SC 560 Gene Set

Dataset CTD Gene-Chemical Interactions
Category physical interactions
Type chemical
Description A member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3 and 5 by 4-methoxyphenyl, trifluoromethyl and 4-chlorophenyl groups, respectively. Unlike many members of the diaryl heterocycle class of cyclooxygenase (COX) inhibitors, SC-560 is selective for COX-1. (Chemical Entities of Biological Interest Ontology, CHEBI_76274)
External Link http://ctdbase.org/detail.go?type=chem&acc=C115461
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Genes

29 genes/proteins interacting with the chemical SC 560 from the curated CTD Gene-Chemical Interactions dataset.

Symbol Name
ALOX5 arachidonate 5-lipoxygenase
APP amyloid beta (A4) precursor protein
ATF3 activating transcription factor 3
BAK1 BCL2-antagonist/killer 1
BCL2 B-cell CLL/lymphoma 2
BIRC5 baculoviral IAP repeat containing 5
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CCL2 chemokine (C-C motif) ligand 2
CCND1 cyclin D1
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
GDF15 growth differentiation factor 15
IL1B interleukin 1, beta
IL6 interleukin 6
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MPO myeloperoxidase
MSX1 msh homeobox 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOS2 nitric oxide synthase 2, inducible
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TIMP1 TIMP metallopeptidase inhibitor 1
TNF tumor necrosis factor
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase