SAT Gene Set

Dataset DepMap CRISPR Gene Dependency
Category disease or phenotype associations
Type cell line
Description cell line derived from -666 (Catalogue of Somatic Mutations In Cancer)
External Link https://depmap.org/portal/cell_line/ACH-001641
Similar Terms
Downloads & Tools

Genes

256 gene knockdowns changing fitness of SAT relative to other cell lines from the DepMap CRISPR Gene Dependency Dataset.

Symbol Name Standardized Value
ATOH7 atonal homolog 7 (Drosophila) 9.238
CELF6 CUGBP, Elav-like family member 6 9.17905
CLSTN2 calsyntenin 2 8.06022
AQP9 aquaporin 9 7.54064
FADS2 fatty acid desaturase 2 6.77176
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 6.53287
FNDC5 fibronectin type III domain containing 5 6.26256
TRPC7 transient receptor potential cation channel, subfamily C, member 7 6.1479
AMHR2 anti-Mullerian hormone receptor, type II 6.0776
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 6.04139
FBP2 fructose-1,6-bisphosphatase 2 5.33298
CST6 cystatin E/M 5.32684
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 5.28913
CAMK1G calcium/calmodulin-dependent protein kinase IG 5.26181
GLYCTK glycerate kinase 5.25464
OR9G4 olfactory receptor, family 9, subfamily G, member 4 5.14372
GPR6 G protein-coupled receptor 6 5.06878
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 5.0354
BIN2 bridging integrator 2 5.00882
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 4.81001
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 4.75699
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 4.69992
OR5D16 olfactory receptor, family 5, subfamily D, member 16 4.6983
PLA2G4F phospholipase A2, group IVF 4.66725
FRZB frizzled-related protein 4.62962
ANKDD1A ankyrin repeat and death domain containing 1A 4.54118
BPI bactericidal/permeability-increasing protein 4.52391
ENHO energy homeostasis associated 4.4602
VPS37C vacuolar protein sorting 37 homolog C (S. cerevisiae) 4.45994
CEP44 centrosomal protein 44kDa 4.36348
TAGLN3 transgelin 3 4.32241
OR4D6 olfactory receptor, family 4, subfamily D, member 6 4.279
PDE8B phosphodiesterase 8B 4.23371
OR10AD1 olfactory receptor, family 10, subfamily AD, member 1 4.13058
FAM189A1 family with sequence similarity 189, member A1 4.0885
PRDX1 peroxiredoxin 1 4.07143
GJD4 gap junction protein, delta 4, 40.1kDa 4.00086
HOXC4 homeobox C4 4.00083
TTBK1 tau tubulin kinase 1 3.99685
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2 3.99081
SLC51B solute carrier family 51, beta subunit 3.96667
ANKRD34C ankyrin repeat domain 34C 3.96539
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5 3.95315
CAPRIN1 cell cycle associated protein 1 3.94588
RIMS3 regulating synaptic membrane exocytosis 3 3.89932
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 3.89123
PDE1B phosphodiesterase 1B, calmodulin-dependent 3.83964
COL4A4 collagen, type IV, alpha 4 3.83109
SLC22A17 solute carrier family 22, member 17 3.80426
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1) 3.79193
OR10J5 olfactory receptor, family 10, subfamily J, member 5 3.78057
F5 coagulation factor V (proaccelerin, labile factor) 3.77471
SP9 Sp9 transcription factor 3.76701
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 3.72427
NMUR2 neuromedin U receptor 2 3.72376
MS4A10 membrane-spanning 4-domains, subfamily A, member 10 3.72032
GRM2 glutamate receptor, metabotropic 2 3.70618
KLF17 Kruppel-like factor 17 3.69744
TBC1D21 TBC1 domain family, member 21 3.68292
BATF2 basic leucine zipper transcription factor, ATF-like 2 3.681
VSTM2B V-set and transmembrane domain containing 2B 3.62443
DCAF4 DDB1 and CUL4 associated factor 4 3.59528
TP63 tumor protein p63 3.59297
EDF1 endothelial differentiation-related factor 1 3.56036
HAO2 hydroxyacid oxidase 2 (long chain) 3.52268
OR5T2 olfactory receptor, family 5, subfamily T, member 2 3.49813
APOBR apolipoprotein B receptor 3.48352
MIIP migration and invasion inhibitory protein 3.48099
CHRM1 cholinergic receptor, muscarinic 1 3.45468
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 3.44453
CCDC180 coiled-coil domain containing 180 3.43646
CRABP1 cellular retinoic acid binding protein 1 3.43502
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 3.34564
MS4A8 membrane-spanning 4-domains, subfamily A, member 8 3.33346
TMOD2 tropomodulin 2 (neuronal) 3.30143
ADRA2B adrenoceptor alpha 2B 3.29752
GJD2 gap junction protein, delta 2, 36kDa 3.29709
SCN2A sodium channel, voltage gated, type II alpha subunit 3.28271
HPCAL4 hippocalcin like 4 3.25733
