SBI-0640756_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description SBI-0640756 perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the SBI-0640756_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0933888
PTMA prothymosin, alpha 0.0930278
AKAP12 A kinase (PRKA) anchor protein 12 0.0911846
RPS3 ribosomal protein S3 0.0841008
VIM vimentin 0.0761706
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0698909
EGR1 early growth response 1 0.0669374
TPI1 triosephosphate isomerase 1 0.0645105
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0639842
RPL37A ribosomal protein L37a 0.0632672
KTN1 kinectin 1 (kinesin receptor) 0.0615806
RPS8 ribosomal protein S8 0.0581531
ENO1 enolase 1, (alpha) 0.0562705
TMSB10 thymosin beta 10 0.0557789
TPM3 tropomyosin 3 0.0550727
RPS12 ribosomal protein S12 0.054438
EIF1 eukaryotic translation initiation factor 1 0.0484254
RPL4 ribosomal protein L4 0.0469068
RPL12 ribosomal protein L12 0.0460618
EEF2 eukaryotic translation elongation factor 2 0.0444924
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0441996
RPL5 ribosomal protein L5 0.0431871
FTL ferritin, light polypeptide 0.0426106
MT2A metallothionein 2A 0.0413261
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0411431
SRRM2 serine/arginine repetitive matrix 2 0.0409101
RPL35A ribosomal protein L35a 0.0386143
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0384992
RPS27 ribosomal protein S27 0.0378272
RPL37 ribosomal protein L37 0.0377766
KPNB1 karyopherin (importin) beta 1 0.0377132
RPS4X ribosomal protein S4, X-linked 0.0373114
RPS6 ribosomal protein S6 0.0353163
HLA-B major histocompatibility complex, class I, B 0.0352884
RPL26 ribosomal protein L26 0.0319337
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.0317968
RPLP1 ribosomal protein, large, P1 0.0317455
RPL9 ribosomal protein L9 0.0315611
TLN1 talin 1 0.0312857
BRD2 bromodomain containing 2 0.0308167
HLA-A major histocompatibility complex, class I, A 0.0304467
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0303015
FN1 fibronectin 1 0.0292836
RPS17 ribosomal protein S17 0.0290987
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0287105
KRT18 keratin 18, type I 0.0272965
RPS19 ribosomal protein S19 0.027292
RPL36 ribosomal protein L36 0.0272503
AKAP9 A kinase (PRKA) anchor protein 9 0.0270254
PRRC2C proline-rich coiled-coil 2C 0.026897
EIF5B eukaryotic translation initiation factor 5B 0.026864
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.026683
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0260939
PER1 period circadian clock 1 0.0260029
SEPTIN2 septin 2 0.0258817
GOLGB1 golgin B1 0.0257772
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0255402
IGFBP3 insulin-like growth factor binding protein 3 0.0255016
RPLP2 ribosomal protein, large, P2 0.0254743
RPS2 ribosomal protein S2 0.0246284
SET SET nuclear proto-oncogene 0.0246138
RPS14 ribosomal protein S14 0.0244557
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0244057
RPS27A ribosomal protein S27a 0.0242784
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0235199
B2M beta-2-microglobulin 0.0224176
KMT2E lysine (K)-specific methyltransferase 2E 0.022305
RPL23 ribosomal protein L23 0.0222754
ICAM1 intercellular adhesion molecule 1 0.0219053
CALR calreticulin 0.0215251
S100A11 S100 calcium binding protein A11 0.0211953
LOC102724023 ES1 protein homolog, mitochondrial 0.0208995
PKM pyruvate kinase, muscle 0.0208775
RPS18 ribosomal protein S18 0.0207293
RPS13 ribosomal protein S13 0.0204883
RACK1 receptor for activated C kinase 1 0.0203667
NFE2L1 nuclear factor, erythroid 2-like 1 0.0202845
RB1CC1 RB1-inducible coiled-coil 1 0.0202004
SERBP1 SERPINE1 mRNA binding protein 1 0.0201076
IFI6 interferon, alpha-inducible protein 6 0.0198205
RPL28 ribosomal protein L28 0.0197054
RPS29 ribosomal protein S29 0.01941
RPL13A ribosomal protein L13a 0.0192465
WSB1 WD repeat and SOCS box containing 1 0.0190714
PNRC1 proline-rich nuclear receptor coactivator 1 0.0190438
STC1 stanniocalcin 1 0.0188972
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.0185743
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0185692
SRSF11 serine/arginine-rich splicing factor 11 0.0184614
MYO6 myosin VI 0.0182862
RPL11 ribosomal protein L11 0.0181932
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0181552
ANGPTL4 angiopoietin-like 4 0.0180989
RTN4 reticulon 4 0.018085
RPL19 ribosomal protein L19 0.0179597
NACA nascent polypeptide-associated complex alpha subunit 0.0178647
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0178618
CREM cAMP responsive element modulator 0.0176885
KIF5B kinesin family member 5B 0.0174911
WBP11 WW domain binding protein 11 0.01736

decreased expression

Symbol Name Standardized Value
RAD51B RAD51 paralog B -0.127142
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0903975
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0883801
