SBI-0640756_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description SBI-0640756 perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the SBI-0640756_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.157315
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.144623
VIM vimentin 0.144099
SQSTM1 sequestosome 1 0.0922944
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0793281
HDAC9 histone deacetylase 9 0.0663158
CSTB cystatin B (stefin B) 0.0657078
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0656534
PRRC2C proline-rich coiled-coil 2C 0.0636131
PALM2AKAP2 PALM2 and AKAP2 fusion 0.057313
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0561612
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 0.0541338
HLA-B major histocompatibility complex, class I, B 0.0540015
EIF1 eukaryotic translation initiation factor 1 0.052137
ENO1 enolase 1, (alpha) 0.0518219
CALD1 caldesmon 1 0.05041
SP100 SP100 nuclear antigen 0.0483661
RPS3 ribosomal protein S3 0.04555
HLA-A major histocompatibility complex, class I, A 0.0439446
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0430406
SLC39A11 solute carrier family 39, member 11 0.0424034
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0420565
GOLGB1 golgin B1 0.0415107
RPL37A ribosomal protein L37a 0.0410523
BHLHE40 basic helix-loop-helix family, member e40 0.0400386
RPS12 ribosomal protein S12 0.039962
CREB5 cAMP responsive element binding protein 5 0.0397042
DDIT4 DNA-damage-inducible transcript 4 0.0393109
AKAP9 A kinase (PRKA) anchor protein 9 0.039241
ENO2 enolase 2 (gamma, neuronal) 0.0390693
NFE2L1 nuclear factor, erythroid 2-like 1 0.0384263
FTL ferritin, light polypeptide 0.0382003
NAV2 neuron navigator 2 0.0380599
ULK1 unc-51 like autophagy activating kinase 1 0.0375844
SH3KBP1 SH3-domain kinase binding protein 1 0.0373312
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0372361
OGA O-GlcNAcase 0.0371252
IFI6 interferon, alpha-inducible protein 6 0.036932
RSAD2 radical S-adenosyl methionine domain containing 2 0.0361205
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0359242
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.0358308
DST dystonin 0.0354387
ZNF638 zinc finger protein 638 0.034933
ZMIZ1 zinc finger, MIZ-type containing 1 0.0344199
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0342868
RPS27 ribosomal protein S27 0.0341604
PTMA prothymosin, alpha 0.0338002
MYOF myoferlin 0.0337777
CALR calreticulin 0.0334536
CEP350 centrosomal protein 350kDa 0.0327953
PLAUR plasminogen activator, urokinase receptor 0.0324241
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0322839
MT2A metallothionein 2A 0.0321292
RHOBTB3 Rho-related BTB domain containing 3 0.0320759
B2M beta-2-microglobulin 0.0319355
GTF2IRD1 GTF2I repeat domain containing 1 0.0317874
L1CAM L1 cell adhesion molecule 0.0317493
PRELID2 PRELI domain containing 2 0.0315448
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0314004
TPM4 tropomyosin 4 0.0309734
PTPRF protein tyrosine phosphatase, receptor type, F 0.0299605
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0296861
NCOR2 nuclear receptor corepressor 2 0.0296361
MACF1 microtubule-actin crosslinking factor 1 0.0294344
PER1 period circadian clock 1 0.0293729
AHNAK2 AHNAK nucleoprotein 2 0.0289549
BACE2 beta-site APP-cleaving enzyme 2 0.0283167
TBCA tubulin folding cofactor A 0.0280272
SPIRE1 spire-type actin nucleation factor 1 0.0279944
IFI16 interferon, gamma-inducible protein 16 0.0278631
FBXL7 F-box and leucine-rich repeat protein 7 0.0276489
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.02758
DSCAM Down syndrome cell adhesion molecule 0.0274827
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) 0.0274153
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0268648
DTNA dystrobrevin, alpha 0.0267628
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0267583
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 0.0267223
NAP1L1 nucleosome assembly protein 1-like 1 0.026362
ZNF292 zinc finger protein 292 0.0261584
ANKRD12 ankyrin repeat domain 12 0.0254138
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0252326
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.02522
ATF4 activating transcription factor 4 0.0251311
PEA15 phosphoprotein enriched in astrocytes 15 0.0250954
FBXO11 F-box protein 11 0.0248933
SLC38A2 solute carrier family 38, member 2 0.0247075
IFITM3 interferon induced transmembrane protein 3 0.0244821
RPL37 ribosomal protein L37 0.0240923
KIF5B kinesin family member 5B 0.0240431
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0238898
RPS2 ribosomal protein S2 0.0236187
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0235932
ZFP36L1 ZFP36 ring finger protein-like 1 0.0235902
ANKRD11 ankyrin repeat domain 11 0.0235597
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0235213
GOLGA4 golgin A4 0.0235113
GADD45A growth arrest and DNA-damage-inducible, alpha 0.0233765
S100A11 S100 calcium binding protein A11 0.0233658
ISG15 ISG15 ubiquitin-like modifier 0.0233531

