SBI-0640756_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description SBI-0640756 perturbation in SW1417 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the SBI-0640756_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.212192
FTH1 ferritin, heavy polypeptide 1 0.108285
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.105861
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0827342
AKAP12 A kinase (PRKA) anchor protein 12 0.0686203
RPS3 ribosomal protein S3 0.06762
EPS8 epidermal growth factor receptor pathway substrate 8 0.0642718
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.0637641
RPS6 ribosomal protein S6 0.0590684
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.059054
TOP1 topoisomerase (DNA) I 0.0582989
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0530673
MATR3 matrin 3 0.0524523
ERBIN erbb2 interacting protein 0.0506336
RPL4 ribosomal protein L4 0.0485302
ZNF292 zinc finger protein 292 0.0469532
TMSB10 thymosin beta 10 0.0462437
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0460054
MKI67 marker of proliferation Ki-67 0.0455795
RPL18 ribosomal protein L18 0.0439123
BHLHE40 basic helix-loop-helix family, member e40 0.0438095
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.0432944
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0419178
EIF1 eukaryotic translation initiation factor 1 0.0402059
EPCAM epithelial cell adhesion molecule 0.0399564
RPL12 ribosomal protein L12 0.0393995
RPS12 ribosomal protein S12 0.0383687
HLA-A major histocompatibility complex, class I, A 0.0375001
RPL13A ribosomal protein L13a 0.0374316
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0373089
SNX9 sorting nexin 9 0.0363537
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0363001
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0361676
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0351277
GCC2 GRIP and coiled-coil domain containing 2 0.0350563
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0347784
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0344713
ENO1 enolase 1, (alpha) 0.0340434
TGFA transforming growth factor, alpha 0.0338835
FTL ferritin, light polypeptide 0.033794
MED13L mediator complex subunit 13-like 0.0334591
KRT19 keratin 19, type I 0.0333976
STAU1 staufen double-stranded RNA binding protein 1 0.0331084
PIAS1 protein inhibitor of activated STAT, 1 0.0329418
RPS2 ribosomal protein S2 0.0328814
RPL35A ribosomal protein L35a 0.0328437
LOC112694756 uncharaterized LOC112694756 0.032821
RPL37A ribosomal protein L37a 0.0327022
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.032394
PLAUR plasminogen activator, urokinase receptor 0.0323848
EEF2 eukaryotic translation elongation factor 2 0.0323513
TMEM41B transmembrane protein 41B 0.0322477
RPL36 ribosomal protein L36 0.0321409
PHF14 PHD finger protein 14 0.0321023
IWS1 IWS1 homolog (S. cerevisiae) 0.0316569
LAMC2 laminin, gamma 2 0.0315683
TGFBI transforming growth factor, beta-induced, 68kDa 0.0315337
RACK1 receptor for activated C kinase 1 0.0308116
PA2G4 proliferation-associated 2G4, 38kDa 0.0301491
BRD2 bromodomain containing 2 0.0298869
DSPP dentin sialophosphoprotein 0.0297475
CST3 cystatin C 0.029666
NRIP1 nuclear receptor interacting protein 1 0.029608
KTN1 kinectin 1 (kinesin receptor) 0.0295974
SNRK SNF related kinase 0.0295455
S100A2 S100 calcium binding protein A2 0.0294911
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0292791
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0290879
STK38L serine/threonine kinase 38 like 0.0286746
KRT18 keratin 18, type I 0.0286599
EHF ets homologous factor 0.0283346
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0282714
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0280505
JUN jun proto-oncogene 0.0280196
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.027876
FNDC3A fibronectin type III domain containing 3A 0.0278478
WSB1 WD repeat and SOCS box containing 1 0.0275692
YBX1 Y box binding protein 1 0.0273275
KIF5B kinesin family member 5B 0.0273123
PRRC2C proline-rich coiled-coil 2C 0.027182
RPS5 ribosomal protein S5 0.0268951
RPL30 ribosomal protein L30 0.0267179
RPL26 ribosomal protein L26 0.0254558
LAMB3 laminin, beta 3 0.0253814
RPL39 ribosomal protein L39 0.0253711
CALR calreticulin 0.0252868
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa 0.0252671
ACTG1 actin gamma 1 0.0252444
RAB30 RAB30, member RAS oncogene family 0.025196
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0250503
GOLGA4 golgin A4 0.0249605
IFI6 interferon, alpha-inducible protein 6 0.0249309
S100A6 S100 calcium binding protein A6 0.0249226
LIMA1 LIM domain and actin binding 1 0.0248996
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0247998
RPS27A ribosomal protein S27a 0.0246723
RAN RAN, member RAS oncogene family 0.0246391
CBFB core-binding factor, beta subunit 0.024369
AKAP9 A kinase (PRKA) anchor protein 9 0.0242806
ADAM17 ADAM metallopeptidase domain 17 0.0242324

decreased expression

Symbol Name Standardized Value
MAML2 mastermind-like 2 (Drosophila) -0.162643
CEMIP cell migration inducing protein, hyaluronan binding -0.107974
