SBI-0640756_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description SBI-0640756 perturbation in LoVo cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the SBI-0640756_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS12 ribosomal protein S12 0.173511
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.119475
RPL4 ribosomal protein L4 0.0949354
RPL37A ribosomal protein L37a 0.0926962
RPS3 ribosomal protein S3 0.0924478
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0880062
RPS6 ribosomal protein S6 0.0790494
HLA-B major histocompatibility complex, class I, B 0.0720726
RPLP1 ribosomal protein, large, P1 0.0717093
RPS8 ribosomal protein S8 0.0656638
RPS19 ribosomal protein S19 0.0649662
TMSB10 thymosin beta 10 0.0648599
RPS17 ribosomal protein S17 0.0616811
RPL31 ribosomal protein L31 0.0577188
RPS27A ribosomal protein S27a 0.0571699
RPL36 ribosomal protein L36 0.0558595
RPS13 ribosomal protein S13 0.0536011
RPL26 ribosomal protein L26 0.051599
PTMA prothymosin, alpha 0.0491401
AREG amphiregulin 0.0488999
DSPP dentin sialophosphoprotein 0.047447
RPL37 ribosomal protein L37 0.0466232
INTS6 integrator complex subunit 6 0.0457529
RPL9 ribosomal protein L9 0.0455654
RACK1 receptor for activated C kinase 1 0.0436312
ENO1 enolase 1, (alpha) 0.0420874
ZSWIM6 zinc finger, SWIM-type containing 6 0.0382006
HLA-A major histocompatibility complex, class I, A 0.0379213
UBC ubiquitin C 0.0376866
ASPH aspartate beta-hydroxylase 0.0371398
RPLP2 ribosomal protein, large, P2 0.0368546
PKM pyruvate kinase, muscle 0.0364888
BRD2 bromodomain containing 2 0.0357039
TPT1 tumor protein, translationally-controlled 1 0.0346488
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0340128
RPL12 ribosomal protein L12 0.0338722
RPS14 ribosomal protein S14 0.0338209
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0334794
EIF1 eukaryotic translation initiation factor 1 0.0325251
CLDN4 claudin 4 0.0321548
RPS2 ribosomal protein S2 0.0314779
RPL18 ribosomal protein L18 0.0311652
FTL ferritin, light polypeptide 0.0290177
SLC38A2 solute carrier family 38, member 2 0.0289097
RPL35A ribosomal protein L35a 0.0283458
RPL23 ribosomal protein L23 0.0283108
RPS27 ribosomal protein S27 0.028283
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0280132
RPS29 ribosomal protein S29 0.0280088
RPL27 ribosomal protein L27 0.0276985
RPS18 ribosomal protein S18 0.0275169
RPL30 ribosomal protein L30 0.0269618
S100P S100 calcium binding protein P 0.0262422
IFI6 interferon, alpha-inducible protein 6 0.0259045
TPI1 triosephosphate isomerase 1 0.0258186
EEF1G eukaryotic translation elongation factor 1 gamma 0.0255145
EEF2 eukaryotic translation elongation factor 2 0.0253759
RPL19 ribosomal protein L19 0.0243101
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0241077
RPS5 ribosomal protein S5 0.0236971
SET SET nuclear proto-oncogene 0.0234854
RPL3 ribosomal protein L3 0.0232711
LOC102724023 ES1 protein homolog, mitochondrial 0.0231644
SRRM1 serine/arginine repetitive matrix 1 0.0228952
RPL35 ribosomal protein L35 0.0226543
LRRC23 leucine rich repeat containing 23 0.0224983
KRT18 keratin 18, type I 0.0224244
ITPRID2 ITPR interacting domain containing 2 0.022421
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0220221
ENO2 enolase 2 (gamma, neuronal) 0.0218214
KTN1 kinectin 1 (kinesin receptor) 0.021642
TPM4 tropomyosin 4 0.0214706
RPL10A ribosomal protein L10a 0.0211635
S100A11 S100 calcium binding protein A11 0.020549
YBX1 Y box binding protein 1 0.0203659
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0200325
RPL5 ribosomal protein L5 0.0199911
RPL14 ribosomal protein L14 0.0199614
FBXO11 F-box protein 11 0.0199332
IFITM3 interferon induced transmembrane protein 3 0.0198892
PRDX1 peroxiredoxin 1 0.0197297
ATF4 activating transcription factor 4 0.0197088
NAP1L1 nucleosome assembly protein 1-like 1 0.0196525
APLP2 amyloid beta (A4) precursor-like protein 2 0.0186387
LDHA lactate dehydrogenase A 0.0185624
IFI27 interferon, alpha-inducible protein 27 0.0185516
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0183601
CATSPERB catsper channel auxiliary subunit beta 0.0183526
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0183411
JUN jun proto-oncogene 0.0181446
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0180481
AKAP12 A kinase (PRKA) anchor protein 12 0.0175182
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0172068
COX6C cytochrome c oxidase subunit VIc 0.0169864
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0169227
LAMA4 laminin, alpha 4 0.01685
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0168371
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0167173
CALR calreticulin 0.0165907
SRRM2 serine/arginine repetitive matrix 2 0.0164961

decreased expression

Symbol Name Standardized Value
EPS8 epidermal growth factor receptor pathway substrate 8 -0.211913
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.158113
