SCD Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description stearoyl-CoA desaturase (delta-9-desaturase)|This gene encodes an enzyme involved in fatty acid biosynthesis, primarily the synthesis of oleic acid. Transcripts of approximately 3.9 and 5.2 kb, differing only by alternative polyadenlyation signals, have been detected. A gene encoding a similar enzyme is located on chromosome 4 and a pseudogene of this gene is located on chromosome 17. [provided by RefSeq, Feb 2012] (NCBI Entrez Gene Database, 6319)
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Genes

360 genes differentially expressed following the SCD gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha 2.93853
CCNB3 cyclin B3 2.93853
MYBPC1 myosin binding protein C, slow type 2.93853
IL5RA interleukin 5 receptor, alpha 2.93853
DRICH1 aspartate-rich 1 2.93853
OR10A2 olfactory receptor, family 10, subfamily A, member 2 2.93853
SH2D6 SH2 domain containing 6 2.93853
ARHGAP36 Rho GTPase activating protein 36 2.93853
OLIG1 oligodendrocyte transcription factor 1 2.93853
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 2.93853
TUBB8 tubulin, beta 8 class VIII 2.93853
TAS2R8 taste receptor, type 2, member 8 2.93853
GIMAP2 GTPase, IMAP family member 2 2.93853
HORMAD2 HORMA domain containing 2 2.93853
TNNI2 troponin I type 2 (skeletal, fast) 2.93853
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 2.93853
ZNF503 zinc finger protein 503 2.93853
SACK1A scaffolding CK1 anchoring protein A 2.93853
GNLY granulysin 2.93853
BSND barttin CLCNK-type chloride channel accessory beta subunit 2.93853
RSPH6A radial spoke head 6 homolog A (Chlamydomonas) 2.93853
SPINK6 serine peptidase inhibitor, Kazal type 6 2.93853
BTC betacellulin 2.93853
AKR1C2 aldo-keto reductase family 1, member C2 2.93853
PGAM4 phosphoglycerate mutase family member 4 2.93853
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 2.93853
PON1 paraoxonase 1 2.93853
SPINT3 serine peptidase inhibitor, Kunitz type, 3 2.93853
PECAM1 platelet/endothelial cell adhesion molecule 1 2.93853
GNRHR gonadotropin-releasing hormone receptor 2.93853
LRRC66 leucine rich repeat containing 66 2.93853
HBD hemoglobin, delta 2.93853
MRO maestro 2.93853
LBX2 ladybird homeobox 2 2.93853
DIO3 deiodinase, iodothyronine, type III 2.93853
TAS2R13 taste receptor, type 2, member 13 2.93853
AVP arginine vasopressin 2.93853
BMP3 bone morphogenetic protein 3 2.93853
MYO16 myosin XVI 2.93853
THSD1 thrombospondin, type I, domain containing 1 2.93853
SP5 Sp5 transcription factor 2.93853
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 2.93853
WNT8B wingless-type MMTV integration site family, member 8B 2.93853
TRIM72 tripartite motif containing 72, E3 ubiquitin protein ligase 2.93853
ANKRD34A ankyrin repeat domain 34A 2.93853
ZNF792 zinc finger protein 792 2.93853
RGL4 ral guanine nucleotide dissociation stimulator-like 4 2.93853
DRP2 dystrophin related protein 2 2.93853
C1ORF141 chromosome 1 open reading frame 141 2.93853
NLRP10 NLR family, pyrin domain containing 10 2.93853
GLRA3 glycine receptor, alpha 3 2.93853
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 2.93853
RLN1 relaxin 1 2.93853
MEIKIN meiotic kinetochore factor 2.93853
STRIP2 striatin interacting protein 2 2.93853
TPPP tubulin polymerization promoting protein 2.93853
OR5BS1 olfactory receptor family 5 subfamily BS member 1 2.93853
NIBAN3 niban apoptosis regulator 3 2.93853
ANGPTL8 angiopoietin like 8 2.93853
VSIR V-set immunoregulatory receptor 2.93853
STING1 stimulator of interferon response cGAMP interactor 1 2.93853
ZAR1 zygote arrest 1 2.93853
ROPN1L rhophilin associated tail protein 1-like 2.93853
