| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | SBI-0640756 perturbation in A498 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the SBI-0640756_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 0.0794761 |
| ASPH | aspartate beta-hydroxylase | 0.0540656 |
| GLIS3 | GLIS family zinc finger 3 | 0.0513169 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0470223 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0466667 |
| IRS2 | insulin receptor substrate 2 | 0.0464748 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0464466 |
| CA12 | carbonic anhydrase XII | 0.0437832 |
| PBX1 | pre-B-cell leukemia homeobox 1 | 0.0430571 |
| FTL | ferritin, light polypeptide | 0.0421359 |
| MT2A | metallothionein 2A | 0.0414876 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0399106 |
| GPC5 | glypican 5 | 0.0398021 |
| MGST1 | microsomal glutathione S-transferase 1 | 0.0387243 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0386396 |
| CENPF | centromere protein F, 350/400kDa | 0.0384188 |
| OSMR | oncostatin M receptor | 0.0364276 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0362152 |
| CBX3 | chromobox homolog 3 | 0.0345262 |
| NRP1 | neuropilin 1 | 0.0341496 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0336935 |
| TMSB10 | thymosin beta 10 | 0.0326332 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0311973 |
| TSHZ2 | teashirt zinc finger homeobox 2 | 0.031026 |
| ETV6 | ets variant 6 | 0.0309775 |
| EHBP1 | EH domain binding protein 1 | 0.0308527 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0300718 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.029991 |
| RPL4 | ribosomal protein L4 | 0.0293853 |
| RNF213 | ring finger protein 213 | 0.0293462 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.029345 |
| CP | ceruloplasmin (ferroxidase) | 0.0291891 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0290615 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0290208 |
| RDH10 | retinol dehydrogenase 10 (all-trans) | 0.0279425 |
| VCL | vinculin | 0.0276995 |
| RPL12 | ribosomal protein L12 | 0.0265813 |
| APOL1 | apolipoprotein L, 1 | 0.0260201 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0259169 |
| SMAD3 | SMAD family member 3 | 0.0258716 |
| NRP2 | neuropilin 2 | 0.0254571 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0241887 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0241668 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | 0.0234758 |
| MKI67 | marker of proliferation Ki-67 | 0.0228726 |
| B2M | beta-2-microglobulin | 0.0226101 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0225753 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0225359 |
| ACTN4 | actinin, alpha 4 | 0.0223678 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0220499 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0213372 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0212142 |
| RPS2 | ribosomal protein S2 | 0.0205982 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0205734 |
| RPL23 | ribosomal protein L23 | 0.0205409 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | 0.020293 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.02025 |
| OXR1 | oxidation resistance 1 | 0.0201977 |
| JAK1 | Janus kinase 1 | 0.0200367 |
| BCL6 | B-cell CLL/lymphoma 6 | 0.0199984 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0198725 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.0194707 |
| APP | amyloid beta (A4) precursor protein | 0.0189776 |
| ANXA1 | annexin A1 | 0.0189628 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | 0.0189566 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0189107 |
| AHI1 | Abelson helper integration site 1 | 0.0186533 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0185406 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0184791 |
| TPI1 | triosephosphate isomerase 1 | 0.018243 |
| RPL13A | ribosomal protein L13a | 0.0179795 |
| PFKP | phosphofructokinase, platelet | 0.0178439 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0176245 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0175306 |
| TGFB2 | transforming growth factor, beta 2 | 0.0174255 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | 0.0171787 |
| SAA2 | serum amyloid A2 | 0.0170129 |
| FUS | FUS RNA binding protein | 0.0169395 |
| CKAP4 | cytoskeleton-associated protein 4 | 0.0169121 |
| RPL35 | ribosomal protein L35 | 0.0168548 |
| SLC4A4 | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 | 0.0168264 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0165599 |
| RRBP1 | ribosome binding protein 1 | 0.0165392 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | 0.0164053 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0162139 |
| TMOD3 | tropomodulin 3 (ubiquitous) | 0.0161368 |
| RPS19 | ribosomal protein S19 | 0.0161256 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0161088 |
| MYO9A | myosin IXA | 0.0160709 |
| BICC1 | BicC family RNA binding protein 1 | 0.0160464 |
| RPS15A | ribosomal protein S15a | 0.0160124 |
| HLA-C | major histocompatibility complex, class I, C | 0.0158713 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.0158402 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0157828 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0156463 |
| ITSN1 | intersectin 1 (SH3 domain protein) | 0.0156414 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.0155578 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0154872 |
| RPS3 | ribosomal protein S3 | 0.0154775 |
| MSH2 | mutS homolog 2 | 0.0153697 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.166575 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.126211 |