THSD4 thrombospondin, type I, domain containing 4 -0.119153
PTPRR protein tyrosine phosphatase, receptor type, R -0.10392
FLNB filamin B, beta -0.0861263
PDE4D phosphodiesterase 4D, cAMP-specific -0.0803523
PRELID2 PRELI domain containing 2 -0.0799631
FAT1 FAT atypical cadherin 1 -0.0738101
SHROOM3 shroom family member 3 -0.0727434
PTPRK protein tyrosine phosphatase, receptor type, K -0.0715291
MSI2 musashi RNA-binding protein 2 -0.0709935
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.070043
TRIM2 tripartite motif containing 2 -0.0649859
PTPRG protein tyrosine phosphatase, receptor type, G -0.06161
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0608054
RAD51B RAD51 paralog B -0.0597571
PLAC8 placenta-specific 8 -0.0586517
MYOF myoferlin -0.0561495
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0552999
FOXO1 forkhead box O1 -0.0523151
BACE2 beta-site APP-cleaving enzyme 2 -0.0509418
ITGA6 integrin, alpha 6 -0.0506867
FOXP1 forkhead box P1 -0.0494105
MON2 MON2 homolog (S. cerevisiae) -0.0484913
TCF12 transcription factor 12 -0.0481951
GMDS GDP-mannose 4,6-dehydratase -0.0480067
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0467322
SMYD3 SET and MYND domain containing 3 -0.0457425
ZFAND3 zinc finger, AN1-type domain 3 -0.0453525
PKP2 plakophilin 2 -0.0452838
P3H2 prolyl 3-hydroxylase 2 -0.0446607
UBE2H ubiquitin-conjugating enzyme E2H -0.0446504
TAS2R14 taste receptor, type 2, member 14 -0.0441648
ETNK1 ethanolamine kinase 1 -0.0438545
PATJ PATJ crumbs cell polarity complex component -0.0436682
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0434453
PRSS3 protease, serine, 3 -0.0427198
CALB1 calbindin 1, 28kDa -0.0426543
PCDHB16 protocadherin beta 16 -0.0425383
RFX3 regulatory factor X, 3 (influences HLA class II expression) -0.0424323
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0422192
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type -0.042134
SBF2 SET binding factor 2 -0.0415164
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0414701
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.0412239
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0410256
NFIA nuclear factor I/A -0.0407929
BTBD9 BTB (POZ) domain containing 9 -0.0402406
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.039705
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 -0.0386426
RNF213 ring finger protein 213 -0.0385682
LPP LIM domain containing preferred translocation partner in lipoma -0.0382106
ETV6 ets variant 6 -0.0378091
FGD4 FYVE, RhoGEF and PH domain containing 4 -0.0372764
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0365062
ABHD17C abhydrolase domain containing 17C -0.0364949
TXNRD1 thioredoxin reductase 1 -0.0358547
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein -0.0352549
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.0351228
CCSER1 coiled-coil serine-rich protein 1 -0.0350505
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0348698
MYO1D myosin ID -0.0345435
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0342993
WWC1 WW and C2 domain containing 1 -0.0342295
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0335012
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.033417
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0329814
JMJD1C jumonji domain containing 1C -0.0324057
DENND1A DENN/MADD domain containing 1A -0.032139
AOPEP aminopeptidase O (putative) -0.031891
MED13L mediator complex subunit 13-like -0.031829
ANKRD17 ankyrin repeat domain 17 -0.0314819
SEC31A SEC31 homolog A (S. cerevisiae) -0.0311004
TSPAN8 tetraspanin 8 -0.0310688
GDF15 growth differentiation factor 15 -0.0308023
BIRC6 baculoviral IAP repeat containing 6 -0.0304068
AVL9 AVL9 homolog (S. cerevisiase) -0.0301805
ARHGAP26 Rho GTPase activating protein 26 -0.0299779
PPARG peroxisome proliferator-activated receptor gamma -0.0299493
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.029848
TNRC18 trinucleotide repeat containing 18 -0.0296705
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0294979
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 -0.0294901
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0287747
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0287399
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0286599
CDK13 cyclin-dependent kinase 13 -0.0285436
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0285076
CLINT1 clathrin interactor 1 -0.0282912
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) -0.0282233
OSBPL3 oxysterol binding protein-like 3 -0.0281339
CANX calnexin -0.0281157
RIN2 Ras and Rab interactor 2 -0.0278687
MARCHF6 membrane associated ring-CH-type finger 6 -0.0278342
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0276367
SH3RF1 SH3 domain containing ring finger 1 -0.0274153
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.0274104
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0272356
NF1 neurofibromin 1 -0.027094
MAML2 mastermind-like 2 (Drosophila) -0.0270269