SC-58125-507 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the SC-58125-507 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM5 ADAM metallopeptidase domain 5 (pseudogene)
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6
ALK anaplastic lymphoma receptor tyrosine kinase
ATXN8OS ATXN8 opposite strand (non-protein coding)
AVPR1B arginine vasopressin receptor 1B
B3GAT1 beta-1,3-glucuronyltransferase 1
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6
BMP7 bone morphogenetic protein 7
CASZ1 castor zinc finger 1
CCDC176 coiled-coil domain containing 176
CD34 CD34 molecule
CDK19 cyclin-dependent kinase 19
CDRT1 CMT1A duplicated region transcript 1
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CIITA class II, major histocompatibility complex, transactivator
CLDN17 claudin 17
CLEC10A C-type lectin domain family 10, member A
CLIC5 chloride intracellular channel 5
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
ELOVL6 ELOVL fatty acid elongase 6
FH fumarate hydratase
FOXA2 forkhead box A2
FST follistatin
GNG13 guanine nucleotide binding protein (G protein), gamma 13
GOSR1 golgi SNAP receptor complex member 1
GP2 glycoprotein 2 (zymogen granule membrane)
GPATCH3 G patch domain containing 3
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3
IFNA14 interferon, alpha 14
IFNA4 interferon, alpha 4
IL11 interleukin 11
IL1B interleukin 1, beta
IL22 interleukin 22
ITGB8 integrin, beta 8
KANK1 KN motif and ankyrin repeat domains 1
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2
KDM5D lysine (K)-specific demethylase 5D
KIAA0125 KIAA0125
KLK6 kallikrein-related peptidase 6
KLK8 kallikrein-related peptidase 8
KRT85 keratin 85, type II
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LECT1 leukocyte cell derived chemotaxin 1
LGALS4 lectin, galactoside-binding, soluble, 4
LNPEP leucyl/cystinyl aminopeptidase
LPP LIM domain containing preferred translocation partner in lipoma
LUZP1 leucine zipper protein 1
MAOA monoamine oxidase A
MFAP5 microfibrillar associated protein 5
MMP27 matrix metallopeptidase 27
MST1R macrophage stimulating 1 receptor
MYCBP MYC binding protein
NCAM1 neural cell adhesion molecule 1
NDRG2 NDRG family member 2
NIPSNAP3B nipsnap homolog 3B (C. elegans)
NNAT neuronatin
NPAT nuclear protein, ataxia-telangiectasia locus
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OPCML opioid binding protein/cell adhesion molecule-like
PALM paralemmin
PCDHB6 protocadherin beta 6
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha
PDE8B phosphodiesterase 8B
PRB1 proline-rich protein BstNI subfamily 1
PRKCQ protein kinase C, theta
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
RBKS ribokinase
RBM4B RNA binding motif protein 4B
RBM5 RNA binding motif protein 5
RIMS2 regulating synaptic membrane exocytosis 2
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
S100A12 S100 calcium binding protein A12
SCAMP1 secretory carrier membrane protein 1
SEC23IP SEC23 interacting protein
SH2D2A SH2 domain containing 2A
SH3GL3 SH3-domain GRB2-like 3
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
STAT5A signal transducer and activator of transcription 5A
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TBX21 T-box 21
TCP10L t-complex 10-like
TCTN1 tectonic family member 1
TLN2 talin 2
TMEM176A transmembrane protein 176A
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
TRAF4 TNF receptor-associated factor 4
TRIM5 tripartite motif containing 5
TSPAN7 tetraspanin 7
TTC26 tetratricopeptide repeat domain 26
UBA7 ubiquitin-like modifier activating enzyme 7
UPK2 uroplakin 2
ZC3H7B zinc finger CCCH-type containing 7B
ZNF528 zinc finger protein 528

decreased expression

Symbol Name
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
APOC2 apolipoprotein C-II
ARPIN actin-related protein 2/3 complex inhibitor
ATP13A2 ATPase type 13A2
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
C11ORF48
C17ORF80 chromosome 17 open reading frame 80
C2CD5 C2 calcium-dependent domain containing 5
C4BPA complement component 4 binding protein, alpha
CA11 carbonic anhydrase XI
CCDC53 coiled-coil domain containing 53
CCNL2 cyclin L2
CD96 CD96 molecule
CDK3 cyclin-dependent kinase 3
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHN1 chimerin 1
CLDN15 claudin 15
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CYBRD1 cytochrome b reductase 1
DCBLD2 discoidin, CUB and LCCL domain containing 2
DGKD diacylglycerol kinase, delta 130kDa
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DZANK1 double zinc ribbon and ankyrin repeat domains 1
EDC4 enhancer of mRNA decapping 4
EFNA1 ephrin-A1
EXTL1 exostosin-like glycosyltransferase 1
EYA3 EYA transcriptional coactivator and phosphatase 3
FER fer (fps/fes related) tyrosine kinase
FKBPL FK506 binding protein like
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GLMN glomulin, FKBP associated protein
GLTSCR1 glioma tumor suppressor candidate region gene 1
GMEB1 glucocorticoid modulatory element binding protein 1
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GORASP1 golgi reassembly stacking protein 1, 65kDa
HELLS helicase, lymphoid-specific
HIRIP3 HIRA interacting protein 3
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
JMJD4 jumonji domain containing 4
KCTD7 potassium channel tetramerization domain containing 7
KIAA0319L KIAA0319-like
KIFC1 kinesin family member C1
KLF15 Kruppel-like factor 15
KLHL21 kelch-like family member 21
LPCAT1 lysophosphatidylcholine acyltransferase 1
LUZP2 leucine zipper protein 2
MAPKBP1 mitogen-activated protein kinase binding protein 1
MAS1 MAS1 proto-oncogene, G protein-coupled receptor
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MYBPC3 myosin binding protein C, cardiac
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
ORC2 origin recognition complex, subunit 2
PCNT pericentrin
PECR peroxisomal trans-2-enoyl-CoA reductase
PGM3 phosphoglucomutase 3
PHC1 polyhomeotic homolog 1 (Drosophila)
PISD phosphatidylserine decarboxylase
PKN1 protein kinase N1
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PODXL2 podocalyxin-like 2
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
QSOX1 quiescin Q6 sulfhydryl oxidase 1
RAB4B RAB4B, member RAS oncogene family
RFWD3 ring finger and WD repeat domain 3
RNF25 ring finger protein 25
RPL39L ribosomal protein L39-like
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae)
SIAH2 siah E3 ubiquitin protein ligase 2
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SSSCA1 Sjogren syndrome/scleroderma autoantigen 1
STXBP2 syntaxin binding protein 2
SURF2 surfeit 2
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
THAP11 THAP domain containing 11
TMEM127 transmembrane protein 127
TNNT1 troponin T type 1 (skeletal, slow)
TOE1 target of EGR1, member 1 (nuclear)
TRAF2 TNF receptor-associated factor 2
TRIM25 tripartite motif containing 25
TSKU tsukushi, small leucine rich proteoglycan
USP39 ubiquitin specific peptidase 39
WDR13 WD repeat domain 13
WDR18 WD repeat domain 18
WDR46 WD repeat domain 46
ZC3H12A zinc finger CCCH-type containing 12A
ZFP36 ZFP36 ring finger protein
ZKSCAN4 zinc finger with KRAB and SCAN domains 4
ZMAT5 zinc finger, matrin-type 5
ZNF580 zinc finger protein 580
ZXDC ZXD family zinc finger C