SBI-0640756_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description SBI-0640756 perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the SBI-0640756_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.144026
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.140306
PTMA prothymosin, alpha 0.0936748
FTL ferritin, light polypeptide 0.092256
MT2A metallothionein 2A 0.0870063
RPS3 ribosomal protein S3 0.0859907
TMSB10 thymosin beta 10 0.0806155
EGR1 early growth response 1 0.0762949
ENO1 enolase 1, (alpha) 0.076293
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0712749
PKM pyruvate kinase, muscle 0.0671598
RPL37A ribosomal protein L37a 0.0643853
EIF1 eukaryotic translation initiation factor 1 0.0633861
SEC61G Sec61 gamma subunit 0.0600232
RPS12 ribosomal protein S12 0.0556115
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0532119
LOC112694756 uncharaterized LOC112694756 0.0528344
RPL4 ribosomal protein L4 0.0526788
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.05027
RPS6 ribosomal protein S6 0.0500374
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0489492
PRRC2C proline-rich coiled-coil 2C 0.0488214
RPLP1 ribosomal protein, large, P1 0.047923
STC1 stanniocalcin 1 0.0473628
FTH1 ferritin, heavy polypeptide 1 0.0472944
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0448139
TPT1 tumor protein, translationally-controlled 1 0.0412547
RPS8 ribosomal protein S8 0.0412261
RPL12 ribosomal protein L12 0.0407827
LDHA lactate dehydrogenase A 0.0384311
RPL35A ribosomal protein L35a 0.0381529
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0378557
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0358503
B2M beta-2-microglobulin 0.0355275
S100P S100 calcium binding protein P 0.0354624
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0348572
RPL31 ribosomal protein L31 0.0347094
NDRG1 N-myc downstream regulated 1 0.0330363
BRD2 bromodomain containing 2 0.0323105
SRRM2 serine/arginine repetitive matrix 2 0.0321919
RPS19 ribosomal protein S19 0.0310142
AREG amphiregulin 0.0299354
RACK1 receptor for activated C kinase 1 0.0299044
TPI1 triosephosphate isomerase 1 0.0298382
RPL36 ribosomal protein L36 0.0297396
PGK1 phosphoglycerate kinase 1 0.0296055
S100A11 S100 calcium binding protein A11 0.0291125
IFI6 interferon, alpha-inducible protein 6 0.0290657
RPS17 ribosomal protein S17 0.0288074
RAB7A RAB7A, member RAS oncogene family 0.0275904
RPL5 ribosomal protein L5 0.0275101
RPS2 ribosomal protein S2 0.0274622
KMT2E lysine (K)-specific methyltransferase 2E 0.0270538
RPS27 ribosomal protein S27 0.0270312
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0264448
RPS27A ribosomal protein S27a 0.0264172
RPS25 ribosomal protein S25 0.026354
RPL30 ribosomal protein L30 0.0263083
GOLGA4 golgin A4 0.0258457
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.0257786
ATF4 activating transcription factor 4 0.0255011
NSUN6 NOP2/Sun domain family, member 6 0.025385
AKAP9 A kinase (PRKA) anchor protein 9 0.0250476
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0245435
ANGPTL4 angiopoietin-like 4 0.0245352
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0240823
LMO7 LIM domain 7 0.0239748
RPL37 ribosomal protein L37 0.0230672
RPL19 ribosomal protein L19 0.0226445
BLZF1 basic leucine zipper nuclear factor 1 0.022632
GOLGB1 golgin B1 0.0226218
RPS13 ribosomal protein S13 0.0226127
NAP1L1 nucleosome assembly protein 1-like 1 0.0223654
RPL34 ribosomal protein L34 0.0223075
CES1 carboxylesterase 1 0.0220833
HLA-B major histocompatibility complex, class I, B 0.0220724
CST3 cystatin C 0.021997
CIB1 calcium and integrin binding 1 (calmyrin) 0.0212908
TPM3 tropomyosin 3 0.0212376
CALR calreticulin 0.020958
S100A6 S100 calcium binding protein A6 0.020777
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.0207492
RPS29 ribosomal protein S29 0.0207489
SQSTM1 sequestosome 1 0.0204365
SPAG9 sperm associated antigen 9 0.0198691
EZR ezrin 0.0198119
RPL23 ribosomal protein L23 0.0197982
ENO2 enolase 2 (gamma, neuronal) 0.0197332
TTC3 tetratricopeptide repeat domain 3 0.0194317
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0193317
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0192267
ERRFI1 ERBB receptor feedback inhibitor 1 0.0191024
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0190514
SERF2 small EDRK-rich factor 2 0.0188719
LRRC23 leucine rich repeat containing 23 0.0188538
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0187216
JUN jun proto-oncogene 0.018694
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0186649
LAMB3 laminin, beta 3 0.0185121
KPNB1 karyopherin (importin) beta 1 0.0183229

decreased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor -0.493811
THSD4 thrombospondin, type I, domain containing 4 -0.135263
PTPRM protein tyrosine phosphatase, receptor type, M -0.122668
CAV1 caveolin 1, caveolae protein, 22kDa -0.0738251
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0734872
