SBI-0640756_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description SBI-0640756 perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the SBI-0640756_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 0.108898
RPL37A ribosomal protein L37a 0.104196
PTMA prothymosin, alpha 0.100182
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0928415
RPL12 ribosomal protein L12 0.0877887
KRT19 keratin 19, type I 0.0849839
LMO7 LIM domain 7 0.0817593
BACE2 beta-site APP-cleaving enzyme 2 0.0801596
PLAU plasminogen activator, urokinase 0.07227
RPS8 ribosomal protein S8 0.0717475
HLA-B major histocompatibility complex, class I, B 0.0659461
RPS3 ribosomal protein S3 0.0652847
HLA-A major histocompatibility complex, class I, A 0.0648736
INTS6 integrator complex subunit 6 0.0611601
RPS12 ribosomal protein S12 0.0597577
SLC38A2 solute carrier family 38, member 2 0.0583641
DSG2 desmoglein 2 0.0555858
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.0543633
RACK1 receptor for activated C kinase 1 0.0520377
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0513255
RPS27 ribosomal protein S27 0.0497284
IFI27 interferon, alpha-inducible protein 27 0.0497223
G0S2 G0/G1 switch 2 0.0493516
FTL ferritin, light polypeptide 0.0493243
ARHGAP5 Rho GTPase activating protein 5 0.0481612
CD63 CD63 molecule 0.0465679
JUP junction plakoglobin 0.0462621
DSPP dentin sialophosphoprotein 0.0462084
AKAP13 A kinase (PRKA) anchor protein 13 0.04607
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0459875
KYNU kynureninase 0.0455581
KTN1 kinectin 1 (kinesin receptor) 0.0451813
RPL37 ribosomal protein L37 0.0448945
SOX4 SRY (sex determining region Y)-box 4 0.0439075
OGA O-GlcNAcase 0.0431706
RNF213 ring finger protein 213 0.0431677
RPS27A ribosomal protein S27a 0.042789
B2M beta-2-microglobulin 0.0425076
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.0423765
TPM4 tropomyosin 4 0.0419842
RPL31 ribosomal protein L31 0.0415891
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0415167
DTNA dystrobrevin, alpha 0.0413896
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0407711
FTH1 ferritin, heavy polypeptide 1 0.0405643
WSB1 WD repeat and SOCS box containing 1 0.0396987
SH3KBP1 SH3-domain kinase binding protein 1 0.0396747
RPL36 ribosomal protein L36 0.0392159
MX1 MX dynamin-like GTPase 1 0.0391378
ZRANB2 zinc finger, RAN-binding domain containing 2 0.038523
FMNL2 formin-like 2 0.0378447
CAPRIN2 caprin family member 2 0.0374795
SQSTM1 sequestosome 1 0.0373852
ENO2 enolase 2 (gamma, neuronal) 0.0371933
PLAUR plasminogen activator, urokinase receptor 0.0371854
NAV2 neuron navigator 2 0.0371728
IFITM1 interferon induced transmembrane protein 1 0.0369349
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0366978
HMGA1 high mobility group AT-hook 1 0.036652
PTK2B protein tyrosine kinase 2 beta 0.0363862
EPSTI1 epithelial stromal interaction 1 (breast) 0.0362186
YBX3 Y box binding protein 3 0.0358215
LOC112694756 uncharaterized LOC112694756 0.0357937
PKM pyruvate kinase, muscle 0.035091
RPS17 ribosomal protein S17 0.0348561
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.034501
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.033809
ARHGAP29 Rho GTPase activating protein 29 0.0334444
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0322868
VEGFA vascular endothelial growth factor A 0.0320633
RPL11 ribosomal protein L11 0.0319601
SACK1A scaffolding CK1 anchoring protein A 0.031925
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0318545
RPL13A ribosomal protein L13a 0.0318281
C3 complement component 3 0.031563
ATF4 activating transcription factor 4 0.0315565
RPL35A ribosomal protein L35a 0.0315326
BBX bobby sox homolog (Drosophila) 0.0315057
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0314062
RSAD2 radical S-adenosyl methionine domain containing 2 0.0310135
RIGI RNA sensor RIG-I 0.0308567
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0307643
RPL9 ribosomal protein L9 0.0307414
RPS19 ribosomal protein S19 0.0305982
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0305963
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0305656
OPTN optineurin 0.0302211
IFI6 interferon, alpha-inducible protein 6 0.0299995
RPL7A ribosomal protein L7a 0.0298627
RPL30 ribosomal protein L30 0.0298562
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0293354
SP100 SP100 nuclear antigen 0.0290975
TIMP2 TIMP metallopeptidase inhibitor 2 0.0288176
ENO1 enolase 1, (alpha) 0.028795
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0286566
S100A11 S100 calcium binding protein A11 0.0285075
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 0.0284293
CLDN4 claudin 4 0.0282918
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0278367
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.0278138

decreased expression

Symbol Name Standardized Value
RUNX1 runt-related transcription factor 1 -0.08286
EFNA5 ephrin-A5 -0.0736782
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0643621
