SBI-0640756_HOP62 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description SBI-0640756 perturbation in HOP62 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the SBI-0640756_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.130138
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.126591
STC1 stanniocalcin 1 0.0949594
AKAP12 A kinase (PRKA) anchor protein 12 0.0895998
JARID2 jumonji, AT rich interactive domain 2 0.0894895
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0824001
ENO1 enolase 1, (alpha) 0.0808034
RPS6 ribosomal protein S6 0.0788355
MAP1B microtubule-associated protein 1B 0.0712286
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0702685
EGR1 early growth response 1 0.0699055
RPL12 ribosomal protein L12 0.0687893
VIM vimentin 0.0683931
SQSTM1 sequestosome 1 0.0663747
INTS6 integrator complex subunit 6 0.0655186
RPL4 ribosomal protein L4 0.0622372
EIF1 eukaryotic translation initiation factor 1 0.0620795
RPL37A ribosomal protein L37a 0.0599859
FTL ferritin, light polypeptide 0.0592946
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0587375
LAMB3 laminin, beta 3 0.057693
ANGPTL4 angiopoietin-like 4 0.0576578
EGFR epidermal growth factor receptor 0.0573751
PLAUR plasminogen activator, urokinase receptor 0.0550519
KTN1 kinectin 1 (kinesin receptor) 0.0529254
RPS12 ribosomal protein S12 0.0512929
PTPRM protein tyrosine phosphatase, receptor type, M 0.0509033
ANKRD12 ankyrin repeat domain 12 0.049903
RACK1 receptor for activated C kinase 1 0.0478247
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0462275
MT2A metallothionein 2A 0.0461771
RPS8 ribosomal protein S8 0.0461305
PRRC2C proline-rich coiled-coil 2C 0.0460431
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0454846
IL11 interleukin 11 0.0450503
TTC3 tetratricopeptide repeat domain 3 0.0446533
TIMP1 TIMP metallopeptidase inhibitor 1 0.0434318
RPL35A ribosomal protein L35a 0.0416766
PTMA prothymosin, alpha 0.0412887
NDRG1 N-myc downstream regulated 1 0.0399397
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0397402
RPS3 ribosomal protein S3 0.0395943
ENO2 enolase 2 (gamma, neuronal) 0.0386854
GOLGA4 golgin A4 0.0384359
ANKRD11 ankyrin repeat domain 11 0.0381518
WSB1 WD repeat and SOCS box containing 1 0.0379327
KMT2C lysine (K)-specific methyltransferase 2C 0.0375692
RPS19 ribosomal protein S19 0.0372083
HLA-B major histocompatibility complex, class I, B 0.036931
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0369276
CXCL8 chemokine (C-X-C motif) ligand 8 0.0367852
TMSB10 thymosin beta 10 0.0363146
SRRM2 serine/arginine repetitive matrix 2 0.0362305
NAP1L1 nucleosome assembly protein 1-like 1 0.0345331
ARHGAP5 Rho GTPase activating protein 5 0.0340411
RPL9 ribosomal protein L9 0.0339562
OGA O-GlcNAcase 0.0335518
SEPTIN9 septin 9 0.0333104
CAPN2 calpain 2, (m/II) large subunit 0.0329227
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0318107
SCFD1 sec1 family domain containing 1 0.031658
TPI1 triosephosphate isomerase 1 0.0314599
NACA nascent polypeptide-associated complex alpha subunit 0.031386
RUNX3 runt-related transcription factor 3 0.0313242
ATF4 activating transcription factor 4 0.0306444
FERMT2 fermitin family member 2 0.0304041
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.029932
BACE2 beta-site APP-cleaving enzyme 2 0.0296014
RPL26 ribosomal protein L26 0.0295251
FTH1 ferritin, heavy polypeptide 1 0.0294881
RPS17 ribosomal protein S17 0.0294862
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0290452
RPS27 ribosomal protein S27 0.0289286
RPS13 ribosomal protein S13 0.0289192
IGFBP3 insulin-like growth factor binding protein 3 0.0283585
LOC102724023 ES1 protein homolog, mitochondrial 0.0283363
LDHA lactate dehydrogenase A 0.0275639
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0271069
SP100 SP100 nuclear antigen 0.0270614
RPL34 ribosomal protein L34 0.0268808
COL7A1 collagen, type VII, alpha 1 0.0267573
RCOR1 REST corepressor 1 0.0267393
SLC30A1 solute carrier family 30 (zinc transporter), member 1 0.02643
PLAGL1 pleiomorphic adenoma gene-like 1 0.0263772
RAI14 retinoic acid induced 14 0.0260583
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0257595
HOMER1 homer scaffolding protein 1 0.0255646
RPL13A ribosomal protein L13a 0.0254337
AHRR aryl-hydrocarbon receptor repressor 0.025405
EEF2 eukaryotic translation elongation factor 2 0.0253174
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0252204
RBM39 RNA binding motif protein 39 0.0252171
GARS1 glycyl-tRNA synthetase 1 0.0251494
MYO1D myosin ID 0.025047
DTNA dystrobrevin, alpha 0.0249625
RPL19 ribosomal protein L19 0.0249212
ZSWIM6 zinc finger, SWIM-type containing 6 0.0247686
RPL31 ribosomal protein L31 0.0247409
HDAC9 histone deacetylase 9 0.0246564
RPL5 ribosomal protein L5 0.024631

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.228053
