SBF1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description SET binding factor 1|This gene encodes a member of the protein-tyrosine phosphatase family. However, the encoded protein does not appear to be a catalytically active phosphatase because it lacks several amino acids in the catalytic pocket. This protein contains a Guanine nucleotide exchange factor (GEF) domain which is necessary for its role in growth and differentiation. Mutations in this gene have been associated with Charcot-Marie-Tooth disease 4B3. Pseudogenes of this gene have been defined on chromosomes 1 and 8. [provided by RefSeq, Dec 2014] (NCBI Entrez Gene Database, 6305)
Similar Terms
Downloads & Tools

Genes

327 genes differentially expressed following the SBF1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
COL20A1 collagen, type XX, alpha 1 2.80218
LRRC53 leucine rich repeat containing 53 2.80218
MUC5B mucin 5B, oligomeric mucus/gel-forming 2.80218
HBA1 hemoglobin, alpha 1 2.80218
FOXR1 forkhead box R1 2.80218
MBD3L3 methyl-CpG binding domain protein 3-like 3 2.80218
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 2.80218
TCHHL1 trichohyalin-like 1 2.80218
TLX2 T-cell leukemia homeobox 2 2.80218
THRSP thyroid hormone responsive 2.80218
GJB3 gap junction protein, beta 3, 31kDa 2.80218
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 2.80218
NCF4 neutrophil cytosolic factor 4, 40kDa 2.80218
CEMP1 cementum protein 1 2.80218
CDH5 cadherin 5, type 2 (vascular endothelium) 2.80218
IZUMO3 IZUMO family member 3 2.80218
PGAM4 phosphoglycerate mutase family member 4 2.80218
MAGEA1 melanoma antigen family A1 2.80218
FGL2 fibrinogen-like 2 2.80218
ZNF662 zinc finger protein 662 2.80218
MILR1 mast cell immunoglobulin-like receptor 1 2.80218
UNC13C unc-13 homolog C (C. elegans) 2.80218
LY6G6F lymphocyte antigen 6 complex, locus G6F 2.80218
EDDM3A epididymal protein 3A 2.80218
IKZF3 IKAROS family zinc finger 3 (Aiolos) 2.80218
CRYAA crystallin, alpha A 2.80218
RTP3 receptor (chemosensory) transporter protein 3 2.80218
SPAG8 sperm associated antigen 8 2.80218
PCDHGA11 protocadherin gamma subfamily A, 11 2.80218
IL23R interleukin 23 receptor 2.80218
PODN podocan 2.80218
OR6B3 olfactory receptor, family 6, subfamily B, member 3 2.80218
NEUROD1 neuronal differentiation 1 2.80218
RNF133 ring finger protein 133 2.80218
MYO1A myosin IA 2.80218
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 2.80218
LCN10 lipocalin 10 2.80218
LACTBL1 lactamase, beta-like 1 2.80218
CX3CR1 chemokine (C-X3-C motif) receptor 1 2.80218
SETSIP SET-like protein 2.80218
HBB hemoglobin, beta 2.80218
LBX2 ladybird homeobox 2 2.80218
KRT72 keratin 72, type II 2.80218
MMP20 matrix metallopeptidase 20 2.80218
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 2.80218
ASCL5 achaete-scute family bHLH transcription factor 5 2.80218
SPMAP1 sperm microtubule associated protein 1 2.80218
CCDC198 coiled-coil domain containing 198 2.80218
CPHXL2 cytoplasmic polyadenylated homeobox like 2 2.80218
STING1 stimulator of interferon response cGAMP interactor 1 2.80218
MCHR2 melanin-concentrating hormone receptor 2 2.80218
ROPN1L rhophilin associated tail protein 1-like 2.80218
RAX2 retina and anterior neural fold homeobox 2 2.80218
CWC22 CWC22 spliceosome-associated protein 2.80218
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.80218
GIPR gastric inhibitory polypeptide receptor 2.80218
ANKRD40CL ANKRD40 C-terminal like 2.80218
CALHM5 calcium homeostasis modulator family member 5 2.80218
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 2.80218
SPMAP2L sperm microtubule associated protein 2 like 2.80218
TMDD1 transmembrane and death domain 1 2.80218
MDFIC2 MyoD family inhibitor domain containing 2 2.80218
CIBAR2 CBY1 interacting BAR domain containing 2 2.80218
SEPTIN12 septin 12 2.80218
MAJIN membrane anchored junction protein 2.80218
H2BW2 H2B.W histone 2 2.80218
H2AC1 H2A clustered histone 1 2.80218
NFILZ NFIL3 like basic leucine zipper 2.80218
TSPAN8 tetraspanin 8 2.80218
ATP4B ATPase, H+/K+ exchanging, beta polypeptide 2.80218
ITK IL2-inducible T-cell kinase 2.80218
PCDHA2 protocadherin alpha 2 2.80218
PRKAG3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit 2.80218
FAM3D family with sequence similarity 3, member D 2.80218