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.213513
IGFBP3 insulin-like growth factor binding protein 3 -0.168864
FBN1 fibrillin 1 -0.0952993
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0935147
COL5A2 collagen, type V, alpha 2 -0.0919887
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0900747
FNDC3B fibronectin type III domain containing 3B -0.0828782
NAV1 neuron navigator 1 -0.0819172
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0777054
COL1A2 collagen, type I, alpha 2 -0.0723185
COL5A1 collagen, type V, alpha 1 -0.0691092
LOX lysyl oxidase -0.0670464
LOXL2 lysyl oxidase-like 2 -0.0664292
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0657283
AHNAK AHNAK nucleoprotein -0.0631138
POTEF POTE ankyrin domain family, member F -0.0623728
COL8A1 collagen, type VIII, alpha 1 -0.0610418
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0609163
GLIS3 GLIS family zinc finger 3 -0.0576338
CD44 CD44 molecule (Indian blood group) -0.0568199
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0566326
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0523478
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0496536
MYADM myeloid-associated differentiation marker -0.047575
COL3A1 collagen, type III, alpha 1 -0.0470972
SP3 Sp3 transcription factor -0.04551
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0449806
PDIA3 protein disulfide isomerase family A, member 3 -0.0421345
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0408116
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0403682
S100A10 S100 calcium binding protein A10 -0.0401486
UBC ubiquitin C -0.0390048
RUNX1 runt-related transcription factor 1 -0.0382504
TAGLN2 transgelin 2 -0.0358536
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0354497
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.035354
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4 -0.0350935
SOD2 superoxide dismutase 2, mitochondrial -0.0346334
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0345243
FLNB filamin B, beta -0.0339903
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0336823
PODXL podocalyxin-like -0.0328762
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0328493
NDRG1 N-myc downstream regulated 1 -0.0328348
HSPB1 heat shock 27kDa protein 1 -0.0324516
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.032241
FN1 fibronectin 1 -0.0312319
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0309072
THBS2 thrombospondin 2 -0.0303629
TRAM2 translocation associated membrane protein 2 -0.0297449
TAPBP TAP binding protein (tapasin) -0.0292794
RAB1A RAB1A, member RAS oncogene family -0.0289384
FTH1 ferritin, heavy polypeptide 1 -0.0288238
PTK2 protein tyrosine kinase 2 -0.0278739
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0276294
EXT1 exostosin glycosyltransferase 1 -0.027507
JAZF1 JAZF zinc finger 1 -0.0273904
ABI3BP ABI family, member 3 (NESH) binding protein -0.0272658
DPYSL2 dihydropyrimidinase-like 2 -0.0272529
SMYD3 SET and MYND domain containing 3 -0.027013
MT1X metallothionein 1X -0.0269711
CDH13 cadherin 13 -0.0269537
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0268437
ATP13A3 ATPase type 13A3 -0.026724
COPB1 coatomer protein complex, subunit beta 1 -0.0267146
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0264976
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0264061
DCLK2 doublecortin-like kinase 2 -0.0261664
MTCL1 microtubule crosslinking factor 1 -0.026067
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa -0.0258196
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0256869
LAMB1 laminin, beta 1 -0.0254388
ZNF148 zinc finger protein 148 -0.0251108
SBF2 SET binding factor 2 -0.0250625
PSD3 pleckstrin and Sec7 domain containing 3 -0.0249308
KIRREL1 kirre like nephrin family adhesion molecule 1 -0.0249146
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0247437
SEC31A SEC31 homolog A (S. cerevisiae) -0.0246821
TUBA1B tubulin, alpha 1b -0.0243405
EHBP1 EH domain binding protein 1 -0.0241871
DPYSL3 dihydropyrimidinase-like 3 -0.02405
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 -0.0238316
FAM114A1 family with sequence similarity 114, member A1 -0.0235811
CLIC4 chloride intracellular channel 4 -0.0234332
UHMK1 U2AF homology motif (UHM) kinase 1 -0.0234322
TUBB4B tubulin, beta 4B class IVb -0.0234017
ERRFI1 ERBB receptor feedback inhibitor 1 -0.023362
DKK3 dickkopf WNT signaling pathway inhibitor 3 -0.02323
EFNA5 ephrin-A5 -0.0230519
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0229287
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha -0.0227582
COPA coatomer protein complex, subunit alpha -0.0226506
AFAP1 actin filament associated protein 1 -0.0224722
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.022365
ELL2 elongation factor, RNA polymerase II, 2 -0.0222213
DNAAF9 dynein axonemal assembly factor 9 -0.021929
FLT1 fms-related tyrosine kinase 1 -0.0219016
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) -0.0217997
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0216892
CD99 CD99 molecule -0.0216793