SCG2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description secretogranin II|The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7857)
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Genes

298 genes differentially expressed following the SCG2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ZACN zinc activated ligand-gated ion channel 2.67403
CASP6 caspase 6, apoptosis-related cysteine peptidase 2.67403
DDN dendrin 2.67403
NOD2 nucleotide-binding oligomerization domain containing 2 2.67403
OR10A2 olfactory receptor, family 10, subfamily A, member 2 2.67403
LRRC14B leucine rich repeat containing 14B 2.67403
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae) 2.67403
XCL1 chemokine (C motif) ligand 1 2.67403
MUSK muscle, skeletal, receptor tyrosine kinase 2.67403
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 2.67403
UNC13C unc-13 homolog C (C. elegans) 2.67403
TM4SF5 transmembrane 4 L six family member 5 2.67403
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 2.67403
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 2.67403
VWA5B2 von Willebrand factor A domain containing 5B2 2.67403
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 2.67403
HEATR9 HEAT repeat containing 9 2.67403
BTK Bruton agammaglobulinemia tyrosine kinase 2.67403
TRIM15 tripartite motif containing 15 2.67403
MAGEA1 melanoma antigen family A1 2.67403
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 2.67403
SSTR5 somatostatin receptor 5 2.67403
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 2.67403
PECAM1 platelet/endothelial cell adhesion molecule 1 2.67403
BFSP2 beaded filament structural protein 2, phakinin 2.67403
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 2.67403
PRDM16 PR domain containing 16 2.67403
TSHZ1 teashirt zinc finger homeobox 1 2.67403
MRC1 mannose receptor, C type 1 2.67403
CLCN1 chloride channel, voltage-sensitive 1 2.67403
NMUR1 neuromedin U receptor 1 2.67403
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 2.67403
TMEM132C transmembrane protein 132C 2.67403
NPIPA8 nuclear pore complex interacting protein family, member A8 2.67403
GNG13 guanine nucleotide binding protein (G protein), gamma 13 2.67403
ANKRD34A ankyrin repeat domain 34A 2.67403
UBE2U ubiquitin-conjugating enzyme E2U (putative) 2.67403
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 2.67403
TMEM217 transmembrane protein 217 2.67403
LCN12 lipocalin 12 2.67403
G6PD glucose-6-phosphate dehydrogenase 2.67403
PSCA prostate stem cell antigen 2.67403
MAGED2 melanoma antigen family D2 2.67403
MLNR motilin receptor 2.67403
SPAG8 sperm associated antigen 8 2.67403
SPMIP11 sperm microtubule inner protein 11 2.67403
UNC93A unc-93 homolog A (C. elegans) 2.67403
HTRA4 HtrA serine peptidase 4 2.67403
KRT86 keratin 86, type II 2.67403
JADE3 jade family PHD finger 3 2.67403
TBC1D3B TBC1 domain family, member 3B 2.67403
OR6F1 olfactory receptor, family 6, subfamily F, member 1 2.67403
PAPOLB poly(A) polymerase beta (testis specific) 2.67403
NHLH1 nescient helix loop helix 1 2.67403
DOK7 docking protein 7 2.67403
STING1 stimulator of interferon response cGAMP interactor 1 2.67403
NSG2 neuronal vesicle trafficking associated 2 2.67403
SPATA31H1 SPATA31 subfamily H member 1 2.67403
STRIT1 small transmembrane regulator of ion transport 1 2.67403
PPIAP39 peptidylprolyl isomerase A pseudogene 39 2.67403
CIMIP3 ciliary microtubule inner protein 3 2.67403
SMIM35 small integral membrane protein 35 2.67403
LY6L lymphocyte antigen 6 family member L 2.67403
CHCT1 CHD1 helical C-terminal domain containing 1 2.67403
TERB1 telomere repeat binding bouquet formation protein 1 2.67403
SEM1 SEM1 26S proteasome subunit 2.67403
LTK leukocyte receptor tyrosine kinase 2.67403
ACE2 angiotensin I converting enzyme 2 2.67403
GDF9 growth differentiation factor 9 2.67403
