| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | SBI-0640756 perturbation in A549 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the SBI-0640756_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.102729 |
| RPL4 | ribosomal protein L4 | 0.0695263 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0652768 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0560206 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0436489 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0410357 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0400837 |
| RPS3 | ribosomal protein S3 | 0.0383835 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0351657 |
| RPL13A | ribosomal protein L13a | 0.0332554 |
| RPS12 | ribosomal protein S12 | 0.0325582 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0291043 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0278441 |
| RPS2 | ribosomal protein S2 | 0.0277614 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.0268971 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.025843 |
| USP47 | ubiquitin specific peptidase 47 | 0.0245087 |
| ANGPTL4 | angiopoietin-like 4 | 0.024278 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0242002 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0234028 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0233169 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0228306 |
| RPS17 | ribosomal protein S17 | 0.0226463 |
| STC1 | stanniocalcin 1 | 0.0218576 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0215576 |
| TLN1 | talin 1 | 0.0214778 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0212197 |
| TLE4 | transducin-like enhancer of split 4 | 0.0206031 |
| RPL3 | ribosomal protein L3 | 0.0205426 |
| TMEM87A | transmembrane protein 87A | 0.0200923 |
| UBC | ubiquitin C | 0.0199899 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0189593 |
| RPS18 | ribosomal protein S18 | 0.0181587 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0179118 |
| WWOX | WW domain containing oxidoreductase | 0.0178152 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | 0.0177657 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0175044 |
| BMP6 | bone morphogenetic protein 6 | 0.0174106 |
| NMT1 | N-myristoyltransferase 1 | 0.0169954 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0168276 |
| ATP11A | ATPase, class VI, type 11A | 0.0166276 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0166256 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0164931 |
| AXL | AXL receptor tyrosine kinase | 0.0164844 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0164039 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0161515 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0159643 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0159502 |
| R3HDM1 | R3H domain containing 1 | 0.0158198 |
| CNOT8 | CCR4-NOT transcription complex, subunit 8 | 0.0157175 |
| FAM107B | family with sequence similarity 107, member B | 0.0154608 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0154592 |
| HMGN2 | high mobility group nucleosomal binding domain 2 | 0.0153608 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | 0.0149778 |
| CEP290 | centrosomal protein 290kDa | 0.014973 |
| PCBP2 | poly(rC) binding protein 2 | 0.0147167 |
| PSMD3 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 | 0.0144922 |
| CLU | clusterin | 0.0142947 |
| BRD2 | bromodomain containing 2 | 0.0141567 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | 0.0140864 |
| MT1X | metallothionein 1X | 0.0140349 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0140208 |
| SERINC1 | serine incorporator 1 | 0.014006 |
| MAP7 | microtubule-associated protein 7 | 0.014002 |
| CCDC146 | coiled-coil domain containing 146 | 0.0139471 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.01393 |
| CACYBP | calcyclin binding protein | 0.0138845 |
| RBPMS | RNA binding protein with multiple splicing | 0.0138164 |
| WDPCP | WD repeat containing planar cell polarity effector | 0.0137914 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0136827 |
| ADAMTS9 | ADAM metallopeptidase with thrombospondin type 1 motif, 9 | 0.0136728 |
| CNTN1 | contactin 1 | 0.0136335 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0133852 |
| KDM6B | lysine (K)-specific demethylase 6B | 0.0133045 |
| CHMP5 | charged multivesicular body protein 5 | 0.0132978 |
| CMIP | c-Maf inducing protein | 0.0132507 |
| ARHGEF1 | Rho guanine nucleotide exchange factor (GEF) 1 | 0.0128988 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.0128829 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 0.0127425 |
| PPP2R1A | protein phosphatase 2, regulatory subunit A, alpha | 0.0127196 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.01269 |
| TBC1D1 | TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 | 0.0126427 |
| MAMLD1 | mastermind-like domain containing 1 | 0.0126394 |
| FAM219A | family with sequence similarity 219, member A | 0.0125653 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0125236 |
| CA8 | carbonic anhydrase VIII | 0.012431 |
| KLF13 | Kruppel-like factor 13 | 0.0123584 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.012345 |
| NIN | ninein (GSK3B interacting protein) | 0.0123394 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | 0.0123362 |
| ANKRD36C | ankyrin repeat domain 36C | 0.0123276 |
| PNO1 | partner of NOB1 homolog (S. cerevisiae) | 0.0123036 |
| SH3BP5 | SH3-domain binding protein 5 (BTK-associated) | 0.0122796 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0122696 |
| UBE3D | ubiquitin protein ligase E3D | 0.0122418 |
