SCAI Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description suppressor of cancer cell invasion|This gene encodes a regulator of cell migration. The encoded protein appears to function in the RhoA (ras homolog gene family, member A)-Dia1 (diaphanous homolog 1) signal transduction pathway. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010] (NCBI Entrez Gene Database, 286205)
Similar Terms
Downloads & Tools

Genes

343 genes differentially expressed following the SCAI gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
C2ORF78 chromosome 2 open reading frame 78 2.87332
KLHL6 kelch-like family member 6 2.87332
LY6G5C lymphocyte antigen 6 complex, locus G5C 2.87332
SPHK1 sphingosine kinase 1 2.87332
PTPRH protein tyrosine phosphatase, receptor type, H 2.87332
LY96 lymphocyte antigen 96 2.87332
CRYGN crystallin, gamma N 2.87332
MYZAP myocardial zonula adherens protein 2.87332
TDRD9 tudor domain containing 9 2.87332
GJA10 gap junction protein, alpha 10, 62kDa 2.87332
CHIT1 chitinase 1 (chitotriosidase) 2.87332
THEMIS thymocyte selection associated 2.87332
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 2.87332
BSX brain-specific homeobox 2.87332
MMP10 matrix metallopeptidase 10 2.87332
COX7B2 cytochrome c oxidase subunit VIIb2 2.87332
ADAMTSL2 ADAMTS-like 2 2.87332
DIPK1C divergent protein kinase domain 1C 2.87332
TM4SF19 transmembrane 4 L six family member 19 2.87332
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 2.87332
RFPL2 ret finger protein-like 2 2.84631
KIAA0408 KIAA0408 2.84631
ANKRD34C ankyrin repeat domain 34C 2.84631
SIRT2 sirtuin 2 2.84631
SLC46A2 solute carrier family 46, member 2 2.84631
TSGA13 testis specific, 13 2.84631
PDIA2 protein disulfide isomerase family A, member 2 2.84631
PCDHB6 protocadherin beta 6 2.84631
SPDYE4 speedy/RINGO cell cycle regulator family member E4 2.84631
ADAD2 adenosine deaminase domain containing 2 2.84631
FETUB fetuin B 2.84631
DMRTC1B DMRT-like family C1B 2.84631
CEP295NL CEP295 N-terminal like 2.84631
F7 coagulation factor VII (serum prothrombin conversion accelerator) 2.84631
MISP mitotic spindle positioning 2.84631
TMC3 transmembrane channel-like 3 2.84631
OR4D9 olfactory receptor, family 4, subfamily D, member 9 2.84631
ICAM2 intercellular adhesion molecule 2 2.84631
CDRT15 CMT1A duplicated region transcript 15 2.84631
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 2.84631
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 2.84631
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A 2.84631
GHRH growth hormone releasing hormone 2.84631
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene) 2.84631
KRT78 keratin 78, type II 2.84631
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 2.84631
TMEM217 transmembrane protein 217 2.84631
LCN12 lipocalin 12 2.84631
SPNS2 spinster homolog 2 (Drosophila) 2.84631
SMIM5 small integral membrane protein 5 2.84631
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 2.84631
ACVRL1 activin A receptor type II-like 1 2.84631
PRSS36 protease, serine, 36 2.84631
LACTBL1 lactamase, beta-like 1 2.84631
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 2.84631
PARP3 poly (ADP-ribose) polymerase family, member 3 2.84631
OR9H1 olfactory receptor family 9 subfamily H member 1 pseudogene (gene/pseudogene) 2.84631
CLDN14 claudin 14 2.84631
CCER2 coiled-coil glutamate-rich protein 2 2.84631
ACER1 alkaline ceramidase 1 2.84631
ELOVL3 ELOVL fatty acid elongase 3 2.84631
TMPRSS7 transmembrane protease, serine 7 2.84631
