SBI-0640756_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description SBI-0640756 perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the SBI-0640756_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.212471
MT2A metallothionein 2A 0.200427
VIM vimentin 0.191503
TMSB10 thymosin beta 10 0.111376
HLA-B major histocompatibility complex, class I, B 0.107097
FTL ferritin, light polypeptide 0.102922
RPS12 ribosomal protein S12 0.0924138
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0773841
RPL37A ribosomal protein L37a 0.0746439
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.070582
EGR1 early growth response 1 0.0656582
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0653277
RPL35A ribosomal protein L35a 0.0625874
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0615749
RPS19 ribosomal protein S19 0.0586635
RPL36 ribosomal protein L36 0.049324
ENO2 enolase 2 (gamma, neuronal) 0.0476364
NEK10 NIMA-related kinase 10 0.0472853
RPS8 ribosomal protein S8 0.0472332
HLA-A major histocompatibility complex, class I, A 0.0471918
ENO1 enolase 1, (alpha) 0.0445485
RPL37 ribosomal protein L37 0.0421803
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0421014
WSB1 WD repeat and SOCS box containing 1 0.0417647
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0416534
RAB7A RAB7A, member RAS oncogene family 0.0416284
ZFP36L1 ZFP36 ring finger protein-like 1 0.0409408
RPS3 ribosomal protein S3 0.0408992
RPL12 ribosomal protein L12 0.0393866
FTH1 ferritin, heavy polypeptide 1 0.0389857
INTS6 integrator complex subunit 6 0.0386757
RPL26 ribosomal protein L26 0.0383341
TM4SF1 transmembrane 4 L six family member 1 0.0365512
HDAC9 histone deacetylase 9 0.0353812
RPLP1 ribosomal protein, large, P1 0.0353014
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0348762
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0345761
RPLP2 ribosomal protein, large, P2 0.0344696
EIF1 eukaryotic translation initiation factor 1 0.0341809
RPS27A ribosomal protein S27a 0.0340948
RPL31 ribosomal protein L31 0.0340702
RPS6 ribosomal protein S6 0.0337491
B2M beta-2-microglobulin 0.0336953
RBM25 RNA binding motif protein 25 0.0330297
MT1E metallothionein 1E 0.0328751
ZSWIM6 zinc finger, SWIM-type containing 6 0.0328332
CXCL8 chemokine (C-X-C motif) ligand 8 0.0317559
LRRC49 leucine rich repeat containing 49 0.030357
RPS27 ribosomal protein S27 0.0300645
KMT2E lysine (K)-specific methyltransferase 2E 0.0295664
RPS17 ribosomal protein S17 0.0288885
AKAP9 A kinase (PRKA) anchor protein 9 0.0286584
SP100 SP100 nuclear antigen 0.0283854
ANK2 ankyrin 2, neuronal 0.0282711
IFITM1 interferon induced transmembrane protein 1 0.0282633
GPATCH2L G patch domain containing 2-like 0.0279972
SRRM2 serine/arginine repetitive matrix 2 0.0279227
TPI1 triosephosphate isomerase 1 0.0277091
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0272158
PLIN2 perilipin 2 0.0267737
IFI6 interferon, alpha-inducible protein 6 0.0259261
MCTP1 multiple C2 domains, transmembrane 1 0.0248276
NT5E 5'-nucleotidase, ecto (CD73) 0.0247766
PKM pyruvate kinase, muscle 0.0246843
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.024532
VCL vinculin 0.0242919
SQSTM1 sequestosome 1 0.024158
RPL4 ribosomal protein L4 0.0240055
ANKRD11 ankyrin repeat domain 11 0.0237823
RPL28 ribosomal protein L28 0.0235154
IFITM3 interferon induced transmembrane protein 3 0.0233894
PRELID2 PRELI domain containing 2 0.0231221
RPL19 ribosomal protein L19 0.022971
ARL4C ADP-ribosylation factor-like 4C 0.022948
ANGPTL4 angiopoietin-like 4 0.0222514
DDIT4 DNA-damage-inducible transcript 4 0.0220731
TPM4 tropomyosin 4 0.0220355
AKAP12 A kinase (PRKA) anchor protein 12 0.0218288
DSCAM Down syndrome cell adhesion molecule 0.0218105
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0211491
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0209572
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0208251
ASPH aspartate beta-hydroxylase 0.0207706
NDRG1 N-myc downstream regulated 1 0.0206424
NAP1L1 nucleosome assembly protein 1-like 1 0.0205807
PLAU plasminogen activator, urokinase 0.020371
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0201695
RPL27 ribosomal protein L27 0.0200618
ANKRD12 ankyrin repeat domain 12 0.0199882
NR2F1 nuclear receptor subfamily 2, group F, member 1 0.0199775
PTPRF protein tyrosine phosphatase, receptor type, F 0.0199679
PDCD5 programmed cell death 5 0.0194988
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.0192251
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0191782
SRGN serglycin 0.0190046
SDK1 sidekick cell adhesion molecule 1 0.0188008
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0186807
TPT1 tumor protein, translationally-controlled 1 0.0184017
FAM162A family with sequence similarity 162, member A 0.0183238
RPS14 ribosomal protein S14 0.0182373

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.1962
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0880349
TXNRD1 thioredoxin reductase 1 -0.0629246