RNF5 ring finger protein 5, E3 ubiquitin protein ligase 3.23423
CKAP2L cytoskeleton associated protein 2-like 3.232
TMEM174 transmembrane protein 174 3.22847
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 3.22002
XKR4 XK, Kell blood group complex subunit-related family, member 4 3.21395
EPB41L5 erythrocyte membrane protein band 4.1 like 5 3.16179
CAPN5 calpain 5 3.15053
HDAC6 histone deacetylase 6 3.13729
PLVAP plasmalemma vesicle associated protein 3.11792
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 3.11522
GFAP glial fibrillary acidic protein 3.10595
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 3.10206
FFAR1 free fatty acid receptor 1 3.09904
NHLH1 nescient helix loop helix 1 3.0894
LINGO1 leucine rich repeat and Ig domain containing 1 3.07784
CA12 carbonic anhydrase XII 3.07085
CD1A CD1a molecule 3.06776
TEPSIN TEPSIN adaptor related protein complex 4 accessory protein 3.04426
DNAL4 dynein, axonemal, light chain 4 3.03069
QPRT quinolinate phosphoribosyltransferase 3.02452
ACTR5 ARP5 actin-related protein 5 homolog (yeast) 3.02232
NOS2 nitric oxide synthase 2, inducible 3.01593
SCGB1D1 secretoglobin, family 1D, member 1 3.01236
C3ORF18 chromosome 3 open reading frame 18 3.01073
GOLGA7 golgin A7 2.95181
EFS embryonal Fyn-associated substrate 2.94935
STAC2 SH3 and cysteine rich domain 2 2.9471
OR51G2 olfactory receptor, family 51, subfamily G, member 2 2.93577
ERBB3 erb-b2 receptor tyrosine kinase 3 2.92303
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20 2.9081
AQP6 aquaporin 6, kidney specific 2.86392
MAP1A microtubule-associated protein 1A 2.85454
DCAF6 DDB1 and CUL4 associated factor 6 2.84883
PLCH1 phospholipase C, eta 1 2.8487
PPP1R26 protein phosphatase 1, regulatory subunit 26 2.83681
STAP1 signal transducing adaptor family member 1 2.82802
PALD1 phosphatase domain containing, paladin 1 2.81561
NOVA1 neuro-oncological ventral antigen 1 2.7963
GSDMA gasdermin A 2.77196
GTSF1L gametocyte specific factor 1-like 2.7462
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin) 2.73316
GRIK2 glutamate receptor, ionotropic, kainate 2 2.73093
GRB14 growth factor receptor-bound protein 14 2.70442
FMN1 formin 1 2.70273
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 2.67315
KIF22 kinesin family member 22 2.6729
HS3ST4 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 2.67093
TMEM8B transmembrane protein 8B 2.66669
SMOX spermine oxidase 2.64659
BAG6 BCL2-associated athanogene 6 2.6207
DMRTB1 DMRT-like family B with proline-rich C-terminal, 1 2.61883
NEFH neurofilament, heavy polypeptide 2.60422
SKOR1 SKI family transcriptional corepressor 1 2.60294
CFP complement factor properdin 2.58769
FMNL3 formin-like 3 2.58357
GJA3 gap junction protein, alpha 3, 46kDa 2.58187
GSTM3 glutathione S-transferase mu 3 (brain) 2.577
ATF7IP activating transcription factor 7 interacting protein 2.56127
ATF6 activating transcription factor 6 2.56048
ADGRE3 adhesion G protein-coupled receptor E3 2.54851
GSG1L GSG1-like 2.54587
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1 2.53763
H1FNT H1 histone family, member N, testis-specific 2.534
UNC5B unc-5 homolog B (C. elegans) 2.53185
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 2.52394
HCCS holocytochrome c synthase 2.52218
LIN37 lin-37 DREAM MuvB core complex component 2.5199
MVP major vault protein 2.51441
ZNF236 zinc finger protein 236 2.5134
PLA2G3 phospholipase A2, group III 2.50311
LRRC10B leucine rich repeat containing 10B 2.50182
SBK1 SH3 domain binding kinase 1 2.49788
WIZ widely interspaced zinc finger motifs 2.49624
CEP43 centrosomal protein 43 2.49334
CCL21 chemokine (C-C motif) ligand 21 2.47746
PFDN4 prefoldin subunit 4 2.47186
DIRAS3 DIRAS family, GTP-binding RAS-like 3 2.47061
OR2AE1 olfactory receptor, family 2, subfamily AE, member 1 2.46832
REEP1 receptor accessory protein 1 2.46579
TMEM8C transmembrane protein 8C 2.46224
CRACD capping protein inhibiting regulator of actin dynamics 2.44578
TMOD1 tropomodulin 1 2.44089
PARM1 prostate androgen-regulated mucin-like protein 1 2.43933
SYNDIG1L synapse differentiation inducing 1-like 2.43714
TEX29 testis expressed 29 2.43141
KBTBD13 kelch repeat and BTB (POZ) domain containing 13 2.42133
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 2.4115
OCA2 oculocutaneous albinism II 2.40769
NLRC5 NLR family, CARD domain containing 5 2.39278
OR5B2 olfactory receptor, family 5, subfamily B, member 2 2.38873
C5ORF34 chromosome 5 open reading frame 34 2.38813
