SB220025 Gene Set

Dataset DGIdb Drug Targets 2026
Category physical interactions
Type drug
Description Am member of the class of imidazoles carrying piperidin-4-yl, 4-fluophenyl and 2-aminopyrimidin-4-yl substituents at posiitons 1, 4 and 5 respectively. (Chemical Entities of Biological Interest Ontology, CHEBI_82713)
External Link https://dgidb.org/results?searchType=drug&searchTerms=SB220025
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Genes

31 interacting proteins for the SB220025 drug from theDGIdb Drug Targets 2026 dataset.

Symbol Name Standardized Value
CSNK1G2 casein kinase 1, gamma 2 0.121963
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 0.113832
SGK2 serum/glucocorticoid regulated kinase 2 0.10044
MELK maternal embryonic leucine zipper kinase 0.0853742
CSNK1A1 casein kinase 1, alpha 1 0.0813087
CSNK2A1 casein kinase 2, alpha 1 polypeptide 0.0742384
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 0.0742384
IRAK1 interleukin-1 receptor-associated kinase 1 0.0656724
CSNK1D casein kinase 1, delta 0.0632401
PRKCG protein kinase C, gamma 0.0609816
STK3 serine/threonine kinase 3 0.0588787
MINK1 misshapen-like kinase 1 0.0569161
LIMK1 LIM domain kinase 1 0.0550801
GSK3A glycogen synthase kinase 3 alpha 0.0517419
CLK2 CDC-like kinase 2 0.0502201
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0487852
PRKD2 protein kinase D2 0.0487852
PRKD3 protein kinase D3 0.0426871
MAPK9 mitogen-activated protein kinase 9 0.0416459
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0416459
LYN LYN proto-oncogene, Src family tyrosine kinase 0.0348466
PIM1 Pim-1 proto-oncogene, serine/threonine kinase 0.0322167
CLK4 CDC-like kinase 4 0.0310452
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0289404
LCK LCK proto-oncogene, Src family tyrosine kinase 0.0213435
RET ret proto-oncogene 0.01674
MAPK14 mitogen-activated protein kinase 14 0.0162617
FLT4 fms-related tyrosine kinase 4 0.0162617
MAPK1 mitogen-activated protein kinase 1 0.00898676
KDR kinase insert domain receptor 0.00841125
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.00801635