| MAN1A2 | mannosidase, alpha, class 1A, member 2 | 0.0122103 |
| SNX29 | sorting nexin 29 | 0.0121702 |
| PPP6R1 | protein phosphatase 6, regulatory subunit 1 | 0.0121641 |
| HSPA4 | heat shock 70kDa protein 4 | 0.012099 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0120085 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.272974 |
| ANXA2 | annexin A2 | -0.156889 |
| TMSB10 | thymosin beta 10 | -0.148223 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.136454 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.122592 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.106668 |
| ACTG1 | actin gamma 1 | -0.102386 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0887223 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0851036 |
| VIM | vimentin | -0.0841196 |
| AHNAK | AHNAK nucleoprotein | -0.0839352 |
| RPS6 | ribosomal protein S6 | -0.0830489 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0796692 |
| LDHA | lactate dehydrogenase A | -0.0793559 |
| VCL | vinculin | -0.0770264 |
| KRT81 | keratin 81, type II | -0.0751504 |
| EFNA5 | ephrin-A5 | -0.0725104 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0700935 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0686477 |
| S100A10 | S100 calcium binding protein A10 | -0.0670285 |
| EGFR | epidermal growth factor receptor | -0.0668939 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0668482 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0593442 |
| NDRG1 | N-myc downstream regulated 1 | -0.0585902 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0569287 |
| SPAG9 | sperm associated antigen 9 | -0.0561024 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0536288 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0527317 |
| CA12 | carbonic anhydrase XII | -0.0512546 |
| PDE10A | phosphodiesterase 10A | -0.0510364 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.0509165 |
| RPS19 | ribosomal protein S19 | -0.0508071 |
| RAI14 | retinoic acid induced 14 | -0.0487537 |
| PTMA | prothymosin, alpha | -0.0480616 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0479396 |
| GPC6 | glypican 6 | -0.0479129 |
| RPS16 | ribosomal protein S16 | -0.0478214 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0474431 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0467043 |
| MAP1B | microtubule-associated protein 1B | -0.0455462 |
| S100A6 | S100 calcium binding protein A6 | -0.0455098 |
| RPLP1 | ribosomal protein, large, P1 | -0.0453003 |
| RPLP0 | ribosomal protein, large, P0 | -0.0450227 |
| NRG1 | neuregulin 1 | -0.0449175 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0442596 |
| EHBP1 | EH domain binding protein 1 | -0.0438299 |
| SBF2 | SET binding factor 2 | -0.0432276 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0430576 |
| OSMR | oncostatin M receptor | -0.0426748 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0424146 |
| RNF213 | ring finger protein 213 | -0.0423741 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0423131 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0422445 |
| USP3 | ubiquitin specific peptidase 3 | -0.0420517 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | -0.041622 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0411135 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0410678 |
| FLNB | filamin B, beta | -0.0406298 |
| POTEF | POTE ankyrin domain family, member F | -0.0405744 |
| HMGA2 | high mobility group AT-hook 2 | -0.0404318 |
| CLTC | clathrin, heavy chain (Hc) | -0.0398982 |
| RPL8 | ribosomal protein L8 | -0.0396946 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0396327 |
| TNS3 | tensin 3 | -0.0384601 |
| PALLD | palladin, cytoskeletal associated protein | -0.0380859 |
| CCDC88A | coiled-coil domain containing 88A | -0.0379468 |
| FBXO11 | F-box protein 11 | -0.0377647 |
| PKM | pyruvate kinase, muscle | -0.0376452 |
| PFN1 | profilin 1 | -0.0370381 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0370296 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0368259 |
| TPM4 | tropomyosin 4 | -0.0365978 |
| TCF12 | transcription factor 12 | -0.0362271 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | -0.0360009 |
| MYO1E | myosin IE | -0.0354667 |
| PGK1 | phosphoglycerate kinase 1 | -0.0354517 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0354005 |
| MORF4L2 | mortality factor 4 like 2 | -0.0349744 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0349179 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0348163 |
| KRT7 | keratin 7, type II | -0.0344017 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.0341966 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0341439 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0335187 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0334804 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.0332521 |
| RIN2 | Ras and Rab interactor 2 | -0.033215 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0330093 |
| RPS23 | ribosomal protein S23 | -0.0329528 |
| ACTN4 | actinin, alpha 4 | -0.0328993 |
| IER3 | immediate early response 3 | -0.0328259 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0327554 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0323639 |
| TMOD3 | tropomodulin 3 (ubiquitous) | -0.0322369 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0322314 |
| PRKCA | protein kinase C, alpha | -0.0321956 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0319594 |
| CANX | calnexin | -0.0319401 |
| HMGA1 | high mobility group AT-hook 1 | -0.0316941 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0314547 |
