SBI-0640756_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description SBI-0640756 perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the SBI-0640756_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.1966
RPS12 ribosomal protein S12 0.108454
RPS3 ribosomal protein S3 0.0985491
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0944077
RPS6 ribosomal protein S6 0.0880027
RPL35A ribosomal protein L35a 0.0844488
AREG amphiregulin 0.0826272
TMSB10 thymosin beta 10 0.0753408
EIF1 eukaryotic translation initiation factor 1 0.0640345
RPS8 ribosomal protein S8 0.0625318
IER3 immediate early response 3 0.0608386
RPL37A ribosomal protein L37a 0.0605414
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0604603
RPL26 ribosomal protein L26 0.0564304
EGR1 early growth response 1 0.0551745
RPS17 ribosomal protein S17 0.0533284
RPS19 ribosomal protein S19 0.0517856
BIRC3 baculoviral IAP repeat containing 3 0.047718
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0473624
RPL9 ribosomal protein L9 0.0473616
SQSTM1 sequestosome 1 0.0464394
FTL ferritin, light polypeptide 0.0450326
RPL12 ribosomal protein L12 0.0448524
ENO1 enolase 1, (alpha) 0.0446948
BRD2 bromodomain containing 2 0.0429877
RPLP1 ribosomal protein, large, P1 0.0429405
RPL31 ribosomal protein L31 0.0413036
ZFP36L1 ZFP36 ring finger protein-like 1 0.0406583
RPL36 ribosomal protein L36 0.0398244
HILPDA hypoxia inducible lipid droplet-associated 0.0394049
MT2A metallothionein 2A 0.0393672
RPL4 ribosomal protein L4 0.0391049
RPL5 ribosomal protein L5 0.0387269
RACK1 receptor for activated C kinase 1 0.0382762
AKAP9 A kinase (PRKA) anchor protein 9 0.0370316
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0359796
RPS13 ribosomal protein S13 0.0354902
RPL13A ribosomal protein L13a 0.0354097
RPL23 ribosomal protein L23 0.0344916
RPLP2 ribosomal protein, large, P2 0.0336175
RPS27 ribosomal protein S27 0.0333016
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0332992
PRRC2C proline-rich coiled-coil 2C 0.0328109
RPS14 ribosomal protein S14 0.0317448
KTN1 kinectin 1 (kinesin receptor) 0.0317226
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0312986
RPL11 ribosomal protein L11 0.0310887
TPT1 tumor protein, translationally-controlled 1 0.0309996
RPS29 ribosomal protein S29 0.0303296
HLA-B major histocompatibility complex, class I, B 0.029621
RPL37 ribosomal protein L37 0.0294357
SRRM2 serine/arginine repetitive matrix 2 0.0291348
NDRG1 N-myc downstream regulated 1 0.0290192
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.0283494
RPL30 ribosomal protein L30 0.0279509
RPS2 ribosomal protein S2 0.0271328
GOLGA4 golgin A4 0.0265782
ENO2 enolase 2 (gamma, neuronal) 0.0262003
HLA-A major histocompatibility complex, class I, A 0.0261473
RPL34 ribosomal protein L34 0.02539
IGFBP3 insulin-like growth factor binding protein 3 0.0253579
RPL18 ribosomal protein L18 0.0252437
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0248362
NACA nascent polypeptide-associated complex alpha subunit 0.0244319
RPL19 ribosomal protein L19 0.0241919
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0239749
RPL7 ribosomal protein L7 0.0230819
CREB5 cAMP responsive element binding protein 5 0.0228947
RPS27A ribosomal protein S27a 0.0220317
GARS1 glycyl-tRNA synthetase 1 0.0212841
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0204477
SET SET nuclear proto-oncogene 0.0203695
TPI1 triosephosphate isomerase 1 0.0203085
B2M beta-2-microglobulin 0.0200296
LOC112694756 uncharaterized LOC112694756 0.0199748
TPM4 tropomyosin 4 0.0196947
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0196237
RPS5 ribosomal protein S5 0.0195509
RPS16 ribosomal protein S16 0.0190692
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0188354
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0185845
ATF4 activating transcription factor 4 0.0185203
RPL10A ribosomal protein L10a 0.0184785
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0184751
PGK1 phosphoglycerate kinase 1 0.0180378
COX4I1 cytochrome c oxidase subunit IV isoform 1 0.0179562
ACTG1 actin gamma 1 0.017868
RPS20 ribosomal protein S20 0.0173871
RPS15A ribosomal protein S15a 0.0171447
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.017099
PKM pyruvate kinase, muscle 0.0170794
PLAUR plasminogen activator, urokinase receptor 0.0168387
RPS25 ribosomal protein S25 0.0168298
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0167388
RPL15 ribosomal protein L15 0.0164978
RPS18 ribosomal protein S18 0.0164617
DSPP dentin sialophosphoprotein 0.0163276
DDIT4 DNA-damage-inducible transcript 4 0.0161683
PSAT1 phosphoserine aminotransferase 1 0.0160537
NFE2L1 nuclear factor, erythroid 2-like 1 0.0157522

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.206269
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.202993
