SBI-0640756_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description SBI-0640756 perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the SBI-0640756_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.148034
STC1 stanniocalcin 1 0.128551
ENO1 enolase 1, (alpha) 0.126297
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0970621
PTMA prothymosin, alpha 0.0908081
RPS3 ribosomal protein S3 0.0759069
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0694085
INHBA inhibin, beta A 0.0666344
RPL4 ribosomal protein L4 0.0649202
VGF VGF nerve growth factor inducible 0.0618594
CALCA calcitonin-related polypeptide alpha 0.0612183
EGR1 early growth response 1 0.0565731
MAP1B microtubule-associated protein 1B 0.0517838
RPS6 ribosomal protein S6 0.0491216
FTL ferritin, light polypeptide 0.0475403
RPS12 ribosomal protein S12 0.0461056
RPL26 ribosomal protein L26 0.045752
MT2A metallothionein 2A 0.0444766
RPL37A ribosomal protein L37a 0.0444297
RPL37 ribosomal protein L37 0.0437682
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0431989
EIF1 eukaryotic translation initiation factor 1 0.0420351
IFI6 interferon, alpha-inducible protein 6 0.0419331
RPS17 ribosomal protein S17 0.0404744
RPS8 ribosomal protein S8 0.0403133
RPS27A ribosomal protein S27a 0.0400622
FNDC3A fibronectin type III domain containing 3A 0.0379492
RPL7 ribosomal protein L7 0.0374823
RPL23 ribosomal protein L23 0.0370173
RPL5 ribosomal protein L5 0.0370065
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.036591
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0365338
ACTG1 actin gamma 1 0.0357674
DSTN destrin (actin depolymerizing factor) 0.0351198
S100A9 S100 calcium binding protein A9 0.0350263
TMSB4X thymosin beta 4, X-linked 0.0349284
RPS19 ribosomal protein S19 0.034354
RPLP1 ribosomal protein, large, P1 0.0331732
KPNB1 karyopherin (importin) beta 1 0.0330734
LOC112694756 uncharaterized LOC112694756 0.0327993
B2M beta-2-microglobulin 0.0318636
RPL31 ribosomal protein L31 0.0315344
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0313775
ATP5F1E ATP synthase F1 subunit epsilon 0.0311012
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0308533
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0307856
PKM pyruvate kinase, muscle 0.0307283
RPL30 ribosomal protein L30 0.0301699
CPE carboxypeptidase E 0.0301193
HLA-A major histocompatibility complex, class I, A 0.0289713
RPS25 ribosomal protein S25 0.0288325
TMSB10 thymosin beta 10 0.0285746
SCG3 secretogranin III 0.0285086
RPL36 ribosomal protein L36 0.0284695
RPL11 ribosomal protein L11 0.0281549
EEF2 eukaryotic translation elongation factor 2 0.0272791
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0267641
ISG15 ISG15 ubiquitin-like modifier 0.0263008
TENT5A terminal nucleotidyltransferase 5A 0.0262436
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0260167
RPL12 ribosomal protein L12 0.0256018
RPS5 ribosomal protein S5 0.0252371
PGK1 phosphoglycerate kinase 1 0.0250415
RPL35 ribosomal protein L35 0.024753
RACK1 receptor for activated C kinase 1 0.0247316
RPL38 ribosomal protein L38 0.0247306
RPS16 ribosomal protein S16 0.0246281
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0239446
LDHA lactate dehydrogenase A 0.0239287
BZW1 basic leucine zipper and W2 domains 1 0.0236744
RPS27 ribosomal protein S27 0.0232536
TPT1 tumor protein, translationally-controlled 1 0.0231641
RPS29 ribosomal protein S29 0.0227127
ATP5F1B ATP synthase F1 subunit beta 0.0226498
SRRM2 serine/arginine repetitive matrix 2 0.0226491
RPL19 ribosomal protein L19 0.0222047
TOP2A topoisomerase (DNA) II alpha 170kDa 0.022115
RPS21 ribosomal protein S21 0.0218626
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0217306
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.0217209
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0215064
CHGB chromogranin B 0.0214269
KIF5B kinesin family member 5B 0.0212554
RPS14 ribosomal protein S14 0.0211285
CALR calreticulin 0.0211051
RPL18 ribosomal protein L18 0.0209944
YBX1 Y box binding protein 1 0.0208897
RPL8 ribosomal protein L8 0.0208779
SET SET nuclear proto-oncogene 0.0208029
TPM3 tropomyosin 3 0.0204084
RPL32 ribosomal protein L32 0.0203832
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0201176
RPL7A ribosomal protein L7a 0.0199671
MXI1 MAX interactor 1, dimerization protein 0.0198558
RPS2 ribosomal protein S2 0.0197588
CHGA chromogranin A 0.0197338
PA2G4 proliferation-associated 2G4, 38kDa 0.0193605
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0192437
RPL34 ribosomal protein L34 0.0191511
RPL35A ribosomal protein L35a 0.019145

decreased expression

Symbol Name Standardized Value
NALF1 NALCN channel auxiliary factor 1 -0.213468
NRG1 neuregulin 1 -0.111489
GPC6 glypican 6 -0.10255
SMYD3 SET and MYND domain containing 3 -0.0861605
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit -0.0697194
ESRRG estrogen-related receptor gamma -0.0634484
