SBI-0640756_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description SBI-0640756 perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the SBI-0640756_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.0852626
AKAP12 A kinase (PRKA) anchor protein 12 0.0836906
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0635437
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0590854
RPS6 ribosomal protein S6 0.0577144
SEPTIN9 septin 9 0.0547684
RPL35A ribosomal protein L35a 0.0541581
RPL4 ribosomal protein L4 0.0540392
EIF1 eukaryotic translation initiation factor 1 0.0532145
VIM vimentin 0.0492696
FTL ferritin, light polypeptide 0.0451475
NDRG1 N-myc downstream regulated 1 0.0443969
RPL12 ribosomal protein L12 0.0443412
KTN1 kinectin 1 (kinesin receptor) 0.0405346
RPS12 ribosomal protein S12 0.0393061
B2M beta-2-microglobulin 0.0367492
FAM162A family with sequence similarity 162, member A 0.0366427
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0365462
TLN1 talin 1 0.0364536
RPLP1 ribosomal protein, large, P1 0.0345435
ENO1 enolase 1, (alpha) 0.0331065
ANGPTL4 angiopoietin-like 4 0.0323527
PRRC2C proline-rich coiled-coil 2C 0.0321465
GDF15 growth differentiation factor 15 0.0321079
RPS27A ribosomal protein S27a 0.0310587
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0306719
OGA O-GlcNAcase 0.0291011
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0284192
RPL36 ribosomal protein L36 0.0281848
ACTG1 actin gamma 1 0.0276137
ENO2 enolase 2 (gamma, neuronal) 0.0268438
FTH1 ferritin, heavy polypeptide 1 0.0265007
LMO7 LIM domain 7 0.0261912
RPS3 ribosomal protein S3 0.0259401
SIK2 salt-inducible kinase 2 0.0256304
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0255176
RPS17 ribosomal protein S17 0.0242853
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0242109
INTS6 integrator complex subunit 6 0.0241143
RPL37A ribosomal protein L37a 0.0240313
RPL5 ribosomal protein L5 0.0237487
EEF1G eukaryotic translation elongation factor 1 gamma 0.0235289
ATF4 activating transcription factor 4 0.0231325
RPL11 ribosomal protein L11 0.0228007
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0226705
LIMA1 LIM domain and actin binding 1 0.0221579
HOMER1 homer scaffolding protein 1 0.0219574
RACK1 receptor for activated C kinase 1 0.0218608
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0214358
GOLGA4 golgin A4 0.0213724
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0211457
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0206566
EGFR epidermal growth factor receptor 0.0198227
YBX1 Y box binding protein 1 0.0196554
SRRM2 serine/arginine repetitive matrix 2 0.0196536
MAP2K5 mitogen-activated protein kinase kinase 5 0.0195515
PCM1 pericentriolar material 1 0.0195395
BRD2 bromodomain containing 2 0.0194668
KAT6B K(lysine) acetyltransferase 6B 0.0193805
IGFBP3 insulin-like growth factor binding protein 3 0.0192207
SQSTM1 sequestosome 1 0.0191937
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0191481
RPLP2 ribosomal protein, large, P2 0.0190247
PKM pyruvate kinase, muscle 0.0190051
SETD5 SET domain containing 5 0.0188398
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.0187351
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0186566
FNBP1 formin binding protein 1 0.0186351
NFE2L1 nuclear factor, erythroid 2-like 1 0.0184945
ZSWIM6 zinc finger, SWIM-type containing 6 0.01802
SET SET nuclear proto-oncogene 0.0177692
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0177289
ZNF638 zinc finger protein 638 0.0176662
LMAN1 lectin, mannose-binding, 1 0.0175811
SERBP1 SERPINE1 mRNA binding protein 1 0.0175508
GPBP1 GC-rich promoter binding protein 1 0.017429
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.0173001
ERRFI1 ERBB receptor feedback inhibitor 1 0.0172331
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 0.0170329
RPL30 ribosomal protein L30 0.0170112
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0169803
AKAP9 A kinase (PRKA) anchor protein 9 0.0169304
GDI2 GDP dissociation inhibitor 2 0.0168561
MYO1E myosin IE 0.0168392
RPS8 ribosomal protein S8 0.0167329
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.0166173
RPS16 ribosomal protein S16 0.0164221
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0163913
DLG1 discs, large homolog 1 (Drosophila) 0.0163424
RPL31 ribosomal protein L31 0.0163191
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) 0.0162887
DDIT4 DNA-damage-inducible transcript 4 0.0162497
VDAC1 voltage-dependent anion channel 1 0.0161741
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0161571
GOLGB1 golgin B1 0.0161559
RBM25 RNA binding motif protein 25 0.0159671
SAP30BP SAP30 binding protein 0.0159208
PRELID2 PRELI domain containing 2 0.0158252
LEO1 Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.0158025
PDE7A phosphodiesterase 7A 0.0157309

decreased expression

Symbol Name Standardized Value
LSAMP limbic system-associated membrane protein -0.200214
