SBI-0640756_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description SBI-0640756 perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the SBI-0640756_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 0.0788436
IGFBP3 insulin-like growth factor binding protein 3 0.0670103
PRRC2C proline-rich coiled-coil 2C 0.0618794
INTS6 integrator complex subunit 6 0.0596269
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.057401
PTK2 protein tyrosine kinase 2 0.0550109
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0544114
ANGPTL4 angiopoietin-like 4 0.0489036
ENO2 enolase 2 (gamma, neuronal) 0.0477342
RPS3 ribosomal protein S3 0.047358
FBXL7 F-box and leucine-rich repeat protein 7 0.0447099
BASP1 brain abundant, membrane attached signal protein 1 0.044247
MT2A metallothionein 2A 0.0431977
BICD1 bicaudal D homolog 1 (Drosophila) 0.0426968
RPS20 ribosomal protein S20 0.0420204
RPL31 ribosomal protein L31 0.0418149
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0417062
TMSB10 thymosin beta 10 0.0414727
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0406756
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0404321
RAI14 retinoic acid induced 14 0.0396962
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.0384088
CEP350 centrosomal protein 350kDa 0.0378427
AHNAK2 AHNAK nucleoprotein 2 0.0375004
GPC5 glypican 5 0.0373926
RPL37A ribosomal protein L37a 0.0371614
RPLP1 ribosomal protein, large, P1 0.0370661
BRD4 bromodomain containing 4 0.0365582
SMAD3 SMAD family member 3 0.0364853
TPM4 tropomyosin 4 0.0364139
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0363217
DOCK5 dedicator of cytokinesis 5 0.0358023
CTIF CBP80/20-dependent translation initiation factor 0.0343455
ARHGAP21 Rho GTPase activating protein 21 0.0343079
NIPBL Nipped-B homolog (Drosophila) 0.0339816
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0339724
RPS12 ribosomal protein S12 0.0339642
RPL26 ribosomal protein L26 0.0337689
ITGA10 integrin, alpha 10 0.0337067
GPC6 glypican 6 0.0335019
IRAK2 interleukin-1 receptor-associated kinase 2 0.033407
ASPH aspartate beta-hydroxylase 0.0330243
FTH1 ferritin, heavy polypeptide 1 0.0327857
PTMA prothymosin, alpha 0.0326587
RPL9 ribosomal protein L9 0.031713
GPBP1 GC-rich promoter binding protein 1 0.030626
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0303506
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0300285
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.029521
NAV2 neuron navigator 2 0.0294129
ARLN allregulin 0.029008
SHB Src homology 2 domain containing adaptor protein B 0.0289679
CDC73 cell division cycle 73 0.0285056
RPS6 ribosomal protein S6 0.0279096
ZSWIM6 zinc finger, SWIM-type containing 6 0.0278198
CEMIP2 cell migration inducing hyaluronidase 2 0.0274249
RPLP2 ribosomal protein, large, P2 0.0271866
TBC1D32 TBC1 domain family, member 32 0.0271665
KMT5B lysine methyltransferase 5B 0.027079
ARHGAP12 Rho GTPase activating protein 12 0.0268919
KIZ kizuna centrosomal protein 0.0266461
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0264058
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.0263571
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0262953
RPL11 ribosomal protein L11 0.0262391
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0258891
ITGB5 integrin, beta 5 0.0258542
LPP LIM domain containing preferred translocation partner in lipoma 0.0256224
DST dystonin 0.0255851
GOLGA4 golgin A4 0.0254228
NEK1 NIMA-related kinase 1 0.0252643
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) 0.0251972
APLP2 amyloid beta (A4) precursor-like protein 2 0.0251965
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0251059
EXT1 exostosin glycosyltransferase 1 0.0250936
TMEM87B transmembrane protein 87B 0.0249925
WSB1 WD repeat and SOCS box containing 1 0.024384
EGR1 early growth response 1 0.0242802
KLF12 Kruppel-like factor 12 0.0241506
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0241169
SCYL2 SCY1-like 2 (S. cerevisiae) 0.0240508
VBP1 von Hippel-Lindau binding protein 1 0.024001
EIF5B eukaryotic translation initiation factor 5B 0.0238674
TLN1 talin 1 0.0238612
ADM adrenomedullin 0.0237212
TMED3 transmembrane emp24 protein transport domain containing 3 0.0236171
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 0.0235504
CDK17 cyclin-dependent kinase 17 0.0233998
MACF1 microtubule-actin crosslinking factor 1 0.0231426
SRSF11 serine/arginine-rich splicing factor 11 0.0230828
SYNJ2 synaptojanin 2 0.0230239
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.0230059
NFE2L2 nuclear factor, erythroid 2-like 2 0.0230023
GMDS GDP-mannose 4,6-dehydratase 0.0228361
RRBP1 ribosome binding protein 1 0.0227885
LRRC69 leucine rich repeat containing 69 0.0225088
IL1RAP interleukin 1 receptor accessory protein 0.0224991
WHRN whirlin 0.0224613
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0224312
RSRP1 arginine/serine-rich protein 1 0.0224113

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.282721
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0593521
