SCC-4 Gene Set

Dataset GDSC Cell Line Gene Expression Profiles
Category transcriptomics
Type cell line
Description Human squamous cell carcinoma cell line; established from the squamous cell carcinoma of the tongue from a 55-year-old man after radio- and chemotherapy in 1980. (BRENDA Tissue and Enzyme Source Ontology, BTO_0003775)
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Genes

325 genes with high or low expression in SCC-4 relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.

high expression

Symbol Name Standardized Value
CAB39 calcium binding protein 39 3.09125
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) 3.07102
VBP1 von Hippel-Lindau binding protein 1 3.01309
MTCP1 mature T-cell proliferation 1 2.9486
PAAF1 proteasomal ATPase-associated factor 1 2.87408
MAP3K13 mitogen-activated protein kinase kinase kinase 13 2.53945
BRCC3 BRCA1/BRCA2-containing complex, subunit 3 2.42753
VNN3 vanin 3 2.16857
CDCA4 cell division cycle associated 4 2.08961
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 2.05
CLDN1 claudin 1 2.04785
LAMC2 laminin, gamma 2 2.03043
RSPH6A radial spoke head 6 homolog A (Chlamydomonas) 2.02898
DBF4 DBF4 zinc finger 2.02571
ALKBH1 alkB, alkylation repair homolog 1 (E. coli) 2.02533
FOLR3 folate receptor 3 (gamma) 2.02513
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2 2.00138
CLIC2 chloride intracellular channel 2 2.00098
CXCL10 chemokine (C-X-C motif) ligand 10 1.99276
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 1.97156
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 1.96614
PPY2P pancreatic polypeptide 2, pseudogene 1.94958
PF4V1 platelet factor 4 variant 1 1.91925
GSK3B glycogen synthase kinase 3 beta 1.89976
OSR2 odd-skipped related transciption factor 2 1.89419
MED6 mediator complex subunit 6 1.89167
MRPL48 mitochondrial ribosomal protein L48 1.87244
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1 1.85913
RBX1 ring-box 1, E3 ubiquitin protein ligase 1.84117
FADD Fas (TNFRSF6)-associated via death domain 1.83626
DAAM1 dishevelled associated activator of morphogenesis 1 1.81785
LPAR3 lysophosphatidic acid receptor 3 1.79169
ZNHIT1 zinc finger, HIT-type containing 1 1.78998
RIMS2 regulating synaptic membrane exocytosis 2 1.78805
DUSP10 dual specificity phosphatase 10 1.7853
TP53TG1 TP53 target 1 (non-protein coding) 1.7823
POP7 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae) 1.77973
UBE2L3 ubiquitin-conjugating enzyme E2L 3 1.77426
SPRR2B small proline-rich protein 2B 1.77228
ANXA2 annexin A2 1.76529
SAV1 salvador family WW domain containing protein 1 1.74828
GPR176 G protein-coupled receptor 176 1.74043
SHFM1 split hand/foot malformation (ectrodactyly) type 1 1.73284
NUBP1 nucleotide binding protein 1 1.73253
OTC ornithine carbamoyltransferase 1.73005
TNNT3 troponin T type 3 (skeletal, fast) 1.72706
VSNL1 visinin-like 1 1.72194
SCT secretin 1.72012
HIST1H2BJ histone cluster 1, H2bj 1.71324
NMU neuromedin U 1.71227
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.71011
KRT31 keratin 31, type I 1.70182
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 1.69854
MTMR1 myotubularin related protein 1 1.6945
CNGB1 cyclic nucleotide gated channel beta 1 1.68812
SAA4 serum amyloid A4, constitutive 1.6759
MYH13 myosin, heavy chain 13, skeletal muscle 1.66745
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa 1.65533
ZC3H12A zinc finger CCCH-type containing 12A 1.64024
ATP5J2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2 1.63599
SSFA2 sperm specific antigen 2 1.61854
OVOL1 ovo-like zinc finger 1 1.60883
MATN3 matrilin 3 1.60438
ADORA2B adenosine A2b receptor 1.60389
SRI sorcin 1.59864
PDCD6 programmed cell death 6 1.59783
ROM1 retinal outer segment membrane protein 1 1.59457
GPR87 G protein-coupled receptor 87 1.59359
GOLGA5 golgin A5 1.5922
GLRX5 glutaredoxin 5 1.58197
LAIR2 leukocyte-associated immunoglobulin-like receptor 2 1.57343
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.56778
KLF3 Kruppel-like factor 3 (basic) 1.56531
SLC25A40 solute carrier family 25, member 40 1.55948
IL36G interleukin 36, gamma 1.55815