NCBP2L nuclear cap binding protein subunit 2-like 2.80218
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 2.80218
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 2.80218
GJA3 gap junction protein, alpha 3, 46kDa 2.80218
FAM187B family with sequence similarity 187, member B 2.80218
AKR1D1 aldo-keto reductase family 1, member D1 2.80218
TMCO2 transmembrane and coiled-coil domains 2 2.80218
GDF10 growth differentiation factor 10 2.80218
CLEC6A C-type lectin domain family 6, member A 2.80218
CSAG1 chondrosarcoma associated gene 1 2.80218
PRG4 proteoglycan 4 2.80218
PNPLA1 patatin-like phospholipase domain containing 1 2.80218
OR2D3 olfactory receptor, family 2, subfamily D, member 3 2.80218
TACR2 tachykinin receptor 2 2.80218
TCF23 transcription factor 23 2.80218
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 2.80218
SLAMF6 SLAM family member 6 2.80218
ENPP7 ectonucleotide pyrophosphatase/phosphodiesterase 7 2.80218
ASCL1 achaete-scute family bHLH transcription factor 1 2.80218
CABP7 calcium binding protein 7 2.80218
DQX1 DEAQ box RNA-dependent ATPase 1 2.80218
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 2.80218
OAZ3 ornithine decarboxylase antizyme 3 2.80218
GLT1D1 glycosyltransferase 1 domain containing 1 2.80218
AKNAD1 AKNA domain containing 1 2.80218
SPATA4 spermatogenesis associated 4 2.80218
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 2.80218
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) 2.80218
WNT7B wingless-type MMTV integration site family, member 7B 2.80218
CST7 cystatin F (leukocystatin) 2.80218
ZNF541 zinc finger protein 541 2.80218
GP2 glycoprotein 2 (zymogen granule membrane) 2.80218
APOD apolipoprotein D 2.80218
GP1BB glycoprotein Ib (platelet), beta polypeptide 2.80218
PRF1 perforin 1 (pore forming protein) 2.80218
FNDC9 fibronectin type III domain containing 9 2.80218
TMEM132E transmembrane protein 132E 2.80218
KCNK9 potassium channel, two pore domain subfamily K, member 9 2.80218
EREG epiregulin 2.80218
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 2.80218
SHOX2 short stature homeobox 2 2.80218
LMOD2 leiomodin 2 (cardiac) 2.80218
ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B 2.80218
EGR3 early growth response 3 2.80218
DLX1 distal-less homeobox 1 2.80218
PENK proenkephalin 2.80218
PSG6 pregnancy specific beta-1-glycoprotein 6 2.80218
CD27 CD27 molecule 2.80218
DEFB135 defensin, beta 135 2.80218
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7 2.80218
IL27 interleukin 27 2.80218
CCDC70 coiled-coil domain containing 70 2.80218
LRRC23 leucine rich repeat containing 23 2.80218
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like 2.80218
CDH17 cadherin 17, LI cadherin (liver-intestine) 2.80218
GSTA2 glutathione S-transferase alpha 2 2.80218
SIRPD signal-regulatory protein delta 2.80218
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) 2.80218
HK3 hexokinase 3 (white cell) 2.80218
C8G complement component 8, gamma polypeptide 2.80218
CTXN2 cortexin 2 2.80218
ARL13A ADP-ribosylation factor-like 13A 2.80218
ZC3H12D zinc finger CCCH-type containing 12D 2.80218
COL9A2 collagen, type IX, alpha 2 2.80218
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 2.80218
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 2.80218
NLRP5 NLR family, pyrin domain containing 5 2.80218
DUOXA1 dual oxidase maturation factor 1 2.80218
CYBB cytochrome b-245, beta polypeptide 2.80218
APOL3 apolipoprotein L, 3 2.80218
COL22A1 collagen, type XXII, alpha 1 2.80218
GPR50 G protein-coupled receptor 50 2.80218
FITM1 fat storage-inducing transmembrane protein 1 2.80218
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular) 2.80218
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 2.80218
PRSS55 protease, serine, 55 2.80218
POTEF POTE ankyrin domain family, member F 2.80218
SLFN12L schlafen family member 12-like 2.80218
GNG8 guanine nucleotide binding protein (G protein), gamma 8 2.80218
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 2.80218
IL10RA interleukin 10 receptor, alpha 2.80218
GCSAML germinal center-associated, signaling and motility-like 2.80218
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) 2.80218
IL37 interleukin 37 2.80218
HEPACAM hepatic and glial cell adhesion molecule 2.80218
