SBI-0640756_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description SBI-0640756 perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the SBI-0640756_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS12 ribosomal protein S12 0.104782
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.101167
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.088065
PTMA prothymosin, alpha 0.0824878
FTL ferritin, light polypeptide 0.0792497
RPL37A ribosomal protein L37a 0.0718189
RPS8 ribosomal protein S8 0.0642614
RPLP1 ribosomal protein, large, P1 0.0631754
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0588057
RPL35A ribosomal protein L35a 0.0572981
TMSB10 thymosin beta 10 0.0548814
NDRG1 N-myc downstream regulated 1 0.0540932
LMO7 LIM domain 7 0.0531383
RPS3 ribosomal protein S3 0.051002
RPL4 ribosomal protein L4 0.0497216
TPT1 tumor protein, translationally-controlled 1 0.0492634
FTH1 ferritin, heavy polypeptide 1 0.0481123
MXI1 MAX interactor 1, dimerization protein 0.0462415
RPL5 ribosomal protein L5 0.045091
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 0.0440753
RPL34 ribosomal protein L34 0.0436782
SRRM2 serine/arginine repetitive matrix 2 0.0436752
RPLP2 ribosomal protein, large, P2 0.0435858
MUC6 mucin 6, oligomeric mucus/gel-forming 0.0433304
AREG amphiregulin 0.0431324
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0416372
RPL9 ribosomal protein L9 0.0402668
B2M beta-2-microglobulin 0.0401658
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0392395
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0373156
ATF4 activating transcription factor 4 0.0364781
RPS14 ribosomal protein S14 0.0362081
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.035203
JUP junction plakoglobin 0.0348859
RPL26 ribosomal protein L26 0.0346324
LOC112694756 uncharaterized LOC112694756 0.0340583
RPS17 ribosomal protein S17 0.0339227
PSD3 pleckstrin and Sec7 domain containing 3 0.0337572
OCIAD2 OCIA domain containing 2 0.0334398
MT2A metallothionein 2A 0.0331804
ANKRD12 ankyrin repeat domain 12 0.0314281
ENO2 enolase 2 (gamma, neuronal) 0.0303853
ACTG1 actin gamma 1 0.0302163
RPL27 ribosomal protein L27 0.0301895
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0301549
ENO1 enolase 1, (alpha) 0.0301413
RPL12 ribosomal protein L12 0.0300849
MYDGF myeloid-derived growth factor 0.029614
RPL36 ribosomal protein L36 0.0293109
KRT17 keratin 17, type I 0.0290767
GOLGA4 golgin A4 0.0284397
ZNF503 zinc finger protein 503 0.0282503
EIF1 eukaryotic translation initiation factor 1 0.0275762
RACK1 receptor for activated C kinase 1 0.0273458
CALR calreticulin 0.0271126
LGALS3 lectin, galactoside-binding, soluble, 3 0.0270423
MYO1E myosin IE 0.0268074
RPS19 ribosomal protein S19 0.0266927
RPS6 ribosomal protein S6 0.0264711
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0260022
RPS2 ribosomal protein S2 0.0259046
RPS27 ribosomal protein S27 0.0253212
RPL30 ribosomal protein L30 0.025293
S100P S100 calcium binding protein P 0.0250542
TLN1 talin 1 0.0249152
BMP4 bone morphogenetic protein 4 0.0247905
PGM3 phosphoglucomutase 3 0.0239739
RPL31 ribosomal protein L31 0.0237583
ISG15 ISG15 ubiquitin-like modifier 0.0235284
KRT19 keratin 19, type I 0.0235208
LDHA lactate dehydrogenase A 0.0234963
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0234903
RPL37 ribosomal protein L37 0.0233802
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0232879
RPL18 ribosomal protein L18 0.0231158
ERBB3 erb-b2 receptor tyrosine kinase 3 0.0225999
NUCB2 nucleobindin 2 0.022239
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0221138
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0220432
PPIL4 peptidylprolyl isomerase (cyclophilin)-like 4 0.0218599
RB1CC1 RB1-inducible coiled-coil 1 0.0213914
RPS29 ribosomal protein S29 0.0212898
GOLGB1 golgin B1 0.0212891
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0212414
ASPH aspartate beta-hydroxylase 0.0209258
ADM adrenomedullin 0.0208554
RPS20 ribosomal protein S20 0.0207904
VEGFA vascular endothelial growth factor A 0.0207143
BHLHE40 basic helix-loop-helix family, member e40 0.0203927
TMBIM1 transmembrane BAX inhibitor motif containing 1 0.0202858
TFF1 trefoil factor 1 0.0198888
TUG1 taurine up-regulated 1 (non-protein coding) 0.0197996
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0196249
CIRSR corepressor of RBPJ and splicing regulator 0.0195327
GSTP1 glutathione S-transferase pi 1 0.0193785
NACA nascent polypeptide-associated complex alpha subunit 0.0192715
RPL23 ribosomal protein L23 0.0190475
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0190026
RPL19 ribosomal protein L19 0.0189075
PNRC1 proline-rich nuclear receptor coactivator 1 0.0187788

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.16137
NALF1 NALCN channel auxiliary factor 1 -0.144609
CEMIP cell migration inducing protein, hyaluronan binding -0.138364
GPHN gephyrin -0.109739
