| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | SBI-0640756 perturbation in SK-MEL-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the SBI-0640756_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.12527 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.115852 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0917348 |
| ANGPTL4 | angiopoietin-like 4 | 0.0820207 |
| ENO1 | enolase 1, (alpha) | 0.0644902 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0619424 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0571999 |
| ASPH | aspartate beta-hydroxylase | 0.053266 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0529357 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0526116 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0483315 |
| RNF213 | ring finger protein 213 | 0.0467744 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0466636 |
| SQSTM1 | sequestosome 1 | 0.0418781 |
| HLA-B | major histocompatibility complex, class I, B | 0.0401969 |
| ATF4 | activating transcription factor 4 | 0.0389813 |
| HLA-A | major histocompatibility complex, class I, A | 0.0378512 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.0376984 |
| RUNX1 | runt-related transcription factor 1 | 0.0375202 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0368119 |
| ADAR | adenosine deaminase, RNA-specific | 0.0357418 |
| FLNA | filamin A, alpha | 0.0350681 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.034231 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0334224 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.032384 |
| RPS17 | ribosomal protein S17 | 0.0318035 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0317879 |
| PKM | pyruvate kinase, muscle | 0.0315142 |
| TLN1 | talin 1 | 0.031187 |
| TPI1 | triosephosphate isomerase 1 | 0.030625 |
| RPS3 | ribosomal protein S3 | 0.029876 |
| CCND1 | cyclin D1 | 0.0297647 |
| EHBP1 | EH domain binding protein 1 | 0.0293281 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0292385 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0290773 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0289561 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0287121 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.027971 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0278017 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.0271831 |
| SVIL | supervillin | 0.0271351 |
| TENM3 | teneurin transmembrane protein 3 | 0.026762 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0265102 |
| SATB2 | SATB homeobox 2 | 0.0264074 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | 0.0262257 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0260417 |
| RPS12 | ribosomal protein S12 | 0.0256154 |
| EFCAB13 | EF-hand calcium binding domain 13 | 0.0252799 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | 0.0251195 |
| IFI44L | interferon-induced protein 44-like | 0.0243963 |
| INTS6 | integrator complex subunit 6 | 0.0243857 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0243549 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0241852 |
| GOLGB1 | golgin B1 | 0.0240879 |
| S100A13 | S100 calcium binding protein A13 | 0.0238549 |
| BPTF | bromodomain PHD finger transcription factor | 0.0235712 |
| WNT2B | wingless-type MMTV integration site family, member 2B | 0.023478 |
| BRD2 | bromodomain containing 2 | 0.0234634 |
| CHMP5 | charged multivesicular body protein 5 | 0.0228565 |
| SHISA5 | shisa family member 5 | 0.0228541 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.022671 |
| CHRM3 | cholinergic receptor, muscarinic 3 | 0.0225517 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0223771 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0218986 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0217315 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0216901 |
| CREBBP | CREB binding protein | 0.021647 |
| AMOTL1 | angiomotin like 1 | 0.0216017 |
| WAPL | WAPL cohesin release factor | 0.0211194 |
| CADM2 | cell adhesion molecule 2 | 0.0210647 |
| PLEC | plectin | 0.0210302 |
| TULP4 | tubby like protein 4 | 0.0208969 |
| LRAT | lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) | 0.0204618 |
| FRMD4A | FERM domain containing 4A | 0.0204447 |
| PARP12 | poly (ADP-ribose) polymerase family, member 12 | 0.0203173 |
| SMAD3 | SMAD family member 3 | 0.0202798 |
| EGR1 | early growth response 1 | 0.0202492 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0200639 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.020043 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0200262 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0199994 |
| MTAP | methylthioadenosine phosphorylase | 0.0198916 |
| DNM3 | dynamin 3 | 0.0198868 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | 0.0198646 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.0198541 |
| OGA | O-GlcNAcase | 0.0197989 |
| LRRC23 | leucine rich repeat containing 23 | 0.0197635 |
| KIF5B | kinesin family member 5B | 0.0197374 |
| SOX10 | SRY (sex determining region Y)-box 10 | 0.0197054 |
| BAZ1B | bromodomain adjacent to zinc finger domain, 1B | 0.0195788 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0195651 |
| CYB5R3 | cytochrome b5 reductase 3 | 0.0195372 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0195087 |
| KYNU | kynureninase | 0.0194479 |
| FBXO11 | F-box protein 11 | 0.0191199 |
| RPL31 | ribosomal protein L31 | 0.0190199 |
| PARD3B | par-3 family cell polarity regulator beta | 0.018999 |
| LOC112694756 | uncharaterized LOC112694756 | 0.018994 |
