SBI-0640756_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description SBI-0640756 perturbation in SW480 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the SBI-0640756_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGR1 early growth response 1 0.090085
INTS6 integrator complex subunit 6 0.0843042
NKD1 naked cuticle homolog 1 (Drosophila) 0.0785303
AKAP12 A kinase (PRKA) anchor protein 12 0.0751429
LOC102724023 ES1 protein homolog, mitochondrial 0.0622245
RPS12 ribosomal protein S12 0.0547632
RPL4 ribosomal protein L4 0.0535319
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0407757
ENO1 enolase 1, (alpha) 0.0394678
APLP2 amyloid beta (A4) precursor-like protein 2 0.0384542
IGFBP3 insulin-like growth factor binding protein 3 0.0355805
NTSR1 neurotensin receptor 1 (high affinity) 0.0349699
ZSWIM6 zinc finger, SWIM-type containing 6 0.0327088
BRD2 bromodomain containing 2 0.0317449
RPS2 ribosomal protein S2 0.0303473
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0297576
DSPP dentin sialophosphoprotein 0.0296623
RPL37A ribosomal protein L37a 0.0292544
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0287311
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.02828
ASPH aspartate beta-hydroxylase 0.0282106
CCDC88A coiled-coil domain containing 88A 0.0279706
WSB1 WD repeat and SOCS box containing 1 0.0278728
EGFR epidermal growth factor receptor 0.0275531
SRRM2 serine/arginine repetitive matrix 2 0.0261257
EIF1 eukaryotic translation initiation factor 1 0.0260682
RCOR1 REST corepressor 1 0.0257623
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0257136
PDLIM5 PDZ and LIM domain 5 0.0255218
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0254338
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0253002
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0250013
MT2A metallothionein 2A 0.02498
KTN1 kinectin 1 (kinesin receptor) 0.0248921
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0244766
BCL2L1 BCL2-like 1 0.0241262
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0238364
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 0.0235682
RPS15A ribosomal protein S15a 0.023555
LAMA4 laminin, alpha 4 0.0233121
STC2 stanniocalcin 2 0.0227819
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 0.0227577
ANKRD11 ankyrin repeat domain 11 0.0226028
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0225387
RPS3 ribosomal protein S3 0.0222813
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0221475
ZFP36L1 ZFP36 ring finger protein-like 1 0.0221439
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0220972
NFE2L1 nuclear factor, erythroid 2-like 1 0.0219353
ENO2 enolase 2 (gamma, neuronal) 0.0217345
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.02161
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.0214182
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0212636
LMO7 LIM domain 7 0.0208092
SQSTM1 sequestosome 1 0.0207608
RPS18 ribosomal protein S18 0.0204273
YARS1 tyrosyl-tRNA synthetase 1 0.0195798
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0195573
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0195444
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0194597
EPHB2 EPH receptor B2 0.0193101
PSAT1 phosphoserine aminotransferase 1 0.019178
HLA-A major histocompatibility complex, class I, A 0.0191576
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0186044
KMT2D lysine (K)-specific methyltransferase 2D 0.0182656
AKAP9 A kinase (PRKA) anchor protein 9 0.0182491
KLF12 Kruppel-like factor 12 0.0179345
GPBP1 GC-rich promoter binding protein 1 0.0175539
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.017376
FGFR1 fibroblast growth factor receptor 1 0.017234
PCLO piccolo presynaptic cytomatrix protein 0.0172274
OTUD5 OTU deubiquitinase 5 0.0171364
PPL periplakin 0.0170338
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1 0.0169117
ZMIZ1 zinc finger, MIZ-type containing 1 0.0169096
AFAP1L2 actin filament associated protein 1-like 2 0.0168644
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0164998
TIMP2 TIMP metallopeptidase inhibitor 2 0.0164976
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0163351
RBM25 RNA binding motif protein 25 0.0163
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0162568
TLE4 transducin-like enhancer of split 4 0.0161314
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.016051
MAGED1 melanoma antigen family D1 0.0160326
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0159282
TMEM117 transmembrane protein 117 0.015838
IGF2 insulin-like growth factor 2 0.015816
TLN1 talin 1 0.0155884
HDAC9 histone deacetylase 9 0.0155716
DDIT3 DNA-damage-inducible transcript 3 0.0154031
HOMER1 homer scaffolding protein 1 0.0153369
KDM6B lysine (K)-specific demethylase 6B 0.0153176
BRD4 bromodomain containing 4 0.0153124
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0150984
ATF4 activating transcription factor 4 0.0150567