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.104202
ITGA6 integrin, alpha 6 -0.0949939
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0914459
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0858183
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0838555
GMDS GDP-mannose 4,6-dehydratase -0.0782592
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0747537
ALCAM activated leukocyte cell adhesion molecule -0.0667591
ANKRD17 ankyrin repeat domain 17 -0.0605145
PIGR polymeric immunoglobulin receptor -0.0588629
TRIM2 tripartite motif containing 2 -0.0564688
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0561698
CANX calnexin -0.0539468
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0515698
BIRC6 baculoviral IAP repeat containing 6 -0.0510859
AHNAK AHNAK nucleoprotein -0.0510129
PDE4D phosphodiesterase 4D, cAMP-specific -0.050664
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0505202
ANTXR2 anthrax toxin receptor 2 -0.0462273
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.045674
SEC31A SEC31 homolog A (S. cerevisiae) -0.0455579
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0452906
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -0.0448228
MSI2 musashi RNA-binding protein 2 -0.0444968
MED13L mediator complex subunit 13-like -0.0443135
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0442159
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.044101
CCNY cyclin Y -0.0439853
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0435421
GREB1L growth regulation by estrogen in breast cancer-like -0.0435248
LPP LIM domain containing preferred translocation partner in lipoma -0.0434268
NFIA nuclear factor I/A -0.0433329
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0421051
RAD51B RAD51 paralog B -0.0420123
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0414287
SAMD5 sterile alpha motif domain containing 5 -0.0411215
RNF43 ring finger protein 43 -0.0410993
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0409856
KDM4C lysine (K)-specific demethylase 4C -0.0406419
MON2 MON2 homolog (S. cerevisiae) -0.0402131
PATJ PATJ crumbs cell polarity complex component -0.0400918
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0394041
MYO1D myosin ID -0.0392415
SLC35F3 solute carrier family 35, member F3 -0.0387812
KRT8 keratin 8, type II -0.0383206
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0380257
SERINC5 serine incorporator 5 -0.0373347
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0370909
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0365887
UBE2H ubiquitin-conjugating enzyme E2H -0.0362807
CTBP2 C-terminal binding protein 2 -0.0361057
FHIT fragile histidine triad -0.0358887
ANKRD10 ankyrin repeat domain 10 -0.0356632
CDK13 cyclin-dependent kinase 13 -0.0351118
DENND1A DENN/MADD domain containing 1A -0.0349125
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) -0.0345933
EXOC4 exocyst complex component 4 -0.034532
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.034227
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0340736
PTPRK protein tyrosine phosphatase, receptor type, K -0.0339158
MAML3 mastermind-like 3 (Drosophila) -0.0336786
MBD5 methyl-CpG binding domain protein 5 -0.0336316
ETV6 ets variant 6 -0.0336092
PPARG peroxisome proliferator-activated receptor gamma -0.0333464
RNF217 ring finger protein 217 -0.0332792
TAS2R14 taste receptor, type 2, member 14 -0.0331961
CD46 CD46 molecule, complement regulatory protein -0.0331658
RAB1A RAB1A, member RAS oncogene family -0.033116
IARS1 isoleucyl-tRNA synthetase 1 -0.0329518
MECOM MDS1 and EVI1 complex locus -0.0327941
EHF ets homologous factor -0.0324578
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.032345
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0320933
ARHGAP32 Rho GTPase activating protein 32 -0.0318888
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0317386
TSC22D1 TSC22 domain family, member 1 -0.0315711
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0313068
ANXA2 annexin A2 -0.0311758
ARB2A ARB2 cotranscriptional regulator A -0.0309527
PKP2 plakophilin 2 -0.0309107
SENP6 SUMO1/sentrin specific peptidase 6 -0.0306252
SLCO3A1 solute carrier organic anion transporter family, member 3A1 -0.0304243
MLEC malectin -0.0301073
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.0300683
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0300382
FRYL FRY-like -0.0298735
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.0297971
EHBP1 EH domain binding protein 1 -0.0297504
ARHGAP6 Rho GTPase activating protein 6 -0.0292393
UBE3C ubiquitin protein ligase E3C -0.0291595
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0291374
ZNF644 zinc finger protein 644 -0.0290422
ANKRD11 ankyrin repeat domain 11 -0.0288364
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0285567
USP34 ubiquitin specific peptidase 34 -0.0285328
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0283218