FN1 fibronectin 1 -0.175889
FNDC3B fibronectin type III domain containing 3B -0.107767
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.107518
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0722739
EXT1 exostosin glycosyltransferase 1 -0.0673077
CENPF centromere protein F, 350/400kDa -0.0569376
TRIO trio Rho guanine nucleotide exchange factor -0.0548419
ANKRD28 ankyrin repeat domain 28 -0.047666
TENM2 teneurin transmembrane protein 2 -0.046781
SMAD3 SMAD family member 3 -0.0432907
SBF2 SET binding factor 2 -0.0430448
CCND1 cyclin D1 -0.0415507
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0403963
ZBTB20 zinc finger and BTB domain containing 20 -0.0402677
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0391597
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0389855
CDCP1 CUB domain containing protein 1 -0.0380174
CD109 CD109 molecule -0.0378346
ACTG1 actin gamma 1 -0.0372751
ACTN4 actinin, alpha 4 -0.0370249
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0368829
VEGFC vascular endothelial growth factor C -0.0349796
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0345052
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0330325
GLIS3 GLIS family zinc finger 3 -0.0312635
PDE10A phosphodiesterase 10A -0.0311888
TPX2 TPX2, microtubule-associated -0.03088
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0304611
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0303546
CALU calumenin -0.0302359
SMC4 structural maintenance of chromosomes 4 -0.0301263
DIAPH2 diaphanous-related formin 2 -0.029789
MKI67 marker of proliferation Ki-67 -0.0296675
PTK2 protein tyrosine kinase 2 -0.0295618
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0292401
ETV6 ets variant 6 -0.0285074
RAB1A RAB1A, member RAS oncogene family -0.0279053
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0276254
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0274643
ANLN anillin, actin binding protein -0.0270087
TUBB tubulin, beta class I -0.0268353
COL6A2 collagen, type VI, alpha 2 -0.0267774
KDM2A lysine (K)-specific demethylase 2A -0.0263482
ANTXR2 anthrax toxin receptor 2 -0.026161
RRM2 ribonucleotide reductase M2 -0.0260119
COL6A1 collagen, type VI, alpha 1 -0.0259714
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0259329
ANTXR1 anthrax toxin receptor 1 -0.0258795
COL1A1 collagen, type I, alpha 1 -0.0255852
EFNA5 ephrin-A5 -0.0254398
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 -0.0252845
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0250825
ZMYND8 zinc finger, MYND-type containing 8 -0.0248855
FSTL1 follistatin-like 1 -0.0242965
MYO10 myosin X -0.0242634
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -0.0241518
PTPRG protein tyrosine phosphatase, receptor type, G -0.0235964
MSN moesin -0.0234984
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0233625
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0229941
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0229402
PRR11 proline rich 11 -0.0229206
GRB10 growth factor receptor-bound protein 10 -0.0228218
HMGA2 high mobility group AT-hook 2 -0.0227931
SDK1 sidekick cell adhesion molecule 1 -0.0223382
CEP112 centrosomal protein 112kDa -0.0222846
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0222427
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0221062
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0220548
NAV1 neuron navigator 1 -0.0220281
AHNAK AHNAK nucleoprotein -0.0219478
SGO2 shugoshin 2 -0.0216927
ZFR zinc finger RNA binding protein -0.0214718
ATP13A3 ATPase type 13A3 -0.0214666
NSD2 nuclear receptor binding SET domain protein 2 -0.0212392
CDK14 cyclin-dependent kinase 14 -0.0211367
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0210445
RHOA ras homolog family member A -0.0209669
SYAP1 synapse associated protein 1 -0.0208051
BICD1 bicaudal D homolog 1 (Drosophila) -0.0205031
RNF149 ring finger protein 149 -0.0204317
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0203972
ADAM9 ADAM metallopeptidase domain 9 -0.020307
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0202415
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0202214
TBC1D5 TBC1 domain family, member 5 -0.0200692
TUBA1B tubulin, alpha 1b -0.0200538
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.0199574
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) -0.0199262
RIN2 Ras and Rab interactor 2 -0.0199142
TPM1 tropomyosin 1 (alpha) -0.0197803
NALF1 NALCN channel auxiliary factor 1 -0.0197652
SP3 Sp3 transcription factor -0.0197266
MIS18BP1 MIS18 binding protein 1 -0.0197216
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0195981
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 -0.0195152
FTO fat mass and obesity associated -0.0192964
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0192915
FRYL FRY-like -0.019288