SBI-0640756_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description SBI-0640756 perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the SBI-0640756_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.176074
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.118551
MT2A metallothionein 2A 0.106738
TPM4 tropomyosin 4 0.0925256
ENO1 enolase 1, (alpha) 0.0908873
ASPH aspartate beta-hydroxylase 0.0893011
SRRM2 serine/arginine repetitive matrix 2 0.0841347
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0826471
NDRG1 N-myc downstream regulated 1 0.0809898
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0761256
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0719832
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0669348
CDCP1 CUB domain containing protein 1 0.0641331
SQSTM1 sequestosome 1 0.0607463
GOLGA4 golgin A4 0.0578867
PTMA prothymosin, alpha 0.0497768
RPS3 ribosomal protein S3 0.0492244
DDIT4 DNA-damage-inducible transcript 4 0.0490192
AKAP12 A kinase (PRKA) anchor protein 12 0.0480839
PRELID2 PRELI domain containing 2 0.0468016
FTL ferritin, light polypeptide 0.0465898
GOLGB1 golgin B1 0.0458013
AKAP9 A kinase (PRKA) anchor protein 9 0.0453651
DSPP dentin sialophosphoprotein 0.045105
CAPN2 calpain 2, (m/II) large subunit 0.0443025
LDHA lactate dehydrogenase A 0.0438701
RPL4 ribosomal protein L4 0.0434019
LOC102724023 ES1 protein homolog, mitochondrial 0.0416865
PLEC plectin 0.0407773
ANGPTL4 angiopoietin-like 4 0.0406221
TPI1 triosephosphate isomerase 1 0.0398409
PLAUR plasminogen activator, urokinase receptor 0.0385238
TTC3 tetratricopeptide repeat domain 3 0.038177
BPTF bromodomain PHD finger transcription factor 0.0381468
KIF5B kinesin family member 5B 0.0380257
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.0379248
ITGA6 integrin, alpha 6 0.0368699
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0367132
COG6 component of oligomeric golgi complex 6 0.0358438
PLAU plasminogen activator, urokinase 0.035416
COPA coatomer protein complex, subunit alpha 0.0347256
DSG2 desmoglein 2 0.0341829
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12 0.0340739
RPL26 ribosomal protein L26 0.0338218
N4BP2L2 NEDD4 binding protein 2-like 2 0.0333296
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0330855
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0324073
ERRFI1 ERBB receptor feedback inhibitor 1 0.0313552
SPAG9 sperm associated antigen 9 0.030561
CANX calnexin 0.0305233
TPM3 tropomyosin 3 0.030474
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.0302786
RSL1D1 ribosomal L1 domain containing 1 0.030257
NEK1 NIMA-related kinase 1 0.0301275
BRD2 bromodomain containing 2 0.0298747
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0293955
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0293201
ENO2 enolase 2 (gamma, neuronal) 0.0290515
LASP1 LIM and SH3 protein 1 0.0288584
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.028733
LAMC2 laminin, gamma 2 0.0274736
SETX senataxin 0.0273404
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.027305
FCHSD2 FCH and double SH3 domains 2 0.0271082
TMF1 TATA element modulatory factor 1 0.0267079
KRT19 keratin 19, type I 0.0262757
NRDC nardilysin convertase 0.0262565
SET SET nuclear proto-oncogene 0.0260087
CEMIP2 cell migration inducing hyaluronidase 2 0.0258301
DIAPH3 diaphanous-related formin 3 0.0257945
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0256664
EGR1 early growth response 1 0.0252139
SP100 SP100 nuclear antigen 0.0251457
BHLHE40 basic helix-loop-helix family, member e40 0.0251228
TLN1 talin 1 0.0248507
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0245782
NUP58 nucleoporin 58 0.0245579
GYS1 glycogen synthase 1 (muscle) 0.0244905
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0243365
SRSF11 serine/arginine-rich splicing factor 11 0.0236842
TMEM87B transmembrane protein 87B 0.02358
GATAD1 GATA zinc finger domain containing 1 0.0233476
TUBB6 tubulin, beta 6 class V 0.0233463
JUN jun proto-oncogene 0.0233421
CEP350 centrosomal protein 350kDa 0.023167
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0231266
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0230194
ZFP36L1 ZFP36 ring finger protein-like 1 0.0230105
RSRC2 arginine/serine-rich coiled-coil 2 0.0229756
ITGB4 integrin, beta 4 0.0228557
MBD5 methyl-CpG binding domain protein 5 0.0227833
POM121C POM121 transmembrane nucleoporin C 0.0227569
S100A11 S100 calcium binding protein A11 0.0226559
ERBIN erbb2 interacting protein 0.0226485
STXBP4 syntaxin binding protein 4 0.022528
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0225175
RRBP1 ribosome binding protein 1 0.0224628
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0224138
GNAS GNAS complex locus 0.0221828
CALD1 caldesmon 1 0.0219535

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.187828
ITGB8 integrin, beta 8 -0.0767174
RHEX regulator of hemoglobinization and erythroid cell expansion -0.0647678