NXPE1 neurexophilin and PC-esterase domain family, member 1 2.67403
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 2.67403
RHOXF2 Rhox homeobox family, member 2 2.67403
CATSPERT catsper channel auxiliary subunit tau 2.67403
FABP9 fatty acid binding protein 9, testis 2.67403
PLVAP plasmalemma vesicle associated protein 2.67403
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 2.67403
GJA9 gap junction protein, alpha 9, 59kDa 2.67403
HLF hepatic leukemia factor 2.67403
OR7C1 olfactory receptor, family 7, subfamily C, member 1 2.67403
MAL mal, T-cell differentiation protein 2.67403
HAL histidine ammonia-lyase 2.67403
C7 complement component 7 2.67403
CNTFR ciliary neurotrophic factor receptor 2.67403
CCR4 chemokine (C-C motif) receptor 4 2.67403
C1QTNF8 C1q and tumor necrosis factor related protein 8 2.67403
GLP2R glucagon-like peptide 2 receptor 2.67403
TPTE transmembrane phosphatase with tensin homology 2.67403
ADGRG1 adhesion G protein-coupled receptor G1 2.67403
TLR2 toll-like receptor 2 2.67403
HMGCLL1 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1 2.67403
DUSP26 dual specificity phosphatase 26 (putative) 2.67403
RNASE10 ribonuclease, RNase A family, 10 (non-active) 2.67403
WFDC1 WAP four-disulfide core domain 1 2.67403
CALHM2 calcium homeostasis modulator 2 2.67403
CPA4 carboxypeptidase A4 2.67403
CPA2 carboxypeptidase A2 (pancreatic) 2.67403
PAGE1 P antigen family, member 1 (prostate associated) 2.67403
PCDHGA4 protocadherin gamma subfamily A, 4 2.67403
COX7B2 cytochrome c oxidase subunit VIIb2 2.67403
VWA3B von Willebrand factor A domain containing 3B 2.67403
RTBDN retbindin 2.67403
CXCR5 chemokine (C-X-C motif) receptor 5 2.67403
NPIPB15 nuclear pore complex interacting protein family, member B15 2.67403
IGFBP3 insulin-like growth factor binding protein 3 2.67403
F10 coagulation factor X 2.67403
RNF112 ring finger protein 112 2.67403
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) 2.67403
OR56A4 olfactory receptor, family 56, subfamily A, member 4 2.67403
CST2 cystatin SA 2.67403
GPR12 G protein-coupled receptor 12 2.67403
SYNE1 spectrin repeat containing, nuclear envelope 1 2.67403
PCDH12 protocadherin 12 2.67403
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 2.67403
THBD thrombomodulin 2.67403
EAF2 ELL associated factor 2 2.67403
SPATA16 spermatogenesis associated 16 2.67403
CASQ2 calsequestrin 2 (cardiac muscle) 2.67403
GBX1 gastrulation brain homeobox 1 2.67403
C10ORF105 chromosome 10 open reading frame 105 2.67403
LRRN4 leucine rich repeat neuronal 4 2.67403
ZNF831 zinc finger protein 831 2.67403
EVI2A ecotropic viral integration site 2A 2.67403
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 2.67403
DEFB135 defensin, beta 135 2.67403
NYX nyctalopin 2.67403
ZCCHC12 zinc finger, CCHC domain containing 12 2.67403
CAMLG calcium modulating ligand 2.67403
ITGA11 integrin, alpha 11 2.67403
MORN5 MORN repeat containing 5 2.67403
PRSS38 protease, serine, 38 2.67403
NT5C1A 5'-nucleotidase, cytosolic IA 2.67403
SLC38A8 solute carrier family 38, member 8 2.67403
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 2.67403
CFAP126 cilia and flagella associated protein 126 2.67403
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 2.67403
KIAA1755 KIAA1755 2.67403
CIB3 calcium and integrin binding family member 3 2.67403
C10ORF90 chromosome 10 open reading frame 90 2.67403
CHRDL2 chordin-like 2 2.67403
LYZL1 lysozyme-like 1 2.67403
TGM6 transglutaminase 6 2.67403
TAS2R46 taste receptor, type 2, member 46 2.67403
MMP10 matrix metallopeptidase 10 2.67403
MMP19 matrix metallopeptidase 19 2.67403
TMEM215 transmembrane protein 215 2.67403
LOXL4 lysyl oxidase-like 4 2.67403
ICAM2 intercellular adhesion molecule 2 2.67403
OR6B1 olfactory receptor, family 6, subfamily B, member 1 2.67403
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.67403
