SCF ubiquitin ligase complex Gene Set

Dataset GO Cellular Component Annotations 2025
Category structural or functional annotations
Type cellular component
Description A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1). (Gene Ontology, GO_0019005)
External Link http://amigo.geneontology.org/amigo/term/GO:0019005
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59 proteins localized to the SCF ubiquitin ligase complex cellular component from the curated GO Cellular Component Annotations 2025 dataset.

Symbol Name
AMN1 antagonist of mitotic exit network 1 homolog (S. cerevisiae)
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CCNF cyclin F
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CUL1 cullin 1
CUL2 cullin 2
CUL5 cullin 5
DAW1 dynein assembly factor with WDR repeat domains 1
DMAC2 distal membrane arm assembly component 2
FBH1 F-box DNA helicase 1
FBXL13 F-box and leucine-rich repeat protein 13
FBXL14 F-box and leucine-rich repeat protein 14
FBXL15 F-box and leucine-rich repeat protein 15
FBXL16 F-box and leucine-rich repeat protein 16
FBXL17 F-box and leucine-rich repeat protein 17
FBXL19 F-box and leucine-rich repeat protein 19
FBXL2 F-box and leucine-rich repeat protein 2
FBXL20 F-box and leucine-rich repeat protein 20
FBXL3 F-box and leucine-rich repeat protein 3
FBXL4 F-box and leucine-rich repeat protein 4
FBXL5 F-box and leucine-rich repeat protein 5
FBXL6 F-box and leucine-rich repeat protein 6
FBXL7 F-box and leucine-rich repeat protein 7
FBXO15 F-box protein 15
FBXO17 F-box protein 17
FBXO2 F-box protein 2
FBXO25 F-box protein 25
FBXO27 F-box protein 27
FBXO3 F-box protein 3
FBXO31 F-box protein 31
FBXO32 F-box protein 32
FBXO38 F-box protein 38
FBXO39 F-box protein 39
FBXO4 F-box protein 4
FBXO42 F-box protein 42
FBXO44 F-box protein 44
FBXO45 F-box protein 45
FBXO48 F-box protein 48
FBXO6 F-box protein 6
FBXO7 F-box protein 7
FBXO9 F-box protein 9
FBXW11 F-box and WD repeat domain containing 11
FBXW4 F-box and WD repeat domain containing 4
FBXW5 F-box and WD repeat domain containing 5
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
NCCRP1 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish)
PRKN parkin RBR E3 ubiquitin protein ligase
RBX1 ring-box 1, E3 ubiquitin protein ligase
SKP1 S-phase kinase-associated protein 1
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SPSB2 splA/ryanodine receptor domain and SOCS box containing 2
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
SPSB4 splA/ryanodine receptor domain and SOCS box containing 4
TMEM183A transmembrane protein 183A
TRIM21 tripartite motif containing 21
USP47 ubiquitin specific peptidase 47
UXT ubiquitously-expressed, prefoldin-like chaperone