DKC1 dyskeratosis congenita 1, dyskerin 1.5459
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4 1.54564
IRX4 iroquois homeobox 4 1.54381
ALCAM activated leukocyte cell adhesion molecule 1.54267
TEX11 testis expressed 11 1.54036
FST follistatin 1.53269
SNAP29 synaptosomal-associated protein, 29kDa 1.52544
PDZD2 PDZ domain containing 2 1.52398
FOLR2 folate receptor 2 (fetal) 1.52035
NMB neuromedin B 1.5175
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 1.51717
EFCAB1 EF-hand calcium binding domain 1 1.51212
SOX15 SRY (sex determining region Y)-box 15 1.5117
CKM creatine kinase, muscle 1.49706
DEXI Dexi homolog (mouse) 1.496
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 1.49206
ERO1L ERO1-like (S. cerevisiae) 1.48963
LITAF lipopolysaccharide-induced TNF factor 1.48608
RBP1 retinol binding protein 1, cellular 1.48596
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 1.47699
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 1.4735
PDAP1 PDGFA associated protein 1 1.46845
HMOX2 heme oxygenase 2 1.46769
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 1.46657
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 1.4651
PTTG1 pituitary tumor-transforming 1 1.45642
FGFBP1 fibroblast growth factor binding protein 1 1.4557
UPK1B uroplakin 1B 1.45472
ADRB2 adrenoceptor beta 2, surface 1.45343
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 1.45331
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 1.45106
ANXA2P2 annexin A2 pseudogene 2 1.44537
OSBPL3 oxysterol binding protein-like 3 1.43824
GFI1B growth factor independent 1B transcription repressor 1.43598
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 1.43403
CLDN6 claudin 6 1.43072
SELT selenoprotein T 1.42958
CALML5 calmodulin-like 5 1.42484
SIX5 SIX homeobox 5 1.42388
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 1.42295
MCAT malonyl CoA:ACP acyltransferase (mitochondrial) 1.41988

low expression

Symbol Name Standardized Value
RPRD2 regulation of nuclear pre-mRNA domain containing 2 -3.53725
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 -3.53725
SUZ12 SUZ12 polycomb repressive complex 2 subunit -3.53724
MTG1 mitochondrial ribosome-associated GTPase 1 -3.53717
HDAC5 histone deacetylase 5 -3.53562
WDR19 WD repeat domain 19 -3.53239
GCN1L1 GCN1 general control of amino-acid synthesis 1-like 1 (yeast) -3.52415
POLDIP2 polymerase (DNA-directed), delta interacting protein 2 -3.42544
HTRA2 HtrA serine peptidase 2 -3.38963
GOSR1 golgi SNAP receptor complex member 1 -3.21387
POGZ pogo transposable element with ZNF domain -2.95312
ZNF767P zinc finger family member 767, pseudogene -2.88304
NXPE3 neurexophilin and PC-esterase domain family, member 3 -2.88161
WDR47 WD repeat domain 47 -2.86729
ATXN2L ataxin 2-like -2.80037
METTL16 methyltransferase like 16 -2.79959
RHOT1 ras homolog family member T1 -2.66596
REM1 RAS (RAD and GEM)-like GTP-binding 1 -2.64815
IFT20 intraflagellar transport 20 -2.63721
ESYT1 extended synaptotagmin-like protein 1 -2.60222
VAMP7 vesicle-associated membrane protein 7 -2.6014
TIGD6 tigger transposable element derived 6 -2.4866
WSB1 WD repeat and SOCS box containing 1 -2.44945
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -2.44768
CRLF3 cytokine receptor-like factor 3 -2.43781
DCAF8 DDB1 and CUL4 associated factor 8 -2.42832
ZNF202 zinc finger protein 202 -2.39134
SLC35E3 solute carrier family 35, member E3 -2.38094
USP34 ubiquitin specific peptidase 34 -2.36927
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -2.35255
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae) -2.32868
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 -2.32615
DMXL1 Dmx-like 1 -2.29464
FBXO11 F-box protein 11 -2.29378
MED12 mediator complex subunit 12 -2.28275
POGK pogo transposable element with KRAB domain -2.26959
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) -2.26514
GLTSCR1 glioma tumor suppressor candidate region gene 1 -2.25043
UBTF upstream binding transcription factor, RNA polymerase I -2.23825
TBCC tubulin folding cofactor C -2.22847
NPDC1 neural proliferation, differentiation and control, 1 -2.20599
EXOC7 exocyst complex component 7 -2.19273
