SBI-0640756_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description SBI-0640756 perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the SBI-0640756_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.156118
MT2A metallothionein 2A 0.100167
TMSB10 thymosin beta 10 0.0945661
FTH1 ferritin, heavy polypeptide 1 0.0907321
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0862694
IGF2 insulin-like growth factor 2 0.0835003
FTL ferritin, light polypeptide 0.0723237
MAP1B microtubule-associated protein 1B 0.0679643
RPS6 ribosomal protein S6 0.0662786
CALR calreticulin 0.0649608
KMT2E lysine (K)-specific methyltransferase 2E 0.0615874
B2M beta-2-microglobulin 0.0614636
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0527313
DST dystonin 0.0524292
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0517349
PKM pyruvate kinase, muscle 0.0514913
SRRM2 serine/arginine repetitive matrix 2 0.0499605
STC2 stanniocalcin 2 0.0496115
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0478503
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0472569
AKAP9 A kinase (PRKA) anchor protein 9 0.0453188
TLN1 talin 1 0.0452259
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0423094
SAMD4A sterile alpha motif domain containing 4A 0.040254
TPI1 triosephosphate isomerase 1 0.0400764
ANKRD12 ankyrin repeat domain 12 0.0395143
KYNU kynureninase 0.0382625
ACTG1 actin gamma 1 0.0379857
POTEF POTE ankyrin domain family, member F 0.0376603
TIMP1 TIMP metallopeptidase inhibitor 1 0.0376227
IFI44 interferon-induced protein 44 0.0372368
SP100 SP100 nuclear antigen 0.0370254
RPS12 ribosomal protein S12 0.0365509
IGFBP7 insulin-like growth factor binding protein 7 0.0363913
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0361253
DSCAM Down syndrome cell adhesion molecule 0.0359462
HLA-B major histocompatibility complex, class I, B 0.0352369
BSG basigin (Ok blood group) 0.0352158
ZBTB38 zinc finger and BTB domain containing 38 0.0351222
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0350062
RPL5 ribosomal protein L5 0.0345689
PARD3 par-3 family cell polarity regulator 0.0341047
AKAP12 A kinase (PRKA) anchor protein 12 0.0336852
IL6 interleukin 6 0.0335528
IGFBP3 insulin-like growth factor binding protein 3 0.033465
STC1 stanniocalcin 1 0.0333655
MYOF myoferlin 0.0330528
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0328353
SKAP2 src kinase associated phosphoprotein 2 0.0322949
MDK midkine (neurite growth-promoting factor 2) 0.0321875
CERT1 ceramide transporter 1 0.0319307
ENO1 enolase 1, (alpha) 0.0315007
SET SET nuclear proto-oncogene 0.031106
CALD1 caldesmon 1 0.0296003
RPS8 ribosomal protein S8 0.0294667
TXNIP thioredoxin interacting protein 0.029429
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0293402
SH3GLB1 SH3-domain GRB2-like endophilin B1 0.0292733
TNPO3 transportin 3 0.0291316
S100A9 S100 calcium binding protein A9 0.0291069
L1CAM L1 cell adhesion molecule 0.0290007
RBM25 RNA binding motif protein 25 0.0281128
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0275606
TXNRD1 thioredoxin reductase 1 0.0273625
VEGFA vascular endothelial growth factor A 0.0271957
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.0270796
LOXL2 lysyl oxidase-like 2 0.0270227
ATM ATM serine/threonine kinase 0.0264018
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 0.026186
TOM1L2 target of myb1-like 2 (chicken) 0.0257382
RPS17 ribosomal protein S17 0.0252527
LAMP2 lysosomal-associated membrane protein 2 0.0251992
POMP proteasome maturation protein 0.0251697
RPS19 ribosomal protein S19 0.0250935
RPS2 ribosomal protein S2 0.0249692
GTF2I general transcription factor IIi 0.024939
PMP22 peripheral myelin protein 22 0.0249284
FAT1 FAT atypical cadherin 1 0.0249234
SMYD3 SET and MYND domain containing 3 0.0246037
PRRC2C proline-rich coiled-coil 2C 0.0245061
PID1 phosphotyrosine interaction domain containing 1 0.0243695
PTPRK protein tyrosine phosphatase, receptor type, K 0.0242182
SPATA6 spermatogenesis associated 6 0.024181
ERGIC3 ERGIC and golgi 3 0.0240495
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0239736
SOX9 SRY (sex determining region Y)-box 9 0.0239413
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.023772
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0236499
KTN1 kinectin 1 (kinesin receptor) 0.0235927
AXL AXL receptor tyrosine kinase 0.0235899
MLF1 myeloid leukemia factor 1 0.0235888
HILPDA hypoxia inducible lipid droplet-associated 0.0235252
RHBDF2 rhomboid 5 homolog 2 (Drosophila) 0.023444
CREB5 cAMP responsive element binding protein 5 0.0233873
TGFB2 transforming growth factor, beta 2 0.0233476
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.0229446
UGCG UDP-glucose ceramide glucosyltransferase 0.0228558
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0227022
STK4 serine/threonine kinase 4 0.0225349
MAST2 microtubule associated serine/threonine kinase 2 0.0221828

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.193934
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.135961
VIM vimentin -0.071239