IFIT1B interferon-induced protein with tetratricopeptide repeats 1B 2.84631
ZNF441 zinc finger protein 441 2.84631
TSPAN4 tetraspanin 4 2.84631
FAM228A family with sequence similarity 228, member A 2.84631
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.84631
AVPR1A arginine vasopressin receptor 1A 2.84631
MCHR1 melanin-concentrating hormone receptor 1 2.84631
SERTM2 serine rich and transmembrane domain containing 2 2.84631
DEFB131A defensin beta 131A 2.84631
TMEM225B transmembrane protein 225B 2.84631
CFAP107 cilia and flagella associated protein 107 2.84631
PLAAT4 phospholipase A and acyltransferase 4 2.84631
SMIM40 small integral membrane protein 40 2.84631
STING1 stimulator of interferon response cGAMP interactor 1 2.84631
NECTIN4 nectin cell adhesion molecule 4 2.84631
HAO2 hydroxyacid oxidase 2 (long chain) 2.84631
LAMA5 laminin, alpha 5 2.84631
UBE2QL1 ubiquitin-conjugating enzyme E2Q family-like 1 2.84631
DSG1 desmoglein 1 2.84631
VSX2 visual system homeobox 2 2.84631
IZUMO4 IZUMO family member 4 2.84631
PVRIG poliovirus receptor related immunoglobulin domain containing 2.84631
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 2.84631
IL4I1 interleukin 4 induced 1 2.84631
CXCL14 chemokine (C-X-C motif) ligand 14 2.84631
RHOXF2B Rhox homeobox family, member 2B 2.84631
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 2.84631
C3ORF80 chromosome 3 open reading frame 80 2.84631
PTP4A1 protein tyrosine phosphatase type IVA, member 1 2.84631
MSX2 msh homeobox 2 2.84631
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 2.84631
PXDC1 PX domain containing 1 2.84631
ZAR1L zygote arrest 1-like 2.84631
C7 complement component 7 2.84631
GSC goosecoid homeobox 2.84631
SLAMF6 SLAM family member 6 2.84631
MYH15 myosin, heavy chain 15 2.84631
TLR3 toll-like receptor 3 2.84631
TMCO2 transmembrane and coiled-coil domains 2 2.84631
NAPSA napsin A aspartic peptidase 2.84631
ASTL astacin-like metallo-endopeptidase (M12 family) 2.84631
CSTA cystatin A (stefin A) 2.84631
ZBP1 Z-DNA binding protein 1 2.84631
OR56A3 olfactory receptor, family 56, subfamily A, member 3 2.84631
IGFBP3 insulin-like growth factor binding protein 3 2.84631
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 2.84631
A3GALT2 alpha 1,3-galactosyltransferase 2 2.84631
PCDHGB2 protocadherin gamma subfamily B, 2 2.84631
APOF apolipoprotein F 2.84631
MORC1 MORC family CW-type zinc finger 1 2.84631
FEZF2 FEZ family zinc finger 2 2.84631
TF transferrin 2.84631
HMOX2 heme oxygenase 2 2.84631
OR14J1 olfactory receptor, family 14, subfamily J, member 1 2.84631
TMEM31 transmembrane protein 31 2.84631
GPR62 G protein-coupled receptor 62 2.84631
LHX5 LIM homeobox 5 2.84631
FCRL1 Fc receptor-like 1 2.84631
TESPA1 thymocyte expressed, positive selection associated 1 2.84631
CFAP47 cilia and flagella associated protein 47 2.84631
VWA3A von Willebrand factor A domain containing 3A 2.84631
SPRR2G small proline-rich protein 2G 2.84631
TAT tyrosine aminotransferase 2.84631
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1 2.84631
AGXT2 alanine--glyoxylate aminotransferase 2 2.84631
SHISA8 shisa family member 8 2.84631
IRGM immunity-related GTPase family, M 2.84631
IL36R interleukin 36 receptor 2.84631
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin) 2.84631
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 2.84631
SCML4 sex comb on midleg-like 4 (Drosophila) 2.84631
C9ORF64 chromosome 9 open reading frame 64 2.84631