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.064496
PAX8 paired box 8 -0.0633554
WWC1 WW and C2 domain containing 1 -0.0600392
ZBTB20 zinc finger and BTB domain containing 20 -0.0597814
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0590552
ANKRD17 ankyrin repeat domain 17 -0.0544833
RPL23 ribosomal protein L23 -0.0535573
TMSB10 thymosin beta 10 -0.0504663
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0486803
FNDC3B fibronectin type III domain containing 3B -0.0483646
SBF2 SET binding factor 2 -0.0478493
ECT2 epithelial cell transforming 2 -0.0475095
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0455002
ANKRD10 ankyrin repeat domain 10 -0.0452321
TPT1 tumor protein, translationally-controlled 1 -0.0430419
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0420489
TXNRD1 thioredoxin reductase 1 -0.0420093
RPL32 ribosomal protein L32 -0.0416721
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0408008
PUM2 pumilio RNA-binding family member 2 -0.0402825
RHOA ras homolog family member A -0.039666
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0394207
PUM1 pumilio RNA-binding family member 1 -0.038786
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0381224
ADAM10 ADAM metallopeptidase domain 10 -0.037557
RPS11 ribosomal protein S11 -0.0367423
RNF145 ring finger protein 145 -0.0364767
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0363616
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.036226
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0361349
PTPRK protein tyrosine phosphatase, receptor type, K -0.0356751
PTK2 protein tyrosine kinase 2 -0.0354163
NF1 neurofibromin 1 -0.0349105
JAZF1 JAZF zinc finger 1 -0.0348111
POTEF POTE ankyrin domain family, member F -0.0343816
RPL8 ribosomal protein L8 -0.034283
TAOK1 TAO kinase 1 -0.0342133
BIRC6 baculoviral IAP repeat containing 6 -0.0337253
UTRN utrophin -0.0337237
APP amyloid beta (A4) precursor protein -0.0336766
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0336674
ACACA acetyl-CoA carboxylase alpha -0.03358
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0335269
SSH2 slingshot protein phosphatase 2 -0.0335082
RPS24 ribosomal protein S24 -0.0334845
UGCG UDP-glucose ceramide glucosyltransferase -0.0330135
BICC1 BicC family RNA binding protein 1 -0.0325379
JMJD1C jumonji domain containing 1C -0.0324197
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -0.0320528
ANKRD33B ankyrin repeat domain 33B -0.0320429
VMP1 vacuole membrane protein 1 -0.032006
ZNF292 zinc finger protein 292 -0.0318295
ANKRD28 ankyrin repeat domain 28 -0.0316713
SVIL supervillin -0.0316151
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0315979
KDM6A lysine (K)-specific demethylase 6A -0.0314407
BICD1 bicaudal D homolog 1 (Drosophila) -0.0309202
ALCAM activated leukocyte cell adhesion molecule -0.0306774
KRT7 keratin 7, type II -0.0304607
SLMAP sarcolemma associated protein -0.0303878
LPP LIM domain containing preferred translocation partner in lipoma -0.0302573
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0300501
PARD3B par-3 family cell polarity regulator beta -0.03002
SETD2 SET domain containing 2 -0.0297136
DNM2 dynamin 2 -0.0296652
RPS25 ribosomal protein S25 -0.0287814
TCERG1 transcription elongation regulator 1 -0.0284951
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0283502
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.028326
GATAD2A GATA zinc finger domain containing 2A -0.0281824
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0281274
RPS6 ribosomal protein S6 -0.0280968
USP9X ubiquitin specific peptidase 9, X-linked -0.0280853
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -0.0278828
RPLP0 ribosomal protein, large, P0 -0.0276365
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.0275918
PGK1 phosphoglycerate kinase 1 -0.0275848
SPIDR scaffolding protein involved in DNA repair -0.0275668
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0275018
ANXA2 annexin A2 -0.0271344
RPS23 ribosomal protein S23 -0.0268888
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0267266
AHCTF1 AT hook containing transcription factor 1 -0.0266852
NDUFAF2 NADH dehydrogenase (ubiquinone) complex I, assembly factor 2 -0.0265691
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0264806
ATXN1 ataxin 1 -0.0262698
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0262482
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0261876
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit -0.0261614
WDR43 WD repeat domain 43 -0.0260368
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein -0.0260092
SIK3 SIK family kinase 3 -0.0258365
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.0256581
FAF1 Fas (TNFRSF6) associated factor 1 -0.0254905
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0254408
RPS4X ribosomal protein S4, X-linked -0.0253459
TRIO trio Rho guanine nucleotide exchange factor -0.0253297