SC 560 Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/4306515
Similar Terms
Downloads & Tools

Genes

200 proteins with high or low expression in SC 560 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
NEB nebulin 2.58
SRD5A3 steroid 5 alpha-reductase 3 1.81
DOCK11 dedicator of cytokinesis 11 0.83
AASDH aminoadipate-semialdehyde dehydrogenase 0.78
AMD1 adenosylmethionine decarboxylase 1 0.63
TUBAL3 tubulin, alpha-like 3 0.59
BLOC1S5 biogenesis of lysosomal organelles complex-1, subunit 5, muted 0.58
PMF1 polyamine-modulated factor 1 0.55
LTBP1 latent transforming growth factor beta binding protein 1 0.52
TMEM128 transmembrane protein 128 0.52
TRPT1 tRNA phosphotransferase 1 0.51
BDNF brain-derived neurotrophic factor 0.49
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.49
CTDNEP1 CTD nuclear envelope phosphatase 1 0.47
ITGB8 integrin, beta 8 0.47
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.46
FTL ferritin, light polypeptide 0.46
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.45
CBX7 chromobox homolog 7 0.45
FADS3 fatty acid desaturase 3 0.45
FSTL1 follistatin-like 1 0.43
WDR19 WD repeat domain 19 0.42
SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1 0.4
TULP3 tubby like protein 3 0.39
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1 0.38
LZTS1 leucine zipper, putative tumor suppressor 1 0.38
COX10 COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor 0.37
ARL4C ADP-ribosylation factor-like 4C 0.37
PEX5 peroxisomal biogenesis factor 5 0.37
ZSWIM1 zinc finger, SWIM-type containing 1 0.36
BMP4 bone morphogenetic protein 4 0.36
MYPOP Myb-related transcription factor, partner of profilin 0.36
C15ORF40 chromosome 15 open reading frame 40 0.35
CDC25B cell division cycle 25B 0.35
HPCAL4 hippocalcin like 4 0.35
DCTN2 dynactin 2 (p50) 0.35
TTLL4 tubulin tyrosine ligase-like family member 4 0.35
LYRM1 LYR motif containing 1 0.34
PML promyelocytic leukemia 0.34
ZNF776 zinc finger protein 776 0.34
TNNC2 troponin C type 2 (fast) 0.33
FIZ1 FLT3-interacting zinc finger 1 0.33
ABTB1 ankyrin repeat and BTB (POZ) domain containing 1 0.33
CALU calumenin 0.33
RBL2 retinoblastoma-like 2 0.33
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.32
ZMAT5 zinc finger, matrin-type 5 0.32
MSX1 msh homeobox 1 0.32
UBAP1 ubiquitin associated protein 1 0.32
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria 0.32
ERICH5 glutamate-rich 5 0.32
TMEM94 transmembrane protein 94 0.31
CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa 0.31
PPTC7 PTC7 protein phosphatase homolog (S. cerevisiae) 0.31
SLC38A2 solute carrier family 38, member 2 0.31
PIH1D1 PIH1 domain containing 1 0.31
GATA2 GATA binding protein 2 0.31
FAM177A1 family with sequence similarity 177, member A1 0.3
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 0.3
VSNL1 visinin-like 1 0.3
USP6NL USP6 N-terminal like 0.3
NCOA1 nuclear receptor coactivator 1 0.3
MTM1 myotubularin 1 0.29
ARMC7 armadillo repeat containing 7 0.29
FKBP14 FK506 binding protein 14, 22 kDa 0.29
SERBP1 SERPINE1 mRNA binding protein 1 0.29
NFU1 NFU1 iron-sulfur cluster scaffold 0.29
DHRS1 dehydrogenase/reductase (SDR family) member 1 0.29
RASSF3 Ras association (RalGDS/AF-6) domain family member 3 0.29
RILPL2 Rab interacting lysosomal protein-like 2 0.29
LSM1 LSM1, U6 small nuclear RNA associated 0.29
METTL7A methyltransferase like 7A 0.29
KSR1 kinase suppressor of ras 1 0.28
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.28
CDCA4 cell division cycle associated 4 0.28
DES desmin 0.28
RABEP1 rabaptin, RAB GTPase binding effector protein 1 0.28
SGMS2 sphingomyelin synthase 2 0.28
GLRX glutaredoxin (thioltransferase) 0.28
LYSMD2 LysM, putative peptidoglycan-binding, domain containing 2 0.28
EPHB3 EPH receptor B3 0.28
MCFD2 multiple coagulation factor deficiency 2 0.28
MISP3 MISP family member 3 0.28
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) 0.28
MED10 mediator complex subunit 10 0.27
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.27
ANKRD12 ankyrin repeat domain 12 0.27
BCL6 B-cell CLL/lymphoma 6 0.27
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 0.27
LRP5 low density lipoprotein receptor-related protein 5 0.27
SOX4 SRY (sex determining region Y)-box 4 0.27
CCDC138 coiled-coil domain containing 138 0.27
AKAP6 A kinase (PRKA) anchor protein 6 0.27
DPY30 dpy-30 homolog (C. elegans) 0.27
DDAH2 dimethylarginine dimethylaminohydrolase 2 0.27
MED12L mediator complex subunit 12-like 0.27
SH3BP4 SH3-domain binding protein 4 0.27
HSPA1L heat shock 70kDa protein 1-like 0.27
EHD2 EH-domain containing 2 0.26
FMNL3 formin-like 3 0.26

