SBI-0640756_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description SBI-0640756 perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the SBI-0640756_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.168349
VIM vimentin 0.116362
DST dystonin 0.109267
RPS3 ribosomal protein S3 0.0999791
RPS12 ribosomal protein S12 0.0970902
RPL37A ribosomal protein L37a 0.0914287
ENO1 enolase 1, (alpha) 0.0907243
RPS6 ribosomal protein S6 0.0849761
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0849077
RPL4 ribosomal protein L4 0.0815637
HLA-A major histocompatibility complex, class I, A 0.0791818
EIF1 eukaryotic translation initiation factor 1 0.0775219
RACK1 receptor for activated C kinase 1 0.0748957
SQSTM1 sequestosome 1 0.0745601
RPL31 ribosomal protein L31 0.0704414
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0670424
TBXT T-box transcription factor T 0.0651369
HLA-B major histocompatibility complex, class I, B 0.0631085
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0627765
RPL26 ribosomal protein L26 0.0602535
INHBA inhibin, beta A 0.0597836
TPT1 tumor protein, translationally-controlled 1 0.0593053
COL4A5 collagen, type IV, alpha 5 0.0573611
PDLIM5 PDZ and LIM domain 5 0.0565436
COL5A2 collagen, type V, alpha 2 0.0563807
EEF2 eukaryotic translation elongation factor 2 0.0558207
RPS8 ribosomal protein S8 0.0554119
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0554113
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0540827
STC1 stanniocalcin 1 0.0532766
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.048749
FN1 fibronectin 1 0.0475929
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.0475828
RPL12 ribosomal protein L12 0.0471859
SH3KBP1 SH3-domain kinase binding protein 1 0.0469629
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0467609
SOX4 SRY (sex determining region Y)-box 4 0.044745
LOC112694756 uncharaterized LOC112694756 0.0439458
NCAM1 neural cell adhesion molecule 1 0.0438312
RPLP1 ribosomal protein, large, P1 0.0434507
RPS19 ribosomal protein S19 0.0434221
LDHA lactate dehydrogenase A 0.0430525
APLP2 amyloid beta (A4) precursor-like protein 2 0.0429899
RPL35A ribosomal protein L35a 0.0414905
SRRM2 serine/arginine repetitive matrix 2 0.0414844
TPI1 triosephosphate isomerase 1 0.0408658
RPL9 ribosomal protein L9 0.040512
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0400077
P3H2 prolyl 3-hydroxylase 2 0.0399789
RPL37 ribosomal protein L37 0.0398713
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.03935
CDH13 cadherin 13 0.0381768
AKAP12 A kinase (PRKA) anchor protein 12 0.0379951
PDE10A phosphodiesterase 10A 0.0374629
MAP7 microtubule-associated protein 7 0.0364923
TIMP1 TIMP metallopeptidase inhibitor 1 0.0364081
INTS6 integrator complex subunit 6 0.036287
PAPPA2 pappalysin 2 0.0361637
SET SET nuclear proto-oncogene 0.0360847
PRKN parkin RBR E3 ubiquitin protein ligase 0.0356184
NTN4 netrin 4 0.0353668
RGS2 regulator of G-protein signaling 2 0.0353085
FTH1 ferritin, heavy polypeptide 1 0.0347138
FTL ferritin, light polypeptide 0.0343982
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0340023
ATF4 activating transcription factor 4 0.0339391
RPS27A ribosomal protein S27a 0.0339009
CTSL cathepsin L 0.033393
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.032873
DOCK5 dedicator of cytokinesis 5 0.0327723
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0318788
GLCCI1 glucocorticoid induced 1 0.0314101
PRELID2 PRELI domain containing 2 0.0314063
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0306375
BZW1 basic leucine zipper and W2 domains 1 0.0306103
RPL18 ribosomal protein L18 0.0303169
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0302453
RPL36 ribosomal protein L36 0.0301776
RBBP6 retinoblastoma binding protein 6 0.0301239
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0295444
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0290901
RSL1D1 ribosomal L1 domain containing 1 0.0290018
RPS2 ribosomal protein S2 0.0289472
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0288172
RPL35 ribosomal protein L35 0.0285413
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0284882
GNAS GNAS complex locus 0.0283199
CENPF centromere protein F, 350/400kDa 0.0282373
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0279687
ARHGAP5 Rho GTPase activating protein 5 0.0278999
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0276687
RPS13 ribosomal protein S13 0.0270541
RPS27 ribosomal protein S27 0.0268791
CTNND1 catenin (cadherin-associated protein), delta 1 0.0263783
PM20D1 peptidase M20 domain containing 1 0.0261798
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0261729
ASPH aspartate beta-hydroxylase 0.0257379
RPLP2 ribosomal protein, large, P2 0.025703
TPM3 tropomyosin 3 0.0256799
LGALS8 lectin, galactoside-binding, soluble, 8 0.0254398

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.143485
EFNA5 ephrin-A5 -0.103447
NAMPT nicotinamide phosphoribosyltransferase -0.10172
TRIO trio Rho guanine nucleotide exchange factor -0.0996528