EFNA5 ephrin-A5 -0.0704539
PDE4D phosphodiesterase 4D, cAMP-specific -0.0675536
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0608593
SMAD3 SMAD family member 3 -0.0579418
FNDC3B fibronectin type III domain containing 3B -0.0573034
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0556109
PDLIM5 PDZ and LIM domain 5 -0.0549671
MYOF myoferlin -0.0533834
RNF213 ring finger protein 213 -0.0512068
OSMR oncostatin M receptor -0.0501947
ASPH aspartate beta-hydroxylase -0.0487508
TBC1D22A TBC1 domain family, member 22A -0.0485329
LRP1B low density lipoprotein receptor-related protein 1B -0.0466065
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0460424
LPP LIM domain containing preferred translocation partner in lipoma -0.0446963
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0420679
AHNAK AHNAK nucleoprotein -0.041882
MAML3 mastermind-like 3 (Drosophila) -0.0418797
DOCK5 dedicator of cytokinesis 5 -0.0417947
SLTM SAFB-like, transcription modulator -0.0409
IGF1R insulin-like growth factor 1 receptor -0.040634
PATJ PATJ crumbs cell polarity complex component -0.0405882
LGALS12 lectin, galactoside-binding, soluble, 12 -0.0398731
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.03933
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0383718
LAMC2 laminin, gamma 2 -0.0378337
SUMF1 sulfatase modifying factor 1 -0.0374968
NABP1 nucleic acid binding protein 1 -0.0357265
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0350168
NCOA3 nuclear receptor coactivator 3 -0.0346311
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0339324
SOD2 superoxide dismutase 2, mitochondrial -0.0335878
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0326035
RAD51B RAD51 paralog B -0.0325736
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0323268
ARHGAP32 Rho GTPase activating protein 32 -0.0322405
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0308623
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0304289
TNS3 tensin 3 -0.0304111
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0303002
RIMS2 regulating synaptic membrane exocytosis 2 -0.0301776
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0289388
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0284068
GCLC glutamate-cysteine ligase, catalytic subunit -0.0280451
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0276879
CUX1 cut-like homeobox 1 -0.0275523
ZBTB20 zinc finger and BTB domain containing 20 -0.0267243
SCEL sciellin -0.026529
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0259268
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0258198
SAMD4A sterile alpha motif domain containing 4A -0.0254027
FOXP1 forkhead box P1 -0.0250132
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0248816
SMAD2 SMAD family member 2 -0.0248435
PCED1B PC-esterase domain containing 1B -0.0248059
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0247911
GRAMD1B GRAM domain containing 1B -0.0246311
DOCK9 dedicator of cytokinesis 9 -0.0244134
NCOA2 nuclear receptor coactivator 2 -0.0244126
SMYD3 SET and MYND domain containing 3 -0.0243219
TBC1D5 TBC1 domain family, member 5 -0.0242933
NRIP1 nuclear receptor interacting protein 1 -0.0241696
DOCK1 dedicator of cytokinesis 1 -0.0240855
FAF1 Fas (TNFRSF6) associated factor 1 -0.0239674
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0239211
CAMK2D calcium/calmodulin-dependent protein kinase II delta -0.0234821
PM20D1 peptidase M20 domain containing 1 -0.0234365
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0232641
PTK2 protein tyrosine kinase 2 -0.0230586
KRT8 keratin 8, type II -0.0230468
BRWD1 bromodomain and WD repeat domain containing 1 -0.0226618
RASA2 RAS p21 protein activator 2 -0.0226565
CTBP2 C-terminal binding protein 2 -0.0225092
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0224579
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0218829
RABGAP1L RAB GTPase activating protein 1-like -0.0217787
MGAT4C MGAT4 family, member C -0.0216567
TAS2R14 taste receptor, type 2, member 14 -0.0215427
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0209643
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0209256
CMIP c-Maf inducing protein -0.0208987
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0206975
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0206173
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0204917
EHBP1 EH domain binding protein 1 -0.0204648
NPAS2 neuronal PAS domain protein 2 -0.020463
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -0.0204371
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0201304
PRKCA protein kinase C, alpha -0.0198577
BMAL2 basic helix-loop-helix ARNT like 2 -0.0197766
TRAPPC9 trafficking protein particle complex 9 -0.0197713
CCDC91 coiled-coil domain containing 91 -0.0196591
FER fer (fps/fes related) tyrosine kinase -0.019404
MSN moesin -0.0193824
FRYL FRY-like -0.019347