ANP32D acidic (leucine-rich) nuclear phosphoprotein 32 family, member D 2.37984
EPB42 erythrocyte membrane protein band 4.2 2.37807
ARGFX arginine-fifty homeobox 2.36712
EGFR epidermal growth factor receptor 2.36165
UNC13C unc-13 homolog C (C. elegans) 2.36066
OR5J2 olfactory receptor, family 5, subfamily J, member 2 2.35494
OSBPL9 oxysterol binding protein-like 9 2.35065
WFDC12 WAP four-disulfide core domain 12 2.33871
OR6C3 olfactory receptor, family 6, subfamily C, member 3 2.33556
OR4K15 olfactory receptor, family 4, subfamily K, member 15 2.32913
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled 2.32359
EHF ets homologous factor 2.31769
SIRT3 sirtuin 3 2.31318
CLNK cytokine-dependent hematopoietic cell linker 2.31282
FABP12 fatty acid binding protein 12 2.30998
TGM5 transglutaminase 5 2.3087
CYP8B1 cytochrome P450, family 8, subfamily B, polypeptide 1 2.3016
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast) 2.30039
SLC26A3 solute carrier family 26 (anion exchanger), member 3 2.29949
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 2.28041
CBLN1 cerebellin 1 precursor 2.27329
ARHGAP5 Rho GTPase activating protein 5 2.27313
ERBB2 erb-b2 receptor tyrosine kinase 2 2.27186
ZFHX2 zinc finger homeobox 2 2.26403
SACK1D scaffolding CK1 anchoring protein D 2.25322
SLC4A3 solute carrier family 4 (anion exchanger), member 3 2.25163
KLHL1 kelch-like family member 1 2.25151
SLC30A2 solute carrier family 30 (zinc transporter), member 2 2.24666
PGLYRP3 peptidoglycan recognition protein 3 2.23979
OR6Y1 olfactory receptor, family 6, subfamily Y, member 1 2.23535
OR2K2 olfactory receptor, family 2, subfamily K, member 2 2.2247
OR7D2 olfactory receptor, family 7, subfamily D, member 2 2.22262
OR6C76 olfactory receptor, family 6, subfamily C, member 76 2.22108
TMPRSS12 transmembrane (C-terminal) protease, serine 12 2.2142
PCM1 pericentriolar material 1 2.21234
NXPH4 neurexophilin 4 2.21155
OR5T1 olfactory receptor, family 5, subfamily T, member 1 2.2115
NEUROG1 neurogenin 1 2.20095
LALBA lactalbumin, alpha- 2.19714
CD5 CD5 molecule 2.19545
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 2.18244
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) 2.17395
DCTN1 dynactin 1 2.16872
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) 2.15523
LMAN1L lectin, mannose-binding, 1 like 2.1545
KRT79 keratin 79, type II 2.15149
CACNG5 calcium channel, voltage-dependent, gamma subunit 5 2.14931
PAXIP1 PAX interacting (with transcription-activation domain) protein 1 2.14633
GTF2I general transcription factor IIi 2.14594
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) 2.14466
PHC1 polyhomeotic homolog 1 (Drosophila) 2.14085
SIM1 single-minded family bHLH transcription factor 1 2.13958
CEP250 centrosomal protein 250kDa 2.13238
EDDM3A epididymal protein 3A 2.1304
LRRC31 leucine rich repeat containing 31 2.12605
YBX2 Y box binding protein 2 2.12574
MOS v-mos Moloney murine sarcoma viral oncogene homolog 2.12121
ASIC1 acid sensing (proton gated) ion channel 1 2.11873
CCL26 chemokine (C-C motif) ligand 26 2.11325
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 2.10905
THEM5 thioesterase superfamily member 5 2.10318
KNCN kinocilin 2.09892
KHDC4 KH domain containing 4, pre-mRNA splicing factor 2.08501
MSC musculin 2.07139
PDS5B PDS5 cohesin associated factor B 2.06983
NEUROG3 neurogenin 3 2.06831
MYL4 myosin, light chain 4, alkali; atrial, embryonic 2.06029
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 2.05954
RNH1 ribonuclease/angiogenin inhibitor 1 2.05928
BPIFA2 BPI fold containing family A, member 2 2.05461
SACK1B scaffolding CK1 anchoring protein B 2.04927
RGS8 regulator of G-protein signaling 8 2.04925
IRG1 immunoresponsive 1 homolog (mouse) 2.04777
ASPHD1 aspartate beta-hydroxylase domain containing 1 2.04391
ANKS6 ankyrin repeat and sterile alpha motif domain containing 6 2.04225
CEPT1 choline/ethanolamine phosphotransferase 1 2.02888
IMMT inner membrane protein, mitochondrial 2.02864
C9ORF16 chromosome 9 open reading frame 16 2.02355
REXO2 RNA exonuclease 2 2.01624
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle 2.01592
OPRK1 opioid receptor, kappa 1 2.01202
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 2.01085
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 2.0091
PTP4A1 protein tyrosine phosphatase type IVA, member 1 2.00643
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 2.0031
SCUBE3 signal peptide, CUB domain, EGF-like 3 2.00088