SBI-0640756_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description SBI-0640756 perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the SBI-0640756_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGR1 early growth response 1 0.146764
B2M beta-2-microglobulin 0.144117
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.130221
INTS6 integrator complex subunit 6 0.120216
AREG amphiregulin 0.111439
SP100 SP100 nuclear antigen 0.104405
LCN2 lipocalin 2 0.103605
LMO7 LIM domain 7 0.0988162
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0916735
IFI6 interferon, alpha-inducible protein 6 0.0879857
MT2A metallothionein 2A 0.0821068
FTL ferritin, light polypeptide 0.0777554
PKM pyruvate kinase, muscle 0.0749103
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0709543
IFI27 interferon, alpha-inducible protein 27 0.0702484
FTH1 ferritin, heavy polypeptide 1 0.0665897
HLA-B major histocompatibility complex, class I, B 0.0630558
ACTG1 actin gamma 1 0.0610672
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0551558
ERBIN erbb2 interacting protein 0.0539462
RPS3 ribosomal protein S3 0.0518383
HLA-A major histocompatibility complex, class I, A 0.0513825
TMC5 transmembrane channel-like 5 0.0492914
AKAP13 A kinase (PRKA) anchor protein 13 0.0479644
C6ORF132 chromosome 6 open reading frame 132 0.0472749
HKDC1 hexokinase domain containing 1 0.0468025
LOC102724023 ES1 protein homolog, mitochondrial 0.0460293
ATF4 activating transcription factor 4 0.0456873
RPS6 ribosomal protein S6 0.0453552
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0449364
PTMA prothymosin, alpha 0.0445138
EIF1 eukaryotic translation initiation factor 1 0.0434358
EXT1 exostosin glycosyltransferase 1 0.0430251
TMSB10 thymosin beta 10 0.0429163
EFNB2 ephrin-B2 0.0418917
TJP1 tight junction protein 1 0.0415655
IGFBP3 insulin-like growth factor binding protein 3 0.0413826
SRRM2 serine/arginine repetitive matrix 2 0.0413336
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0409925
ZSWIM6 zinc finger, SWIM-type containing 6 0.0409325
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0409186
RAB7A RAB7A, member RAS oncogene family 0.0395046
RPS12 ribosomal protein S12 0.0388454
RPL37A ribosomal protein L37a 0.0386622
SOX9 SRY (sex determining region Y)-box 9 0.0375475
ZFP36L1 ZFP36 ring finger protein-like 1 0.0369513
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0361539
RPL35A ribosomal protein L35a 0.0361186
MCTP1 multiple C2 domains, transmembrane 1 0.0358414
IER2 immediate early response 2 0.0352488
ERRFI1 ERBB receptor feedback inhibitor 1 0.0352277
ZNFX1 zinc finger, NFX1-type containing 1 0.0350927
ENO2 enolase 2 (gamma, neuronal) 0.0346103
ENO1 enolase 1, (alpha) 0.0342649
S100P S100 calcium binding protein P 0.0342068
EREG epiregulin 0.0335621
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0332376
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0319782
CLDN4 claudin 4 0.0296788
NSUN6 NOP2/Sun domain family, member 6 0.0293285
CALR calreticulin 0.0287094
BRD2 bromodomain containing 2 0.0286828
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.0285784
RPL5 ribosomal protein L5 0.0285475
RPL23 ribosomal protein L23 0.028303
KYNU kynureninase 0.0282606
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.028256
CXCL8 chemokine (C-X-C motif) ligand 8 0.0281185
POTEF POTE ankyrin domain family, member F 0.0276982
RPS27 ribosomal protein S27 0.0272085
SEPTIN9 septin 9 0.0269392
MYH14 myosin, heavy chain 14, non-muscle 0.0263434
ANKRD12 ankyrin repeat domain 12 0.0260259
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0260164
RPS14 ribosomal protein S14 0.0257989
DST dystonin 0.0256843
SH3PXD2A SH3 and PX domains 2A 0.025638
SLC38A2 solute carrier family 38, member 2 0.0255229
RPLP2 ribosomal protein, large, P2 0.0254315
RNF213 ring finger protein 213 0.0252953
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 0.0250825
ANKRD11 ankyrin repeat domain 11 0.0250633
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 0.0248045
APLP2 amyloid beta (A4) precursor-like protein 2 0.0245884
HOMER1 homer scaffolding protein 1 0.0245283
TFF3 trefoil factor 3 (intestinal) 0.0244129
RPL26 ribosomal protein L26 0.024315
IFITM3 interferon induced transmembrane protein 3 0.0242869
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0242413
LAMA4 laminin, alpha 4 0.0242045
PRRC2C proline-rich coiled-coil 2C 0.0241718
LEMD1 LEM domain containing 1 0.0240964
RPLP1 ribosomal protein, large, P1 0.0240911
PRSS3 protease, serine, 3 0.0240739
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0239267
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0235966
JUP junction plakoglobin 0.0235342
SMAD3 SMAD family member 3 0.0235149
ZC3H12A zinc finger CCCH-type containing 12A 0.0235103
LIMA1 LIM domain and actin binding 1 0.0233089

decreased expression

Symbol Name Standardized Value
BTBD9 BTB (POZ) domain containing 9 -0.128712
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0976783
TPT1 tumor protein, translationally-controlled 1 -0.0676657
