SBI-0640756_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description SBI-0640756 perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the SBI-0640756_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 0.0903904
STC1 stanniocalcin 1 0.0827291
HLA-B major histocompatibility complex, class I, B 0.0791719
INTS6 integrator complex subunit 6 0.0786236
ENO1 enolase 1, (alpha) 0.0677217
PRRC2C proline-rich coiled-coil 2C 0.0649327
LOC112694756 uncharaterized LOC112694756 0.0606144
EIF1 eukaryotic translation initiation factor 1 0.0602891
PTMA prothymosin, alpha 0.0581201
SQSTM1 sequestosome 1 0.0572626
ATF4 activating transcription factor 4 0.0543398
MPRIP myosin phosphatase Rho interacting protein 0.0522327
RPL4 ribosomal protein L4 0.0505007
EGR1 early growth response 1 0.0485762
RPS27A ribosomal protein S27a 0.0482398
RPS12 ribosomal protein S12 0.047328
GOLGB1 golgin B1 0.0466297
PDLIM5 PDZ and LIM domain 5 0.0446608
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0445257
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0439812
SMAD3 SMAD family member 3 0.0430064
GPATCH2L G patch domain containing 2-like 0.0429396
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0424643
RRBP1 ribosome binding protein 1 0.0424236
HLA-A major histocompatibility complex, class I, A 0.0422769
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0415722
MEGF6 multiple EGF-like-domains 6 0.0414215
RPS3 ribosomal protein S3 0.0407735
DSCAM Down syndrome cell adhesion molecule 0.0402896
RPL13A ribosomal protein L13a 0.0397488
SPINK5 serine peptidase inhibitor, Kazal type 5 0.0397375
ACTN1 actinin, alpha 1 0.0388341
TJP1 tight junction protein 1 0.0382997
RPL26 ribosomal protein L26 0.0382758
ZSWIM6 zinc finger, SWIM-type containing 6 0.038155
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.037094
EXT1 exostosin glycosyltransferase 1 0.0362153
ACTG1 actin gamma 1 0.034904
NRIP1 nuclear receptor interacting protein 1 0.0345789
FAM107B family with sequence similarity 107, member B 0.0343794
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0342542
RPL37 ribosomal protein L37 0.034016
VMP1 vacuole membrane protein 1 0.0338974
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0338838
RAI14 retinoic acid induced 14 0.0326469
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 0.0325543
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0322242
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0318183
BRD4 bromodomain containing 4 0.0318122
AKAP9 A kinase (PRKA) anchor protein 9 0.0312791
NAV2 neuron navigator 2 0.0311997
GOLGA3 golgin A3 0.0311001
RPL30 ribosomal protein L30 0.03098
THBD thrombomodulin 0.0309604
ANKRD11 ankyrin repeat domain 11 0.0307755
KDM3A lysine (K)-specific demethylase 3A 0.0306271
TMSB10 thymosin beta 10 0.0303507
CYTH3 cytohesin 3 0.0302029
IFI6 interferon, alpha-inducible protein 6 0.0301698
JUN jun proto-oncogene 0.0301513
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0301467
RBM25 RNA binding motif protein 25 0.029978
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.0299666
TLN1 talin 1 0.0299011
RPL37A ribosomal protein L37a 0.0297282
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0296362
RPS2 ribosomal protein S2 0.0291419
TRIM38 tripartite motif containing 38 0.028998
TM4SF1 transmembrane 4 L six family member 1 0.0288282
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0287769
WNT2B wingless-type MMTV integration site family, member 2B 0.0286836
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0285831
PRPF6 pre-mRNA processing factor 6 0.0282215
FTL ferritin, light polypeptide 0.0280595
TPM4 tropomyosin 4 0.0279798
CSTB cystatin B (stefin B) 0.027599
ZMIZ1 zinc finger, MIZ-type containing 1 0.0274951
IRAK2 interleukin-1 receptor-associated kinase 2 0.0273625
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0270926
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0267755
RPS14 ribosomal protein S14 0.0266457
AKAP12 A kinase (PRKA) anchor protein 12 0.0265855
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0265597
TPT1 tumor protein, translationally-controlled 1 0.0263993
SLC35F3 solute carrier family 35, member F3 0.0263601
IGF2 insulin-like growth factor 2 0.0262393
FXYD5 FXYD domain containing ion transport regulator 5 0.0262354
SRRM2 serine/arginine repetitive matrix 2 0.0260041
BBS9 Bardet-Biedl syndrome 9 0.0258258
RPS27 ribosomal protein S27 0.0257781
TPR translocated promoter region, nuclear basket protein 0.0257728
MAPK8 mitogen-activated protein kinase 8 0.0256296
RPS15A ribosomal protein S15a 0.0255167
RPS8 ribosomal protein S8 0.0252788
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0252703
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0251084
H1-0 H1.0 linker histone 0.0250248
SIK3 SIK family kinase 3 0.0249831
EIF4H eukaryotic translation initiation factor 4H 0.0249734
RPL36 ribosomal protein L36 0.0248362

decreased expression

Symbol Name Standardized Value
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.168334
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.136552