| DHX40 | DEAH (Asp-Glu-Ala-His) box polypeptide 40 | 0.0188816 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0188606 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.140472 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.132292 |
| FN1 | fibronectin 1 | -0.0983914 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0800757 |
| FMN1 | formin 1 | -0.0620683 |
| SPAG9 | sperm associated antigen 9 | -0.0574211 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0544524 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0537708 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0499975 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0493992 |
| GOLGA4 | golgin A4 | -0.0488857 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0474675 |
| VIM | vimentin | -0.0445787 |
| LSAMP | limbic system-associated membrane protein | -0.0441166 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0431651 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0428922 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0425167 |
| CANX | calnexin | -0.0418858 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0403351 |
| TXNRD1 | thioredoxin reductase 1 | -0.0401953 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0385101 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0378888 |
| PMEL | premelanosome protein | -0.036929 |
| RPL23 | ribosomal protein L23 | -0.0364324 |
| RHOA | ras homolog family member A | -0.0362064 |
| SBF2 | SET binding factor 2 | -0.0361299 |
| TENM1 | teneurin transmembrane protein 1 | -0.0359641 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0345422 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0345399 |
| TRIM33 | tripartite motif containing 33 | -0.0344199 |
| SFTPA2 | surfactant protein A2 | -0.0338739 |
| CENPF | centromere protein F, 350/400kDa | -0.0338158 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0323747 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0316497 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0316207 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0316105 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.0315809 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0309445 |
| STAG2 | stromal antigen 2 | -0.0308558 |
| CLIC4 | chloride intracellular channel 4 | -0.0308346 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0307706 |
| RNF145 | ring finger protein 145 | -0.030762 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0305902 |
| KLF6 | Kruppel-like factor 6 | -0.029966 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0297709 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0291536 |
| OLA1 | Obg-like ATPase 1 | -0.0290516 |
| TSC22D2 | TSC22 domain family, member 2 | -0.029015 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0287023 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0284807 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0284149 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0280234 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0280006 |
| UBC | ubiquitin C | -0.0278446 |
| SETD5 | SET domain containing 5 | -0.0277294 |
| EMP1 | epithelial membrane protein 1 | -0.027471 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0274384 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0270544 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.0268645 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0268012 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0266882 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0265252 |
| NGLY1 | N-glycanase 1 | -0.0264781 |
| MSN | moesin | -0.0264728 |
| CLTC | clathrin, heavy chain (Hc) | -0.0262732 |
| WDR36 | WD repeat domain 36 | -0.0261789 |
| TPD52 | tumor protein D52 | -0.026142 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0260815 |
| KLHL24 | kelch-like family member 24 | -0.0260387 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0259088 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0258917 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0256446 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0256234 |
| YEATS2 | YEATS domain containing 2 | -0.0254756 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0254617 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | -0.0253632 |
| SNX9 | sorting nexin 9 | -0.0253415 |
| CALU | calumenin | -0.025109 |
| ANLN | anillin, actin binding protein | -0.0250969 |
| CUL3 | cullin 3 | -0.0250891 |
| DSCAM | Down syndrome cell adhesion molecule | -0.024997 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0247738 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0247646 |
| MT1X | metallothionein 1X | -0.0247058 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0245522 |
| JMJD1C | jumonji domain containing 1C | -0.024534 |
| ZNF292 | zinc finger protein 292 | -0.0242667 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0242484 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0241513 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0241187 |
| KAZN | kazrin, periplakin interacting protein | -0.0238075 |
| CSNK1E | casein kinase 1, epsilon | -0.02363 |
| SCARB2 | scavenger receptor class B, member 2 | -0.0234403 |
| GLG1 | golgi glycoprotein 1 | -0.0234261 |
| SEPTIN7 | septin 7 | -0.0233649 |
| RPS23 | ribosomal protein S23 | -0.0231772 |
| AKAP10 | A kinase (PRKA) anchor protein 10 | -0.0231374 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.022959 |
| QKI | QKI, KH domain containing, RNA binding | -0.0229345 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | -0.0229205 |