ACSBG2 acyl-CoA synthetase bubblegum family member 2 2.84631
AQP7 aquaporin 7 2.84631
KCNS2 potassium voltage-gated channel, modifier subfamily S, member 2 2.84631
SUN3 Sad1 and UNC84 domain containing 3 2.84631
DMRTB1 DMRT-like family B with proline-rich C-terminal, 1 2.84631
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 2.84631
IFNK interferon, kappa 2.84631
CLCA2 chloride channel accessory 2 2.84631
FKBP1C FK506 binding protein 1C 2.84631
GCM2 glial cells missing homolog 2 (Drosophila) 2.84631
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c 2.84631
LAMP5 lysosomal-associated membrane protein family, member 5 2.84631
CIB3 calcium and integrin binding family member 3 2.84631
BPIFC BPI fold containing family C 2.84631
ZNF835 zinc finger protein 835 2.84631
PPP1R3G protein phosphatase 1, regulatory subunit 3G 2.84631
VMO1 vitelline membrane outer layer 1 homolog (chicken) 2.84631
MAEL maelstrom spermatogenic transposon silencer 2.84631
MYDGF myeloid-derived growth factor 2.84631
FGF17 fibroblast growth factor 17 2.84631
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) 2.84631
FITM1 fat storage-inducing transmembrane protein 1 2.84631
MYLK2 myosin light chain kinase 2 2.84631
POTEC POTE ankyrin domain family, member C 2.84631
DEFB134 defensin, beta 134 2.84631
LYPD5 LY6/PLAUR domain containing 5 2.84631
ERP27 endoplasmic reticulum protein 27 2.84631
GPR142 G protein-coupled receptor 142 2.84631
LACC1 laccase (multicopper oxidoreductase) domain containing 1 2.83916
KCNIP3 Kv channel interacting protein 3, calsenilin 2.77777
PCDHA10 protocadherin alpha 10 2.77777
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 2.77777
ZNG1C Zn regulated GTPase metalloprotein activator 1C 2.741
NTNG1 netrin G1 2.63451
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) 2.63034
TMED7 transmembrane emp24 protein transport domain containing 7 2.57082
SALL3 spalt-like transcription factor 3 2.54055
AQP5 aquaporin 5 2.52627
TSPO translocator protein (18kDa) 2.52297
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) 2.51851
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 2.51793
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 2.50906
ERG28 ergosterol biosynthesis 28 homolog 2.50782
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 2.45239
CCNH cyclin H 2.41055
C6ORF132 chromosome 6 open reading frame 132 2.41055
AK9 adenylate kinase 9 2.40175
C2CD2L C2CD2-like 2.37902
FHAD1 forkhead-associated (FHA) phosphopeptide binding domain 1 2.376
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 2.3727
ANO6 anoctamin 6 2.3727
PANO1 proapoptotic nucleolar protein 1 2.3727
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 2.3727
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 2.3727
SORCS1 sortilin-related VPS10 domain containing receptor 1 2.37195
ANKRD36C ankyrin repeat domain 36C 2.36511
TCF19 transcription factor 19 2.36279
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator 2.32862
SYNPO2 synaptopodin 2 2.32157
OVOL2 ovo-like zinc finger 2 2.29037
LSG1 large 60S subunit nuclear export GTPase 1 2.27765
KIF18A kinesin family member 18A 2.27491
MT2A metallothionein 2A 2.27295
PGBD4 piggyBac transposable element derived 4 2.27033
RGS6 regulator of G-protein signaling 6 2.26648
KAT14 lysine acetyltransferase 14 2.24551
MYOZ3 myozenin 3 2.24344
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 2.232
TONSL tonsoku-like, DNA repair protein 2.23051
BLTP2 bridge-like lipid transfer protein family member 2 2.19753