SMCO3 single-pass membrane protein with coiled-coil domains 3 2.67403
CCDC87 coiled-coil domain containing 87 2.67403
MIXL1 Mix paired-like homeobox 2.67403
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 2.67403
GRAPL GRB2-related adaptor protein-like 2.67403
TCF21 transcription factor 21 2.67403
ZNF474 zinc finger protein 474 2.67403
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 2.67403
SCN3A sodium channel, voltage gated, type III alpha subunit 2.67403
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 2.67403
WDFY4 WDFY family member 4 2.67403
LAMP3 lysosomal-associated membrane protein 3 2.67403
PRRX1 paired related homeobox 1 2.67403
PLA2G4E phospholipase A2, group IVE 2.67403
PHOSPHO1 phosphatase, orphan 1 2.67403
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 2.67403
GPER1 G protein-coupled estrogen receptor 1 2.67403
CACNB1 calcium channel, voltage-dependent, beta 1 subunit 2.60664
RASL11B RAS-like, family 11, member B 2.59788
CDCA3 cell division cycle associated 3 2.5956
TMEM253 transmembrane protein 253 2.54033
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 2.54033
SPOCD1 SPOC domain containing 1 2.54033
RAE1 ribonucleic acid export 1 2.53722
PEX1 peroxisomal biogenesis factor 1 2.51721
CHUK conserved helix-loop-helix ubiquitous kinase 2.44387
MOB3C MOB kinase activator 3C 2.42149
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 2.42149
EPS8L2 EPS8-like 2 2.36722
PLPP1 phospholipid phosphatase 1 2.31145
AQP4 aquaporin 4 2.2929
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.2897
CUL7 cullin 7 2.28355
WDR24 WD repeat domain 24 2.26367
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 2.25164
TXNDC15 thioredoxin domain containing 15 2.20846
DZANK1 double zinc ribbon and ankyrin repeat domains 1 2.19749
ANXA2 annexin A2 2.14626
EEIG1 estrogen-induced osteoclastogenesis regulator 1 2.13451
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 2.12184
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1 2.11167
BID BH3 interacting domain death agonist 2.11167
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12 2.08729
TBC1D8B TBC1 domain family, member 8B (with GRAM domain) 2.07378
ZNF839 zinc finger protein 839 2.06911
WDR33 WD repeat domain 33 2.06165
TP53I3 tumor protein p53 inducible protein 3 2.05209
ZCCHC4 zinc finger, CCHC domain containing 4 2.04535
UXT ubiquitously-expressed, prefoldin-like chaperone 2.04465
ASNS asparagine synthetase (glutamine-hydrolyzing) 2.04465
GTF2IRD2 GTF2I repeat domain containing 2 2.04249
SLC35F2 solute carrier family 35, member F2 2.04157
CENPK centromere protein K 2.01829
PET100 PET100 homolog (S. cerevisiae) 2.01621
CACNB3 calcium channel, voltage-dependent, beta 3 subunit 2.01249

decreased expression

Symbol Name Standardized Value
XKR3 XK, Kell blood group complex subunit-related family, member 3 -2.67403
CRACDL CRACD like -2.67403
PLPP4 phospholipid phosphatase 4 -2.67403
ATG4A autophagy related 4A, cysteine peptidase -2.67403
TP53TG5 TP53 target 5 -2.67403
SPACDR sperm acrosome developmental regulator -2.67403
JHY junctional cadherin complex regulator -2.67403
GRM6 glutamate receptor, metabotropic 6 -2.67403
OR52A1 olfactory receptor, family 52, subfamily A, member 1 -2.67403
H4C13 H4 clustered histone 13 -2.67403
MAFA v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A -2.67403
CFAP299 cilia and flagella associated protein 299 -2.67403
VWC2L von Willebrand factor C domain containing protein 2-like -2.67403
CCN3 cellular communication network factor 3 -2.67403
ZNF45 zinc finger protein 45 -2.67403
CCDC68 coiled-coil domain containing 68 -2.67403
ARMC12 armadillo repeat containing 12 -2.67403
MYOT myotilin -2.67403
SCRT2 scratch family zinc finger 2 -2.67403
CD48 CD48 molecule -2.67403
FAM78A family with sequence similarity 78, member A -2.67403