APP amyloid beta (A4) precursor protein -0.0628492
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0529021
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0525538
MACF1 microtubule-actin crosslinking factor 1 -0.0503023
EZR ezrin -0.0495668
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0481949
PSD3 pleckstrin and Sec7 domain containing 3 -0.0474309
AHNAK AHNAK nucleoprotein -0.045687
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0422342
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0412227
CD44 CD44 molecule (Indian blood group) -0.03917
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0391485
EMP1 epithelial membrane protein 1 -0.0350408
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.034373
PTK2 protein tyrosine kinase 2 -0.0339953
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.033508
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0327175
CENPF centromere protein F, 350/400kDa -0.0326527
TMEM123 transmembrane protein 123 -0.0324849
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0301424
DPYSL2 dihydropyrimidinase-like 2 -0.0280094
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0274705
RAI1 retinoic acid induced 1 -0.0272153
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0271227
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0268083
TRIO trio Rho guanine nucleotide exchange factor -0.0266585
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0263162
YEATS2 YEATS domain containing 2 -0.0259304
FMNL2 formin-like 2 -0.0258447
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0258175
CKAP5 cytoskeleton associated protein 5 -0.0252069
XPO1 exportin 1 -0.0251896
EEF2 eukaryotic translation elongation factor 2 -0.0248349
PUM2 pumilio RNA-binding family member 2 -0.0244988
EHBP1 EH domain binding protein 1 -0.024005
CEP170 centrosomal protein 170kDa -0.0234797
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0230548
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0230233
RIGI RNA sensor RIG-I -0.0229125
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0224399
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0224333
MBNL2 muscleblind-like splicing regulator 2 -0.0221574
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0219312
SLC38A2 solute carrier family 38, member 2 -0.0217963
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0214705
CANX calnexin -0.0214654
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0213866
ECT2 epithelial cell transforming 2 -0.0210487
CCNL1 cyclin L1 -0.020769
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -0.0203282
NCKAP1 NCK-associated protein 1 -0.02026
GPAT3 glycerol-3-phosphate acyltransferase 3 -0.0200815
SRPK2 SRSF protein kinase 2 -0.0199693
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0199667
EPS15 epidermal growth factor receptor pathway substrate 15 -0.0199338
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0196554
IPO7 importin 7 -0.0195212
CFAP299 cilia and flagella associated protein 299 -0.0194584
MT1X metallothionein 1X -0.0194022
ACACA acetyl-CoA carboxylase alpha -0.0192478
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0189868
UBE3C ubiquitin protein ligase E3C -0.0189228
ADGRG6 adhesion G protein-coupled receptor G6 -0.0188064
QSER1 glutamine and serine rich 1 -0.0186296
MIB1 mindbomb E3 ubiquitin protein ligase 1 -0.018536
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0184366
UBC ubiquitin C -0.0183036
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0182342
RAB10 RAB10, member RAS oncogene family -0.0180801
ATP13A3 ATPase type 13A3 -0.0180193
SENP6 SUMO1/sentrin specific peptidase 6 -0.0179936
RTN4 reticulon 4 -0.0179452
RHOA ras homolog family member A -0.0178989
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0178182
HSPA8 heat shock 70kDa protein 8 -0.0177634
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0177169
DOCK11 dedicator of cytokinesis 11 -0.0176678
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein -0.0174698
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0174612
LOXL2 lysyl oxidase-like 2 -0.0174124
BRWD1 bromodomain and WD repeat domain containing 1 -0.0173959
ZFR zinc finger RNA binding protein -0.0172845
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0171214
AFAP1 actin filament associated protein 1 -0.0166896
MBNL1 muscleblind-like splicing regulator 1 -0.0166536
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0166233
TRIP12 thyroid hormone receptor interactor 12 -0.0165477
NAMPT nicotinamide phosphoribosyltransferase -0.0164616
CBFB core-binding factor, beta subunit -0.0164513
PARD3 par-3 family cell polarity regulator -0.0163431
NCEH1 neutral cholesterol ester hydrolase 1 -0.0162717
AVL9 AVL9 homolog (S. cerevisiase) -0.0162135
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0161496
CAPRIN1 cell cycle associated protein 1 -0.0160443
PODXL podocalyxin-like -0.0159919
HMGA1 high mobility group AT-hook 1 -0.0158859
ANKRD28 ankyrin repeat domain 28 -0.0158401