| VIM | vimentin | -0.101983 |
| GPC6 | glypican 6 | -0.101247 |
| FRMD4A | FERM domain containing 4A | -0.0924935 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0924337 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0917321 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0867252 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0860952 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0845215 |
| CADM1 | cell adhesion molecule 1 | -0.0707279 |
| SPAG9 | sperm associated antigen 9 | -0.0698767 |
| NDRG1 | N-myc downstream regulated 1 | -0.0689035 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0638588 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0608655 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.054813 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0546801 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0525418 |
| COPA | coatomer protein complex, subunit alpha | -0.0510267 |
| NAV2 | neuron navigator 2 | -0.050412 |
| FMNL2 | formin-like 2 | -0.0503129 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0498147 |
| COG5 | component of oligomeric golgi complex 5 | -0.0487685 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0486014 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0483987 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.044994 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0437681 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0431509 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0427973 |
| RAI14 | retinoic acid induced 14 | -0.0418022 |
| POTEF | POTE ankyrin domain family, member F | -0.0416289 |
| PAX8 | paired box 8 | -0.0412782 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0406438 |
| COG6 | component of oligomeric golgi complex 6 | -0.0403138 |
| SDCBP | syndecan binding protein (syntenin) | -0.0400095 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.039875 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0398379 |
| SETX | senataxin | -0.039249 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0386168 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | -0.0384513 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0381574 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0376095 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.037459 |
| RAB7A | RAB7A, member RAS oncogene family | -0.037368 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0359924 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0356841 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.035428 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0346251 |
| CALU | calumenin | -0.0340033 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0339136 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0337297 |
| ANKRD33B | ankyrin repeat domain 33B | -0.0333112 |
| FNIP1 | folliculin interacting protein 1 | -0.0329885 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0328831 |
| SUCO | SUN domain containing ossification factor | -0.0324696 |
| NDEL1 | nudE neurodevelopment protein 1-like 1 | -0.0322736 |
| SBF2 | SET binding factor 2 | -0.0320831 |
| MORF4L2 | mortality factor 4 like 2 | -0.0317672 |
| SEC24A | SEC24 family member A | -0.0317505 |
| SQSTM1 | sequestosome 1 | -0.0317278 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | -0.0312185 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0307144 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | -0.0307083 |
| FAM107B | family with sequence similarity 107, member B | -0.0306755 |
| ATP13A3 | ATPase type 13A3 | -0.0305837 |
| HMGA1 | high mobility group AT-hook 1 | -0.0305446 |
| SCFD2 | sec1 family domain containing 2 | -0.0303848 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | -0.0300242 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0298842 |
| HELZ | helicase with zinc finger | -0.0298014 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0295138 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0293795 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0293783 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0293342 |
| MAP1B | microtubule-associated protein 1B | -0.0292841 |
| RIGI | RNA sensor RIG-I | -0.0290609 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.02902 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0289969 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.028945 |
| SRP54 | signal recognition particle 54kDa | -0.0288135 |
| GOLGB1 | golgin B1 | -0.0285045 |
| TMEM263 | transmembrane protein 263 | -0.0284964 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0284759 |
| UBAP2 | ubiquitin associated protein 2 | -0.0284116 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0284112 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0283808 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0282888 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | -0.0281204 |
| RUNX1 | runt-related transcription factor 1 | -0.0280616 |
| PNPLA8 | patatin-like phospholipase domain containing 8 | -0.0280596 |
| RND3 | Rho family GTPase 3 | -0.028025 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0280198 |
| GOLGA4 | golgin A4 | -0.0278276 |
| RNF220 | ring finger protein 220 | -0.027667 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0276625 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0275127 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0272212 |
| CREB5 | cAMP responsive element binding protein 5 | -0.026789 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0266896 |
| AFTPH | aftiphilin | -0.0266519 |