PROP1 PROP paired-like homeobox 1 2.93853
AANAT aralkylamine N-acetyltransferase 2.93853
TBC1D3B TBC1 domain family, member 3B 2.93853
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 2.93853
TMPRSS5 transmembrane protease, serine 5 2.93853
BDKRB1 bradykinin receptor B1 2.93853
MYORG myogenesis regulating glycosidase (putative) 2.93853
SMIM41 small integral membrane protein 41 2.93853
TEKTL1 tektin like 1 2.93853
C1ORF202 chromosome 1 open reading frame 202 2.93853
TMEM238L transmembrane protein 238 like 2.93853
CCDC196 coiled-coil domain containing 196 2.93853
H2BC3 H2B clustered histone 3 2.93853
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 2.93853
VXN vexin 2.93853
RNF227 ring finger protein 227 2.93853
CABCOCO1 ciliary associated calcium binding coiled-coil 1 2.93853
GK3 glycerol kinase 3 2.93853
LOC122539214 Zinc finger protein LOC122539214 2.93853
LOC112694756 uncharaterized LOC112694756 2.93853
MYL10 myosin, light chain 10, regulatory 2.93853
SMTNL1 smoothelin-like 1 2.93853
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 2.93853
THPO thrombopoietin 2.93853
OR1F1 olfactory receptor, family 1, subfamily F, member 1 2.93853
ACOT1 acyl-CoA thioesterase 1 2.93853
ACTL8 actin-like 8 2.93853
DNAI2 dynein, axonemal, intermediate chain 2 2.93853
ERAS ES cell expressed Ras 2.93853
TBX22 T-box 22 2.93853
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 2.93853
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 2.93853
GJA4 gap junction protein, alpha 4, 37kDa 2.93853
CD96 CD96 molecule 2.93853
GOLGA6L4 golgin A6 family-like 4 2.93853
VASH1 vasohibin 1 2.93853
VSIG8 V-set and immunoglobulin domain containing 8 2.93853
C15ORF62 chromosome 15 open reading frame 62 2.93853
GATA4 GATA binding protein 4 2.93853
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 2.93853
SOAT2 sterol O-acyltransferase 2 2.93853
CFAP52 cilia and flagella associated protein 52 2.93853
WNT9B wingless-type MMTV integration site family, member 9B 2.93853
PABPC1L2A poly(A) binding protein, cytoplasmic 1-like 2A 2.93853
BLNK B-cell linker 2.93853
PGA3 pepsinogen 3, group I (pepsinogen A) 2.93853
CLDN22 claudin 22 2.93853
EXOC3L1 exocyst complex component 3-like 1 2.93853
IL11RA interleukin 11 receptor, alpha 2.93853
PRSS55 protease, serine, 55 2.93853
SHISA8 shisa family member 8 2.93853
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 2.93853
VNN2 vanin 2 2.93853
CRYBB3 crystallin, beta B3 2.93853
C2ORF66 chromosome 2 open reading frame 66 2.93853
JSRP1 junctional sarcoplasmic reticulum protein 1 2.93853
PRM1 protamine 1 2.93853
HPX hemopexin 2.93853
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 2.93853
PCDHGA3 protocadherin gamma subfamily A, 3 2.93853
VWA3A von Willebrand factor A domain containing 3A 2.93853
DQX1 DEAQ box RNA-dependent ATPase 1 2.93853
TNR tenascin R 2.93853
HSPB9 heat shock protein, alpha-crystallin-related, B9 2.93853
ZNF471 zinc finger protein 471 2.93853
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 2.93853
OR9Q1 olfactory receptor, family 9, subfamily Q, member 1 2.93853
LRRC36 leucine rich repeat containing 36 2.93853
MBOAT4 membrane bound O-acyltransferase domain containing 4 2.93853
DUSP26 dual specificity phosphatase 26 (putative) 2.93853
FNDC8 fibronectin type III domain containing 8 2.93853
RGS11 regulator of G-protein signaling 11 2.93853
CLDN34 claudin 34 2.93853
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 2.93853
C17ORF99 chromosome 17 open reading frame 99 2.93853
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C 2.93853
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 2.93853
DND1 DND microRNA-mediated repression inhibitor 1 2.93853
