SBI-0640756_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description SBI-0640756 perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the SBI-0640756_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
WSB1 WD repeat and SOCS box containing 1 0.0693277
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0590906
PRRC2C proline-rich coiled-coil 2C 0.0544042
EGR1 early growth response 1 0.0515107
ZFP36L1 ZFP36 ring finger protein-like 1 0.0480076
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0467394
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0441581
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0398608
EXT1 exostosin glycosyltransferase 1 0.0397383
IGFBP3 insulin-like growth factor binding protein 3 0.037084
TTC3 tetratricopeptide repeat domain 3 0.0352025
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0333583
ZSWIM6 zinc finger, SWIM-type containing 6 0.0319452
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0312857
DDIT3 DNA-damage-inducible transcript 3 0.0282884
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.0279948
SDC4 syndecan 4 0.0269313
RBM25 RNA binding motif protein 25 0.0268678
DSPP dentin sialophosphoprotein 0.0264267
SH3RF1 SH3 domain containing ring finger 1 0.02623
LAMB3 laminin, beta 3 0.0257344
MT2A metallothionein 2A 0.0252088
INTS6 integrator complex subunit 6 0.0245565
RASAL2 RAS protein activator like 2 0.0235918
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0232445
LOC102724023 ES1 protein homolog, mitochondrial 0.0227627
ARHGAP42 Rho GTPase activating protein 42 0.0222215
MYO9A myosin IXA 0.0220344
SRSF11 serine/arginine-rich splicing factor 11 0.0215565
HDAC9 histone deacetylase 9 0.0214923
FAM13A family with sequence similarity 13, member A 0.0213391
RCOR1 REST corepressor 1 0.0213384
MAST4 microtubule associated serine/threonine kinase family member 4 0.021299
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0211942
JUN jun proto-oncogene 0.021115
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0206786
PLAUR plasminogen activator, urokinase receptor 0.0206178
BHLHE40 basic helix-loop-helix family, member e40 0.0201732
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0199657
JARID2 jumonji, AT rich interactive domain 2 0.0194805
DGKD diacylglycerol kinase, delta 130kDa 0.0194557
NEBL nebulette 0.0191869
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0189641
RPS3 ribosomal protein S3 0.0188451
USP53 ubiquitin specific peptidase 53 0.0187513
HIPK2 homeodomain interacting protein kinase 2 0.0186045
IFI44L interferon-induced protein 44-like 0.018548
KRT19 keratin 19, type I 0.0184429
KIAA1217 KIAA1217 0.0182912
PLEC plectin 0.0182082
TJP1 tight junction protein 1 0.0179293
SRRM2 serine/arginine repetitive matrix 2 0.0178001
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0177134
MIDEAS mitotic deacetylase associated SANT domain protein 0.0176502
TMEM117 transmembrane protein 117 0.0175703
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0174664
HLA-B major histocompatibility complex, class I, B 0.0173855
PTK2B protein tyrosine kinase 2 beta 0.0173534
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.017142
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0169253
MTCH1 mitochondrial carrier 1 0.0165282
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0164444
RYBP RING1 and YY1 binding protein 0.0160506
TRIP11 thyroid hormone receptor interactor 11 0.0160241
AKAP9 A kinase (PRKA) anchor protein 9 0.0159765
ATG13 autophagy related 13 0.0157737
FHIT fragile histidine triad 0.0153878
CLIC4 chloride intracellular channel 4 0.0153387
KTN1 kinectin 1 (kinesin receptor) 0.015201
RAD51B RAD51 paralog B 0.0151897
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0150337
ACSL4 acyl-CoA synthetase long-chain family member 4 0.0150221
RASA2 RAS p21 protein activator 2 0.0149325
SERTAD2 SERTA domain containing 2 0.0148814
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 0.014641
ENO2 enolase 2 (gamma, neuronal) 0.0146409
HOMER1 homer scaffolding protein 1 0.0145637
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0145078
ARHGAP5 Rho GTPase activating protein 5 0.0144607
CHMP1B charged multivesicular body protein 1B 0.0144166
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0143941
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0143744
SGMS2 sphingomyelin synthase 2 0.0143722
SNX9 sorting nexin 9 0.0143142
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0139595
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 0.0138529
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0138517
TARS3 threonyl-tRNA synthetase 3 0.0136939
STK10 serine/threonine kinase 10 0.0136906
DZIP3 DAZ interacting zinc finger protein 3 0.0136202
ZRANB1 zinc finger, RAN-binding domain containing 1 0.0134536
BRD2 bromodomain containing 2 0.0133914
ICA1 islet cell autoantigen 1, 69kDa 0.0132926
DST dystonin 0.0132806