RAD51B RAD51 paralog B -0.133006
CD36 CD36 molecule (thrombospondin receptor) -0.112135
HMGA2 high mobility group AT-hook 2 -0.102109
FHIT fragile histidine triad -0.0980802
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0905106
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0870786
CCSER1 coiled-coil serine-rich protein 1 -0.074979
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0678135
GPHN gephyrin -0.0653787
ATXN1 ataxin 1 -0.0633563
VCL vinculin -0.0574297
HDAC2 histone deacetylase 2 -0.0552659
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0534109
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0526011
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0504917
EXOC4 exocyst complex component 4 -0.0502884
SMYD3 SET and MYND domain containing 3 -0.0502177
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -0.0472187
MTAP methylthioadenosine phosphorylase -0.0462447
PRELID2 PRELI domain containing 2 -0.0461151
PARD3 par-3 family cell polarity regulator -0.0455966
MBNL1 muscleblind-like splicing regulator 1 -0.044896
CUX1 cut-like homeobox 1 -0.0445381
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0435629
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0429226
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0422577
ZNRF3 zinc and ring finger 3 -0.0418546
ARID1B AT rich interactive domain 1B (SWI1-like) -0.041719
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0404336
SMAD3 SMAD family member 3 -0.0401903
RCOR1 REST corepressor 1 -0.0394108
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0392378
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0390203
ANKRD17 ankyrin repeat domain 17 -0.0389364
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0386483
AOPEP aminopeptidase O (putative) -0.0383129
RUNX2 runt-related transcription factor 2 -0.038096
FERMT1 fermitin family member 1 -0.0380778
ANXA2 annexin A2 -0.037831
EHBP1 EH domain binding protein 1 -0.0377821
DIAPH2 diaphanous-related formin 2 -0.037255
MED13L mediator complex subunit 13-like -0.0372305
SERINC5 serine incorporator 5 -0.0345802
MTUS1 microtubule associated tumor suppressor 1 -0.0344615
LPP LIM domain containing preferred translocation partner in lipoma -0.0340515
TNS3 tensin 3 -0.0340172
ECT2 epithelial cell transforming 2 -0.0336511
ACTN4 actinin, alpha 4 -0.0334749
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0332644
OXR1 oxidation resistance 1 -0.033231
EZR ezrin -0.0324025
PDE4B phosphodiesterase 4B, cAMP-specific -0.0323852
SKAP1 src kinase associated phosphoprotein 1 -0.0323736
FLOT1 flotillin 1 -0.0323418
ARHGAP42 Rho GTPase activating protein 42 -0.03231
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.032014
GMDS GDP-mannose 4,6-dehydratase -0.0318849
EGFR epidermal growth factor receptor -0.031756
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0316836
LMO7 LIM domain 7 -0.0315008
DOCK5 dedicator of cytokinesis 5 -0.0313969
DENND1A DENN/MADD domain containing 1A -0.0312815
YAP1 Yes-associated protein 1 -0.0311002
ESYT2 extended synaptotagmin-like protein 2 -0.030813
PATJ PATJ crumbs cell polarity complex component -0.0308018
LAMB3 laminin, beta 3 -0.0307602
AHNAK AHNAK nucleoprotein -0.0304734
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0301086
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.0301029
FAF1 Fas (TNFRSF6) associated factor 1 -0.0297936
TRIO trio Rho guanine nucleotide exchange factor -0.0295126
TENM3 teneurin transmembrane protein 3 -0.0292731
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0291501
MAML3 mastermind-like 3 (Drosophila) -0.0290336
TBC1D5 TBC1 domain family, member 5 -0.0290003
NF1 neurofibromin 1 -0.0284565
ZBTB7C zinc finger and BTB domain containing 7C -0.0283286
PHF14 PHD finger protein 14 -0.0282295
PARD3B par-3 family cell polarity regulator beta -0.0278704
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0278107
RBM25 RNA binding motif protein 25 -0.0273604
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0271641
PCNX1 pecanex 1 -0.0270905
SBF2 SET binding factor 2 -0.0269762
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0268927
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0266922
OSBPL3 oxysterol binding protein-like 3 -0.0265146
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 -0.0264395
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor -0.026296
NEK7 NIMA-related kinase 7 -0.0262501
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0260741
TCF12 transcription factor 12 -0.0258099
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0257791
SNX9 sorting nexin 9 -0.0251695
PTPRK protein tyrosine phosphatase, receptor type, K -0.0251457
FRMD5 FERM domain containing 5 -0.025099
SAMD4A sterile alpha motif domain containing 4A -0.0247905
SPIDR scaffolding protein involved in DNA repair -0.024748