| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | SBI-0640756 perturbation in RKO cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the SBI-0640756_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0786971 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0784601 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.066674 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0627897 |
| TTR | transthyretin | 0.0568273 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.056494 |
| RPS3 | ribosomal protein S3 | 0.0449495 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0440548 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.043756 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0434701 |
| CAMSAP2 | calmodulin regulated spectrin-associated protein family, member 2 | 0.0428322 |
| RPL4 | ribosomal protein L4 | 0.041293 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | 0.0386733 |
| GOLGA4 | golgin A4 | 0.034886 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0345733 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0333587 |
| EGR1 | early growth response 1 | 0.0330098 |
| CAPRIN2 | caprin family member 2 | 0.0327837 |
| TRIB1 | tribbles pseudokinase 1 | 0.0323128 |
| LARS1 | leucyl-tRNA synthetase 1 | 0.0321165 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0315944 |
| LAMB3 | laminin, beta 3 | 0.0309084 |
| SETD5 | SET domain containing 5 | 0.0299333 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0297326 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.029668 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0279214 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0266188 |
| ANK2 | ankyrin 2, neuronal | 0.0256051 |
| NPTN | neuroplastin | 0.0253237 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0248807 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.024826 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0247866 |
| SQSTM1 | sequestosome 1 | 0.0244328 |
| JMJD1C | jumonji domain containing 1C | 0.0244145 |
| CORO1C | coronin, actin binding protein, 1C | 0.023662 |
| KIF1B | kinesin family member 1B | 0.0234405 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | 0.0229791 |
| ATM | ATM serine/threonine kinase | 0.0226491 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.0224263 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | 0.0223279 |
| DENR | density-regulated protein | 0.0221925 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.0221386 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 0.0219778 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0219395 |
| TUT7 | terminal uridylyl transferase 7 | 0.021897 |
| DNAJC2 | DnaJ (Hsp40) homolog, subfamily C, member 2 | 0.0218887 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 0.0218012 |
| ATF4 | activating transcription factor 4 | 0.0217805 |
| CD68 | CD68 molecule | 0.0216093 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0215736 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0213945 |
| TAB2 | TGF-beta activated kinase 1/MAP3K7 binding protein 2 | 0.0211152 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0208778 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0206184 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0205749 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0205329 |
| ESF1 | ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) | 0.0204394 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0202583 |
| YBX1 | Y box binding protein 1 | 0.0200838 |
| USO1 | USO1 vesicle transport factor | 0.0200293 |
| FOSL1 | FOS-like antigen 1 | 0.0199642 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | 0.0199313 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0198348 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.0197714 |
| CD164 | CD164 molecule, sialomucin | 0.0196958 |
| UBXN4 | UBX domain protein 4 | 0.0195702 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0192883 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0187917 |
| SCFD1 | sec1 family domain containing 1 | 0.0187512 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0186476 |
| RIOK2 | RIO kinase 2 | 0.018612 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0185476 |
| CLTC | clathrin, heavy chain (Hc) | 0.0183456 |
| CDC27 | cell division cycle 27 | 0.0182889 |
| HDLBP | high density lipoprotein binding protein | 0.0181359 |
| TLN1 | talin 1 | 0.0181217 |
| KRIT1 | KRIT1, ankyrin repeat containing | 0.0180988 |
| RPS12 | ribosomal protein S12 | 0.0180512 |
| CCNC | cyclin C | 0.0180162 |
| DYNLRB1 | dynein, light chain, roadblock-type 1 | 0.0178392 |
| RPS15A | ribosomal protein S15a | 0.0178324 |
| PPP1CC | protein phosphatase 1, catalytic subunit, gamma isozyme | 0.0176149 |
| NKTR | natural killer cell triggering receptor | 0.0173983 |
| BOD1L1 | biorientation of chromosomes in cell division 1-like 1 | 0.0173833 |
| STAG2 | stromal antigen 2 | 0.0173454 |
| LDHA | lactate dehydrogenase A | 0.0171702 |
| PPP2R3A | protein phosphatase 2, regulatory subunit B'', alpha | 0.0171318 |
| NDRG1 | N-myc downstream regulated 1 | 0.0170699 |
| HGS | hepatocyte growth factor-regulated tyrosine kinase substrate | 0.0170628 |
| TOR1AIP2 | torsin A interacting protein 2 | 0.0169347 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0169343 |
| BRD4 | bromodomain containing 4 | 0.0168512 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0168489 |
| ATXN2L | ataxin 2-like | 0.0168402 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0168142 |
| RPL13A | ribosomal protein L13a | 0.0166243 |
