SBI-0640756_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description SBI-0640756 perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the SBI-0640756_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.163322
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.112569
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0963097
FTL ferritin, light polypeptide 0.0771995
AREG amphiregulin 0.0684507
TPI1 triosephosphate isomerase 1 0.0591714
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0560773
ASPH aspartate beta-hydroxylase 0.0555335
RPS12 ribosomal protein S12 0.0519742
GCG glucagon 0.0505504
EGR1 early growth response 1 0.0488334
ZNF804A zinc finger protein 804A 0.0471699
ANKRD12 ankyrin repeat domain 12 0.0464639
PTMA prothymosin, alpha 0.0456239
PCDH9 protocadherin 9 0.0447733
RPS3 ribosomal protein S3 0.0446601
ENO1 enolase 1, (alpha) 0.0440957
RPL37A ribosomal protein L37a 0.042517
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0408001
AKAP9 A kinase (PRKA) anchor protein 9 0.0394631
GOLGB1 golgin B1 0.0391685
RPS8 ribosomal protein S8 0.0375713
INTS6 integrator complex subunit 6 0.0371621
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0370942
DSCAM Down syndrome cell adhesion molecule 0.0355186
DTNA dystrobrevin, alpha 0.0353226
HLA-A major histocompatibility complex, class I, A 0.0343096
MED13L mediator complex subunit 13-like 0.0339625
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0335021
LRRC23 leucine rich repeat containing 23 0.0334837
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0326893
LDHB lactate dehydrogenase B 0.0311506
DDIT3 DNA-damage-inducible transcript 3 0.0310761
PKM pyruvate kinase, muscle 0.0306111
RPL35A ribosomal protein L35a 0.0298928
LOC102724023 ES1 protein homolog, mitochondrial 0.0294552
ZSWIM6 zinc finger, SWIM-type containing 6 0.0276773
ANKRD11 ankyrin repeat domain 11 0.0275211
PFN1 profilin 1 0.027196
EIF5B eukaryotic translation initiation factor 5B 0.0268044
RPL4 ribosomal protein L4 0.0266812
AHRR aryl-hydrocarbon receptor repressor 0.0259002
BRD2 bromodomain containing 2 0.0256571
RPS27A ribosomal protein S27a 0.0254056
PEG10 paternally expressed 10 0.0253846
RPS13 ribosomal protein S13 0.0253351
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0251241
NACA nascent polypeptide-associated complex alpha subunit 0.0250966
TTC3 tetratricopeptide repeat domain 3 0.0249534
ANKRD17 ankyrin repeat domain 17 0.0249111
RPS10 ribosomal protein S10 0.0244157
MBD5 methyl-CpG binding domain protein 5 0.0240511
ANKHD1 ankyrin repeat and KH domain containing 1 0.0229969
PRRC2C proline-rich coiled-coil 2C 0.022913
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0225847
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.022168
SRRM2 serine/arginine repetitive matrix 2 0.0220264
PAIP2 poly(A) binding protein interacting protein 2 0.021902
TIMP2 TIMP metallopeptidase inhibitor 2 0.0216022
RPL10A ribosomal protein L10a 0.0211518
RPS2 ribosomal protein S2 0.0208506
RPS6 ribosomal protein S6 0.0206516
NAP1L1 nucleosome assembly protein 1-like 1 0.0206169
CCT4 chaperonin containing TCP1, subunit 4 (delta) 0.0204158
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0201525
GON4L gon-4-like (C. elegans) 0.0200626
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.0199506
RCOR1 REST corepressor 1 0.0198146
RACK1 receptor for activated C kinase 1 0.0197329
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) 0.0195337
TM9SF4 transmembrane 9 superfamily protein member 4 0.0195237
KIF1B kinesin family member 1B 0.0194388
GPHN gephyrin 0.0190561
SNX10 sorting nexin 10 0.0187596
TFCP2 transcription factor CP2 0.0187189
RPL31 ribosomal protein L31 0.0186364
HDGF hepatoma-derived growth factor 0.0185311
HMGA2 high mobility group AT-hook 2 0.0183771
PHF21A PHD finger protein 21A 0.0183679
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0182825
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0182799
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0180893
SET SET nuclear proto-oncogene 0.0180802
FAM162A family with sequence similarity 162, member A 0.0180578
RPL37 ribosomal protein L37 0.0179984
POTEF POTE ankyrin domain family, member F 0.017879
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0175443
AHCYL2 adenosylhomocysteinase-like 2 0.0175251
SARNP SAP domain containing ribonucleoprotein 0.0174521
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 0.0173465
EZR ezrin 0.017203
ADM adrenomedullin 0.0171583
RAB7A RAB7A, member RAS oncogene family 0.0170352
UBE2B ubiquitin-conjugating enzyme E2B 0.016959
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0169234
NR2F1 nuclear receptor subfamily 2, group F, member 1 0.0169062
PHACTR4 phosphatase and actin regulator 4 0.0169028
DOCK1 dedicator of cytokinesis 1 0.0168286
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0168175
KPNB1 karyopherin (importin) beta 1 0.0166813

decreased expression

Symbol Name Standardized Value
NLGN1 neuroligin 1 -0.174241