SSBP3 single stranded DNA binding protein 3 -2.19023
ZCCHC8 zinc finger, CCHC domain containing 8 -2.18472
NLK nemo-like kinase -2.18458
NFRKB nuclear factor related to kappaB binding protein -2.17737
SCUBE3 signal peptide, CUB domain, EGF-like 3 -2.17092
HINFP histone H4 transcription factor -2.159
TBCD tubulin folding cofactor D -2.15506
WAS Wiskott-Aldrich syndrome -2.15066
CENPT centromere protein T -2.13757
SLC4A2 solute carrier family 4 (anion exchanger), member 2 -2.13604
WDR60 WD repeat domain 60 -2.12748
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -2.12031
ARNT aryl hydrocarbon receptor nuclear translocator -2.11048
SNX27 sorting nexin family member 27 -2.10269
INTS3 integrator complex subunit 3 -2.09525
TIAM2 T-cell lymphoma invasion and metastasis 2 -2.09401
RGL1 ral guanine nucleotide dissociation stimulator-like 1 -2.09078
EIF1AX eukaryotic translation initiation factor 1A, X-linked -2.0895
GPD1L glycerol-3-phosphate dehydrogenase 1-like -2.08025
CABIN1 calcineurin binding protein 1 -2.0748
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked -2.06751
TRAK2 trafficking protein, kinesin binding 2 -2.06506
PI4KB phosphatidylinositol 4-kinase, catalytic, beta -2.0618
TTLL3 tubulin tyrosine ligase-like family member 3 -2.04733
PHF21A PHD finger protein 21A -2.04599
TRIM3 tripartite motif containing 3 -2.03657
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -2.02813
RAD51D RAD51 paralog D -2.02475
HOXA7 homeobox A7 -2.01997
ABHD6 abhydrolase domain containing 6 -2.01928
CDK5 cyclin-dependent kinase 5 -2.01744
SEH1L SEH1-like (S. cerevisiae) -2.00685
COX10 COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor -2.00556
TCF25 transcription factor 25 (basic helix-loop-helix) -1.99455
CAMLG calcium modulating ligand -1.9895
MSTO1 misato 1, mitochondrial distribution and morphology regulator -1.9817
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 -1.97795
FASN fatty acid synthase -1.94902
ASNSD1 asparagine synthetase domain containing 1 -1.94165
AGTPBP1 ATP/GTP binding protein 1 -1.9361
ERAL1 Era-like 12S mitochondrial rRNA chaperone 1 -1.93028
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -1.92473
SCAP SREBF chaperone -1.92325
UBA1 ubiquitin-like modifier activating enzyme 1 -1.88943
MATR3 matrin 3 -1.87955
IDUA iduronidase, alpha-L- -1.8728
IQSEC2 IQ motif and Sec7 domain 2 -1.86598
LZTR1 leucine-zipper-like transcription regulator 1 -1.861
PRPF3 pre-mRNA processing factor 3 -1.85345
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) -1.85205
RBM6 RNA binding motif protein 6 -1.85137
LIMS2 LIM and senescent cell antigen-like domains 2 -1.84914
ATM ATM serine/threonine kinase -1.83131
NRG2 neuregulin 2 -1.82818
LIN7B lin-7 homolog B (C. elegans) -1.82451
DAAM2 dishevelled associated activator of morphogenesis 2 -1.81945
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 -1.81606
CDK10 cyclin-dependent kinase 10 -1.81223
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1 -1.80696
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) -1.80584
PMVK phosphomevalonate kinase -1.80498
DEPTOR DEP domain containing MTOR-interacting protein -1.79188
AXIN1 axin 1 -1.77918
PLIN2 perilipin 2 -1.77842
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein -1.76964
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -1.76085
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 -1.73639
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit -1.72762
SMYD5 SMYD family member 5 -1.72537
SFSWAP splicing factor, suppressor of white-apricot family -1.72293
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) -1.72112
RNF40 ring finger protein 40, E3 ubiquitin protein ligase -1.71724
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 -1.71408
PAQR6 progestin and adipoQ receptor family member VI -1.70967
PMPCB peptidase (mitochondrial processing) beta -1.70646
PCOLCE2 procollagen C-endopeptidase enhancer 2 -1.70029
UFC1 ubiquitin-fold modifier conjugating enzyme 1 -1.69002
RRP1 ribosomal RNA processing 1 -1.68276
SF3B4 splicing factor 3b, subunit 4, 49kDa -1.68251
GYPB glycophorin B (MNS blood group) -1.66955