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.103166
SDK1 sidekick cell adhesion molecule 1 -0.100707
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0852672
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0803462
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0775878
ZBTB20 zinc finger and BTB domain containing 20 -0.0767221
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0687683
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0684762
FRMD5 FERM domain containing 5 -0.0663713
FNDC3B fibronectin type III domain containing 3B -0.0591994
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0540481
EHBP1 EH domain binding protein 1 -0.0529534
GMDS GDP-mannose 4,6-dehydratase -0.0528881
IFRD1 interferon-related developmental regulator 1 -0.0482884
NAV2 neuron navigator 2 -0.0480809
MSI2 musashi RNA-binding protein 2 -0.0470261
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.046719
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.045474
NFIA nuclear factor I/A -0.0448916
NEBL nebulette -0.0446219
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0444655
EXOC4 exocyst complex component 4 -0.0431447
USP34 ubiquitin specific peptidase 34 -0.0431234
CDK13 cyclin-dependent kinase 13 -0.0425575
OSBPL10 oxysterol binding protein-like 10 -0.0416589
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0410342
PTK2 protein tyrosine kinase 2 -0.0404159
DLG1 discs, large homolog 1 (Drosophila) -0.0394774
SAMD4A sterile alpha motif domain containing 4A -0.0386988
AGO2 argonaute RISC catalytic component 2 -0.038348
CADPS Ca++-dependent secretion activator -0.0381355
CEMIP2 cell migration inducing hyaluronidase 2 -0.0380183
RUNX1 runt-related transcription factor 1 -0.0375507
PRELID2 PRELI domain containing 2 -0.0370402
ADNP activity-dependent neuroprotector homeobox -0.0365203
VCL vinculin -0.036111
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.0360437
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0354861
MBNL1 muscleblind-like splicing regulator 1 -0.035377
MAP4 microtubule-associated protein 4 -0.0353569
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0344963
PTPRK protein tyrosine phosphatase, receptor type, K -0.0339868
PATJ PATJ crumbs cell polarity complex component -0.0335775
NKD1 naked cuticle homolog 1 (Drosophila) -0.0332954
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0332858
NABP1 nucleic acid binding protein 1 -0.0331608
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0327688
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0324992
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.0318819
MYH14 myosin, heavy chain 14, non-muscle -0.0315804
RAD51B RAD51 paralog B -0.0308564
NDRG1 N-myc downstream regulated 1 -0.0306294
COBL cordon-bleu WH2 repeat protein -0.0306062
ATXN1 ataxin 1 -0.0305149
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0301605
CTBP2 C-terminal binding protein 2 -0.0299334
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0298105
RNF43 ring finger protein 43 -0.0294008
ZNRF3 zinc and ring finger 3 -0.0287073
GLS2 glutaminase 2 (liver, mitochondrial) -0.0284757
CDK6 cyclin-dependent kinase 6 -0.0279542
CARD16 caspase recruitment domain family, member 16 -0.0279387
SND1 staphylococcal nuclease and tudor domain containing 1 -0.027579
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0273516
TRAPPC9 trafficking protein particle complex 9 -0.0272465
PCLO piccolo presynaptic cytomatrix protein -0.0271358
ESYT2 extended synaptotagmin-like protein 2 -0.02712
INTS6 integrator complex subunit 6 -0.0265738
EZR ezrin -0.0262686
EFNB2 ephrin-B2 -0.0259809
TSC22D2 TSC22 domain family, member 2 -0.0257303
AHNAK AHNAK nucleoprotein -0.0254389
PUM2 pumilio RNA-binding family member 2 -0.0252947
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0252515
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H -0.0248505
GOLGB1 golgin B1 -0.0248493
PPP4R2 protein phosphatase 4, regulatory subunit 2 -0.0248343
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0246611
PRKCE protein kinase C, epsilon -0.0245021
PELI2 pellino E3 ubiquitin protein ligase family member 2 -0.0243979
BBX bobby sox homolog (Drosophila) -0.024391
DENND1A DENN/MADD domain containing 1A -0.0243906
SLC38A2 solute carrier family 38, member 2 -0.0241419
PCSK5 proprotein convertase subtilisin/kexin type 5 -0.0240103
NHSL1 NHS-like 1 -0.0239523
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0238783
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -0.0238587
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.023784
HMGA2 high mobility group AT-hook 2 -0.0237799
ACTN4 actinin, alpha 4 -0.0236256
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma -0.0235162
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0232905
ARF4 ADP-ribosylation factor 4 -0.0231349
ARHGAP12 Rho GTPase activating protein 12 -0.0230968
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.0230797
SFPQ splicing factor proline/glutamine-rich -0.0225848
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0225514
METTL15 methyltransferase like 15 -0.0224633