RORA RAR-related orphan receptor A -0.0621677
TENM1 teneurin transmembrane protein 1 -0.0611268
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0590838
PDE10A phosphodiesterase 10A -0.0589093
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 -0.0583474
PDE4B phosphodiesterase 4B, cAMP-specific -0.0575208
DTNA dystrobrevin, alpha -0.0573385
GMDS GDP-mannose 4,6-dehydratase -0.0563606
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 -0.0553041
GRB10 growth factor receptor-bound protein 10 -0.0529526
PELI2 pellino E3 ubiquitin protein ligase family member 2 -0.045037
ADGRL3 adhesion G protein-coupled receptor L3 -0.0449978
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0444335
NKAIN2 Na+/K+ transporting ATPase interacting 2 -0.0410541
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.040877
MCTP1 multiple C2 domains, transmembrane 1 -0.0403159
EPHA6 EPH receptor A6 -0.0401526
TRIO trio Rho guanine nucleotide exchange factor -0.0396725
GPC5 glypican 5 -0.0392297
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0391746
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.03824
MSI2 musashi RNA-binding protein 2 -0.0381396
DENND1A DENN/MADD domain containing 1A -0.0376895
CADM1 cell adhesion molecule 1 -0.0367258
BCL2 B-cell CLL/lymphoma 2 -0.0361083
RAD51B RAD51 paralog B -0.0352807
SNTG1 syntrophin, gamma 1 -0.0351024
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0350368
CNTNAP2 contactin associated protein-like 2 -0.0348433
EXT1 exostosin glycosyltransferase 1 -0.0339178
NIPBL Nipped-B homolog (Drosophila) -0.0322148
CHD7 chromodomain helicase DNA binding protein 7 -0.0318874
RPH3AL rabphilin 3A-like (without C2 domains) -0.0316993
TSHZ2 teashirt zinc finger homeobox 2 -0.0312528
FNDC3B fibronectin type III domain containing 3B -0.0305602
MBNL2 muscleblind-like splicing regulator 2 -0.0304469
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) -0.0303224
SCFD2 sec1 family domain containing 2 -0.0299896
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0298836
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0296885
NELL1 NEL-like 1 (chicken) -0.0295647
FHIT fragile histidine triad -0.0293986
NLGN1 neuroligin 1 -0.0292244
PCBP3 poly(rC) binding protein 3 -0.0291272
EFNA5 ephrin-A5 -0.0287419
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0286401
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0286375
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.028283
ADGRL2 adhesion G protein-coupled receptor L2 -0.0279643
AUTS2 autism susceptibility candidate 2 -0.0279162
GRIK1 glutamate receptor, ionotropic, kainate 1 -0.0277274
NOVA1 neuro-oncological ventral antigen 1 -0.0276011
GLS2 glutaminase 2 (liver, mitochondrial) -0.0274946
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0269629
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.026956
NFIA nuclear factor I/A -0.0262761
PSD3 pleckstrin and Sec7 domain containing 3 -0.0257914
RIMS2 regulating synaptic membrane exocytosis 2 -0.0256297
RALYL RALY RNA binding protein-like -0.0253296
SERGEF secretion regulating guanine nucleotide exchange factor -0.0251743
PIAS2 protein inhibitor of activated STAT, 2 -0.0250172
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0249961
EXOC4 exocyst complex component 4 -0.024726
KLHL29 kelch-like family member 29 -0.0243615
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0239012
RPTOR regulatory associated protein of MTOR, complex 1 -0.0238933
ZNF804A zinc finger protein 804A -0.0235934
PTK2 protein tyrosine kinase 2 -0.0235535
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0233435
TOX thymocyte selection-associated high mobility group box -0.0232836
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0232086
JAZF1 JAZF zinc finger 1 -0.0229225
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0228318
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 -0.0226737
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0224843
DACH1 dachshund family transcription factor 1 -0.0224701
NRXN1 neurexin 1 -0.0224475
ASIC2 acid sensing (proton gated) ion channel 2 -0.0224042
TBC1D22A TBC1 domain family, member 22A -0.0221014
PCDH9 protocadherin 9 -0.0218209
RNF213 ring finger protein 213 -0.0217342
AUH AU RNA binding protein/enoyl-CoA hydratase -0.0216614
SYT1 synaptotagmin I -0.0216481
FAF1 Fas (TNFRSF6) associated factor 1 -0.0215383
ANKRD28 ankyrin repeat domain 28 -0.0215382
ERRFI1 ERBB receptor feedback inhibitor 1 -0.021528
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 -0.0214935
CAMTA1 calmodulin binding transcription activator 1 -0.0214426
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0214135
TPD52 tumor protein D52 -0.0213109
EYA2 EYA transcriptional coactivator and phosphatase 2 -0.0212437
PITPNM2 phosphatidylinositol transfer protein, membrane-associated 2 -0.02112
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) -0.0211185
HDAC9 histone deacetylase 9 -0.0207854