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0639176
CANX calnexin -0.0606004
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0601983
IGF1R insulin-like growth factor 1 receptor -0.0597542
PHF3 PHD finger protein 3 -0.0573512
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.056901
SPATA13 spermatogenesis associated 13 -0.054546
LYZ lysozyme -0.054091
UBR2 ubiquitin protein ligase E3 component n-recognin 2 -0.0528992
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0511714
SAMD12 sterile alpha motif domain containing 12 -0.0510963
GMDS GDP-mannose 4,6-dehydratase -0.0496745
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0494367
PDIA3 protein disulfide isomerase family A, member 3 -0.0491654
ANKRD10 ankyrin repeat domain 10 -0.0490537
PRELID2 PRELI domain containing 2 -0.0490016
PRKCA protein kinase C, alpha -0.0489097
FNDC3A fibronectin type III domain containing 3A -0.0487877
NPSR1 neuropeptide S receptor 1 -0.0482663
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0481587
RHOBTB3 Rho-related BTB domain containing 3 -0.0475596
SEC31A SEC31 homolog A (S. cerevisiae) -0.047548
AHI1 Abelson helper integration site 1 -0.0467399
ARHGAP26 Rho GTPase activating protein 26 -0.0455393
NCKAP5 NCK-associated protein 5 -0.0452066
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0447401
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0444987
RAB1A RAB1A, member RAS oncogene family -0.0441923
ZMYM2 zinc finger, MYM-type 2 -0.0441226
TXNIP thioredoxin interacting protein -0.0440217
TM9SF2 transmembrane 9 superfamily member 2 -0.0436831
MSI2 musashi RNA-binding protein 2 -0.0435972
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0429917
MAP7 microtubule-associated protein 7 -0.042657
ZBTB20 zinc finger and BTB domain containing 20 -0.0424719
TRIO trio Rho guanine nucleotide exchange factor -0.0424334
ATP11A ATPase, class VI, type 11A -0.042383
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0420862
GRK3 G protein-coupled receptor kinase 3 -0.0410708
LCORL ligand dependent nuclear receptor corepressor-like -0.0406424
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0405594
MBNL2 muscleblind-like splicing regulator 2 -0.0404372
TRIM2 tripartite motif containing 2 -0.0392687
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0388975
BICRAL BICRA like chromatin remodeling complex associated protein -0.0386854
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0376265
TM9SF3 transmembrane 9 superfamily member 3 -0.0370789
RNF149 ring finger protein 149 -0.036341
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic -0.036329
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.035593
ATXN1 ataxin 1 -0.0350298
AHNAK AHNAK nucleoprotein -0.0348031
UBC ubiquitin C -0.0347648
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0346985
HELZ helicase with zinc finger -0.0346343
GCLC glutamate-cysteine ligase, catalytic subunit -0.0344642
FNIP1 folliculin interacting protein 1 -0.0344338
DENND4C DENN/MADD domain containing 4C -0.0344333
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0337836
NPEPPS aminopeptidase puromycin sensitive -0.0334307
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme -0.0334239
EZR ezrin -0.032858
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0317735
TAOK3 TAO kinase 3 -0.0315975
APP amyloid beta (A4) precursor protein -0.0315238
PTEN phosphatase and tensin homolog -0.0313503
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0310031
MARCHF6 membrane associated ring-CH-type finger 6 -0.0305177
LPP LIM domain containing preferred translocation partner in lipoma -0.0303375
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.03017
SREBF2 sterol regulatory element binding transcription factor 2 -0.0301068
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0300169
RABGAP1 RAB GTPase activating protein 1 -0.0299294
UBL3 ubiquitin-like 3 -0.0298711
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0296158
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0291638
ABHD2 abhydrolase domain containing 2 -0.0287509
ADD3 adducin 3 (gamma) -0.0286756
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0285904
SEC24D SEC24 family member D -0.0285804
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.0285734
CEP350 centrosomal protein 350kDa -0.0285167
BIRC6 baculoviral IAP repeat containing 6 -0.0283906
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0281456
TMEM62 transmembrane protein 62 -0.027885
BRWD3 bromodomain and WD repeat domain containing 3 -0.0278722
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0277211
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0275183
RAD51B RAD51 paralog B -0.0274543
TM4SF1 transmembrane 4 L six family member 1 -0.0271955
AFF1 AF4/FMR2 family, member 1 -0.0270785
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0270291
CALU calumenin -0.0269851
NCOA7 nuclear receptor coactivator 7 -0.0264857
HBS1L HBS1-like translational GTPase -0.0264778
WDR45B WD repeat domain 45B -0.0264124
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.0263532