| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | SBI-0640756 perturbation in HT-29 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the SBI-0640756_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0929334 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0900443 |
| FTL | ferritin, light polypeptide | 0.0715506 |
| RPL4 | ribosomal protein L4 | 0.0707582 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0631082 |
| NTN4 | netrin 4 | 0.0618108 |
| RPS12 | ribosomal protein S12 | 0.0597143 |
| RPS3 | ribosomal protein S3 | 0.0547117 |
| RPL37A | ribosomal protein L37a | 0.0484984 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0456703 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0413904 |
| INTS6 | integrator complex subunit 6 | 0.0407547 |
| HKDC1 | hexokinase domain containing 1 | 0.0405121 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.039669 |
| EGR1 | early growth response 1 | 0.0394865 |
| OGA | O-GlcNAcase | 0.0394214 |
| UBXN4 | UBX domain protein 4 | 0.0378959 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0376659 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0375665 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0363834 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0353446 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0343164 |
| AREG | amphiregulin | 0.034291 |
| VCL | vinculin | 0.0326253 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0326236 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0325727 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0323802 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0319738 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0318399 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0318171 |
| HLA-A | major histocompatibility complex, class I, A | 0.0311322 |
| NUP58 | nucleoporin 58 | 0.0309574 |
| DDIT3 | DNA-damage-inducible transcript 3 | 0.0303443 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | 0.0299412 |
| JAK1 | Janus kinase 1 | 0.0291118 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0289506 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0274575 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.0266735 |
| S100P | S100 calcium binding protein P | 0.0265525 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0263759 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | 0.0262769 |
| YTHDC1 | YTH domain containing 1 | 0.02624 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0260466 |
| BRD2 | bromodomain containing 2 | 0.0260417 |
| AHDC1 | AT hook, DNA binding motif, containing 1 | 0.0253757 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | 0.0251843 |
| EGFR | epidermal growth factor receptor | 0.0250498 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0250106 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0249397 |
| ADM | adrenomedullin | 0.0247847 |
| SKP1 | S-phase kinase-associated protein 1 | 0.0247073 |
| ATF3 | activating transcription factor 3 | 0.0246238 |
| SNX14 | sorting nexin 14 | 0.0245495 |
| MYO6 | myosin VI | 0.0245094 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0244948 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0244763 |
| SRPK2 | SRSF protein kinase 2 | 0.0241817 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0241624 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | 0.024141 |
| RPS18 | ribosomal protein S18 | 0.0241102 |
| GLCCI1 | glucocorticoid induced 1 | 0.0240519 |
| HBP1 | HMG-box transcription factor 1 | 0.024012 |
| PRPF4B | pre-mRNA processing factor 4B | 0.0239236 |
| SEC62 | SEC62 homolog (S. cerevisiae) | 0.0234954 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | 0.02346 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0234427 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0231959 |
| GANAB | glucosidase, alpha; neutral AB | 0.0226517 |
| SRSF9 | serine/arginine-rich splicing factor 9 | 0.0226277 |
| MARS1 | methionyl-tRNA synthetase 1 | 0.0223228 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.021789 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | 0.0213639 |
| GOLM2 | golgi membrane protein 2 | 0.021054 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0205507 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0204982 |
| TLK1 | tousled-like kinase 1 | 0.020414 |
| VIM | vimentin | 0.0203759 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0202358 |
| RPL13A | ribosomal protein L13a | 0.020191 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0201537 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0201373 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.0200924 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0199693 |
| SLMAP | sarcolemma associated protein | 0.0199227 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0198922 |
| TPI1 | triosephosphate isomerase 1 | 0.0198641 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0197883 |
| GGNBP2 | gametogenetin binding protein 2 | 0.0197028 |
| PRRC2B | proline-rich coiled-coil 2B | 0.0196462 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0195849 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0193733 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.019244 |
| LCN2 | lipocalin 2 | 0.01916 |
| RLF | rearranged L-myc fusion | 0.0191241 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0187447 |
| RIC8A | RIC8 guanine nucleotide exchange factor A | 0.0186129 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | 0.0185991 |
| CTDSPL2 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 | 0.0185393 |
