SBI-0640756_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description SBI-0640756 perturbation in HCT15 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the SBI-0640756_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ENO1 enolase 1, (alpha) 0.130661
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.116097
PTMA prothymosin, alpha 0.107945
EGR1 early growth response 1 0.0955259
INTS6 integrator complex subunit 6 0.0635414
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0576716
PKM pyruvate kinase, muscle 0.0533821
FTL ferritin, light polypeptide 0.0520103
RPS12 ribosomal protein S12 0.0513453
TLN1 talin 1 0.0486502
TMSB10 thymosin beta 10 0.0482425
MT2A metallothionein 2A 0.0470421
RAB7A RAB7A, member RAS oncogene family 0.0462086
KRT19 keratin 19, type I 0.0456027
LOC112694756 uncharaterized LOC112694756 0.0455158
RPS3 ribosomal protein S3 0.0452641
ACTG1 actin gamma 1 0.0406134
PGK1 phosphoglycerate kinase 1 0.0399184
RPL4 ribosomal protein L4 0.039715
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0370904
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0367925
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0357515
ENO2 enolase 2 (gamma, neuronal) 0.0347177
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0342604
RPL18 ribosomal protein L18 0.0328539
RPL13A ribosomal protein L13a 0.0327826
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0325411
SLC38A1 solute carrier family 38, member 1 0.0317075
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0316645
RPL12 ribosomal protein L12 0.0313155
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0312338
IGF2 insulin-like growth factor 2 0.0311699
RPS6 ribosomal protein S6 0.0311053
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0308717
BRD2 bromodomain containing 2 0.0306832
TPI1 triosephosphate isomerase 1 0.0300084
ATF4 activating transcription factor 4 0.0296157
ERRFI1 ERBB receptor feedback inhibitor 1 0.0293621
LRRC23 leucine rich repeat containing 23 0.0287765
PSD3 pleckstrin and Sec7 domain containing 3 0.0287055
SP100 SP100 nuclear antigen 0.0285
LDHA lactate dehydrogenase A 0.027421
AKAP12 A kinase (PRKA) anchor protein 12 0.0268916
SRRM2 serine/arginine repetitive matrix 2 0.0267867
SDC4 syndecan 4 0.0267308
RPL37A ribosomal protein L37a 0.0264329
CADPS Ca++-dependent secretion activator 0.0264253
RPS27A ribosomal protein S27a 0.026351
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0262104
RPS17 ribosomal protein S17 0.0261545
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0253906
GSE1 Gse1 coiled-coil protein 0.0248373
IGFBP3 insulin-like growth factor binding protein 3 0.0248343
KRT18 keratin 18, type I 0.0248252
RPS27 ribosomal protein S27 0.0246882
S100A10 S100 calcium binding protein A10 0.0246801
HLA-B major histocompatibility complex, class I, B 0.0245949
AREG amphiregulin 0.0245509
GPATCH2L G patch domain containing 2-like 0.0245415
ANGPTL4 angiopoietin-like 4 0.0244702
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0243131
RACK1 receptor for activated C kinase 1 0.0242516
RPS2 ribosomal protein S2 0.0237777
LIMA1 LIM domain and actin binding 1 0.0233312
RPL5 ribosomal protein L5 0.023009
ENAH enabled homolog (Drosophila) 0.0227408
FN1 fibronectin 1 0.0227311
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0223424
TPM3 tropomyosin 3 0.0222593
POTEF POTE ankyrin domain family, member F 0.0222542
LMNA lamin A/C 0.022194
EGFR epidermal growth factor receptor 0.0220545
RPS29 ribosomal protein S29 0.0219327
HLA-A major histocompatibility complex, class I, A 0.021862
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0218136
RPL26 ribosomal protein L26 0.0211358
ZEB1 zinc finger E-box binding homeobox 1 0.0209454
ZFP36L1 ZFP36 ring finger protein-like 1 0.0209396
INTS3 integrator complex subunit 3 0.0208611
PPP1R13B protein phosphatase 1, regulatory subunit 13B 0.0208568
STC1 stanniocalcin 1 0.0206903
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0206002
CDCP1 CUB domain containing protein 1 0.0204327
PDLIM5 PDZ and LIM domain 5 0.020279
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0200448
YARS1 tyrosyl-tRNA synthetase 1 0.0199095
JUN jun proto-oncogene 0.0198759
IFI6 interferon, alpha-inducible protein 6 0.0198709
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0198011
RPL30 ribosomal protein L30 0.0194344
ARID1A AT rich interactive domain 1A (SWI-like) 0.0193657
BZW2 basic leucine zipper and W2 domains 2 0.0192239
CNN3 calponin 3, acidic 0.0191745
NUCB2 nucleobindin 2 0.0191728
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0191135
RPS8 ribosomal protein S8 0.018765
GPC6 glypican 6 0.0186655
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0186323
APLP2 amyloid beta (A4) precursor-like protein 2 0.0186131
MPRIP myosin phosphatase Rho interacting protein 0.0185433

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.206608
FAT1 FAT atypical cadherin 1 -0.115616
AHNAK AHNAK nucleoprotein -0.107683
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0976145
