.00042
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 2.99744
CCDC77 coiled-coil domain containing 77 2.98074
TLR9 toll-like receptor 9 2.97203
AMBRA1 autophagy/beclin-1 regulator 1 2.96867
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 2.94686
VSTM5 V-set and transmembrane domain containing 5 2.93338
MAPK1 mitogen-activated protein kinase 1 2.93128
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F 2.90549
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 2.90513
CABP2 calcium binding protein 2 2.90213
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1 2.88435
ZNF696 zinc finger protein 696 2.88071
CAPRIN1 cell cycle associated protein 1 2.84782
ELL2 elongation factor, RNA polymerase II, 2 2.8306
TNNC1 troponin C type 1 (slow) 2.82444
APEH acylaminoacyl-peptide hydrolase 2.80817
YIF1A Yip1 interacting factor homolog A (S. cerevisiae) 2.79835
IQGAP1 IQ motif containing GTPase activating protein 1 2.78411
CNIH2 cornichon family AMPA receptor auxiliary protein 2 2.78311
SUGP2 SURP and G patch domain containing 2 2.78204
RAB18 RAB18, member RAS oncogene family 2.77787
RAD23A RAD23 homolog A (S. cerevisiae) 2.77623
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 2.77232
SNX32 sorting nexin 32 2.76228
HAX1 HCLS1 associated protein X-1 2.75717
GLT8D1 glycosyltransferase 8 domain containing 1 2.73595
NUDT17 nudix (nucleoside diphosphate linked moiety X)-type motif 17 2.72857
SIPA1 signal-induced proliferation-associated 1 2.71981
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 2.71852
OXSM 3-oxoacyl-ACP synthase, mitochondrial 2.71662
PANX1 pannexin 1 2.71177
TENT4B terminal nucleotidyltransferase 4B 2.70591
EPC2 enhancer of polycomb homolog 2 (Drosophila) 2.69141
CD58 CD58 molecule 2.68761
ZNF75A zinc finger protein 75a 2.67787
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 2.66276
EHBP1L1 EH domain binding protein 1-like 1 2.65415
SPRED2 sprouty-related, EVH1 domain containing 2 2.6487
ARC activity-regulated cytoskeleton-associated protein 2.64656
TPRA1 transmembrane protein, adipocyte asscociated 1 2.64094
IWS1 IWS1 homolog (S. cerevisiae) 2.62324
ANKRD52 ankyrin repeat domain 52 2.61914
CEP57 centrosomal protein 57kDa 2.6177
CPM carboxypeptidase M 2.60563
CKAP2L cytoskeleton associated protein 2-like 2.59714
NSUN5 NOP2/Sun domain family, member 5 2.59684
TWF2 twinfilin actin binding protein 2 2.59358
RNF181 ring finger protein 181 2.58956
CLCF1 cardiotrophin-like cytokine factor 1 2.56323
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 2.55348
PEAK1 pseudopodium-enriched atypical kinase 1 2.54957
ALG10 ALG10, alpha-1,2-glucosyltransferase 2.54327
HIKESHI heat shock protein nuclear import factor hikeshi 2.53952
IQCF2 IQ motif containing F2 2.52165
H4C1 H4 clustered histone 1 2.51018
FAM104B family with sequence similarity 104, member B 2.4971
CORO7 coronin 7 2.49637
PPP1R37 protein phosphatase 1, regulatory subunit 37 2.47508
OTUD5 OTU deubiquitinase 5 2.4734
B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 2.4678
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast) 2.46556
EGFR epidermal growth factor receptor 2.46449
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae) 2.46376
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 2.45676
CDCA3 cell division cycle associated 3 2.45671
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2 2.45309
NAALADL1 N-acetylated alpha-linked acidic dipeptidase-like 1 2.44557
NME6 NME/NM23 nucleoside diphosphate kinase 6 2.43896
GNAT1 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 2.43452
ESRP2 epithelial splicing regulatory protein 2 2.43119
RMI2 RecQ mediated genome instability 2 2.42984
MPRIP myosin phosphatase Rho interacting protein 2.41565
RNF123 ring finger protein 123 2.3969
TMOD2 tropomodulin 2 (neuronal) 2.39569
HNRNPF heterogeneous nuclear ribonucleoprotein F 2.39259
SSR2 signal sequence receptor, beta (translocon-associated protein beta) 2.38405
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) 2.38226
C3ORF62 chromosome 3 open reading frame 62 2.37225
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated) 2.35666
CCDC6 coiled-coil domain containing 6 2.34176
HMOX2 heme oxygenase 2 2.33498
MTIF2 mitochondrial translational initiation factor 2 2.33183
HTRA2 HtrA serine peptidase 2 2.3313
PTPN20 protein tyrosine phosphatase, non-receptor type 20 2.32246
SYT12 synaptotagmin XII 2.321
HSPA13 heat shock protein 70kDa family, member 13 2.31453