| TOP6BL | TOP6B like initiator of meiotic double strand breaks | 0.0185041 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0184003 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.152007 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.123238 |
| ANXA2 | annexin A2 | -0.111807 |
| KRT20 | keratin 20, type I | -0.109043 |
| LYZ | lysozyme | -0.107127 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.100323 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0964907 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0878162 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0864074 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0863625 |
| ACTN4 | actinin, alpha 4 | -0.0855072 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0846694 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0824841 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0781138 |
| ATXN1 | ataxin 1 | -0.0759926 |
| EZR | ezrin | -0.0758107 |
| FRY | furry homolog (Drosophila) | -0.0737122 |
| LMO7 | LIM domain 7 | -0.0726868 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0704725 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0699568 |
| POTEF | POTE ankyrin domain family, member F | -0.0689092 |
| DIAPH2 | diaphanous-related formin 2 | -0.0673873 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0667423 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0634266 |
| DGKH | diacylglycerol kinase, eta | -0.0613211 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.0605944 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0555114 |
| RPL23 | ribosomal protein L23 | -0.0548111 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | -0.0535082 |
| KRT18 | keratin 18, type I | -0.0532159 |
| KRT8 | keratin 8, type II | -0.0531726 |
| TM4SF4 | transmembrane 4 L six family member 4 | -0.0514544 |
| EMP1 | epithelial membrane protein 1 | -0.0510062 |
| S100A6 | S100 calcium binding protein A6 | -0.048938 |
| TJP1 | tight junction protein 1 | -0.0480668 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0478736 |
| LAMA4 | laminin, alpha 4 | -0.0477311 |
| RPS5 | ribosomal protein S5 | -0.0476215 |
| AGR2 | anterior gradient 2 | -0.0475539 |
| S100A10 | S100 calcium binding protein A10 | -0.0474544 |
| PRELID2 | PRELI domain containing 2 | -0.0473964 |
| PTK2 | protein tyrosine kinase 2 | -0.04657 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.046396 |
| AHNAK | AHNAK nucleoprotein | -0.046304 |
| ITGA6 | integrin, alpha 6 | -0.0462455 |
| RPL21 | ribosomal protein L21 | -0.0462315 |
| PDZD8 | PDZ domain containing 8 | -0.0458317 |
| TMEM123 | transmembrane protein 123 | -0.0457838 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0456246 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0447956 |
| EXOC4 | exocyst complex component 4 | -0.0444054 |
| TRAPPC9 | trafficking protein particle complex 9 | -0.0442842 |
| LDHA | lactate dehydrogenase A | -0.0440887 |
| NDRG1 | N-myc downstream regulated 1 | -0.0435211 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.042343 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0421116 |
| RPS23 | ribosomal protein S23 | -0.0407478 |
| SKIL | SKI-like proto-oncogene | -0.040688 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0403161 |
| RPS6 | ribosomal protein S6 | -0.0400223 |
| ASTN2 | astrotactin 2 | -0.0398789 |
| WASF2 | WAS protein family, member 2 | -0.039706 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.039381 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | -0.0389125 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0385956 |
| SMAD3 | SMAD family member 3 | -0.0380952 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0378574 |
| RPS21 | ribosomal protein S21 | -0.0366835 |
| MYO1E | myosin IE | -0.0362829 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0361187 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0360826 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0360039 |
| TXNRD1 | thioredoxin reductase 1 | -0.0358975 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0353989 |
| CD164 | CD164 molecule, sialomucin | -0.035335 |
| MLLT3 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 | -0.0353044 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0350628 |
| GCNT3 | glucosaminyl (N-acetyl) transferase 3, mucin type | -0.035038 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0350209 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0347428 |
| BPTF | bromodomain PHD finger transcription factor | -0.0343885 |
| ZNF609 | zinc finger protein 609 | -0.0343815 |
| ABHD2 | abhydrolase domain containing 2 | -0.0342345 |
| TMEM65 | transmembrane protein 65 | -0.0341404 |
| CYSTM1 | cysteine-rich transmembrane module containing 1 | -0.0341346 |
| RPL8 | ribosomal protein L8 | -0.0339694 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.0338945 |
| MMP7 | matrix metallopeptidase 7 | -0.0336135 |
| RPL27A | ribosomal protein L27a | -0.0335759 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0333343 |
| ACTG1 | actin gamma 1 | -0.032718 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | -0.0325874 |
| ETNK1 | ethanolamine kinase 1 | -0.0325249 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.03251 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0320355 |
| MYH14 | myosin, heavy chain 14, non-muscle | -0.0319605 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0317486 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0316323 |
| RTN3 | reticulon 3 | -0.0315272 |
| TAOK1 | TAO kinase 1 | -0.0311663 |