MBNL2 muscleblind-like splicing regulator 2 -0.0592067
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0565924
CANX calnexin -0.0540741
SMYD3 SET and MYND domain containing 3 -0.0535305
ZFAND3 zinc finger, AN1-type domain 3 -0.0531467
CCNL1 cyclin L1 -0.049944
TXNIP thioredoxin interacting protein -0.0465027
FNDC3B fibronectin type III domain containing 3B -0.0463511
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.044877
OSBPL3 oxysterol binding protein-like 3 -0.0445345
EMP1 epithelial membrane protein 1 -0.0443278
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0440799
MKI67 marker of proliferation Ki-67 -0.044021
MBNL1 muscleblind-like splicing regulator 1 -0.0431175
ECT2 epithelial cell transforming 2 -0.0430696
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0414293
CD47 CD47 molecule -0.0410495
FAM3C family with sequence similarity 3, member C -0.0410234
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0399792
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0393322
MAML2 mastermind-like 2 (Drosophila) -0.0391512
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0387394
KRT17 keratin 17, type I -0.0385319
SENP6 SUMO1/sentrin specific peptidase 6 -0.0381349
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0370188
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.036474
NPEPPS aminopeptidase puromycin sensitive -0.0362406
FAF1 Fas (TNFRSF6) associated factor 1 -0.035391
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0353636
DIAPH3 diaphanous-related formin 3 -0.0352265
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0350417
ARHGAP26 Rho GTPase activating protein 26 -0.0347845
ZNF148 zinc finger protein 148 -0.0346654
MACF1 microtubule-actin crosslinking factor 1 -0.0344779
FRMD5 FERM domain containing 5 -0.0342644
DLG1 discs, large homolog 1 (Drosophila) -0.0342093
EXT1 exostosin glycosyltransferase 1 -0.0340856
CLIP4 CAP-GLY domain containing linker protein family, member 4 -0.0336585
RASA2 RAS p21 protein activator 2 -0.033521
CCNY cyclin Y -0.0332946
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0327934
SRPK2 SRSF protein kinase 2 -0.0324105
DPYD dihydropyrimidine dehydrogenase -0.0319607
DSCAM Down syndrome cell adhesion molecule -0.0316745
CENPF centromere protein F, 350/400kDa -0.0313031
SMC4 structural maintenance of chromosomes 4 -0.0311858
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0309408
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0308355
CDK6 cyclin-dependent kinase 6 -0.0296798
CLMN calmin (calponin-like, transmembrane) -0.0294585
RASAL2 RAS protein activator like 2 -0.0285112
FRYL FRY-like -0.0284906
AHNAK AHNAK nucleoprotein -0.0284089
NFIB nuclear factor I/B -0.0283137
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 -0.0279667
TMEM123 transmembrane protein 123 -0.0279077
LY6E lymphocyte antigen 6 complex, locus E -0.0277763
KRT8 keratin 8, type II -0.027738
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 -0.0276631
ANLN anillin, actin binding protein -0.0276266
CKAP5 cytoskeleton associated protein 5 -0.0275688
FN1 fibronectin 1 -0.0274371
FCHSD2 FCH and double SH3 domains 2 -0.0269727
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.026593
LOC102724023 ES1 protein homolog, mitochondrial -0.0265062
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0264609
ARHGAP32 Rho GTPase activating protein 32 -0.0261891
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.026187
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0259181
ZNF207 zinc finger protein 207 -0.025759
DENND4C DENN/MADD domain containing 4C -0.0256568
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0252968
SAMD12 sterile alpha motif domain containing 12 -0.0252954
TAS2R14 taste receptor, type 2, member 14 -0.0250316
TM9SF3 transmembrane 9 superfamily member 3 -0.024671
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma -0.0243528
ZBTB20 zinc finger and BTB domain containing 20 -0.0242776
PHC3 polyhomeotic homolog 3 (Drosophila) -0.0239888
TAOK1 TAO kinase 1 -0.0239615
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0239473
RAB1A RAB1A, member RAS oncogene family -0.0238453
CXADR coxsackie virus and adenovirus receptor -0.0238163
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0237758
ETNK1 ethanolamine kinase 1 -0.0235863
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0232402
MECOM MDS1 and EVI1 complex locus -0.0231805
ADAM10 ADAM metallopeptidase domain 10 -0.0231561
NAMPT nicotinamide phosphoribosyltransferase -0.0226791
SHROOM3 shroom family member 3 -0.0226446
CHD1 chromodomain helicase DNA binding protein 1 -0.0226017
TM4SF1 transmembrane 4 L six family member 1 -0.0225246
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.0224507
COPB1 coatomer protein complex, subunit beta 1 -0.0222962
SETD2 SET domain containing 2 -0.022009
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0219969
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0219959
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0219364