SBI-0640756_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description SBI-0640756 perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the SBI-0640756_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.143606
ENO1 enolase 1, (alpha) 0.140586
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.123108
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.108608
ASPH aspartate beta-hydroxylase 0.0818263
RPS12 ribosomal protein S12 0.0756663
ERRFI1 ERBB receptor feedback inhibitor 1 0.0660495
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0615927
RPL37A ribosomal protein L37a 0.0568285
PLIN2 perilipin 2 0.0552993
DSPP dentin sialophosphoprotein 0.0518395
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0494454
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0449187
MACF1 microtubule-actin crosslinking factor 1 0.0444158
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.0438508
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0401704
PDLIM5 PDZ and LIM domain 5 0.0399044
HDLBP high density lipoprotein binding protein 0.0395959
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0371097
FILIP1L filamin A interacting protein 1-like 0.035242
DST dystonin 0.0344828
JAK1 Janus kinase 1 0.0340104
RPL26 ribosomal protein L26 0.0329816
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0327884
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0326129
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0319966
RPS3 ribosomal protein S3 0.0313837
HMGA1 high mobility group AT-hook 1 0.0303719
GARS1 glycyl-tRNA synthetase 1 0.0297886
FTH1 ferritin, heavy polypeptide 1 0.0295531
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 0.0294819
NFE2L1 nuclear factor, erythroid 2-like 1 0.0292747
PALLD palladin, cytoskeletal associated protein 0.0288442
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 0.0286647
MAP1B microtubule-associated protein 1B 0.0280312
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 0.0278343
INTS6 integrator complex subunit 6 0.0277393
IGFBP3 insulin-like growth factor binding protein 3 0.0270118
PTPRF protein tyrosine phosphatase, receptor type, F 0.0268745
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0261278
STC2 stanniocalcin 2 0.0259346
TLN1 talin 1 0.0256382
TXNRD1 thioredoxin reductase 1 0.0256127
CLMN calmin (calponin-like, transmembrane) 0.0255653
EEF2 eukaryotic translation elongation factor 2 0.0252791
LARS1 leucyl-tRNA synthetase 1 0.0248869
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 0.0248713
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0247902
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0245638
ATF4 activating transcription factor 4 0.0244846
RPS18 ribosomal protein S18 0.0241214
RPS6 ribosomal protein S6 0.0240688
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0239776
RACK1 receptor for activated C kinase 1 0.023772
WSB1 WD repeat and SOCS box containing 1 0.0232129
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0231708
SERTAD2 SERTA domain containing 2 0.0227654
CDV3 CDV3 homolog (mouse) 0.0225229
CLIP1 CAP-GLY domain containing linker protein 1 0.022503
TTC3 tetratricopeptide repeat domain 3 0.0223908
HM13 histocompatibility (minor) 13 0.0223633
MYO1B myosin IB 0.0218559
CAPN2 calpain 2, (m/II) large subunit 0.0217203
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0215627
ATXN1 ataxin 1 0.0214883
DTNA dystrobrevin, alpha 0.021481
WWC2 WW and C2 domain containing 2 0.0214782
JUN jun proto-oncogene 0.021444
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0214088
PKM pyruvate kinase, muscle 0.0213544
FAM107B family with sequence similarity 107, member B 0.0211307
CCNC cyclin C 0.0208374
RPS2 ribosomal protein S2 0.0207404
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0206434
RPS27A ribosomal protein S27a 0.0206381
GOLGA4 golgin A4 0.0205403
GCC2 GRIP and coiled-coil domain containing 2 0.0205073
ASXL2 additional sex combs like transcriptional regulator 2 0.0204331
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0202619
FNDC3A fibronectin type III domain containing 3A 0.019738
GDI2 GDP dissociation inhibitor 2 0.0196296
ANKH ANKH inorganic pyrophosphate transport regulator 0.0195819
AARS1 alanyl-tRNA synthetase 1 0.0195151
BZW1 basic leucine zipper and W2 domains 1 0.0195088
TLK2 tousled-like kinase 2 0.0192977
FLNA filamin A, alpha 0.019285
MPZL2 myelin protein zero-like 2 0.0192514
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0192152
SEPTIN2 septin 2 0.0192121
EIF1 eukaryotic translation initiation factor 1 0.0190986
SQSTM1 sequestosome 1 0.0188124
SRRM1 serine/arginine repetitive matrix 1 0.0187198
LDHA lactate dehydrogenase A 0.0184691
LCN2 lipocalin 2 0.0183034
PRPF4B pre-mRNA processing factor 4B 0.0180392
GRB10 growth factor receptor-bound protein 10 0.0180376
SPIRE1 spire-type actin nucleation factor 1 0.0179404
RPL4 ribosomal protein L4 0.0178799
GOLGA3 golgin A3 0.0178264
SMAP1 small ArfGAP 1 0.0176195

decreased expression

Symbol Name Standardized Value
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.238943
APOB apolipoprotein B -0.224834