NRG1 neuregulin 1 -0.151901
NALF1 NALCN channel auxiliary factor 1 -0.140363
FMN1 formin 1 -0.113197
VCL vinculin -0.0953652
SYT1 synaptotagmin I -0.0866341
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0827082
PTPRD protein tyrosine phosphatase, receptor type, D -0.0812722
BCAS3 breast carcinoma amplified sequence 3 -0.0692958
TRIO trio Rho guanine nucleotide exchange factor -0.064632
COL3A1 collagen, type III, alpha 1 -0.0645666
UNC5C unc-5 homolog C (C. elegans) -0.0620937
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.06083
SOS1 son of sevenless homolog 1 (Drosophila) -0.0594843
THSD4 thrombospondin, type I, domain containing 4 -0.0588356
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0587149
ANTXR1 anthrax toxin receptor 1 -0.0581698
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0578106
RNF213 ring finger protein 213 -0.0569743
MSI2 musashi RNA-binding protein 2 -0.0561404
AUTS2 autism susceptibility candidate 2 -0.0559709
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0554397
ZNF804A zinc finger protein 804A -0.0530642
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0530596
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.0499264
KLHL13 kelch-like family member 13 -0.0467553
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0463199
ZBTB20 zinc finger and BTB domain containing 20 -0.0447796
NCAM2 neural cell adhesion molecule 2 -0.0447494
MEIS2 Meis homeobox 2 -0.0442678
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.044022
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0435289
DLC1 DLC1 Rho GTPase activating protein -0.0422904
PDZRN3 PDZ domain containing ring finger 3 -0.0398368
CNTN4 contactin 4 -0.0388815
PTPRM protein tyrosine phosphatase, receptor type, M -0.0384488
TRIB2 tribbles pseudokinase 2 -0.0383441
COL1A1 collagen, type I, alpha 1 -0.0369369
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0365692
NREP neuronal regeneration related protein -0.0359825
NRP1 neuropilin 1 -0.0353953
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0346611
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0345282
MBNL1 muscleblind-like splicing regulator 1 -0.0331862
CACNB2 calcium channel, voltage-dependent, beta 2 subunit -0.0331516
TTC17 tetratricopeptide repeat domain 17 -0.0327154
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.0323852
PRKCA protein kinase C, alpha -0.0322471
RALYL RALY RNA binding protein-like -0.0319128
CLTC clathrin, heavy chain (Hc) -0.0315649
ADGRG6 adhesion G protein-coupled receptor G6 -0.0311649
BICD1 bicaudal D homolog 1 (Drosophila) -0.030833
ANKRD17 ankyrin repeat domain 17 -0.0305876
AOPEP aminopeptidase O (putative) -0.0305506
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0304567
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0295125
LPIN1 lipin 1 -0.0289403
IGF1R insulin-like growth factor 1 receptor -0.0280298
DNAH14 dynein, axonemal, heavy chain 14 -0.0278985
TAS2R14 taste receptor, type 2, member 14 -0.0278215
GREM2 gremlin 2, DAN family BMP antagonist -0.0278137
PCDH9 protocadherin 9 -0.0277759
ADGRL2 adhesion G protein-coupled receptor L2 -0.0277228
GLG1 golgi glycoprotein 1 -0.0266388
LRP1B low density lipoprotein receptor-related protein 1B -0.0265701
EFNA5 ephrin-A5 -0.0262135
AEBP2 AE binding protein 2 -0.0254519
ANGPT1 angiopoietin 1 -0.0254022
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 -0.0252056
DST dystonin -0.0241947
FRMD4A FERM domain containing 4A -0.024149
HIP1 huntingtin interacting protein 1 -0.0241048
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0240172
TENM4 teneurin transmembrane protein 4 -0.0239678
ARHGAP24 Rho GTPase activating protein 24 -0.0238938
LRRC7 leucine rich repeat containing 7 -0.0237726
SLIT2 slit homolog 2 (Drosophila) -0.0235005
DNM3 dynamin 3 -0.0234787
MAP1B microtubule-associated protein 1B -0.0234294
DACH2 dachshund family transcription factor 2 -0.0231906
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.023036
TLE4 transducin-like enhancer of split 4 -0.0228986
MMP16 matrix metallopeptidase 16 (membrane-inserted) -0.0228864
CENPF centromere protein F, 350/400kDa -0.0225623
NCOA7 nuclear receptor coactivator 7 -0.0223438
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.022244
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0219629
PCDH15 protocadherin-related 15 -0.021909
AHR aryl hydrocarbon receptor -0.0216061
KCNIP4 Kv channel interacting protein 4 -0.0214264
ITGA1 integrin, alpha 1 -0.0211392
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0211345
FKBP10 FK506 binding protein 10, 65 kDa -0.0209177
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0209142
MAPK10 mitogen-activated protein kinase 10 -0.0209051
CADM2 cell adhesion molecule 2 -0.0207654
RCOR3 REST corepressor 3 -0.0207109
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0206914
CADM1 cell adhesion molecule 1 -0.0205322
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase -0.0205144