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) 2.80218
AGBL4 ATP/GTP binding protein-like 4 2.80218
CSF3R colony stimulating factor 3 receptor (granulocyte) 2.80218
AGBL5 ATP/GTP binding protein-like 5 2.80218
LRRC31 leucine rich repeat containing 31 2.80218
KCNK15 potassium channel, two pore domain subfamily K, member 15 2.7321
MNMIP1 manchette microtubule inner protein 1 2.72569
CRIP1 cysteine-rich protein 1 (intestinal) 2.70384
IRF7 interferon regulatory factor 7 2.68553
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.59209
ZNF333 zinc finger protein 333 2.51977
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 2.47787
CPNE8 copine VIII 2.45732
LTA4H leukotriene A4 hydrolase 2.43076
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2 2.42659
DMC1 DNA meiotic recombinase 1 2.41306
VCX variable charge, X-linked 2.35946
MRPS34 mitochondrial ribosomal protein S34 2.35946
PTPRN protein tyrosine phosphatase, receptor type, N 2.3356
DPYD dihydropyrimidine dehydrogenase 2.3356
TBC1D2B TBC1 domain family, member 2B 2.3356
STXBP4 syntaxin binding protein 4 2.33142
CA9 carbonic anhydrase IX 2.32628
OR52N2 olfactory receptor, family 52, subfamily N, member 2 2.32628
MSRB1 methionine sulfoxide reductase B1 2.31388
SH3RF3 SH3 domain containing ring finger 3 2.28545
MATN1 matrilin 1, cartilage matrix protein 2.27077
ACTR8 ARP8 actin-related protein 8 homolog (yeast) 2.26137
NECAP1 NECAP endocytosis associated 1 2.24595
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 2.24546
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) 2.24119
ACVRL1 activin A receptor type II-like 1 2.23391
UPB1 ureidopropionase, beta 2.23391
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like 2.23003
SDR42E1 short chain dehydrogenase/reductase family 42E, member 1 2.23003
NUP210 nucleoporin 210kDa 2.19603
MARS1 methionyl-tRNA synthetase 1 2.18382
RPTOR regulatory associated protein of MTOR, complex 1 2.18382
PANX1 pannexin 1 2.17805
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 2.1773
MTPN myotrophin 2.12954
DNAH7 dynein, axonemal, heavy chain 7 2.09627
CMTR2 cap methyltransferase 2 2.09094
CAPN10 calpain 10 2.0902
SMIM12 small integral membrane protein 12 2.0869
GEN1 GEN1 Holliday junction 5' flap endonuclease 2.0803
ACAD11 acyl-CoA dehydrogenase family, member 11 2.07678
DPP8 dipeptidyl-peptidase 8 2.07654
RFC1 replication factor C (activator 1) 1, 145kDa 2.07573
TRPV1 transient receptor potential cation channel, subfamily V, member 1 2.06131
EBF2 early B-cell factor 2 2.06131
TMEM31 transmembrane protein 31 2.06131
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1 2.05183
ZNF689 zinc finger protein 689 2.04852
TMEM109 transmembrane protein 109 2.03472
TM2D1 TM2 domain containing 1 2.03107
BRD9 bromodomain containing 9 2.02972
ZBTB5 zinc finger and BTB domain containing 5 2.02565
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.01438
PAXIP1 PAX interacting (with transcription-activation domain) protein 1 2.01438
SMAP2 small ArfGAP2 2.01245
ZNF584 zinc finger protein 584 2.00776
C2CD2 C2 calcium-dependent domain containing 2 2.00052
PTTG1 pituitary tumor-transforming 1 2.00038

decreased expression

Symbol Name Standardized Value
KIF12 kinesin family member 12 -2.80218
TTN titin -2.80218
TMEM187 transmembrane protein 187 -2.80218
TMEM100 transmembrane protein 100 -2.80218
TUBB tubulin, beta class I -2.80218
FREM2 FRAS1 related extracellular matrix protein 2 -2.80218
AARSD1 alanyl-tRNA synthetase domain containing 1 -2.80218
DGCR6 DiGeorge syndrome critical region gene 6 -2.80218
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 -2.80218
DIRAS2 DIRAS family, GTP-binding RAS-like 2 -2.80218
GCKR glucokinase (hexokinase 4) regulator -2.80218
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) -2.80218
PANO1 proapoptotic nucleolar protein 1 -2.80218
PLA2G10 phospholipase A2, group X -2.80218
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -2.80218
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 -2.80218
SBF1 SET binding factor 1 -2.80218
NAT16 N-acetyltransferase 16 (GCN5-related, putative) -2.80218
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial -2.80218
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10 -2.80218
PRKD1 protein kinase D1 -2.80218
