SCC-25 Gene Set

Dataset COSMIC Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description Human squamous cell carcinoma cell line; established from the biopsy of a squamous cell carcinoma of the tongue of a 70-year-old man. (BRENDA Tissue and Enzyme Source Ontology, BTO_0003774)
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Genes

258 genes mutated in the SCC-25 cell line from the COSMIC Cell Line Gene Mutation Profiles dataset.

Symbol Name
A1BG alpha-1-B glycoprotein
ABHD16B abhydrolase domain containing 16B
ACACA acetyl-CoA carboxylase alpha
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain
ACO2 aconitase 2, mitochondrial
ADAM12 ADAM metallopeptidase domain 12
ADAMTSL2 ADAMTS-like 2
ADGRF1 adhesion G protein-coupled receptor F1
ADGRV1 adhesion G protein-coupled receptor V1
ADRA1A adrenoceptor alpha 1A
ALPL alkaline phosphatase, liver/bone/kidney
AMY1A amylase, alpha 1A (salivary)
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ARHGAP36 Rho GTPase activating protein 36
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ASPG asparaginase
ATF7 activating transcription factor 7
ATL1 atlastin GTPase 1
ATP13A5 ATPase type 13A5
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
ATXN2 ataxin 2
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BCHE butyrylcholinesterase
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
BHLHB9 basic helix-loop-helix domain containing, class B, 9
BIRC6 baculoviral IAP repeat containing 6
BRSK2 BR serine/threonine kinase 2
BTBD10 BTB (POZ) domain containing 10
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CAPN11 calpain 11
CARD11 caspase recruitment domain family, member 11
CCDC109B coiled-coil domain containing 109B
CDHR3 cadherin-related family member 3
CDRT15L2 CMT1A duplicated region transcript 15-like 2
CELA2A chymotrypsin-like elastase family, member 2A
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1
CENPT centromere protein T
CEP89 centrosomal protein 89kDa
CHRM2 cholinergic receptor, muscarinic 2
CHURC1 churchill domain containing 1
CLASP1 cytoplasmic linker associated protein 1
CNTNAP4 contactin associated protein-like 4
COL20A1 collagen, type XX, alpha 1
COL4A4 collagen, type IV, alpha 4
CPNE3 copine III
CRIPAK cysteine-rich PAK1 inhibitor
CRNKL1 crooked neck pre-mRNA splicing factor 1
CSMD3 CUB and Sushi multiple domains 3
CTNND2 catenin (cadherin-associated protein), delta 2
CUL9 cullin 9
CWC22 CWC22 spliceosome-associated protein
CXXC1 CXXC finger protein 1
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1
DAW1 dynein assembly factor with WDR repeat domains 1
DAXX death-domain associated protein
DBX2 developing brain homeobox 2
DCBLD2 discoidin, CUB and LCCL domain containing 2
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
DENND1A DENN/MADD domain containing 1A
DGKB diacylglycerol kinase, beta 90kDa
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila)
DIS3L DIS3 like exosome 3'-5' exoribonuclease
DMBT1 deleted in malignant brain tumors 1
DMXL2 Dmx-like 2
ECHDC1 ethylmalonyl-CoA decarboxylase 1
ECM1 extracellular matrix protein 1
EEF1B2 eukaryotic translation elongation factor 1 beta 2
EEF2K eukaryotic elongation factor 2 kinase
EML1 echinoderm microtubule associated protein like 1
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans)
EPHA8 EPH receptor A8
EPHB3 EPH receptor B3
EXOC6 exocyst complex component 6
EYS eyes shut homolog (Drosophila)
F2R coagulation factor II (thrombin) receptor
FAM111A family with sequence similarity 111, member A
