SBI-0640756_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description SBI-0640756 perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the SBI-0640756_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LOC102724023 ES1 protein homolog, mitochondrial 0.0516053
RPL4 ribosomal protein L4 0.0494445
RPS3 ribosomal protein S3 0.0454621
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.043161
RPS12 ribosomal protein S12 0.0374367
EIF1 eukaryotic translation initiation factor 1 0.0356914
INTS6 integrator complex subunit 6 0.0351141
GOLGB1 golgin B1 0.0347355
ATF5 activating transcription factor 5 0.0344067
SRRM2 serine/arginine repetitive matrix 2 0.0331437
HKDC1 hexokinase domain containing 1 0.032544
SQSTM1 sequestosome 1 0.0299699
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0294936
ATF4 activating transcription factor 4 0.0289562
EXT1 exostosin glycosyltransferase 1 0.0283062
AKAP9 A kinase (PRKA) anchor protein 9 0.0279453
NFE2L1 nuclear factor, erythroid 2-like 1 0.0271711
RPL13A ribosomal protein L13a 0.0268181
RPL37A ribosomal protein L37a 0.0264561
NUPR1 nuclear protein, transcriptional regulator, 1 0.0245177
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0241786
FTL ferritin, light polypeptide 0.023755
TLN1 talin 1 0.0226505
ENO2 enolase 2 (gamma, neuronal) 0.0209338
HDAC9 histone deacetylase 9 0.0208971
RPS15A ribosomal protein S15a 0.020407
HLA-B major histocompatibility complex, class I, B 0.020345
WSB1 WD repeat and SOCS box containing 1 0.0203213
PTMA prothymosin, alpha 0.0195512
KLHL29 kelch-like family member 29 0.0193034
RPL26 ribosomal protein L26 0.0192376
KDM3A lysine (K)-specific demethylase 3A 0.0191788
HLA-A major histocompatibility complex, class I, A 0.0190365
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0188067
PRRC2C proline-rich coiled-coil 2C 0.0182361
DDIT4 DNA-damage-inducible transcript 4 0.0178928
GOLGA4 golgin A4 0.0177258
S100P S100 calcium binding protein P 0.0176927
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0173816
TAC4 tachykinin 4 (hemokinin) 0.0168494
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0165809
AKAP12 A kinase (PRKA) anchor protein 12 0.0165577
BUD31 BUD31 homolog (S. cerevisiae) 0.0162183
SLC38A2 solute carrier family 38, member 2 0.0160584
RPS17 ribosomal protein S17 0.016032
GOSR2 golgi SNAP receptor complex member 2 0.0158011
CDC5L cell division cycle 5-like 0.0157097
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0156975
BCAS3 breast carcinoma amplified sequence 3 0.0152148
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.0152031
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0151418
SLFN5 schlafen family member 5 0.015139
RPL9 ribosomal protein L9 0.0149904
TTC3 tetratricopeptide repeat domain 3 0.0149212
FTH1 ferritin, heavy polypeptide 1 0.0147494
RBBP6 retinoblastoma binding protein 6 0.014489
FAAH2 fatty acid amide hydrolase 2 0.0144264
LURAP1L leucine rich adaptor protein 1-like 0.0143771
DSPP dentin sialophosphoprotein 0.0141339
CLIP1 CAP-GLY domain containing linker protein 1 0.0141076
GNL2 guanine nucleotide binding protein-like 2 (nucleolar) 0.0140755
LCN2 lipocalin 2 0.0140493
ZBTB20 zinc finger and BTB domain containing 20 0.0136947
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 0.0136738
PNRC1 proline-rich nuclear receptor coactivator 1 0.0135877
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.0134842
GOLGA3 golgin A3 0.0131445
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0131439
RPL12 ribosomal protein L12 0.0131272
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 0.0129117
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0128818
RPL14 ribosomal protein L14 0.012869
ZC3H13 zinc finger CCCH-type containing 13 0.0128351
YARS1 tyrosyl-tRNA synthetase 1 0.0128095
ATXN2L ataxin 2-like 0.012801
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0126466
KCNIP4 Kv channel interacting protein 4 0.0126072
RSL1D1 ribosomal L1 domain containing 1 0.0123991
FUS FUS RNA binding protein 0.012355
MMP24OS MMP24 opposite strand 0.0123268
DDIT3 DNA-damage-inducible transcript 3 0.0123111
PRRC2A proline-rich coiled-coil 2A 0.0122951
RPS18 ribosomal protein S18 0.0122522
POU2F2 POU class 2 homeobox 2 0.0121897
NAP1L1 nucleosome assembly protein 1-like 1 0.0121731
GLIS3 GLIS family zinc finger 3 0.0118562
PRPF6 pre-mRNA processing factor 6 0.0117166
ATM ATM serine/threonine kinase 0.0116953
EIF4H eukaryotic translation initiation factor 4H 0.0116857
LARP1B La ribonucleoprotein domain family, member 1B 0.0116697
SENP5 SUMO1/sentrin specific peptidase 5 0.011639
UBAP2 ubiquitin associated protein 2 0.0116115
KDM5C lysine (K)-specific demethylase 5C 0.0116031
TCP11L2 t-complex 11, testis-specific-like 2 0.0115474
GOLGA8A golgin A8 family, member A 0.0114457
RPS2 ribosomal protein S2 0.0114375
OGA O-GlcNAcase 0.0113577
RPL31 ribosomal protein L31 0.0113163
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0113064
UBE2O ubiquitin-conjugating enzyme E2O 0.0112061

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.26496