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0655348
SPDYA speedy/RINGO cell cycle regulator family member A -0.0601801
DPYD dihydropyrimidine dehydrogenase -0.0591085
PSD3 pleckstrin and Sec7 domain containing 3 -0.0559125
SEC31A SEC31 homolog A (S. cerevisiae) -0.0549331
HMGA2 high mobility group AT-hook 2 -0.0540187
GOLGA4 golgin A4 -0.0535365
AHNAK AHNAK nucleoprotein -0.05189
BIRC6 baculoviral IAP repeat containing 6 -0.0514758
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0503756
SEC24D SEC24 family member D -0.0500366
KMT2C lysine (K)-specific methyltransferase 2C -0.0496764
CALU calumenin -0.048994
CDH13 cadherin 13 -0.0488079
SOD2 superoxide dismutase 2, mitochondrial -0.0465532
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0457239
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0441716
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0438068
NDRG1 N-myc downstream regulated 1 -0.0431269
HM13 histocompatibility (minor) 13 -0.0420691
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.041694
PDLIM5 PDZ and LIM domain 5 -0.040653
PGK1 phosphoglycerate kinase 1 -0.0404445
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0392779
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0391537
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0385128
COL6A3 collagen, type VI, alpha 3 -0.0382324
EFNA5 ephrin-A5 -0.0382133
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0380954
CADM1 cell adhesion molecule 1 -0.0375434
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0373297
CLIC4 chloride intracellular channel 4 -0.0370268
TMEM263 transmembrane protein 263 -0.0369535
RAB1A RAB1A, member RAS oncogene family -0.0367522
LPP LIM domain containing preferred translocation partner in lipoma -0.0366559
KAZN kazrin, periplakin interacting protein -0.0363996
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0361041
CA12 carbonic anhydrase XII -0.0356539
RUNX1 runt-related transcription factor 1 -0.0354049
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0348202
MMP12 matrix metallopeptidase 12 -0.0347856
DKK3 dickkopf WNT signaling pathway inhibitor 3 -0.0336525
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0334177
LOX lysyl oxidase -0.0329606
ANKHD1 ankyrin repeat and KH domain containing 1 -0.032936
BZW1 basic leucine zipper and W2 domains 1 -0.0328829
GLS2 glutaminase 2 (liver, mitochondrial) -0.0328685
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.032166
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0318266
HIPK2 homeodomain interacting protein kinase 2 -0.0317995
GCC2 GRIP and coiled-coil domain containing 2 -0.0317486
GLIS3 GLIS family zinc finger 3 -0.0314898
MCL1 myeloid cell leukemia 1 -0.0313639
RBM33 RNA binding motif protein 33 -0.0312906
NKTR natural killer cell triggering receptor -0.0309752
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0307689
STAU1 staufen double-stranded RNA binding protein 1 -0.0306615
NAV2 neuron navigator 2 -0.0306457
PHF21A PHD finger protein 21A -0.0305076
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0303257
PNPLA8 patatin-like phospholipase domain containing 8 -0.0302495
NBEAL1 neurobeachin-like 1 -0.029803
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 -0.0295393
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0291594
ATP13A3 ATPase type 13A3 -0.0291058
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0283435
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0283127
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0280561
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0278168
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0277837
BACE2 beta-site APP-cleaving enzyme 2 -0.0276388
COPB1 coatomer protein complex, subunit beta 1 -0.0274691
RAB7A RAB7A, member RAS oncogene family -0.0274085
QKI QKI, KH domain containing, RNA binding -0.0273437
EXT1 exostosin glycosyltransferase 1 -0.0268829
TAS2R14 taste receptor, type 2, member 14 -0.0266972
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0266533
RINT1 RAD50 interactor 1 -0.0265351
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0264058
ANLN anillin, actin binding protein -0.0263924
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 -0.0263679
FAM3C family with sequence similarity 3, member C -0.0262276
LASP1 LIM and SH3 protein 1 -0.0261033
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0256955
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0256876
RPS23 ribosomal protein S23 -0.0256293
CLMP CXADR-like membrane protein -0.025583
PUM2 pumilio RNA-binding family member 2 -0.0254023
AFF3 AF4/FMR2 family, member 3 -0.0251083
SETBP1 SET binding protein 1 -0.025051
MACF1 microtubule-actin crosslinking factor 1 -0.0248082
LTN1 listerin E3 ubiquitin protein ligase 1 -0.0244573
HLA-C major histocompatibility complex, class I, C -0.0242672
SKIC3 SKI3 subunit of superkiller complex -0.0238956
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0238833
PRELID2 PRELI domain containing 2 -0.0238032
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0236965