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0150467
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0146876
DST dystonin 0.0146035
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0145303
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.0144971

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.333672
TPT1 tumor protein, translationally-controlled 1 -0.140438
AHNAK AHNAK nucleoprotein -0.100102
KRT18 keratin 18, type I -0.0928768
KRT8 keratin 8, type II -0.0923529
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0909456
RPS24 ribosomal protein S24 -0.0885067
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0813439
ANXA2 annexin A2 -0.081328
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0810571
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.080634
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0766305
ACTG1 actin gamma 1 -0.0725991
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0678952
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.067765
CANX calnexin -0.0672357
TMEM123 transmembrane protein 123 -0.0635452
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0628052
RPS6 ribosomal protein S6 -0.0588304
ESYT2 extended synaptotagmin-like protein 2 -0.058112
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0575869
TUBA1B tubulin, alpha 1b -0.0575611
PGK1 phosphoglycerate kinase 1 -0.057488
RPLP0 ribosomal protein, large, P0 -0.0573032
ANLN anillin, actin binding protein -0.0570712
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.056804
RPS23 ribosomal protein S23 -0.0567467
RPL32 ribosomal protein L32 -0.0551731
PDE4D phosphodiesterase 4D, cAMP-specific -0.0550814
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0549067
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0524349
RPL36A ribosomal protein L36a -0.0518058
RPLP1 ribosomal protein, large, P1 -0.0492351
RPS21 ribosomal protein S21 -0.0491568
RUNX1 runt-related transcription factor 1 -0.0480965
SKAP1 src kinase associated phosphoprotein 1 -0.0478706
PTMA prothymosin, alpha -0.0478598
ETNK1 ethanolamine kinase 1 -0.0474012
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0461728
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0460717
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0457429
RPL23 ribosomal protein L23 -0.0457028
OXR1 oxidation resistance 1 -0.0455251
CENPF centromere protein F, 350/400kDa -0.0452473
PERP PERP, TP53 apoptosis effector -0.0445975
RPS25 ribosomal protein S25 -0.0444861
RPL8 ribosomal protein L8 -0.0444267
MKI67 marker of proliferation Ki-67 -0.0443058
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0439585
DEK DEK proto-oncogene -0.0438173
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0435131
OSBPL3 oxysterol binding protein-like 3 -0.0422777
RPL27A ribosomal protein L27a -0.0416603
RAB1A RAB1A, member RAS oncogene family -0.0416088
S100A10 S100 calcium binding protein A10 -0.0413822
MSI2 musashi RNA-binding protein 2 -0.0413716
SMC4 structural maintenance of chromosomes 4 -0.0402257
XPO1 exportin 1 -0.0399493
TMSB4X thymosin beta 4, X-linked -0.0398
ZNF292 zinc finger protein 292 -0.0393771
RPLP2 ribosomal protein, large, P2 -0.0393501
KDM3A lysine (K)-specific demethylase 3A -0.0393008
TMSB10 thymosin beta 10 -0.0392561
CDK6 cyclin-dependent kinase 6 -0.0386662
USP34 ubiquitin specific peptidase 34 -0.0386197
RPL19 ribosomal protein L19 -0.038579
MAML2 mastermind-like 2 (Drosophila) -0.0383935
VIM vimentin -0.0378791
ZFR zinc finger RNA binding protein -0.0376303
H1-0 H1.0 linker histone -0.0375403
RPL11 ribosomal protein L11 -0.0373783
RPL7A ribosomal protein L7a -0.0370279
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0366676
EZR ezrin -0.0359679
MYOF myoferlin -0.0358302
GLG1 golgi glycoprotein 1 -0.0357408
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0354537
WASF2 WAS protein family, member 2 -0.0353304
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0352646
RPS11 ribosomal protein S11 -0.0351029
TUBB tubulin, beta class I -0.0350001
BIRC6 baculoviral IAP repeat containing 6 -0.0349272
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0346535
ARHGAP32 Rho GTPase activating protein 32 -0.0345761
MORF4L2 mortality factor 4 like 2 -0.034549
TXNIP thioredoxin interacting protein -0.0343038
HMGA1 high mobility group AT-hook 1 -0.0341298
TRIO trio Rho guanine nucleotide exchange factor -0.0339115
RPS4X ribosomal protein S4, X-linked -0.0337181
COG5 component of oligomeric golgi complex 5 -0.0336776
CSDE1 cold shock domain containing E1, RNA-binding -0.0336714
ACTN4 actinin, alpha 4 -0.0336137
ABHD2 abhydrolase domain containing 2 -0.0335586
APP amyloid beta (A4) precursor protein -0.0334728
DIAPH3 diaphanous-related formin 3 -0.0331809
RPS19 ribosomal protein S19 -0.0329648
RPL38 ribosomal protein L38 -0.0329426
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0327861
FNIP1 folliculin interacting protein 1 -0.0327527
RBMX RNA binding motif protein, X-linked -0.0326779