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0941695
PRELID2 PRELI domain containing 2 -0.0877855
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0793131
CANX calnexin -0.0783915
TXNRD1 thioredoxin reductase 1 -0.0746193
FHIT fragile histidine triad -0.0666446
KDM4C lysine (K)-specific demethylase 4C -0.0643439
RAD51B RAD51 paralog B -0.063952
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0610629
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0534517
NDRG1 N-myc downstream regulated 1 -0.0531208
PDIA3 protein disulfide isomerase family A, member 3 -0.0530752
MED13L mediator complex subunit 13-like -0.0497872
RPLP0 ribosomal protein, large, P0 -0.049394
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0492309
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0483161
ZFAND3 zinc finger, AN1-type domain 3 -0.0462542
JMJD1C jumonji domain containing 1C -0.0461129
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0460339
EEF2 eukaryotic translation elongation factor 2 -0.0449876
ZNF292 zinc finger protein 292 -0.0440653
KRT8 keratin 8, type II -0.043557
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0428124
DLG1 discs, large homolog 1 (Drosophila) -0.0423793
BIRC6 baculoviral IAP repeat containing 6 -0.0413443
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0407427
HELZ helicase with zinc finger -0.0404778
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0404133
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0393679
PATJ PATJ crumbs cell polarity complex component -0.0382405
FAF1 Fas (TNFRSF6) associated factor 1 -0.0378684
APP amyloid beta (A4) precursor protein -0.0373413
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0367412
DSG2 desmoglein 2 -0.0367117
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0366459
ZC3H12B zinc finger CCCH-type containing 12B -0.0365806
CLTC clathrin, heavy chain (Hc) -0.0362237
PUM2 pumilio RNA-binding family member 2 -0.036028
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0360183
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0358195
SSH2 slingshot protein phosphatase 2 -0.0356473
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.035262
MBD5 methyl-CpG binding domain protein 5 -0.0352241
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0352091
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0350229
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0348638
STRN3 striatin, calmodulin binding protein 3 -0.0343287
RHOA ras homolog family member A -0.0336758
ZCCHC7 zinc finger, CCHC domain containing 7 -0.033623
BBX bobby sox homolog (Drosophila) -0.0328587
DENND1A DENN/MADD domain containing 1A -0.0321921
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0321556
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0318755
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein -0.0315113
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase -0.0314567
LPP LIM domain containing preferred translocation partner in lipoma -0.0314449
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0313268
LMAN1 lectin, mannose-binding, 1 -0.0311126
FAM117B family with sequence similarity 117, member B -0.0307105
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0305573
CEP95 centrosomal protein 95kDa -0.030476
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0301941
ACBD6 acyl-CoA binding domain containing 6 -0.0300507
RLF rearranged L-myc fusion -0.029715
CD2AP CD2-associated protein -0.0295529
MYOF myoferlin -0.0292776
MSI2 musashi RNA-binding protein 2 -0.0290513
TENM3 teneurin transmembrane protein 3 -0.0290195
UBE2K ubiquitin-conjugating enzyme E2K -0.0287214
KDM2A lysine (K)-specific demethylase 2A -0.0285972
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0285134
RBM26 RNA binding motif protein 26 -0.0283692
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0280387
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0279867
DEK DEK proto-oncogene -0.0277061
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0276535
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0276166
NUP153 nucleoporin 153kDa -0.0274486
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.027238
COPA coatomer protein complex, subunit alpha -0.0270503
DENND4C DENN/MADD domain containing 4C -0.0269691
TMEM263 transmembrane protein 263 -0.0268821
ZC3H11A zinc finger CCCH-type containing 11A -0.0265424
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0265276
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0264105
ZMYM2 zinc finger, MYM-type 2 -0.0262274
ETNK1 ethanolamine kinase 1 -0.0261989
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0259664
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme -0.0257278
NF1 neurofibromin 1 -0.025553
ZNF638 zinc finger protein 638 -0.0255369
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0252125
BRWD3 bromodomain and WD repeat domain containing 3 -0.0251138
TLK1 tousled-like kinase 1 -0.025047
BTBD9 BTB (POZ) domain containing 9 -0.0250322
WAC WW domain containing adaptor with coiled-coil -0.0250311