LHX2 LIM homeobox 2 2.93853
LRRC25 leucine rich repeat containing 25 2.93853
GFY golgi-associated, olfactory signaling regulator 2.93853
MGP matrix Gla protein 2.93853
LAMB4 laminin, beta 4 2.93853
FAM151A family with sequence similarity 151, member A 2.93853
ADAM18 ADAM metallopeptidase domain 18 2.93853
TMEM255A transmembrane protein 255A 2.93853
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 2.93853
NLRP14 NLR family, pyrin domain containing 14 2.93853
NT5C1A 5'-nucleotidase, cytosolic IA 2.93853
PRH2 proline-rich protein HaeIII subfamily 2 2.93853
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 2.93853
MLIP muscular LMNA-interacting protein 2.93853
FBXL22 F-box and leucine-rich repeat protein 22 2.93853
KLK6 kallikrein-related peptidase 6 2.93853
CALR3 calreticulin 3 2.93853
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 2.93853
LY96 lymphocyte antigen 96 2.93853
TRAK1 trafficking protein, kinesin binding 1 2.93853
TF transferrin 2.93853
TPPP2 tubulin polymerization-promoting protein family member 2 2.93853
PRSS38 protease, serine, 38 2.93853
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 2.93853
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 2.93853
APOL6 apolipoprotein L, 6 2.93853
GCSAML germinal center-associated, signaling and motility-like 2.93853
EN1 engrailed homeobox 1 2.93853
KCNK15 potassium channel, two pore domain subfamily K, member 15 2.93853
RTN4RL1 reticulon 4 receptor-like 1 2.93853
IL23R interleukin 23 receptor 2.93853
PPP1R3G protein phosphatase 1, regulatory subunit 3G 2.93853
MMP13 matrix metallopeptidase 13 2.93853
NRGN neurogranin (protein kinase C substrate, RC3) 2.93853
ACAN aggrecan 2.93853
TGM4 transglutaminase 4 2.93853
PADI4 peptidyl arginine deiminase, type IV 2.93853
KCTD4 potassium channel tetramerization domain containing 4 2.93853
ANXA8 annexin A8 2.93853
ASCL2 achaete-scute family bHLH transcription factor 2 2.93853
OR52I2 olfactory receptor, family 52, subfamily I, member 2 2.93853
PRSS27 protease, serine 27 2.93853
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28 2.93853
LOXL4 lysyl oxidase-like 4 2.93853
C5ORF46 chromosome 5 open reading frame 46 2.93853
BATF2 basic leucine zipper transcription factor, ATF-like 2 2.93853
TMIGD2 transmembrane and immunoglobulin domain containing 2 2.93853
ZNF396 zinc finger protein 396 2.93853
PRR29 proline rich 29 2.93853
SLC10A6 solute carrier family 10 (sodium/bile acid cotransporter), member 6 2.93853
IL17B interleukin 17B 2.93853
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 2.93853
MMP12 matrix metallopeptidase 12 2.93853
KCNJ13 potassium channel, inwardly rectifying subfamily J, member 13 2.93853
FOXG1 forkhead box G1 2.93853
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 2.93853
MPPE1 metallophosphoesterase 1 2.9066
MUC1 mucin 1, cell surface associated 2.82786
UBXN8 UBX domain protein 8 2.82428
EMX1 empty spiracles homeobox 1 2.78391
COMMD3 COMM domain containing 3 2.75279
ELOVL2 ELOVL fatty acid elongase 2 2.75279
FBXO8 F-box protein 8 2.73397
SLIRP SRA stem-loop interacting RNA binding protein 2.7326
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 2.71919
C12ORF75 chromosome 12 open reading frame 75 2.71919
STK38 serine/threonine kinase 38 2.70303
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit 2.70064
NTNG1 netrin G1 2.69191
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 2.63108
STKLD1 serine/threonine kinase-like domain containing 1 2.58868
ASMT acetylserotonin O-methyltransferase 2.58868
TMEM204 transmembrane protein 204 2.58868
HNRNPL heterogeneous nuclear ribonucleoprotein L 2.53726