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.180763
GMDS GDP-mannose 4,6-dehydratase -0.178186
FGFR2 fibroblast growth factor receptor 2 -0.173648
MAML2 mastermind-like 2 (Drosophila) -0.166129
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.142477
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.139664
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.136114
POTEF POTE ankyrin domain family, member F -0.131862
PDIA3 protein disulfide isomerase family A, member 3 -0.131167
EMP1 epithelial membrane protein 1 -0.117606
CEMIP cell migration inducing protein, hyaluronan binding -0.114447
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.101821
S100A6 S100 calcium binding protein A6 -0.090675
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.08974
KRT18 keratin 18, type I -0.0891024
S100A10 S100 calcium binding protein A10 -0.0889088
ITGA6 integrin, alpha 6 -0.0863919
FLNB filamin B, beta -0.0850244
ANXA2 annexin A2 -0.0838695
KRT8 keratin 8, type II -0.0762167
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0722253
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.071913
TMEM123 transmembrane protein 123 -0.0702895
TNIK TRAF2 and NCK interacting kinase -0.0700791
EHBP1 EH domain binding protein 1 -0.0696098
TMSB10 thymosin beta 10 -0.0678952
ACTN4 actinin, alpha 4 -0.0629913
FAT1 FAT atypical cadherin 1 -0.0615504
CDK6 cyclin-dependent kinase 6 -0.0609692
PDIA6 protein disulfide isomerase family A, member 6 -0.0607818
AGR2 anterior gradient 2 -0.0572385
EZR ezrin -0.0568376
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.0558458
MBNL2 muscleblind-like splicing regulator 2 -0.0556682
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.05436
ASPH aspartate beta-hydroxylase -0.0541412
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0518547
KRT19 keratin 19, type I -0.0497604
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.047534
ADAM9 ADAM metallopeptidase domain 9 -0.0473799
BCL2L1 BCL2-like 1 -0.0472186
PGK1 phosphoglycerate kinase 1 -0.0470716
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0468962
CD46 CD46 molecule, complement regulatory protein -0.0467774
LYZ lysozyme -0.0461614
FNDC3B fibronectin type III domain containing 3B -0.0441695
INSIG1 insulin induced gene 1 -0.0433899
LPP LIM domain containing preferred translocation partner in lipoma -0.0433522
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0426035
AHNAK AHNAK nucleoprotein -0.0425239
ARHGAP32 Rho GTPase activating protein 32 -0.0417792
FGD4 FYVE, RhoGEF and PH domain containing 4 -0.0415525
UBE2H ubiquitin-conjugating enzyme E2H -0.0411814
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0410852
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0410496
PCBP2 poly(rC) binding protein 2 -0.040958
ATF7IP2 activating transcription factor 7 interacting protein 2 -0.0404286
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0404147
PRKCA protein kinase C, alpha -0.0400895
PDIA4 protein disulfide isomerase family A, member 4 -0.0397778
AGR3 anterior gradient 3 -0.0397626
SAMD12 sterile alpha motif domain containing 12 -0.0392584
TPT1 tumor protein, translationally-controlled 1 -0.0390891
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0381372
CALR calreticulin -0.0381349
MUC17 mucin 17, cell surface associated -0.0375382
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0374417
COBL cordon-bleu WH2 repeat protein -0.03736
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.037216
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -0.0370226
DEK DEK proto-oncogene -0.0369337
PPARG peroxisome proliferator-activated receptor gamma -0.0366717
DSTN destrin (actin depolymerizing factor) -0.0366567
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0360614
PERP PERP, TP53 apoptosis effector -0.0358645
RAB1A RAB1A, member RAS oncogene family -0.035669
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0356103
TUBA1B tubulin, alpha 1b -0.035604
KRT7 keratin 7, type II -0.034927
DSG2 desmoglein 2 -0.0346067
ADAM10 ADAM metallopeptidase domain 10 -0.0342952
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0341739
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0338103
ABHD2 abhydrolase domain containing 2 -0.0337526
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0335502
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.033393
CLDN7 claudin 7 -0.0332998
WWC1 WW and C2 domain containing 1 -0.0331338
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0327187
HMGA1 high mobility group AT-hook 1 -0.0325531
TXNIP thioredoxin interacting protein -0.0320727
KLK10 kallikrein-related peptidase 10 -0.0318757
ITGB4 integrin, beta 4 -0.0317517
MBNL1 muscleblind-like splicing regulator 1 -0.0313349
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0308726
ZNF292 zinc finger protein 292 -0.0304673
UBASH3B ubiquitin associated and SH3 domain containing B -0.0304197
DOCK5 dedicator of cytokinesis 5 -0.0301037
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0300915