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.20292
FN1 fibronectin 1 -0.190783
GPC3 glypican 3 -0.107683
FNDC3B fibronectin type III domain containing 3B -0.107305
LRMDA leucine rich melanocyte differentiation associated -0.100376
C3 complement component 3 -0.0953016
MAML2 mastermind-like 2 (Drosophila) -0.093177
ELL2 elongation factor, RNA polymerase II, 2 -0.0920876
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0798715
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0789485
FBF1 Fas (TNFRSF6) binding factor 1 -0.077093
GPC6 glypican 6 -0.0720739
APOA2 apolipoprotein A-II -0.0690326
NKD1 naked cuticle homolog 1 (Drosophila) -0.0636699
TRIM26 tripartite motif containing 26 -0.0627319
TPT1 tumor protein, translationally-controlled 1 -0.0599653
EHBP1 EH domain binding protein 1 -0.0584163
DOCK4 dedicator of cytokinesis 4 -0.057999
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0564064
TF transferrin -0.0561455
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0526446
TM4SF1 transmembrane 4 L six family member 1 -0.05194
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0515615
TMEM123 transmembrane protein 123 -0.0494652
SESTD1 SEC14 and spectrin domains 1 -0.0487818
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0482501
EML4 echinoderm microtubule associated protein like 4 -0.0482217
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0474321
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0469739
A2M alpha-2-macroglobulin -0.0466072
PTCHD4 patched domain containing 4 -0.0463232
PARD3 par-3 family cell polarity regulator -0.0449136
SLC38A2 solute carrier family 38, member 2 -0.044572
AHSG alpha-2-HS-glycoprotein -0.0445325
MBNL3 muscleblind-like splicing regulator 3 -0.0440348
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0436277
MSI2 musashi RNA-binding protein 2 -0.0435481
IGF1R insulin-like growth factor 1 receptor -0.0426129
GMDS GDP-mannose 4,6-dehydratase -0.0425373
PTPRM protein tyrosine phosphatase, receptor type, M -0.0424584
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0410949
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0406045
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0405365
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0402238
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0400145
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0394422
TRIO trio Rho guanine nucleotide exchange factor -0.039437
IGFBP1 insulin-like growth factor binding protein 1 -0.0389315
EXT1 exostosin glycosyltransferase 1 -0.0373203
MRTFA myocardin related transcription factor A -0.0371839
RPS21 ribosomal protein S21 -0.0370019
NPAS2 neuronal PAS domain protein 2 -0.0363543
PTBP3 polypyrimidine tract binding protein 3 -0.036158
PATJ PATJ crumbs cell polarity complex component -0.0360572
RPS24 ribosomal protein S24 -0.0350285
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0349794
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.034785
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -0.0343765
MALT1 MALT1 paracaspase -0.0341031
TNS3 tensin 3 -0.0338359
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -0.0335483
FOXN3 forkhead box N3 -0.0335288
BCL2L1 BCL2-like 1 -0.0333534
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0333387
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0330446
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0326613
STK17A serine/threonine kinase 17a -0.0323373
ZBTB20 zinc finger and BTB domain containing 20 -0.031733
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0314959
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 -0.0310942
APOA1 apolipoprotein A-I -0.0310591
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0310313
AMBP alpha-1-microglobulin/bikunin precursor -0.0307928
GNAS GNAS complex locus -0.0301648
SORL1 sortilin-related receptor, L(DLR class) A repeats containing -0.0301077
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0300046
ABI1 abl-interactor 1 -0.0299358
WDFY2 WD repeat and FYVE domain containing 2 -0.0294178
CCL20 chemokine (C-C motif) ligand 20 -0.0289817
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.028747
PTPRG protein tyrosine phosphatase, receptor type, G -0.0284017
RRBP1 ribosome binding protein 1 -0.0280428
ABTB3 ankyrin repeat and BTB domain containing 3 -0.0277055
DLC1 DLC1 Rho GTPase activating protein -0.0272258
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0271612
TMEM51 transmembrane protein 51 -0.0269546
IGF2R insulin-like growth factor 2 receptor -0.0266747
KDM7A lysine (K)-specific demethylase 7A -0.0265864
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0265746
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0265222
GDF15 growth differentiation factor 15 -0.0261813
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0261456
ARHGAP12 Rho GTPase activating protein 12 -0.0260071
ZFHX3 zinc finger homeobox 3 -0.0259754
LYZ lysozyme -0.0258733
DNAH17 dynein, axonemal, heavy chain 17 -0.0258102
OSMR oncostatin M receptor -0.0255536
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0254911