FAM133A family with sequence similarity 133, member A
FAM189A1 family with sequence similarity 189, member A1
FAM20C family with sequence similarity 20, member C
FBLN7 fibulin 7
FMN1 formin 1
FOSL2 FOS-like antigen 2
FOXD4L1 forkhead box D4-like 1
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FUBP3 far upstream element (FUSE) binding protein 3
FUCA2 fucosidase, alpha-L- 2, plasma
GALE UDP-galactose-4-epimerase
GCN1L1 GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
GDAP1L1 ganglioside induced differentiation associated protein 1-like 1
GLDC glycine dehydrogenase (decarboxylating)
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GOLGA8J golgin A8 family, member J
GOLGB1 golgin B1
GSDMC gasdermin C
HPR haptoglobin-related protein
HPS5 Hermansky-Pudlak syndrome 5
IL18RAP interleukin 18 receptor accessory protein
INO80D INO80 complex subunit D
INS insulin
INS-IGF2 INS-IGF2 readthrough
IZUMO1 izumo sperm-egg fusion 1
JMJD7-PLA2G4B JMJD7-PLA2G4B readthrough
JOSD1 Josephin domain containing 1
KAT5 K(lysine) acetyltransferase 5
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA1671 KIAA1671
KMT2D lysine (K)-specific methyltransferase 2D
KRT76 keratin 76, type II
LAMB1 laminin, beta 1
LDB3 LIM domain binding 3
LRP4 low density lipoprotein receptor-related protein 4
LTK leukocyte receptor tyrosine kinase
MAG myelin associated glycoprotein
MAGEB2 melanoma antigen family B2
MAP1A microtubule-associated protein 1A
MAP1S microtubule-associated protein 1S
MAP7D2 MAP7 domain containing 2
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
MC5R melanocortin 5 receptor
MDH2 malate dehydrogenase 2, NAD (mitochondrial)
MDN1 MDN1, midasin homolog (yeast)
MED25 mediator complex subunit 25
MEGF8 multiple EGF-like-domains 8
MFSD4 major facilitator superfamily domain containing 4
MGAT5B mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B
MKI67 marker of proliferation Ki-67
MPHOSPH8 M-phase phosphoprotein 8
MPST mercaptopyruvate sulfurtransferase
MTMR12 myotubularin related protein 12
MUC2 mucin 2, oligomeric mucus/gel-forming
MUC4 mucin 4, cell surface associated
MYLIP myosin regulatory light chain interacting protein
MYO1G myosin IG
MYT1L myelin transcription factor 1-like
NARF nuclear prelamin A recognition factor
NBAS neuroblastoma amplified sequence
NBPF10 neuroblastoma breakpoint family, member 10
NEK4 NIMA-related kinase 4
NEURL4 neuralized E3 ubiquitin protein ligase 4
NLRP8 NLR family, pyrin domain containing 8
NNT nicotinamide nucleotide transhydrogenase
NOVA1 neuro-oncological ventral antigen 1
NSUN5P1 NOP2/Sun domain family, member 5 pseudogene 1
NVL nuclear VCP-like
NWD1 NACHT and WD repeat domain containing 1
OR2G6 olfactory receptor, family 2, subfamily G, member 6
OR4C12 olfactory receptor, family 4, subfamily C, member 12
OR4D1 olfactory receptor, family 4, subfamily D, member 1
OR56B1 olfactory receptor, family 56, subfamily B, member 1
OR7G1 olfactory receptor, family 7, subfamily G, member 1
P2RY13 purinergic receptor P2Y, G-protein coupled, 13
PAPD5 PAP associated domain containing 5
PAPPA2 pappalysin 2
PARP4 poly (ADP-ribose) polymerase family, member 4
PAXBP1 PAX3 and PAX7 binding protein 1
PCDH12 protocadherin 12
PCDHB10 protocadherin beta 10
PGA4 pepsinogen 4, group I (pepsinogen A)
PGA5 pepsinogen 5, group I (pepsinogen A)
PGLYRP2 peptidoglycan recognition protein 2
PHF2 PHD finger protein 2
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLEKHA6 pleckstrin homology domain containing, family A member 6