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 -2.67403
ACSL5 acyl-CoA synthetase long-chain family member 5 -2.67403
FOXL2 forkhead box L2 -2.67403
SLC5A4 solute carrier family 5 (glucose activated ion channel), member 4 -2.67403
LRRTM2 leucine rich repeat transmembrane neuronal 2 -2.67403
AANAT aralkylamine N-acetyltransferase -2.67403
RAB36 RAB36, member RAS oncogene family -2.67403
TMEM213 transmembrane protein 213 -2.67403
SMIM31 small integral membrane protein 31 -2.67403
ARHGAP40 Rho GTPase activating protein 40 -2.67403
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -2.67403
SLCO2A1 solute carrier organic anion transporter family, member 2A1 -2.67403
CRYBB3 crystallin, beta B3 -2.67403
HOGA1 4-hydroxy-2-oxoglutarate aldolase 1 -2.67403
FAM163B family with sequence similarity 163, member B -2.67403
PAGE4 P antigen family, member 4 (prostate associated) -2.67403
RAD51AP2 RAD51 associated protein 2 -2.67403
IGSF6 immunoglobulin superfamily, member 6 -2.67403
LINC02560 long intergenic non-protein coding RNA 2560 -2.67403
PFN4 profilin family, member 4 -2.67403
TNN tenascin N -2.67403
ALOX15B arachidonate 15-lipoxygenase, type B -2.67403
LRRC32 leucine rich repeat containing 32 -2.67403
TCEANC transcription elongation factor A (SII) N-terminal and central domain containing -2.67403
SRRM5 serine/arginine repetitive matrix 5 -2.67403
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1 -2.67403
RAB3IL1 RAB3A interacting protein (rabin3)-like 1 -2.67403
WDR88 WD repeat domain 88 -2.59864
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) -2.59567
IFT70B intraflagellar transport 70B -2.5956
SMTN smoothelin -2.57965
RHBG Rh family, B glycoprotein (gene/pseudogene) -2.57965
PGAP4 post-GPI attachment to proteins GalNAc transferase 4 -2.54033
TIPE3 TNF alpha induced protein 8 like 3 -2.54033
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2 -2.53901
ZNF451 zinc finger protein 451 -2.50744
FAM120AOS family with sequence similarity 120A opposite strand -2.46373
FREM3 FRAS1 related extracellular matrix 3 -2.44318
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit -2.44245
COL27A1 collagen, type XXVII, alpha 1 -2.42565
SPTY2D1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) -2.42079
CAMKMT calmodulin-lysine N-methyltransferase -2.4141
HDDC2 HD domain containing 2 -2.33531
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11 -2.32684
KIF1C kinesin family member 1C -2.32049
RIC8A RIC8 guanine nucleotide exchange factor A -2.30209
SEZ6L2 seizure related 6 homolog (mouse)-like 2 -2.2846
PHYH phytanoyl-CoA 2-hydroxylase -2.22811
SPICP3 Spi-C transcription factor pseudogene 3 -2.20846
IPO5 importin 5 -2.16218
UVRAG UV radiation resistance associated -2.1604
NIN ninein (GSK3B interacting protein) -2.15781
CPSF3 cleavage and polyadenylation specific factor 3, 73kDa -2.15141
HNRNPLL heterogeneous nuclear ribonucleoprotein L-like -2.1505
CHIC1 cysteine-rich hydrophobic domain 1 -2.14626
SEPTIN4 septin 4 -2.14546
ZGRF1 zinc finger, GRF-type containing 1 -2.13756
MCMDC2 minichromosome maintenance domain containing 2 -2.13033
BBS10 Bardet-Biedl syndrome 10 -2.13033
NDUFB4 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa -2.11874
COL1A1 collagen, type I, alpha 1 -2.11801
KIF2A kinesin heavy chain member 2A -2.11298
MED1 mediator complex subunit 1 -2.11167
AURKC aurora kinase C -2.10254
CSE1L CSE1 chromosome segregation 1-like (yeast) -2.10254
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 -2.09485
NLRX1 NLR family member X1 -2.07613
KIAA0930 KIAA0930 -2.06917
PIGT phosphatidylinositol glycan anchor biosynthesis, class T -2.06165
TMTC3 transmembrane and tetratricopeptide repeat containing 3 -2.06073
GSTO2 glutathione S-transferase omega 2 -2.03957
OTUD6B OTU domain containing 6B -2.02726
RCN1 reticulocalbin 1, EF-hand calcium binding domain -2.01621