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 2.19126
THOC6 THO complex 6 2.18783
MTMR9 myotubularin related protein 9 2.18666
PCIF1 PDX1 C-terminal inhibiting factor 1 2.18549
TANGO6 transport and golgi organization 6 homolog (Drosophila) 2.18265
POLR3GL polymerase (RNA) III (DNA directed) polypeptide G (32kD)-like 2.16856
NARS1 asparaginyl-tRNA synthetase 1 2.16825
MARVELD3 MARVEL domain containing 3 2.16222
MARCHF2 membrane associated ring-CH-type finger 2 2.15377
LCOR ligand dependent nuclear receptor corepressor 2.11847
GPC1 glypican 1 2.10415
FIBP fibroblast growth factor (acidic) intracellular binding protein 2.09661
SRSF12 serine/arginine-rich splicing factor 12 2.09243
IFRD2 interferon-related developmental regulator 2 2.09243
DHRS13 dehydrogenase/reductase (SDR family) member 13 2.09243
GANC glucosidase, alpha; neutral C 2.09078
RAB27B RAB27B, member RAS oncogene family 2.08169
ACSL4 acyl-CoA synthetase long-chain family member 4 2.06963
SPATA24 spermatogenesis associated 24 2.06963
EXOSC2 exosome component 2 2.0659
HASPIN histone H3 associated protein kinase 2.04808
GRAMD1B GRAM domain containing 1B 2.04166
SUSD6 sushi domain containing 6 2.0391
XPC xeroderma pigmentosum, complementation group C 2.0391
COL24A1 collagen, type XXIV, alpha 1 2.03904
YJU2 YJU2 splicing factor homolog 2.03889
VIM vimentin 2.01965
E2F8 E2F transcription factor 8 2.01877
PDCD2 programmed cell death 2 2.01877
CLN3 ceroid-lipofuscinosis, neuronal 3 2.00567
ADPRHL1 ADP-ribosylhydrolase like 1 2.00298
TP53I3 tumor protein p53 inducible protein 3 2.00284
NATD1 N-acetyltransferase domain containing 1 2.00284
COPZ1 coatomer protein complex, subunit zeta 1 2.00022

decreased expression

Symbol Name Standardized Value
ZNF365 zinc finger protein 365 -2.87332
HYAL1 hyaluronoglucosaminidase 1 -2.87332
SCAI suppressor of cancer cell invasion -2.87332
FXN frataxin -2.84631
MYRFL myelin regulatory factor-like -2.84631
BMP4 bone morphogenetic protein 4 -2.84631
SLC38A2 solute carrier family 38, member 2 -2.84631
OSBPL2 oxysterol binding protein-like 2 -2.84631
KLHL10 kelch-like family member 10 -2.84631
SH2B1 SH2B adaptor protein 1 -2.84631
FAM131C family with sequence similarity 131, member C -2.84631
EFNA1 ephrin-A1 -2.84631
LIF leukemia inhibitory factor -2.84631
GPAT3 glycerol-3-phosphate acyltransferase 3 -2.84631
BVES blood vessel epicardial substance -2.84631
TMEM132E transmembrane protein 132E -2.77777
ACOT12 acyl-CoA thioesterase 12 -2.77777
CLCN1 chloride channel, voltage-sensitive 1 -2.77777
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 -2.77777
SPMIP10 sperm microtubule inner protein 10 -2.77777
LCN15 lipocalin 15 -2.77777
ORAI1 ORAI calcium release-activated calcium modulator 1 -2.77777
PLN phospholamban -2.77777
TREX2 three prime repair exonuclease 2 -2.77777
IMPG1 interphotoreceptor matrix proteoglycan 1 -2.77777
PRRT4 proline-rich transmembrane protein 4 -2.77777
FAM43B family with sequence similarity 43, member B -2.77777
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 -2.77777
ALOX15 arachidonate 15-lipoxygenase -2.77777
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 -2.77777
KCNJ13 potassium channel, inwardly rectifying subfamily J, member 13 -2.77777
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 -2.77777
EMP1 epithelial membrane protein 1 -2.77777
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene) -2.77777
TMEM139 transmembrane protein 139 -2.77777
KLK5 kallikrein-related peptidase 5 -2.77777