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0890355
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0810386
MMP12 matrix metallopeptidase 12 -0.0530921
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0513896
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0495361
TXNRD1 thioredoxin reductase 1 -0.0486756
AHNAK AHNAK nucleoprotein -0.0478376
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0464471
ZBTB20 zinc finger and BTB domain containing 20 -0.0450243
PCDH7 protocadherin 7 -0.0450101
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0441
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0413172
TMEM123 transmembrane protein 123 -0.0410822
NEK7 NIMA-related kinase 7 -0.0374771
PDE4D phosphodiesterase 4D, cAMP-specific -0.0365826
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0356175
ECT2 epithelial cell transforming 2 -0.0348661
YAP1 Yes-associated protein 1 -0.0340847
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0332122
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0325087
BIRC3 baculoviral IAP repeat containing 3 -0.0323908
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0323589
LMO7 LIM domain 7 -0.0319018
BCHE butyrylcholinesterase -0.0316189
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0314508
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0293668
BIRC2 baculoviral IAP repeat containing 2 -0.0290246
ADGRG6 adhesion G protein-coupled receptor G6 -0.0288712
TMEM41B transmembrane protein 41B -0.0288396
GASK1B golgi associated kinase 1B -0.0272485
RRM2 ribonucleotide reductase M2 -0.0259323
IL6ST interleukin 6 signal transducer -0.0259318
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.025655
KLF6 Kruppel-like factor 6 -0.0254079
EHBP1 EH domain binding protein 1 -0.0253369
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.025306
USP34 ubiquitin specific peptidase 34 -0.0249843
MKI67 marker of proliferation Ki-67 -0.0248225
SMC4 structural maintenance of chromosomes 4 -0.0247994
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0247263
MARCHF6 membrane associated ring-CH-type finger 6 -0.024568
CKAP5 cytoskeleton associated protein 5 -0.0242323
NR5A2 nuclear receptor subfamily 5, group A, member 2 -0.023509
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0234714
RAB1A RAB1A, member RAS oncogene family -0.0233375
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.023079
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0230501
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0224582
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0224275
CELF2 CUGBP, Elav-like family member 2 -0.0223491
CENPE centromere protein E, 312kDa -0.022253
CENPF centromere protein F, 350/400kDa -0.0220792
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0220383
EFNA5 ephrin-A5 -0.0217728
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0216691
RAD21 RAD21 homolog (S. pombe) -0.0216444
MIS18BP1 MIS18 binding protein 1 -0.0213822
OXR1 oxidation resistance 1 -0.0213646
NBAS neuroblastoma amplified sequence -0.0212994
TMSB10 thymosin beta 10 -0.0209698
FAT1 FAT atypical cadherin 1 -0.0209626
XPO1 exportin 1 -0.0206076
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0205687
NUP153 nucleoporin 153kDa -0.0205627
SNCA synuclein, alpha (non A4 component of amyloid precursor) -0.0205114
WDR43 WD repeat domain 43 -0.0204509
RIMS2 regulating synaptic membrane exocytosis 2 -0.0199316
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0198992
ARL5B ADP-ribosylation factor-like 5B -0.0195125
CCND1 cyclin D1 -0.0195034
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0192546
ZFR zinc finger RNA binding protein -0.0189704
TPX2 TPX2, microtubule-associated -0.0187043
NUP98 nucleoporin 98kDa -0.0186744
MYL12B myosin, light chain 12B, regulatory -0.018561
CDK17 cyclin-dependent kinase 17 -0.018342
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0182883
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0182263
CEP192 centrosomal protein 192kDa -0.0182154
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0179699
MTAP methylthioadenosine phosphorylase -0.0178966
EXOC6B exocyst complex component 6B -0.017823
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.017713
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 -0.0176728
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0176672
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0176252
MATR3 matrin 3 -0.0175787
CHD1 chromodomain helicase DNA binding protein 1 -0.0175667
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.017542
FER fer (fps/fes related) tyrosine kinase -0.0175021
TUBB tubulin, beta class I -0.017415
THOC1 THO complex 1 -0.0173708
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0173075
CANX calnexin -0.0173067
WWOX WW domain containing oxidoreductase -0.0171469
GOLT1B golgi transport 1B -0.0169522
KIF18B kinesin family member 18B -0.0169457
AVL9 AVL9 homolog (S. cerevisiase) -0.016855
THSD7A thrombospondin, type I, domain containing 7A -0.0168119