RSPH10B2 radial spoke head 10 homolog B2 (Chlamydomonas) -2.80218
KLHL10 kelch-like family member 10 -2.80218
STPG4 sperm-tail PG-rich repeat containing 4 -2.80218
KIFC1 kinesin family member C1 -2.80218
ZNF750 zinc finger protein 750 -2.80218
KY kyphoscoliosis peptidase -2.80218
ELOVL3 ELOVL fatty acid elongase 3 -2.80218
RAMACL RNA guanine-7 methyltransferase activating subunit like -2.80218
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 -2.80218
KCNK4 potassium channel, two pore domain subfamily K, member 4 -2.80218
CXCL16 chemokine (C-X-C motif) ligand 16 -2.80218
GPR75 G protein-coupled receptor 75 -2.80218
F11R F11 receptor -2.80218
CFAP43 cilia and flagella associated protein 43 -2.80218
KLRF1 killer cell lectin-like receptor subfamily F, member 1 -2.80218
CRCP CGRP receptor component -2.70384
NPTX1 neuronal pentraxin I -2.68632
FAM217B family with sequence similarity 217, member B -2.67348
ZNG1B Zn regulated GTPase metalloprotein activator 1B -2.65574
AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2 -2.65504
CAMK2D calcium/calmodulin-dependent protein kinase II delta -2.65504
SWI5 SWI5 recombination repair homolog (yeast) -2.65504
TDP2 tyrosyl-DNA phosphodiesterase 2 -2.63849
AP5S1 adaptor-related protein complex 5, sigma 1 subunit -2.61827
KLHDC1 kelch domain containing 1 -2.61827
ABHD17A abhydrolase domain containing 17A -2.60303
PLAAT5 phospholipase A and acyltransferase 5 -2.57203
BICD1 bicaudal D homolog 1 (Drosophila) -2.50246
CHST6 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6 -2.50212
TBC1D9 TBC1 domain family, member 9 (with GRAM domain) -2.49065
TYRO3 TYRO3 protein tyrosine kinase -2.47313
RNF112 ring finger protein 112 -2.47313
GSTO1 glutathione S-transferase omega 1 -2.44564
DUT deoxyuridine triphosphatase -2.42963
FLT4 fms-related tyrosine kinase 4 -2.4195
CDPF1 cysteine-rich, DPF motif domain containing 1 -2.41332
DERA deoxyribose-phosphate aldolase (putative) -2.37606
CDHR3 cadherin-related family member 3 -2.37268
GLCE glucuronic acid epimerase -2.34698
ZGLP1 zinc finger, GATA-like protein 1 -2.33773
GPKOW G patch domain and KOW motifs -2.3356
ZNF804A zinc finger protein 804A -2.33142
TSSK6 testis-specific serine kinase 6 -2.33142
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2 -2.33142
FXYD1 FXYD domain containing ion transport regulator 1 -2.32964
ATRNL1 attractin-like 1 -2.32426
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 -2.2607
PTPRK protein tyrosine phosphatase, receptor type, K -2.23368
OLFML1 olfactomedin-like 1 -2.23003
MMP28 matrix metallopeptidase 28 -2.23003
ATP23 ATP23 metallopeptidase and ATP synthase assembly factor homolog -2.23003
CHCHD4 coiled-coil-helix-coiled-coil-helix domain containing 4 -2.2297
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) -2.20871
OR2H2 olfactory receptor, family 2, subfamily H, member 2 -2.2078
ZC3H3 zinc finger CCCH-type containing 3 -2.20407
ZMAT4 zinc finger, matrin-type 4 -2.19982
BMAL2 basic helix-loop-helix ARNT like 2 -2.19982
RHOF ras homolog family member F (in filopodia) -2.18382
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) -2.17293
BZW2 basic leucine zipper and W2 domains 2 -2.16478
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 -2.16081
SYVN1 synovial apoptosis inhibitor 1, synoviolin -2.15801
SSC5D scavenger receptor cysteine rich family, 5 domains -2.14486
SCRN3 secernin 3 -2.14364
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2 -2.13974
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -2.13974
TNN tenascin N -2.12465
NOSTRIN nitric oxide synthase trafficking -2.1112
RDM1 RAD52 motif containing 1 -2.09833
ZNF395 zinc finger protein 395 -2.09797
TRAF5 TNF receptor-associated factor 5 -2.09657
SYPL2 synaptophysin-like 2 -2.09066
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6 -2.0803
TOP1MT topoisomerase (DNA) I, mitochondrial -2.06131
ATCAY ataxia, cerebellar, Cayman type -2.05685
MTX1 metaxin 1 -2.04724
TMED1 transmembrane emp24 protein transport domain containing 1 -2.03522
WDR83 WD repeat domain 83 -2.03107
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.02972
ARL2 ADP-ribosylation factor-like 2 -2.02363
ALAD aminolevulinate dehydratase -2.0152
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -2.01438
ZNF711 zinc finger protein 711 -2.01245