SBI-0640756_BT-474 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description SBI-0640756 perturbation in BT-474 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the SBI-0640756_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.16272
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.115337
FTH1 ferritin, heavy polypeptide 1 0.0968544
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0966726
RPS3 ribosomal protein S3 0.0921476
PTMA prothymosin, alpha 0.0913527
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0736702
RPL23 ribosomal protein L23 0.0553997
SET SET nuclear proto-oncogene 0.0525797
RPL35A ribosomal protein L35a 0.0457836
MT2A metallothionein 2A 0.0446332
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0442418
NDRG1 N-myc downstream regulated 1 0.0436159
MUC6 mucin 6, oligomeric mucus/gel-forming 0.0423514
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0404982
FTL ferritin, light polypeptide 0.0404549
RPS12 ribosomal protein S12 0.0397919
RPL12 ribosomal protein L12 0.0395344
SRRM2 serine/arginine repetitive matrix 2 0.0390688
PKM pyruvate kinase, muscle 0.0390651
KMT2E lysine (K)-specific methyltransferase 2E 0.0387411
ENO1 enolase 1, (alpha) 0.0378992
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0376013
LOC102724023 ES1 protein homolog, mitochondrial 0.0370616
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0350847
B2M beta-2-microglobulin 0.033622
KTN1 kinectin 1 (kinesin receptor) 0.0318514
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0314667
GRB10 growth factor receptor-bound protein 10 0.0310822
RPS6 ribosomal protein S6 0.0307356
BHLHE40 basic helix-loop-helix family, member e40 0.0306957
PRRC2C proline-rich coiled-coil 2C 0.0306396
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0304565
RBM25 RNA binding motif protein 25 0.03033
GARS1 glycyl-tRNA synthetase 1 0.0299706
CXCL3 chemokine (C-X-C motif) ligand 3 0.0299687
IGFBP5 insulin-like growth factor binding protein 5 0.0293586
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0279344
RPS8 ribosomal protein S8 0.0277949
CXCL8 chemokine (C-X-C motif) ligand 8 0.0272286
EIF1 eukaryotic translation initiation factor 1 0.0265976
AKAP12 A kinase (PRKA) anchor protein 12 0.0265482
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0264149
RPL26 ribosomal protein L26 0.0261766
FLNB filamin B, beta 0.0259293
UBA6 ubiquitin-like modifier activating enzyme 6 0.0256767
RPS2 ribosomal protein S2 0.0253855
USP53 ubiquitin specific peptidase 53 0.0248989
EGR1 early growth response 1 0.0243423
NAMPT nicotinamide phosphoribosyltransferase 0.0242481
AREG amphiregulin 0.0238995
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0238419
RPL13A ribosomal protein L13a 0.0238225
RPL37A ribosomal protein L37a 0.0235243
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0234641
MAP1B microtubule-associated protein 1B 0.0228864
FAM13A family with sequence similarity 13, member A 0.0228642
UGCG UDP-glucose ceramide glucosyltransferase 0.0227652
RPL5 ribosomal protein L5 0.0226316
CREB5 cAMP responsive element binding protein 5 0.0225212
RBM39 RNA binding motif protein 39 0.0224222
BRD2 bromodomain containing 2 0.0217189
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 0.0214968
APLP2 amyloid beta (A4) precursor-like protein 2 0.0214642
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0212255
KDM5B lysine (K)-specific demethylase 5B 0.0211265
TTC3 tetratricopeptide repeat domain 3 0.0209736
DTNA dystrobrevin, alpha 0.0207638
S100A14 S100 calcium binding protein A14 0.020713
TSC22D2 TSC22 domain family, member 2 0.0206546
BRD4 bromodomain containing 4 0.020494
OGA O-GlcNAcase 0.0203466
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0202622
COX6C cytochrome c oxidase subunit VIc 0.020262
EEF2 eukaryotic translation elongation factor 2 0.0200107
AKAP9 A kinase (PRKA) anchor protein 9 0.0199516
ACBD3 acyl-CoA binding domain containing 3 0.0198992
EXT1 exostosin glycosyltransferase 1 0.0198832
WSB1 WD repeat and SOCS box containing 1 0.0195454
MTDH metadherin 0.0193441
RPS27A ribosomal protein S27a 0.0192736
KLF10 Kruppel-like factor 10 0.0192619
GOLGA4 golgin A4 0.0191743
MIDEAS mitotic deacetylase associated SANT domain protein 0.0191493
RPL36 ribosomal protein L36 0.019011
RPL18 ribosomal protein L18 0.0189457
RSRC2 arginine/serine-rich coiled-coil 2 0.0184453
DDIT4 DNA-damage-inducible transcript 4 0.0181843
HLA-B major histocompatibility complex, class I, B 0.0180041
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0179926
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0176152
CEMIP cell migration inducing protein, hyaluronan binding 0.0176111
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0175929
VIM vimentin 0.01753
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0174467
BIRC3 baculoviral IAP repeat containing 3 0.0172123
MYO6 myosin VI 0.0171834
RPL4 ribosomal protein L4 0.0169498
IFI6 interferon, alpha-inducible protein 6 0.0168829
PPME1 protein phosphatase methylesterase 1 0.0167878

decreased expression

Symbol Name Standardized Value
CATSPERB catsper channel auxiliary subunit beta -0.136901