C1QTNF1 C1q and tumor necrosis factor related protein 1 2.52602
ALK anaplastic lymphoma receptor tyrosine kinase 2.52602
IPP intracisternal A particle-promoted polypeptide 2.5252
TDG thymine-DNA glycosylase 2.51493
DGKE diacylglycerol kinase, epsilon 64kDa 2.51092
LRIF1 ligand dependent nuclear receptor interacting factor 1 2.45015
OTOG otogelin 2.44931
MED14 mediator complex subunit 14 2.42051
DERA deoxyribose-phosphate aldolase (putative) 2.38548
ANKIB1 ankyrin repeat and IBR domain containing 1 2.36968
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme 2.36209
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) 2.36185
BTLA B and T lymphocyte associated 2.35683
AP5B1 adaptor-related protein complex 5, beta 1 subunit 2.35408
STK10 serine/threonine kinase 10 2.35096
ATP5ME ATP synthase membrane subunit e 2.34167
DCX doublecortin 2.32031
CDH5 cadherin 5, type 2 (vascular endothelium) 2.31241
STARD3 StAR-related lipid transfer (START) domain containing 3 2.31241
PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2.30176
COP1 COP1 E3 ubiquitin ligase 2.29127
RELL1 RELT-like 1 2.27476
FHIP2B FHF complex subunit HOOK interacting protein 2B 2.27257
NIPSNAP2 nipsnap homolog 2 2.26018
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 2.25367
EXOSC2 exosome component 2 2.24763
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1 2.24524
DLAT dihydrolipoamide S-acetyltransferase 2.24524
PCCB propionyl CoA carboxylase, beta polypeptide 2.18964
AGTPBP1 ATP/GTP binding protein 1 2.18611
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 2.18247
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.18025
WWP1 WW domain containing E3 ubiquitin protein ligase 1 2.15721
XPA xeroderma pigmentosum, complementation group A 2.15658
TMEM164 transmembrane protein 164 2.15501
ASGR1 asialoglycoprotein receptor 1 2.14477
ART3 ADP-ribosyltransferase 3 2.14028
KDM8 lysine (K)-specific demethylase 8 2.13602
SGTB small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta 2.11929
PTPN1 protein tyrosine phosphatase, non-receptor type 1 2.096
ZNF717 zinc finger protein 717 2.08898
TTC27 tetratricopeptide repeat domain 27 2.08789
OTUD4 OTU deubiquitinase 4 2.08771
CMTM7 CKLF-like MARVEL transmembrane domain containing 7 2.0624
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 2.05907
AGFG2 ArfGAP with FG repeats 2 2.05686
AK8 adenylate kinase 8 2.0106
CFAP44 cilia and flagella associated protein 44 2.0106
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 2.0021

decreased expression

Symbol Name Standardized Value
SMIM47 small integral membrane protein 47 -2.93853
COL8A2 collagen, type VIII, alpha 2 -2.93853
ADAMTSL2 ADAMTS-like 2 -2.93853
FSCN3 fascin actin-bundling protein 3, testicular -2.93853
SLC44A4 solute carrier family 44, member 4 -2.93853
LIPH lipase, member H -2.93853
IGDCC3 immunoglobulin superfamily, DCC subclass, member 3 -2.93853
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 -2.93853
NTSR1 neurotensin receptor 1 (high affinity) -2.93853
PLA2G4B phospholipase A2, group IVB (cytosolic) -2.93853
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit -2.93853
MCM5 minichromosome maintenance complex component 5 -2.93853
CNTNAP5 contactin associated protein-like 5 -2.93853
PTGES prostaglandin E synthase -2.93853
RPSA2 ribosomal protein SA 2 -2.93853
TENT5D terminal nucleotidyltransferase 5D -2.93853
TENT5C terminal nucleotidyltransferase 5C -2.93853
CCDC9B coiled-coil domain containing 9B -2.93853
HSH2D hematopoietic SH2 domain containing -2.93853
STARD6 StAR-related lipid transfer (START) domain containing 6 -2.93853
RNF25 ring finger protein 25 -2.93853
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -2.93853
