SBI-0640756_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description SBI-0640756 perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the SBI-0640756_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.112333
MT2A metallothionein 2A 0.0867663
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0843878
VIM vimentin 0.0728846
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0680531
FTL ferritin, light polypeptide 0.0534303
RPS6 ribosomal protein S6 0.0428134
TGFBI transforming growth factor, beta-induced, 68kDa 0.0425325
EIF1 eukaryotic translation initiation factor 1 0.0413209
TMSB10 thymosin beta 10 0.0382451
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0355472
DCAF7 DDB1 and CUL4 associated factor 7 0.034707
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) 0.0339055
STC1 stanniocalcin 1 0.0312954
LOC112694756 uncharaterized LOC112694756 0.0302561
ASPH aspartate beta-hydroxylase 0.0300496
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.030007
APLP2 amyloid beta (A4) precursor-like protein 2 0.0289878
TIMP3 TIMP metallopeptidase inhibitor 3 0.0283876
TPI1 triosephosphate isomerase 1 0.027136
PDLIM5 PDZ and LIM domain 5 0.0266968
HDLBP high density lipoprotein binding protein 0.026554
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0259484
RACK1 receptor for activated C kinase 1 0.0254637
STXBP1 syntaxin binding protein 1 0.0253492
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0252791
VMP1 vacuole membrane protein 1 0.0250763
ENO1 enolase 1, (alpha) 0.0250513
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0247186
SEM1 SEM1 26S proteasome subunit 0.0243124
BCAR3 breast cancer anti-estrogen resistance 3 0.0238311
HLA-A major histocompatibility complex, class I, A 0.0237333
LOC102724023 ES1 protein homolog, mitochondrial 0.0237304
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0237006
GPATCH2L G patch domain containing 2-like 0.0232334
CTSB cathepsin B 0.0230853
HJURP Holliday junction recognition protein 0.0229238
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.022772
DIAPH3 diaphanous-related formin 3 0.0227475
FTH1 ferritin, heavy polypeptide 1 0.022381
S100A10 S100 calcium binding protein A10 0.0222436
ANKRD12 ankyrin repeat domain 12 0.0218331
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) 0.0216915
IGFBP5 insulin-like growth factor binding protein 5 0.0216211
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0214064
NAV2 neuron navigator 2 0.0213846
RPL4 ribosomal protein L4 0.0208668
CD44 CD44 molecule (Indian blood group) 0.020424
RPL37A ribosomal protein L37a 0.0201862
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 0.0201728
RPL23 ribosomal protein L23 0.0198954
PNRC1 proline-rich nuclear receptor coactivator 1 0.0198888
ENO2 enolase 2 (gamma, neuronal) 0.0198429
PTMA prothymosin, alpha 0.0196281
KDM4C lysine (K)-specific demethylase 4C 0.0193936
SET SET nuclear proto-oncogene 0.0192201
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0191429
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0191175
RAD18 RAD18 E3 ubiquitin protein ligase 0.0190905
MED4 mediator complex subunit 4 0.0189845
ERCC6L2 excision repair cross-complementation group 6-like 2 0.0189165
RPL9 ribosomal protein L9 0.0187873
EIF4B eukaryotic translation initiation factor 4B 0.0185143
SYMPK symplekin 0.0184534
GPBP1 GC-rich promoter binding protein 1 0.0182531
EGR1 early growth response 1 0.018102
RPS19 ribosomal protein S19 0.0181011
WASF2 WAS protein family, member 2 0.0180233
UBE2C ubiquitin-conjugating enzyme E2C 0.0179044
SH3GL1 SH3-domain GRB2-like 1 0.0177836
POTEF POTE ankyrin domain family, member F 0.0177744
CNOT3 CCR4-NOT transcription complex, subunit 3 0.0176762
RPL12 ribosomal protein L12 0.0176659
SEC62 SEC62 homolog (S. cerevisiae) 0.0176308
UBA6 ubiquitin-like modifier activating enzyme 6 0.0175924
SON SON DNA binding protein 0.0172937
RPL35A ribosomal protein L35a 0.0170572
ATP5F1B ATP synthase F1 subunit beta 0.0170035
PHKA2 phosphorylase kinase, alpha 2 (liver) 0.0169408
RPL7 ribosomal protein L7 0.0169289
UBL5 ubiquitin-like 5 0.0167649
AP2M1 adaptor-related protein complex 2, mu 1 subunit 0.0167419
L1CAM L1 cell adhesion molecule 0.0166372
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.01645
KMT2A lysine (K)-specific methyltransferase 2A 0.0163644
POFUT2 protein O-fucosyltransferase 2 0.0162025
UIMC1 ubiquitin interaction motif containing 1 0.0161744
YBX1 Y box binding protein 1 0.0161197
RPL18 ribosomal protein L18 0.0160735
ACBD3 acyl-CoA binding domain containing 3 0.0159594
TUBA1C tubulin, alpha 1c 0.0159441
UBXN4 UBX domain protein 4 0.0158932
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 0.015821
YARS1 tyrosyl-tRNA synthetase 1 0.0157815
KTN1 kinectin 1 (kinesin receptor) 0.0157229
TGFB1 transforming growth factor, beta 1 0.0156081
RPL32 ribosomal protein L32 0.0155161
GLRX glutaredoxin (thioltransferase) 0.0154644
EEF2 eukaryotic translation elongation factor 2 0.0154463
RBM33 RNA binding motif protein 33 0.0154223

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.138147