| AMPD3 | adenosine monophosphate deaminase 3 | 0.0164665 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0164347 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0164056 |
| MPHOSPH6 | M-phase phosphoprotein 6 | 0.0162359 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.157316 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.105744 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.101339 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0996671 |
| FRMD6 | FERM domain containing 6 | -0.0750914 |
| RPL8 | ribosomal protein L8 | -0.0719007 |
| ZNF438 | zinc finger protein 438 | -0.0693304 |
| RPLP1 | ribosomal protein, large, P1 | -0.0682324 |
| RPS6 | ribosomal protein S6 | -0.0676256 |
| RPL35A | ribosomal protein L35a | -0.0661772 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0639022 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0591625 |
| RPL12 | ribosomal protein L12 | -0.0585387 |
| RPL7A | ribosomal protein L7a | -0.0556807 |
| PTMA | prothymosin, alpha | -0.0556151 |
| ACTG1 | actin gamma 1 | -0.0543702 |
| RPS27A | ribosomal protein S27a | -0.0478727 |
| RPS25 | ribosomal protein S25 | -0.0463064 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0446587 |
| RPS21 | ribosomal protein S21 | -0.0445212 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0422174 |
| RPLP0 | ribosomal protein, large, P0 | -0.0416949 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0413984 |
| RPL34 | ribosomal protein L34 | -0.0403961 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0397517 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0390408 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0385559 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0382694 |
| RPL36A | ribosomal protein L36a | -0.0380548 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0374388 |
| RPS29 | ribosomal protein S29 | -0.0373536 |
| FLNB | filamin B, beta | -0.0361999 |
| MTAP | methylthioadenosine phosphorylase | -0.0360587 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0357315 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0356567 |
| DIAPH3 | diaphanous-related formin 3 | -0.0351639 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0347708 |
| DEK | DEK proto-oncogene | -0.0345476 |
| RPS24 | ribosomal protein S24 | -0.0341978 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0337808 |
| S100A9 | S100 calcium binding protein A9 | -0.0336002 |
| NABP1 | nucleic acid binding protein 1 | -0.0335407 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.0332632 |
| RPL7 | ribosomal protein L7 | -0.0326135 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0324401 |
| RPS19 | ribosomal protein S19 | -0.0321767 |
| TPM4 | tropomyosin 4 | -0.0319576 |
| ANXA2 | annexin A2 | -0.0318066 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0317983 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0316038 |
| BNC2 | basonuclin 2 | -0.0316021 |
| RPS8 | ribosomal protein S8 | -0.0309997 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0301182 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.030026 |
| ARHGAP22 | Rho GTPase activating protein 22 | -0.0299793 |
| EFNB2 | ephrin-B2 | -0.0295936 |
| SON | SON DNA binding protein | -0.0291215 |
| RPL30 | ribosomal protein L30 | -0.0290797 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0289802 |
| RPS23 | ribosomal protein S23 | -0.0287681 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0285534 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.0284281 |
| APP | amyloid beta (A4) precursor protein | -0.0282192 |
| RPS15 | ribosomal protein S15 | -0.0280313 |
| PA2G4 | proliferation-associated 2G4, 38kDa | -0.0279796 |
| RPS4X | ribosomal protein S4, X-linked | -0.0279642 |
| RPL15 | ribosomal protein L15 | -0.0278908 |
| RUNX1 | runt-related transcription factor 1 | -0.0276108 |
| RPL19 | ribosomal protein L19 | -0.0273513 |
| PARD3 | par-3 family cell polarity regulator | -0.0272144 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0271549 |
| RPL32 | ribosomal protein L32 | -0.0271364 |
| SSR3 | signal sequence receptor, gamma (translocon-associated protein gamma) | -0.0271196 |
| RPL38 | ribosomal protein L38 | -0.026996 |
| B2M | beta-2-microglobulin | -0.0269752 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.026898 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0268894 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0266551 |
| RPLP2 | ribosomal protein, large, P2 | -0.0266069 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0265791 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0264968 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0263644 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | -0.0262365 |
| AHNAK | AHNAK nucleoprotein | -0.0255987 |
| FMNL2 | formin-like 2 | -0.0255413 |
| GPHN | gephyrin | -0.0255189 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0253946 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0252123 |
| RPL35 | ribosomal protein L35 | -0.0250725 |
| RRM2 | ribonucleotide reductase M2 | -0.0249046 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0248183 |
| SRPK2 | SRSF protein kinase 2 | -0.024681 |
| RPS11 | ribosomal protein S11 | -0.0245771 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0245153 |
| FBXO11 | F-box protein 11 | -0.0244694 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0243508 |
| MT1X | metallothionein 1X | -0.0240771 |
| MAP4 | microtubule-associated protein 4 | -0.0240278 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0238063 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0237194 |