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0132575
BICD1 bicaudal D homolog 1 (Drosophila) 0.0131471
MAP3K15 mitogen-activated protein kinase kinase kinase 15 0.0131394
TUT4 terminal uridylyl transferase 4 0.0130999
CRYBG3 beta-gamma crystallin domain containing 3 0.0130382
STK38L serine/threonine kinase 38 like 0.0130336

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.296149
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.261297
ACTG1 actin gamma 1 -0.163257
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.105644
TMSB4X thymosin beta 4, X-linked -0.0965917
FNDC3B fibronectin type III domain containing 3B -0.0836717
UBC ubiquitin C -0.0833067
TMSB10 thymosin beta 10 -0.0808649
S100A6 S100 calcium binding protein A6 -0.0742188
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0692637
TPT1 tumor protein, translationally-controlled 1 -0.0688884
TM4SF1 transmembrane 4 L six family member 1 -0.0680466
POTEF POTE ankyrin domain family, member F -0.0679678
PTK2 protein tyrosine kinase 2 -0.0679074
RPS23 ribosomal protein S23 -0.0678809
UBE2H ubiquitin-conjugating enzyme E2H -0.0674161
RPLP1 ribosomal protein, large, P1 -0.0663212
FTL ferritin, light polypeptide -0.0613934
ANXA2 annexin A2 -0.0584876
RPL8 ribosomal protein L8 -0.0563619
RPL34 ribosomal protein L34 -0.0553444
RPLP0 ribosomal protein, large, P0 -0.054736
NPEPPS aminopeptidase puromycin sensitive -0.0504003
LPP LIM domain containing preferred translocation partner in lipoma -0.0503118
CANX calnexin -0.0501967
FBXO32 F-box protein 32 -0.0488729
RPS24 ribosomal protein S24 -0.0487096
RPL23 ribosomal protein L23 -0.0485599
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0479427
RPL35A ribosomal protein L35a -0.0468526
RPS6 ribosomal protein S6 -0.0465734
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0464822
TPM4 tropomyosin 4 -0.0463394
RHOA ras homolog family member A -0.0463347
CD2AP CD2-associated protein -0.04517
HMGA1 high mobility group AT-hook 1 -0.0447823
TSC22D2 TSC22 domain family, member 2 -0.0443117
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0442113
RPL32 ribosomal protein L32 -0.043773
RPS8 ribosomal protein S8 -0.0434556
CCND1 cyclin D1 -0.0432245
RPLP2 ribosomal protein, large, P2 -0.0425314
RAD21 RAD21 homolog (S. pombe) -0.0425258
RACK1 receptor for activated C kinase 1 -0.0412909
PGK1 phosphoglycerate kinase 1 -0.0410759
RPS13 ribosomal protein S13 -0.0410751
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.040346
ZFAND3 zinc finger, AN1-type domain 3 -0.0398199
KDM2A lysine (K)-specific demethylase 2A -0.0396365
RPL15 ribosomal protein L15 -0.0396036
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0393362
VIM vimentin -0.0391979
S100A10 S100 calcium binding protein A10 -0.0382817
TMEM123 transmembrane protein 123 -0.0377816
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0370605
KRT18 keratin 18, type I -0.0368614
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0364999
AHNAK AHNAK nucleoprotein -0.0361475
RPL11 ribosomal protein L11 -0.0360945
RPL12 ribosomal protein L12 -0.0360359
RPS25 ribosomal protein S25 -0.0359129
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0355131
RAB1A RAB1A, member RAS oncogene family -0.0352915
KRT7 keratin 7, type II -0.0351967
CD109 CD109 molecule -0.0351964
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0347514
ZNF292 zinc finger protein 292 -0.0340596
MYOF myoferlin -0.0339228
SEC31A SEC31 homolog A (S. cerevisiae) -0.0335895
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0332731
LMNA lamin A/C -0.0328342
RAI14 retinoic acid induced 14 -0.0328304
RPL27A ribosomal protein L27a -0.0321889
EIF1 eukaryotic translation initiation factor 1 -0.0320717
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0319328
OSBPL3 oxysterol binding protein-like 3 -0.0317995
ZNF207 zinc finger protein 207 -0.0315773
MCU mitochondrial calcium uniporter -0.0314069
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0309769
LY6E lymphocyte antigen 6 complex, locus E -0.0309622
CSTB cystatin B (stefin B) -0.0309165
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0309072
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0307965
TMEM263 transmembrane protein 263 -0.0306813
DEK DEK proto-oncogene -0.0306431
TRIO trio Rho guanine nucleotide exchange factor -0.0304687
FNIP1 folliculin interacting protein 1 -0.0295029
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0292991
SQSTM1 sequestosome 1 -0.0292185
RPS15 ribosomal protein S15 -0.0291938
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -0.029159
ITCH itchy E3 ubiquitin protein ligase -0.0290338
SLMAP sarcolemma associated protein -0.0290141
LMO7 LIM domain 7 -0.0287699
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0286304
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0284617
RPL7A ribosomal protein L7a -0.0282167
KRT8 keratin 8, type II -0.028165
MYO6 myosin VI -0.0281028
SEPTIN11 septin 11 -0.028039