PLEKHG4B pleckstrin homology domain containing, family G (with RhoGef domain) member 4B
PMPCB peptidase (mitochondrial processing) beta
POTEH POTE ankyrin domain family, member H
PPIE peptidylprolyl isomerase E (cyclophilin E)
PPP1R3A protein phosphatase 1, regulatory subunit 3A
PPP2R2D protein phosphatase 2, regulatory subunit B, delta
PROSC proline synthetase co-transcribed homolog (bacterial)
PRR15 proline rich 15
PRRC2A proline-rich coiled-coil 2A
PTCD1 pentatricopeptide repeat domain 1
PTPRJ protein tyrosine phosphatase, receptor type, J
RADIL Ras association and DIL domains
RANBP2 RAN binding protein 2
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
RBBP4 retinoblastoma binding protein 4
RBBP6 retinoblastoma binding protein 6
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SACK1A scaffolding CK1 anchoring protein A
SAP30BP SAP30 binding protein
SCAF1 SR-related CTD-associated factor 1
SCN2A sodium channel, voltage gated, type II alpha subunit
SEC16B SEC16 homolog B (S. cerevisiae)
SEC23A Sec23 homolog A (S. cerevisiae)
SH2D4A SH2 domain containing 4A
SIGLEC10 sialic acid binding Ig-like lectin 10
SIGLEC12 sialic acid binding Ig-like lectin 12 (gene/pseudogene)
SLC25A41 solute carrier family 25, member 41
SLC25A47 solute carrier family 25, member 47
SLC26A7 solute carrier family 26 (anion exchanger), member 7
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLIT3 slit homolog 3 (Drosophila)
SLITRK3 SLIT and NTRK-like family, member 3
SMOX spermine oxidase
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5)
SP4 Sp4 transcription factor
SPATA18 spermatogenesis associated 18
SPICE1 spindle and centriole associated protein 1
SPNS1 spinster homolog 1 (Drosophila)
STIM1 stromal interaction molecule 1
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
TCF3 transcription factor 3
TENM2 teneurin transmembrane protein 2
TGOLN2 trans-golgi network protein 2
TLK2 tousled-like kinase 2
TMEM194A transmembrane protein 194A
TMEM214 transmembrane protein 214
TMEM9 transmembrane protein 9
TP53 tumor protein p53
TP53BP2 tumor protein p53 binding protein 2
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TRPM3 transient receptor potential cation channel, subfamily M, member 3
TSPAN10 tetraspanin 10
TTC29 tetratricopeptide repeat domain 29
TTN titin
TUBGCP2 tubulin, gamma complex associated protein 2
UBN2 ubinuclein 2
UNC45B unc-45 homolog B (C. elegans)
USP43 ubiquitin specific peptidase 43
VAV3 vav 3 guanine nucleotide exchange factor
VNN1 vanin 1
VPS18 vacuolar protein sorting 18 homolog (S. cerevisiae)
VWA5B2 von Willebrand factor A domain containing 5B2
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial
WDR24 WD repeat domain 24
WDR35 WD repeat domain 35
WDR76 WD repeat domain 76
WDR81 WD repeat domain 81
WEE1 WEE1 G2 checkpoint kinase
WFS1 Wolfram syndrome 1 (wolframin)
ZBTB10 zinc finger and BTB domain containing 10
ZBTB14 zinc finger and BTB domain containing 14
ZBTB7C zinc finger and BTB domain containing 7C
ZDHHC5 zinc finger, DHHC-type containing 5
ZDHHC6 zinc finger, DHHC-type containing 6
ZFPM2 zinc finger protein, FOG family member 2
ZMAT1 zinc finger, matrin-type 1
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF609 zinc finger protein 609
ZNF682 zinc finger protein 682
ZNF699 zinc finger protein 699
ZNF716 zinc finger protein 716
ZNF740 zinc finger protein 740
ZNF749 zinc finger protein 749
ZNF814 zinc finger protein 814
ZSCAN20 zinc finger and SCAN domain containing 20