YME1L1 YME1-like 1 ATPase 2.31298
ATP5PO ATP synthase peripheral stalk subunit OSCP 2.31149
PCBP4 poly(rC) binding protein 4 2.3084
PPP6R3 protein phosphatase 6, regulatory subunit 3 2.30701
JUNB jun B proto-oncogene 2.30032
ETV7 ets variant 7 2.29817
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 2.29136
REXO2 RNA exonuclease 2 2.28428
SREBF1 sterol regulatory element binding transcription factor 1 2.28316
MAP3K11 mitogen-activated protein kinase kinase kinase 11 2.26643
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 2.26397
IRF9 interferon regulatory factor 9 2.25748
UCHL5 ubiquitin carboxyl-terminal hydrolase L5 2.25624
MMGT1 membrane magnesium transporter 1 2.25337
CCDC88B coiled-coil domain containing 88B 2.25094
ZNF462 zinc finger protein 462 2.24788
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta 2.24767
PRKCD protein kinase C, delta 2.24696
FGD2 FYVE, RhoGEF and PH domain containing 2 2.24638
NPAS4 neuronal PAS domain protein 4 2.24616
PABIR1 PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1 2.24509
RNH1 ribonuclease/angiogenin inhibitor 1 2.24207
CYB5R4 cytochrome b5 reductase 4 2.23496
MED23 mediator complex subunit 23 2.23101
WISP3 WNT1 inducible signaling pathway protein 3 2.22964
PCM1 pericentriolar material 1 2.22624
PRMT7 protein arginine methyltransferase 7 2.22492
ZFP41 ZFP41 zinc finger protein 2.22004
TMEM19 transmembrane protein 19 2.21759
SACK1H scaffolding CK1 anchoring protein H 2.21652
CCDC97 coiled-coil domain containing 97 2.21593
MAGT1 magnesium transporter 1 2.21469
ISYNA1 inositol-3-phosphate synthase 1 2.2106
CABIN1 calcineurin binding protein 1 2.20039
C2CD4D C2 calcium-dependent domain containing 4D 2.19956
PEX11B peroxisomal biogenesis factor 11 beta 2.19713
CYB5B cytochrome b5 type B (outer mitochondrial membrane) 2.19048
TOMM70 translocase of outer mitochondrial membrane 70 2.1892
C12ORF49 chromosome 12 open reading frame 49 2.18623
RGS22 regulator of G-protein signaling 22 2.18167
ABHD14A abhydrolase domain containing 14A 2.17812
POLG polymerase (DNA directed), gamma 2.17652
PITRM1 pitrilysin metallopeptidase 1 2.17258
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 2.16853
ATAD5 ATPase family, AAA domain containing 5 2.1559
TARBP2 TAR (HIV-1) RNA binding protein 2 2.14684
CDC42BPG CDC42 binding protein kinase gamma (DMPK-like) 2.14521
GPATCH1 G patch domain containing 1 2.14393
M1AP meiosis 1 associated protein 2.14351
GTPBP3 GTP binding protein 3 (mitochondrial) 2.14187
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 2.13968
DNASE1 deoxyribonuclease I 2.13755
ACTR5 ARP5 actin-related protein 5 homolog (yeast) 2.13104
DUSP12 dual specificity phosphatase 12 2.12855
RCOR2 REST corepressor 2 2.12705
TEDC1 tubulin epsilon and delta complex 1 2.12495
PIAS3 protein inhibitor of activated STAT, 3 2.11604
ACSL3 acyl-CoA synthetase long-chain family member 3 2.10521
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) 2.09969
LRG1 leucine-rich alpha-2-glycoprotein 1 2.09749
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa 2.09698
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28 2.0958
KIF12 kinesin family member 12 2.09489
TMEM53 transmembrane protein 53 2.0939
SLIRP SRA stem-loop interacting RNA binding protein 2.09181
MTO1 mitochondrial tRNA translation optimization 1 2.09054
CFAP57 cilia and flagella associated protein 57 2.07555
PAQR4 progestin and adipoQ receptor family member IV 2.07478
CD101 CD101 molecule 2.07268
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 2.06743
MRPL46 mitochondrial ribosomal protein L46 2.06336
POU1F1 POU class 1 homeobox 1 2.06293
GJB3 gap junction protein, beta 3, 31kDa 2.06097
LTF lactotransferrin 2.05734
NSFL1C NSFL1 (p97) cofactor (p47) 2.05516
CDC42SE1 CDC42 small effector 1 2.05453
CCNC cyclin C 2.04738
CEP43 centrosomal protein 43 2.04557
C1ORF194 chromosome 1 open reading frame 194 2.04399
SLC26A6 solute carrier family 26 (anion exchanger), member 6 2.04267
WDR4 WD repeat domain 4 2.03923
C1D C1D nuclear receptor corepressor 2.03584
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 2.02552
NET1 neuroepithelial cell transforming 1 2.02524
LOXL3 lysyl oxidase-like 3 2.02359
TMEM110 transmembrane protein 110 2.01772
CLEC3B C-type lectin domain family 3, member B 2.01647
GPRIN2 G protein regulated inducer of neurite outgrowth 2 2.01536
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 2.0149
POT1 protection of telomeres 1 2.00923