low expression

Symbol Name Standardized Value
HIPK2 homeodomain interacting protein kinase 2 -1.23
UPP1 uridine phosphorylase 1 -0.73
TRIB3 tribbles pseudokinase 3 -0.65
ABHD18 abhydrolase domain containing 18 -0.64
WDR5B WD repeat domain 5B -0.62
TIGD5 tigger transposable element derived 5 -0.62
SMOX spermine oxidase -0.58
MKS1 Meckel syndrome, type 1 -0.57
NR1D2 nuclear receptor subfamily 1, group D, member 2 -0.54
MFAP3 microfibrillar-associated protein 3 -0.53
BOK BCL2-related ovarian killer -0.53
TMEM208 transmembrane protein 208 -0.52
LRRC8B leucine rich repeat containing 8 family, member B -0.51
TMC4 transmembrane channel-like 4 -0.51
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.47
CR2 complement component (3d/Epstein Barr virus) receptor 2 -0.47
BTBD3 BTB (POZ) domain containing 3 -0.46
STC2 stanniocalcin 2 -0.45
PLIN2 perilipin 2 -0.45
PLAAT3 phospholipase A and acyltransferase 3 -0.44
FBXW4 F-box and WD repeat domain containing 4 -0.43
DMWD dystrophia myotonica, WD repeat containing -0.43
FAM3A family with sequence similarity 3, member A -0.42
ADIPOR1 adiponectin receptor 1 -0.42
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 -0.41
KCTD6 potassium channel tetramerization domain containing 6 -0.41
CETN1 centrin, EF-hand protein, 1 -0.41
LRIG3 leucine-rich repeats and immunoglobulin-like domains 3 -0.41
NAA20 N(alpha)-acetyltransferase 20, NatB catalytic subunit -0.41
MRVI1 murine retrovirus integration site 1 homolog -0.4
MID1IP1 MID1 interacting protein 1 -0.4
TEDC2 tubulin epsilon and delta complex 2 -0.39
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase -0.39
SOX12 SRY (sex determining region Y)-box 12 -0.39
NPDC1 neural proliferation, differentiation and control, 1 -0.39
C14ORF93 chromosome 14 open reading frame 93 -0.39
KLHL5 kelch-like family member 5 -0.38
HOXB9 homeobox B9 -0.38
KRT222 keratin 222, type II -0.38
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -0.37
SNAPC3 small nuclear RNA activating complex, polypeptide 3, 50kDa -0.37
COMTD1 catechol-O-methyltransferase domain containing 1 -0.37
NPEPL1 aminopeptidase-like 1 -0.37
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase -0.36
ALG6 ALG6, alpha-1,3-glucosyltransferase -0.36
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14 -0.35
ATP5PF ATP synthase peripheral stalk subunit F6 -0.35
SLC19A2 solute carrier family 19 (thiamine transporter), member 2 -0.35
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.35
EVL Enah/Vasp-like -0.34
ZNF692 zinc finger protein 692 -0.34
HIST3H2BB histone cluster 3, H2bb -0.34
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.34
TSPAN4 tetraspanin 4 -0.34
FAM241A family with sequence similarity 241 member A -0.34
RDH10 retinol dehydrogenase 10 (all-trans) -0.34
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 -0.33
MT-ND4 NADH dehydrogenase, subunit 4 (complex I) -0.33
ALKBH5 AlkB family member 5, RNA demethylase -0.33
RXRG retinoid X receptor, gamma -0.33
COMMD5 COMM domain containing 5 -0.32
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase -0.32
KLHDC2 kelch domain containing 2 -0.32
PSAT1 phosphoserine aminotransferase 1 -0.32
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.31
TMSB10 thymosin beta 10 -0.31
FAM135A family with sequence similarity 135, member A -0.31
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit -0.3
AUNIP aurora kinase A and ninein interacting protein -0.3
SESN2 sestrin 2 -0.3
LRATD2 LRAT domain containing 2 -0.3
ZNF142 zinc finger protein 142 -0.3
PGGHG protein-glucosylgalactosylhydroxylysine glucosidase -0.3
HBS1L HBS1-like translational GTPase -0.3
DALRD3 DALR anticodon binding domain containing 3 -0.3
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.29
NRIP1 nuclear receptor interacting protein 1 -0.29
TIMM10 translocase of inner mitochondrial membrane 10 homolog (yeast) -0.29
NAA38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit -0.29
PIGW phosphatidylinositol glycan anchor biosynthesis, class W -0.29
PRKCQ protein kinase C, theta -0.28
UNC13C unc-13 homolog C (C. elegans) -0.28
ANK2 ankyrin 2, neuronal -0.28
EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa -0.28
VWDE von Willebrand factor D and EGF domains -0.28
S100A14 S100 calcium binding protein A14 -0.28
PYCR2 pyrroline-5-carboxylate reductase family, member 2 -0.28
CCDC9B coiled-coil domain containing 9B -0.28
TMEM131L transmembrane 131 like -0.27
BHLHA15 basic helix-loop-helix family, member a15 -0.27
KMT2E lysine (K)-specific methyltransferase 2E -0.27
PAQR7 progestin and adipoQ receptor family member VII -0.27
NRP1 neuropilin 1 -0.27
DENND5A DENN/MADD domain containing 5A -0.27
GPANK1 G patch domain and ankyrin repeats 1 -0.27
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.27
BEND7 BEN domain containing 7 -0.27
TMEM134 transmembrane protein 134 -0.27
MT1F metallothionein 1F -0.27
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.26