SBI-0640756_J82 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description SBI-0640756 perturbation in J82 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the SBI-0640756_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide 0.209494
MT2A metallothionein 2A 0.135033
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.122367
RPS6 ribosomal protein S6 0.0862096
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0783457
PTMA prothymosin, alpha 0.0761395
SRRM2 serine/arginine repetitive matrix 2 0.0667635
KTN1 kinectin 1 (kinesin receptor) 0.0637893
RPS3 ribosomal protein S3 0.0616975
HLA-B major histocompatibility complex, class I, B 0.0611405
INTS6 integrator complex subunit 6 0.0599442
VIM vimentin 0.0573511
SET SET nuclear proto-oncogene 0.0565703
TLE4 transducin-like enhancer of split 4 0.0561069
BRD2 bromodomain containing 2 0.0552188
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0541399
RPL35A ribosomal protein L35a 0.0515695
SQSTM1 sequestosome 1 0.0469198
RPS8 ribosomal protein S8 0.0464688
CLSPN claspin 0.0429233
ZFP36L1 ZFP36 ring finger protein-like 1 0.0428842
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0411502
ZSWIM6 zinc finger, SWIM-type containing 6 0.0401111
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0393045
WSB1 WD repeat and SOCS box containing 1 0.0390458
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0390283
SP100 SP100 nuclear antigen 0.0385263
ADM adrenomedullin 0.038464
GOLGA4 golgin A4 0.0384336
APLP2 amyloid beta (A4) precursor-like protein 2 0.0379709
RPL5 ribosomal protein L5 0.0373852
EIF1 eukaryotic translation initiation factor 1 0.0370317
ANGPTL4 angiopoietin-like 4 0.0364814
RPL37A ribosomal protein L37a 0.036309
TMSB10 thymosin beta 10 0.0359983
OPTN optineurin 0.0358229
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0352035
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0351761
RPS12 ribosomal protein S12 0.0349445
PRRC2C proline-rich coiled-coil 2C 0.0342772
RPL31 ribosomal protein L31 0.0338841
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0337589
SRSF11 serine/arginine-rich splicing factor 11 0.0330763
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0328366
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0326079
RPL11 ribosomal protein L11 0.032594
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0321736
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0321592
FUS FUS RNA binding protein 0.0321298
TPR translocated promoter region, nuclear basket protein 0.0319671
LOC102724023 ES1 protein homolog, mitochondrial 0.0318549
NASP nuclear autoantigenic sperm protein (histone-binding) 0.0318363
DIPK2A divergent protein kinase domain 2A 0.0316379
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0309687
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0309225
SKP1 S-phase kinase-associated protein 1 0.0308922
TIMP2 TIMP metallopeptidase inhibitor 2 0.0307794
BASP1 brain abundant, membrane attached signal protein 1 0.0304156
FMNL2 formin-like 2 0.0302464
JMJD1C jumonji domain containing 1C 0.0300651
ENO2 enolase 2 (gamma, neuronal) 0.0299764
RPL12 ribosomal protein L12 0.029926
TPM4 tropomyosin 4 0.0297054
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0296286
OSBPL8 oxysterol binding protein-like 8 0.0295656
SMC4 structural maintenance of chromosomes 4 0.0294175
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0289643
RPL37 ribosomal protein L37 0.0288548
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0284366
RPL13A ribosomal protein L13a 0.0284243
ZNF841 zinc finger protein 841 0.0279529
KPNB1 karyopherin (importin) beta 1 0.0278594
RPL9 ribosomal protein L9 0.0278447
ANKRD12 ankyrin repeat domain 12 0.0278219
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0277651
JUN jun proto-oncogene 0.0272596
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) 0.0272139
ENO1 enolase 1, (alpha) 0.0271359
RAB7A RAB7A, member RAS oncogene family 0.0270734
STC2 stanniocalcin 2 0.0270344
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0270059
DDIT4 DNA-damage-inducible transcript 4 0.0269714
RPL26 ribosomal protein L26 0.026872
NAP1L1 nucleosome assembly protein 1-like 1 0.0265028
KIF5B kinesin family member 5B 0.0264638
RSRC2 arginine/serine-rich coiled-coil 2 0.0263298
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0261752
HMGB1 high mobility group box 1 0.0261734
RPLP2 ribosomal protein, large, P2 0.0257468
IFITM3 interferon induced transmembrane protein 3 0.0255641
ZNF432 zinc finger protein 432 0.0250147
KLF12 Kruppel-like factor 12 0.0249115
L1CAM L1 cell adhesion molecule 0.0245989
EIF5B eukaryotic translation initiation factor 5B 0.0244931
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0244898
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0244157
SMC3 structural maintenance of chromosomes 3 0.0239499
PABPN1 poly(A) binding protein, nuclear 1 0.0239197
PCLO piccolo presynaptic cytomatrix protein 0.0239092
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0238081

decreased expression

Symbol Name Standardized Value