THSD4 thrombospondin, type I, domain containing 4 -0.0815216
GRAMD1B GRAM domain containing 1B -0.0729395
EXOC4 exocyst complex component 4 -0.0700601
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0641193
HMGA2 high mobility group AT-hook 2 -0.0612044
IGF1R insulin-like growth factor 1 receptor -0.059252
TRIO trio Rho guanine nucleotide exchange factor -0.0585745
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0551623
RIMS2 regulating synaptic membrane exocytosis 2 -0.053967
TAS2R14 taste receptor, type 2, member 14 -0.0511264
EML4 echinoderm microtubule associated protein like 4 -0.0493903
PDE10A phosphodiesterase 10A -0.048981
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0488352
PTK2 protein tyrosine kinase 2 -0.0448007
SMAD3 SMAD family member 3 -0.0425338
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0422715
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0420642
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0410296
PDE4D phosphodiesterase 4D, cAMP-specific -0.0386734
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0375937
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0371614
WWOX WW domain containing oxidoreductase -0.0362725
NF1 neurofibromin 1 -0.0360029
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0355285
PRELID2 PRELI domain containing 2 -0.0351907
DENND1A DENN/MADD domain containing 1A -0.0332678
AFF3 AF4/FMR2 family, member 3 -0.0331964
RNF213 ring finger protein 213 -0.033148
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0326724
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0322699
OSMR oncostatin M receptor -0.032101
NCOA7 nuclear receptor coactivator 7 -0.0317512
EXT1 exostosin glycosyltransferase 1 -0.0309641
USP34 ubiquitin specific peptidase 34 -0.0306168
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.029969
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0299521
WDPCP WD repeat containing planar cell polarity effector -0.0296776
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0295748
DENND5B DENN/MADD domain containing 5B -0.0292751
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.029039
PRKCE protein kinase C, epsilon -0.0289224
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0288145
SAMD4A sterile alpha motif domain containing 4A -0.0284791
RYR3 ryanodine receptor 3 -0.0283056
KDM2A lysine (K)-specific demethylase 2A -0.0282471
ZNF638 zinc finger protein 638 -0.0281508
PUM2 pumilio RNA-binding family member 2 -0.0274238
SPIDR scaffolding protein involved in DNA repair -0.027391
CCND2 cyclin D2 -0.0273876
FAF1 Fas (TNFRSF6) associated factor 1 -0.0271827
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0271699
LARP4B La ribonucleoprotein domain family, member 4B -0.0267922
PCNX1 pecanex 1 -0.0265581
FMNL2 formin-like 2 -0.0265031
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0263406
DIAPH3 diaphanous-related formin 3 -0.0263395
UBE2H ubiquitin-conjugating enzyme E2H -0.0261967
BABAM2 BRISC and BRCA1 A complex member 2 -0.0261029
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0259093
FNDC3B fibronectin type III domain containing 3B -0.0255498
SBF2 SET binding factor 2 -0.0254976
ATG7 autophagy related 7 -0.0254689
ATXN1 ataxin 1 -0.0253989
EGFR epidermal growth factor receptor -0.0252974
RBM39 RNA binding motif protein 39 -0.0249303
MCL1 myeloid cell leukemia 1 -0.0248783
TTC28 tetratricopeptide repeat domain 28 -0.0248324
WDR70 WD repeat domain 70 -0.0247574
HDAC8 histone deacetylase 8 -0.0247027
ANO6 anoctamin 6 -0.0246882
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0243079
PRH1 proline-rich protein HaeIII subfamily 1 -0.0240399
ZFAND3 zinc finger, AN1-type domain 3 -0.0239911
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0238621
AEBP2 AE binding protein 2 -0.0238049
PATJ PATJ crumbs cell polarity complex component -0.0233292
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.023179
NABP1 nucleic acid binding protein 1 -0.0230298
CCDC91 coiled-coil domain containing 91 -0.0226888
ETNK1 ethanolamine kinase 1 -0.0224153
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0223452
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0223016
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.022109
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0220981
ZNF609 zinc finger protein 609 -0.0220719
ARB2A ARB2 cotranscriptional regulator A -0.0216371
VCL vinculin -0.0214666
ETV6 ets variant 6 -0.0212706
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0212659
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0211783
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0208791
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0204631
PYGL phosphorylase, glycogen, liver -0.02044
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0203148
SDK1 sidekick cell adhesion molecule 1 -0.0202622
CPNE8 copine VIII -0.0202257
HELZ helicase with zinc finger -0.0202256