ZMYND8 zinc finger, MYND-type containing 8 -0.123935
ACACA acetyl-CoA carboxylase alpha -0.110893
LPP LIM domain containing preferred translocation partner in lipoma -0.0978043
TRPS1 trichorhinophalangeal syndrome I -0.0945621
CEP250 centrosomal protein 250kDa -0.0931175
ITCH itchy E3 ubiquitin protein ligase -0.0921533
CDK12 cyclin-dependent kinase 12 -0.0826086
CLTC clathrin, heavy chain (Hc) -0.080546
PTPRK protein tyrosine phosphatase, receptor type, K -0.0797778
VMP1 vacuole membrane protein 1 -0.0746471
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0683729
PATJ PATJ crumbs cell polarity complex component -0.0657676
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0650055
ACSS2 acyl-CoA synthetase short-chain family member 2 -0.0638302
DENND1A DENN/MADD domain containing 1A -0.0631075
PBX1 pre-B-cell leukemia homeobox 1 -0.0607116
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0599657
VCP valosin containing protein -0.0583392
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.057535
THSD4 thrombospondin, type I, domain containing 4 -0.0572833
DNAH14 dynein, axonemal, heavy chain 14 -0.0558886
GMDS GDP-mannose 4,6-dehydratase -0.0548835
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0531921
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 -0.0525894
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0517611
SAMD12 sterile alpha motif domain containing 12 -0.0512329
SMYD3 SET and MYND domain containing 3 -0.0494604
TRIO trio Rho guanine nucleotide exchange factor -0.0480477
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 -0.0460328
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0447209
RIMS2 regulating synaptic membrane exocytosis 2 -0.0445055
EXOC4 exocyst complex component 4 -0.0444342
IL1RAPL2 interleukin 1 receptor accessory protein-like 2 -0.0441682
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 -0.0434706
AHNAK AHNAK nucleoprotein -0.0428539
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0427061
NCOA3 nuclear receptor coactivator 3 -0.0404227
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0403001
EFNA5 ephrin-A5 -0.0397429
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 -0.0396889
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.039654
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.039342
CCSER1 coiled-coil serine-rich protein 1 -0.0392282
KRT8 keratin 8, type II -0.0391629
SBF2 SET binding factor 2 -0.038072
RAD51B RAD51 paralog B -0.0377466
CCND1 cyclin D1 -0.0374375
INTS6 integrator complex subunit 6 -0.0371146
MSI2 musashi RNA-binding protein 2 -0.0370905
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0370344
PRELID2 PRELI domain containing 2 -0.0368772
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0366201
FBXL20 F-box and leucine-rich repeat protein 20 -0.0364207
RAB22A RAB22A, member RAS oncogene family -0.0356848
SHROOM3 shroom family member 3 -0.0353632
ANKRD36C ankyrin repeat domain 36C -0.0352798
PLSCR1 phospholipid scramblase 1 -0.0352389
ATXN1 ataxin 1 -0.0351959
LIMCH1 LIM and calponin homology domains 1 -0.0351342
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0347959
PARD3 par-3 family cell polarity regulator -0.034723
PRKCA protein kinase C, alpha -0.0344641
ZBTB20 zinc finger and BTB domain containing 20 -0.0344387
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.0342652
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0337486
EHMT1 euchromatic histone-lysine N-methyltransferase 1 -0.0337309
TNS3 tensin 3 -0.0334078
CANX calnexin -0.0329228
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0322229
ARHGAP32 Rho GTPase activating protein 32 -0.0320149
MLLT6 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 -0.0308794
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0307295
USO1 USO1 vesicle transport factor -0.0299623
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0298333
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0298294
LGALS12 lectin, galactoside-binding, soluble, 12 -0.0295411
VCL vinculin -0.029482
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0292606
RBM47 RNA binding motif protein 47 -0.0291493
TBL1X transducin (beta)-like 1X-linked -0.028742
IGF1R insulin-like growth factor 1 receptor -0.02873
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0287246
AEBP2 AE binding protein 2 -0.0285931
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0283353
CADPS2 Ca++-dependent secretion activator 2 -0.0281614
ACTG1 actin gamma 1 -0.0279425
CUX1 cut-like homeobox 1 -0.0279085
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0274621
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0273103
LASP1 LIM and SH3 protein 1 -0.0267927
FNDC3A fibronectin type III domain containing 3A -0.0266511
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0264817
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0264324
EGFR epidermal growth factor receptor -0.0262982
TAOK1 TAO kinase 1 -0.0262663
RABGAP1 RAB GTPase activating protein 1 -0.025947
ZHX2 zinc fingers and homeoboxes 2 -0.0258271
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 -0.0257933
ZC3H11A zinc finger CCCH-type containing 11A -0.0257722