TRIO trio Rho guanine nucleotide exchange factor -0.178087
NALF1 NALCN channel auxiliary factor 1 -0.151044
FN1 fibronectin 1 -0.138588
GLIS3 GLIS family zinc finger 3 -0.103009
PLCB4 phospholipase C, beta 4 -0.0980809
ABI3BP ABI family, member 3 (NESH) binding protein -0.0949606
SLC12A8 solute carrier family 12, member 8 -0.0929227
IGFBP3 insulin-like growth factor binding protein 3 -0.087077
EXT1 exostosin glycosyltransferase 1 -0.0867414
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0784586
F3 coagulation factor III (thromboplastin, tissue factor) -0.0783797
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0774863
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0738507
TXNRD1 thioredoxin reductase 1 -0.0693762
CCBE1 collagen and calcium binding EGF domains 1 -0.0686311
SAMD12 sterile alpha motif domain containing 12 -0.065582
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.063329
DLG1 discs, large homolog 1 (Drosophila) -0.0619109
PTK2 protein tyrosine kinase 2 -0.0610477
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0587762
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0555235
PHACTR1 phosphatase and actin regulator 1 -0.0538419
ATP13A3 ATPase type 13A3 -0.0531089
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0515116
VEGFC vascular endothelial growth factor C -0.0505796
AHNAK AHNAK nucleoprotein -0.0500237
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0468818
TGFB2 transforming growth factor, beta 2 -0.0466257
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0451939
TMEM178B transmembrane protein 178B -0.0429597
NAMPT nicotinamide phosphoribosyltransferase -0.0420347
ADARB1 adenosine deaminase, RNA-specific, B1 -0.041999
ZEB2 zinc finger E-box binding homeobox 2 -0.0414743
OSMR oncostatin M receptor -0.0409818
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0408046
FLNB filamin B, beta -0.0405853
FNDC3B fibronectin type III domain containing 3B -0.0405438
ERBIN erbb2 interacting protein -0.0404042
PPME1 protein phosphatase methylesterase 1 -0.0401522
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0400331
TENM3 teneurin transmembrane protein 3 -0.0396031
SBF2 SET binding factor 2 -0.0391362
STARD13 StAR-related lipid transfer (START) domain containing 13 -0.0390102
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0387676
POSTN periostin, osteoblast specific factor -0.0384696
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0382984
NEK7 NIMA-related kinase 7 -0.0380538
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0372378
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0371465
TMSB4X thymosin beta 4, X-linked -0.0367524
FSTL1 follistatin-like 1 -0.0365642
LARP4B La ribonucleoprotein domain family, member 4B -0.0365633
PTPRM protein tyrosine phosphatase, receptor type, M -0.036373
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0362542
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0361906
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.036181
TPD52 tumor protein D52 -0.0353171
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0353002
RAI14 retinoic acid induced 14 -0.0352269
EGFR epidermal growth factor receptor -0.0343234
EXOC4 exocyst complex component 4 -0.0341546
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0338465
TUBB tubulin, beta class I -0.033721
AFAP1 actin filament associated protein 1 -0.0336095
LPP LIM domain containing preferred translocation partner in lipoma -0.0336038
COL5A1 collagen, type V, alpha 1 -0.0323556
DIAPH3 diaphanous-related formin 3 -0.0322887
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0322652
DPYD dihydropyrimidine dehydrogenase -0.0319904
LATS2 large tumor suppressor kinase 2 -0.0310414
CDK6 cyclin-dependent kinase 6 -0.0308145
AOPEP aminopeptidase O (putative) -0.0306203
SMAD3 SMAD family member 3 -0.030363
CYTH3 cytohesin 3 -0.0301861
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 -0.0300067
CCND1 cyclin D1 -0.0298037
LIMCH1 LIM and calponin homology domains 1 -0.0297331
SULF1 sulfatase 1 -0.0290592
BMPER BMP binding endothelial regulator -0.0290484
MYLK myosin light chain kinase -0.0287158
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0283984
IL1RAP interleukin 1 receptor accessory protein -0.0279865
P4HB prolyl 4-hydroxylase, beta polypeptide -0.027977
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0279633
SMYD3 SET and MYND domain containing 3 -0.0278896
RAD23B RAD23 homolog B (S. cerevisiae) -0.0278881
TNS3 tensin 3 -0.0276209
ACTN4 actinin, alpha 4 -0.0274716
GRAMD2B GRAM domain containing 2B -0.0272784
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.027222
PARD3B par-3 family cell polarity regulator beta -0.026576
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0264516
TUBA1B tubulin, alpha 1b -0.0262593
ANKRD28 ankyrin repeat domain 28 -0.0262544
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0261392
OLA1 Obg-like ATPase 1 -0.026006
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0259098
ZNF804A zinc finger protein 804A -0.0257884
COPB1 coatomer protein complex, subunit beta 1 -0.0256516
PDE10A phosphodiesterase 10A -0.0256102