ITCH itchy E3 ubiquitin protein ligase -0.0488121
GNAS GNAS complex locus -0.0446845
DPYD dihydropyrimidine dehydrogenase -0.0427053
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.0407029
ZFAND3 zinc finger, AN1-type domain 3 -0.0404992
MBNL1 muscleblind-like splicing regulator 1 -0.0392724
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0390543
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0387267
RTN4 reticulon 4 -0.0380455
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0376983
MED13 mediator complex subunit 13 -0.037247
DERA deoxyribose-phosphate aldolase (putative) -0.0368309
RBM39 RNA binding motif protein 39 -0.0356562
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0348225
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0346077
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.034145
CD44 CD44 molecule (Indian blood group) -0.032895
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0328437
YAP1 Yes-associated protein 1 -0.0326519
DENND4A DENN/MADD domain containing 4A -0.0323391
EXOC4 exocyst complex component 4 -0.0322084
YBX3 Y box binding protein 3 -0.0320389
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0317579
DENND5B DENN/MADD domain containing 5B -0.0312115
TXNRD1 thioredoxin reductase 1 -0.0309934
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.030659
OASL 2'-5'-oligoadenylate synthetase-like -0.0304427
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0304133
MAP1B microtubule-associated protein 1B -0.0302572
OSMR oncostatin M receptor -0.0302351
ATF7IP activating transcription factor 7 interacting protein -0.0301893
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0301044
ARL15 ADP-ribosylation factor-like 15 -0.0297201
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0284106
KDM5A lysine (K)-specific demethylase 5A -0.0283316
ANKRD28 ankyrin repeat domain 28 -0.0282864
ZNF638 zinc finger protein 638 -0.0280685
ZNF644 zinc finger protein 644 -0.0276834
PRH1 proline-rich protein HaeIII subfamily 1 -0.0276621
VCL vinculin -0.0275775
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0274788
SRPK2 SRSF protein kinase 2 -0.0274728
CAPN7 calpain 7 -0.0272053
N4BP2L2 NEDD4 binding protein 2-like 2 -0.027179
WAC WW domain containing adaptor with coiled-coil -0.0271681
NUP58 nucleoporin 58 -0.026988
EHMT1 euchromatic histone-lysine N-methyltransferase 1 -0.0267089
VEZT vezatin, adherens junctions transmembrane protein -0.0265918
TAS2R14 taste receptor, type 2, member 14 -0.0263979
RANBP9 RAN binding protein 9 -0.0257492
SLC38A1 solute carrier family 38, member 1 -0.0256037
NPTN neuroplastin -0.0254012
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.025393
JARID2 jumonji, AT rich interactive domain 2 -0.0250792
ARHGAP5 Rho GTPase activating protein 5 -0.0250294
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0247455
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0247275
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0246469
ECT2 epithelial cell transforming 2 -0.0245205
RAB1A RAB1A, member RAS oncogene family -0.0243747
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0241214
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0240867
PKM pyruvate kinase, muscle -0.0240715
AEBP2 AE binding protein 2 -0.0240484
JMJD1C jumonji domain containing 1C -0.0239019
UBAC2 UBA domain containing 2 -0.0238562
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0238329
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0237996
FBXL17 F-box and leucine-rich repeat protein 17 -0.0237654
UBE2H ubiquitin-conjugating enzyme E2H -0.0234243
DIAPH3 diaphanous-related formin 3 -0.0234074
SLC36A4 solute carrier family 36 (proton/amino acid symporter), member 4 -0.0230636
LDHA lactate dehydrogenase A -0.0229857
SQSTM1 sequestosome 1 -0.02292
DTNA dystrobrevin, alpha -0.0228348
DNER delta/notch-like EGF repeat containing -0.022429
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0222472
WASHC4 WASH complex subunit 4 -0.0220502
NUP98 nucleoporin 98kDa -0.0219998
MED13L mediator complex subunit 13-like -0.0219142
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0218792
ANKRD12 ankyrin repeat domain 12 -0.0218427
BCAS3 breast carcinoma amplified sequence 3 -0.0215963
PALS1 protein associated with LIN7 1, MAGUK p55 family member -0.0215443
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.021466
RAB5A RAB5A, member RAS oncogene family -0.0214221
AHNAK AHNAK nucleoprotein -0.0214079
SMC4 structural maintenance of chromosomes 4 -0.0213977
BAZ1A bromodomain adjacent to zinc finger domain, 1A -0.0213053
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0212425
EPC1 enhancer of polycomb homolog 1 (Drosophila) -0.0210617
IGF1R insulin-like growth factor 1 receptor -0.0210439
ADAM17 ADAM metallopeptidase domain 17 -0.0209894
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0209283
EXOC2 exocyst complex component 2 -0.0208956
TM9SF2 transmembrane 9 superfamily member 2 -0.0208551
TUBA1B tubulin, alpha 1b -0.0208352
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0207679