SDS serine dehydratase -2.77777
BCL2L15 BCL2-like 15 -2.77777
PLCD4 phospholipase C, delta 4 -2.77777
LRRC24 leucine rich repeat containing 24 -2.77777
ACSS1 acyl-CoA synthetase short-chain family member 1 -2.77777
RGPD6 RANBP2-like and GRIP domain containing 6 -2.66286
CPED1 cadherin-like and PC-esterase domain containing 1 -2.65172
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 -2.65172
MICU2 mitochondrial calcium uptake 2 -2.62804
ZNF710 zinc finger protein 710 -2.57082
TULP2 tubby like protein 2 -2.57082
RBBP5 retinoblastoma binding protein 5 -2.52639
TRABD TraB domain containing -2.51851
SAMD4A sterile alpha motif domain containing 4A -2.51793
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase -2.46175
TUT4 terminal uridylyl transferase 4 -2.43246
ZC2HC1C zinc finger, C2HC-type containing 1C -2.42209
MYCBPAP MYCBP associated protein -2.4204
CRTAC1 cartilage acidic protein 1 -2.41055
COPS7B COP9 signalosome subunit 7B -2.41055
PLB1 phospholipase B1 -2.41055
ORC4 origin recognition complex, subunit 4 -2.40175
EHD2 EH-domain containing 2 -2.37902
ASB18 ankyrin repeat and SOCS box containing 18 -2.3727
PTGR3 prostaglandin reductase 3 -2.3727
CASP6 caspase 6, apoptosis-related cysteine peptidase -2.36301
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 -2.36301
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) -2.35428
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1 -2.29031
H2AC21 H2A clustered histone 21 -2.27765
AGO1 argonaute RISC catalytic component 1 -2.26648
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) -2.26134
ARSL arylsulfatase L -2.25957
CCNF cyclin F -2.2567
WDR90 WD repeat domain 90 -2.24947
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B -2.24538
MYO3A myosin IIIA -2.232
EBF4 early B-cell factor 4 -2.20627
TCAIM T cell activation inhibitor, mitochondrial -2.20627
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -2.20627
MOB3A MOB kinase activator 3A -2.18549
CEMIP2 cell migration inducing hyaluronidase 2 -2.18469
GEMIN6 gem (nuclear organelle) associated protein 6 -2.17728
TYW1B tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae) -2.1614
MAX MYC associated factor X -2.1614
HS1BP3 HCLS1 binding protein 3 -2.14345
WDCP WD repeat and coiled coil containing -2.13875
RALB v-ral simian leukemia viral oncogene homolog B -2.13254
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 -2.11984
FBXO44 F-box protein 44 -2.10805
RAB6A RAB6A, member RAS oncogene family -2.08002
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 -2.07231
OR52A1 olfactory receptor, family 52, subfamily A, member 1 -2.06459
ADCY5 adenylate cyclase 5 -2.06303
DOCK1 dedicator of cytokinesis 1 -2.04808
RBFA ribosome binding factor A (putative) -2.04458
TRIM52 tripartite motif containing 52 -2.03904
CAND2 cullin-associated and neddylation-dissociated 2 (putative) -2.03904
CCDC47 coiled-coil domain containing 47 -2.03904
SLC25A29 solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29 -2.03904
MACROD1 MACRO domain containing 1 -2.03889
AKT1 v-akt murine thymoma viral oncogene homolog 1 -2.03889
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 -2.03865
ENGASE endo-beta-N-acetylglucosaminidase -2.01877
SF3B6 splicing factor 3b, subunit 6, 14kDa -2.00298
FAM234B family with sequence similarity 234 member B -2.00298
EPB41L3 erythrocyte membrane protein band 4.1-like 3 -2.00298
PTTG1 pituitary tumor-transforming 1 -2.00298
RBM6 RNA binding motif protein 6 -2.00284