ERVFRD-1 endogenous retrovirus group FRD, member 1 -2.93853
PCDHA5 protocadherin alpha 5 -2.93853
DCAF12L2 DDB1 and CUL4 associated factor 12-like 2 -2.93853
PABPC4L poly(A) binding protein, cytoplasmic 4-like -2.93853
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) -2.93853
RSPH9 radial spoke head 9 homolog (Chlamydomonas) -2.93853
CRHR1 corticotropin releasing hormone receptor 1 -2.93853
KLK11 kallikrein-related peptidase 11 -2.93853
NOTCH4 notch 4 -2.93853
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1 -2.93853
DNAAF1 dynein, axonemal, assembly factor 1 -2.93853
SEC14L6 SEC14-like 6 (S. cerevisiae) -2.93853
STK4 serine/threonine kinase 4 -2.9255
TMEM143 transmembrane protein 143 -2.8091
FOXB1 forkhead box B1 -2.75432
SMOC1 SPARC related modular calcium binding 1 -2.75432
FSIP1 fibrous sheath interacting protein 1 -2.75119
ZNF222 zinc finger protein 222 -2.75119
OAZ2 ornithine decarboxylase antizyme 2 -2.73982
THAP9 THAP domain containing 9 -2.73679
CAB39 calcium binding protein 39 -2.67301
TCEAL5 transcription elongation factor A (SII)-like 5 -2.64091
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -2.62155
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12 -2.60107
GSDMD gasdermin D -2.57077
FAHD2A fumarylacetoacetate hydrolase domain containing 2A -2.55677
DHPS deoxyhypusine synthase -2.55651
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4 -2.55305
ZNF605 zinc finger protein 605 -2.55108
RPS17 ribosomal protein S17 -2.5344
GNPTG N-acetylglucosamine-1-phosphate transferase, gamma subunit -2.42319
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 -2.40926
UBTD2 ubiquitin domain containing 2 -2.40342
GAP43 growth associated protein 43 -2.38548
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 -2.3833
NPR2 natriuretic peptide receptor 2 -2.3833
ZNF470 zinc finger protein 470 -2.37315
IGSF9 immunoglobulin superfamily, member 9 -2.3619
PCED1A PC-esterase domain containing 1A -2.35966
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 -2.35559
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -2.34091
SLC35A5 solute carrier family 35, member A5 -2.33048
SCRN1 secernin 1 -2.32031
BEND4 BEN domain containing 4 -2.32011
ANTKMT adenine nucleotide translocase lysine methyltransferase -2.31537
ANKFN1 ankyrin-repeat and fibronectin type III domain containing 1 -2.31535
CDA cytidine deaminase -2.31241
TEX22 testis expressed 22 -2.29627
SMIM10 small integral membrane protein 10 -2.29627
GRHL1 grainyhead-like 1 (Drosophila) -2.29627
UMPS uridine monophosphate synthetase -2.27476
MRPL35 mitochondrial ribosomal protein L35 -2.27022
MEGF10 multiple EGF-like-domains 10 -2.24183
SOCS4 suppressor of cytokine signaling 4 -2.23239
SETMAR SET domain and mariner transposase fusion gene -2.23152
LAP3 leucine aminopeptidase 3 -2.21406
MACIR macrophage immunometabolism regulator -2.21276
MNT MAX network transcriptional repressor -2.20276
B9D1 B9 protein domain 1 -2.20276
ASS1 argininosuccinate synthase 1 -2.19008
COL5A1 collagen, type V, alpha 1 -2.17614
RPS18 ribosomal protein S18 -2.16716
MRPS31 mitochondrial ribosomal protein S31 -2.10712
KIF17 kinesin family member 17 -2.10106
LIPT2 lipoyl(octanoyl) transferase 2 (putative) -2.09656
ERICH5 glutamate-rich 5 -2.09107
GBGT1 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 -2.0725
ZNF12 zinc finger protein 12 -2.07225
SIRT5 sirtuin 5 -2.04948
MICB MHC class I polypeptide-related sequence B -2.04114
GPR19 G protein-coupled receptor 19 -2.02853
DSE dermatan sulfate epimerase -2.02555
LINGO2 leucine rich repeat and Ig domain containing 2 -2.0245
ZNF428 zinc finger protein 428 -2.0106