CXCL8 chemokine (C-X-C motif) ligand 8 -0.093213
PDE4D phosphodiesterase 4D, cAMP-specific -0.0889389
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0842371
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0828035
FNDC3B fibronectin type III domain containing 3B -0.082334
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.075554
RTN4 reticulon 4 -0.0696259
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.063194
NEK7 NIMA-related kinase 7 -0.0621944
LIMCH1 LIM and calponin homology domains 1 -0.0608376
TXNRD1 thioredoxin reductase 1 -0.0604154
SMYD3 SET and MYND domain containing 3 -0.0595304
PSD3 pleckstrin and Sec7 domain containing 3 -0.0593835
ELL2 elongation factor, RNA polymerase II, 2 -0.0589678
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0565039
SPAG9 sperm associated antigen 9 -0.0492844
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0463396
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0450518
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0447003
PDIA3 protein disulfide isomerase family A, member 3 -0.0435468
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.043212
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0423164
DIAPH2 diaphanous-related formin 2 -0.0416761
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0415894
PALLD palladin, cytoskeletal associated protein -0.0408248
AGFG1 ArfGAP with FG repeats 1 -0.0406983
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0404291
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0400173
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0396477
SRPK2 SRSF protein kinase 2 -0.0391876
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0388971
MFF mitochondrial fission factor -0.0387079
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.038305
KMT2C lysine (K)-specific methyltransferase 2C -0.0381228
PCBP2 poly(rC) binding protein 2 -0.0378256
NBAS neuroblastoma amplified sequence -0.03735
NCOA7 nuclear receptor coactivator 7 -0.0372553
ANXA1 annexin A1 -0.0371632
PTK2 protein tyrosine kinase 2 -0.0371252
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0362337
KDM6A lysine (K)-specific demethylase 6A -0.0359335
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0359128
OLA1 Obg-like ATPase 1 -0.0357086
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0355793
RAB1A RAB1A, member RAS oncogene family -0.0350234
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0348683
ATP13A3 ATPase type 13A3 -0.0343002
USP3 ubiquitin specific peptidase 3 -0.0340925
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.0338666
SOD2 superoxide dismutase 2, mitochondrial -0.0338518
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0338501
WDR43 WD repeat domain 43 -0.0331585
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0331142
PUM2 pumilio RNA-binding family member 2 -0.0330511
NPEPPS aminopeptidase puromycin sensitive -0.0321825
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0320167
FAM13A family with sequence similarity 13, member A -0.0319546
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0316833
GOLGA4 golgin A4 -0.0315477
SSBP2 single-stranded DNA binding protein 2 -0.0314742
MCL1 myeloid cell leukemia 1 -0.0314291
IL1RAP interleukin 1 receptor accessory protein -0.0308223
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0307719
PTGR1 prostaglandin reductase 1 -0.0307446
TPD52 tumor protein D52 -0.0303055
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0302337
COL4A6 collagen, type IV, alpha 6 -0.0299172
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0294291
ECT2 epithelial cell transforming 2 -0.0292476
GLS2 glutaminase 2 (liver, mitochondrial) -0.0291575
PTEN phosphatase and tensin homolog -0.0289936
RHEB Ras homolog enriched in brain -0.0289045
RAP1B RAP1B, member of RAS oncogene family -0.0287611
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0286962
UBE2H ubiquitin-conjugating enzyme E2H -0.028655
KCMF1 potassium channel modulatory factor 1 -0.0278834
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0277551
SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.0276638
PDIA6 protein disulfide isomerase family A, member 6 -0.0273037
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0270213
RAI1 retinoic acid induced 1 -0.0270077
ADAM9 ADAM metallopeptidase domain 9 -0.0269584
SLC38A2 solute carrier family 38, member 2 -0.026794
WDFY2 WD repeat and FYVE domain containing 2 -0.0266636
RHOA ras homolog family member A -0.0266426
ANKRD28 ankyrin repeat domain 28 -0.0265903
MBNL1 muscleblind-like splicing regulator 1 -0.0265209
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0262986
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0259552
DPY19L1 dpy-19-like 1 (C. elegans) -0.0258156
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0257471
TAOK1 TAO kinase 1 -0.025579
HILPDA hypoxia inducible lipid droplet-associated -0.0255533
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0255039
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0252934
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0252891