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.128426
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.112639
COL6A3 collagen, type VI, alpha 3 -0.0973244
NALF1 NALCN channel auxiliary factor 1 -0.0880308
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0762355
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.058621
EXT1 exostosin glycosyltransferase 1 -0.0549525
FNDC3B fibronectin type III domain containing 3B -0.053901
ANTXR2 anthrax toxin receptor 2 -0.052425
GRB10 growth factor receptor-bound protein 10 -0.0508984
LOX lysyl oxidase -0.0494723
ZBTB20 zinc finger and BTB domain containing 20 -0.0494332
PGK1 phosphoglycerate kinase 1 -0.0492017
CANX calnexin -0.0481
DST dystonin -0.0479956
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0473341
AHNAK AHNAK nucleoprotein -0.0451552
PDE4D phosphodiesterase 4D, cAMP-specific -0.0436004
LMAN1 lectin, mannose-binding, 1 -0.0400677
PRSS23 protease, serine, 23 -0.0391631
PTPRK protein tyrosine phosphatase, receptor type, K -0.0390787
SBF2 SET binding factor 2 -0.039061
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0379931
MYLK myosin light chain kinase -0.0372853
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0370513
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.036992
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.035773
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.034352
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0337345
KMT2C lysine (K)-specific methyltransferase 2C -0.0332791
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0323532
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0309686
RIGI RNA sensor RIG-I -0.0308213
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0308161
USP34 ubiquitin specific peptidase 34 -0.0306203
TRIO trio Rho guanine nucleotide exchange factor -0.0305844
HS6ST3 heparan sulfate 6-O-sulfotransferase 3 -0.0305067
AUTS2 autism susceptibility candidate 2 -0.0301391
TAS2R14 taste receptor, type 2, member 14 -0.0298049
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0297284
SEC31A SEC31 homolog A (S. cerevisiae) -0.0294992
MMP12 matrix metallopeptidase 12 -0.0291182
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0288856
RTN4 reticulon 4 -0.028851
NLGN1 neuroligin 1 -0.0286122
INHBA inhibin, beta A -0.0283516
IQGAP1 IQ motif containing GTPase activating protein 1 -0.028347
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0282969
TMEM165 transmembrane protein 165 -0.027759
OSMR oncostatin M receptor -0.0277401
NAV3 neuron navigator 3 -0.027685
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0276426
RAB1A RAB1A, member RAS oncogene family -0.0273675
CALU calumenin -0.0271977
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0269963
COPB1 coatomer protein complex, subunit beta 1 -0.0269537
RNF216 ring finger protein 216 -0.0265353
NAV1 neuron navigator 1 -0.0264714
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0264631
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0263168
TNS3 tensin 3 -0.0262376
VEGFC vascular endothelial growth factor C -0.0261884
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0257857
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0257668
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0256321
MON2 MON2 homolog (S. cerevisiae) -0.0255159
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0252157
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0251157
UBE2H ubiquitin-conjugating enzyme E2H -0.0251004
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0250523
NRXN3 neurexin 3 -0.0249407
AOPEP aminopeptidase O (putative) -0.0246459
OXR1 oxidation resistance 1 -0.0245209
OR51B5 olfactory receptor, family 51, subfamily B, member 5 -0.0242217
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0241347
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0237965
SMAD3 SMAD family member 3 -0.0236756
IL6ST interleukin 6 signal transducer -0.0232313
ZNF841 zinc finger protein 841 -0.023152
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.0231242
RAB7A RAB7A, member RAS oncogene family -0.0228707
HILPDA hypoxia inducible lipid droplet-associated -0.0226435
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -0.022314
AKAP12 A kinase (PRKA) anchor protein 12 -0.0223101
HIP1 huntingtin interacting protein 1 -0.0222908
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0220631
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0219711
NAMPT nicotinamide phosphoribosyltransferase -0.0218409
FBXL17 F-box and leucine-rich repeat protein 17 -0.0216692
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0216562
NPAS2 neuronal PAS domain protein 2 -0.021572
USP9Y ubiquitin specific peptidase 9, Y-linked -0.0214737
SMYD3 SET and MYND domain containing 3 -0.0212382
PDIA5 protein disulfide isomerase family A, member 5 -0.0211226
CLMP CXADR-like membrane protein -0.0210979
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.020818
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0204122
PHF14 PHD finger protein 14 -0.0203606
CCND2 cyclin D2 -0.0202669