BRD8 bromodomain containing 8 -1.6549
GON4L gon-4-like (C. elegans) -1.65402
LPIN2 lipin 2 -1.64373
SIRT2 sirtuin 2 -1.64195
FOXK2 forkhead box K2 -1.64171
ISCA1 iron-sulfur cluster assembly 1 -1.64164
YY1AP1 YY1 associated protein 1 -1.64104
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1 -1.63511
QTRT1 queuine tRNA-ribosyltransferase 1 -1.62488
ACIN1 apoptotic chromatin condensation inducer 1 -1.62434
DCTN1 dynactin 1 -1.62378
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8 -1.62054
RNF14 ring finger protein 14 -1.61183
DYM dymeclin -1.61156
LARP1 La ribonucleoprotein domain family, member 1 -1.59946
ALOX12 arachidonate 12-lipoxygenase -1.59791
MCOLN1 mucolipin 1 -1.59326
USP21 ubiquitin specific peptidase 21 -1.58929
TXLNA taxilin alpha -1.58558
ELK1 ELK1, member of ETS oncogene family -1.5812
TSHR thyroid stimulating hormone receptor -1.57988
RIC8B RIC8 guanine nucleotide exchange factor B -1.57474
NONO non-POU domain containing, octamer-binding -1.57312
DENR density-regulated protein -1.57059
CDK19 cyclin-dependent kinase 19 -1.56792
ADGRB3 adhesion G protein-coupled receptor B3 -1.56673
LNPEP leucyl/cystinyl aminopeptidase -1.56396
PUS7 pseudouridylate synthase 7 (putative) -1.5633
CERS2 ceramide synthase 2 -1.5569
KMT2A lysine (K)-specific methyltransferase 2A -1.5497
RMND5B required for meiotic nuclear division 5 homolog B (S. cerevisiae) -1.54794
INVS inversin -1.54664
BPTF bromodomain PHD finger transcription factor -1.54588
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2 -1.53706
WNK1 WNK lysine deficient protein kinase 1 -1.5359
IARS isoleucyl-tRNA synthetase -1.53114
HEMK1 HemK methyltransferase family member 1 -1.53103
CHD1 chromodomain helicase DNA binding protein 1 -1.53073
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) -1.52544
MARCH3 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase -1.52451
APOE apolipoprotein E -1.52406
SESN1 sestrin 1 -1.5148
CENPO centromere protein O -1.51369
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit -1.50954
GLTSCR1L GLTSCR1-like -1.5083
GIMAP5 GTPase, IMAP family member 5 -1.50683
WDR45 WD repeat domain 45 -1.50679
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) -1.50615
ZNF638 zinc finger protein 638 -1.50263
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like -1.50246
LRPPRC leucine-rich pentatricopeptide repeat containing -1.49531
EHMT2 euchromatic histone-lysine N-methyltransferase 2 -1.49319
NSF N-ethylmaleimide-sensitive factor -1.49298
TRPM3 transient receptor potential cation channel, subfamily M, member 3 -1.48995
MCM3AP minichromosome maintenance complex component 3 associated protein -1.48729
CEP68 centrosomal protein 68kDa -1.48702
PDGFD platelet derived growth factor D -1.48695
CHD1L chromodomain helicase DNA binding protein 1-like -1.48429
ELMO2 engulfment and cell motility 2 -1.48299
NISCH nischarin -1.47821
AUP1 ancient ubiquitous protein 1 -1.47529
IL17RA interleukin 17 receptor A -1.47427
WDTC1 WD and tetratricopeptide repeats 1 -1.47223
AHSA2 AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast) -1.46957
CASC3 cancer susceptibility candidate 3 -1.46408
RNF34 ring finger protein 34, E3 ubiquitin protein ligase -1.46405
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 -1.46015
SPARCL1 SPARC-like 1 (hevin) -1.45653
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -1.45419
OGG1 8-oxoguanine DNA glycosylase -1.45388
MSI1 musashi RNA-binding protein 1 -1.4524
SEPHS2 selenophosphate synthetase 2 -1.45205
MBD5 methyl-CpG binding domain protein 5 -1.45198
ADAR adenosine deaminase, RNA-specific -1.44837
ORC5 origin recognition complex, subunit 5 -1.44626
MED13L mediator complex subunit 13-like -1.44233
SMG7-AS1 SMG7 antisense RNA 1 -1.44219
KIAA0141 KIAA0141 -1.44188
TSC22D4 TSC22 domain family, member 4 -1.4412
THADA thyroid adenoma associated -1.44067
KIAA0355 KIAA0355 -1.43845
HEATR3 HEAT repeat containing 3 -1.43384
CUX1 cut-like homeobox 1 -1.42652
CAPN10 calpain 10 -1.42372
ARHGAP26 Rho GTPase activating protein 26 -1.42162
PPOX protoporphyrinogen oxidase -1.41773
DDT D-dopachrome tautomerase -1.41751