MYOF myoferlin -0.10809
CLU clusterin -0.100432
DPYD dihydropyrimidine dehydrogenase -0.0973715
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0805849
ITGA6 integrin, alpha 6 -0.079576
FOXO1 forkhead box O1 -0.0705568
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0704543
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0688409
MSN moesin -0.0653111
POTEF POTE ankyrin domain family, member F -0.0644601
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0638039
CD44 CD44 molecule (Indian blood group) -0.0623353
NAMPT nicotinamide phosphoribosyltransferase -0.0607016
FOXP1 forkhead box P1 -0.0589351
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0574011
DSTN destrin (actin depolymerizing factor) -0.0564134
MBNL1 muscleblind-like splicing regulator 1 -0.0559402
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0554467
NRG1 neuregulin 1 -0.0532724
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 -0.0525253
CAV1 caveolin 1, caveolae protein, 22kDa -0.0518196
CUL4B cullin 4B -0.0492816
RIN2 Ras and Rab interactor 2 -0.0490706
SULF1 sulfatase 1 -0.0484819
FLNB filamin B, beta -0.048411
PDIA3 protein disulfide isomerase family A, member 3 -0.0466526
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0464718
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0461395
FNDC3A fibronectin type III domain containing 3A -0.0437611
MAML2 mastermind-like 2 (Drosophila) -0.041885
LNPEP leucyl/cystinyl aminopeptidase -0.0415884
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0395245
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0389842
CYB5R3 cytochrome b5 reductase 3 -0.038212
CEMIP cell migration inducing protein, hyaluronan binding -0.0377279
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.0376152
PPP1R12B protein phosphatase 1, regulatory subunit 12B -0.0373127
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.0371495
HSPG2 heparan sulfate proteoglycan 2 -0.0370398
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 -0.0367525
MEF2A myocyte enhancer factor 2A -0.0365291
MTSS1 metastasis suppressor 1 -0.036135
SAMD9 sterile alpha motif domain containing 9 -0.0354385
PDLIM1 PDZ and LIM domain 1 -0.0352092
ZMYND8 zinc finger, MYND-type containing 8 -0.0346727
KDM6A lysine (K)-specific demethylase 6A -0.0345222
NEK7 NIMA-related kinase 7 -0.0338153
TMEM165 transmembrane protein 165 -0.0336634
ADAM10 ADAM metallopeptidase domain 10 -0.0332999
RPL21 ribosomal protein L21 -0.0332417
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.0330906
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0328572
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0324341
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0322708
TXNIP thioredoxin interacting protein -0.0322543
GRB10 growth factor receptor-bound protein 10 -0.0321244
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0320393
MBNL2 muscleblind-like splicing regulator 2 -0.0318347
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0317633
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.031637
KTN1 kinectin 1 (kinesin receptor) -0.0316071
TRIO trio Rho guanine nucleotide exchange factor -0.0316027
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0315559
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0311919
NFIA nuclear factor I/A -0.0303519
AOPEP aminopeptidase O (putative) -0.0302634
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.03007
UBE2H ubiquitin-conjugating enzyme E2H -0.0300215
MYO10 myosin X -0.0298992
MRPS6 mitochondrial ribosomal protein S6 -0.0297951
PLAT plasminogen activator, tissue -0.0295421
WASF2 WAS protein family, member 2 -0.0287363
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 -0.028714
ZNF292 zinc finger protein 292 -0.02857
COL17A1 collagen, type XVII, alpha 1 -0.0284745
S100A10 S100 calcium binding protein A10 -0.0278627
COL4A5 collagen, type IV, alpha 5 -0.0278363
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 -0.0276615
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0276469
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0274405
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.027428
ERAP2 endoplasmic reticulum aminopeptidase 2 -0.0272896
AVL9 AVL9 homolog (S. cerevisiase) -0.0271253
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 -0.0269693
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0269613
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0269544
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) -0.0268266
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 -0.0267974
SKIC3 SKI3 subunit of superkiller complex -0.0265986
XPO1 exportin 1 -0.0265388
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0265348
FCHSD2 FCH and double SH3 domains 2 -0.0264981
FOSL1 FOS-like antigen 1 -0.0263934
DENND4C DENN/MADD domain containing 4C -0.0262535
ADAM17 ADAM metallopeptidase domain 17 -0.0260954
CD99 CD99 molecule -0.0260662
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0260081
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0259996